iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-116530

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

ABQF01035020

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000008128.1	ENSTGUT00000008503.1	ENSTGUP00000008415.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.30e-136	453.5	473	805

Active Site

Position(s)	Description	Evidence
774	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 473  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 560
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ + ken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 561  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWTKEN---SLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 646
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev+ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 647  WRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDMNDWQKNTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 734
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 735  TGTCRLPVGGFAELIgvngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 805
           *********************************************************************96 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

VENRQLTLDL QTENKGSVVS GGELTVFLDS PAVALGSVPD GTAATEGECP VEPGRSGPSP 60
ALLLPSSGSA PSLAGSAPSL AASFSPCSSP NAGSQVPGRD PPSTAVATEG RHQPPSTNCF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGAGAACA GGCAGCTGAC CCTGGACCTG CAGACGGAGA ACAAAGGCAG CGTTGTGTCT 60
GGCGGGGAGC TGACGGTGTT CCTGGACAGC CCGGCTGTTG CTCTGGGCAG CGTTCCCGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	75.92	0.00e+00	1179.00
IUUC-Apl-003912	Anas platyrhynchos	71.53	0.00e+00	1119.00
IUUC-Aca-004291	Anolis carolinensis	74.23	0.00e+00	1174.00
IUUC-Bta-013231	Bos taurus	76.08	0.00e+00	1167.00
IUUC-Cja-019455	Callithrix jacchus	75.46	0.00e+00	1201.00
IUUC-Cfa-021017	Canis familiaris	75.62	0.00e+00	1171.00
IUUC-Cpo-021988	Cavia porcellus	74.51	0.00e+00	1177.00
IUUC-Csa-023549	Chlorocebus sabaeus	75.86	0.00e+00	1210.00
IUUC-Dre-028513	Danio rerio	86.87	0.00e+00	1045.00
IUUC-Dno-028976	Dasypus novemcinctus	76.11	0.00e+00	1177.00
IUUC-Dor-030176	Dipodomys ordii	73.33	0.00e+00	1117.00
IUUC-Eca-033949	Equus caballus	76.23	0.00e+00	1184.00
IUUC-Eeu-034529	Erinaceus europaeus	78.57	0.00e+00	962.00
IUUC-Fca-036236	Felis catus	76.48	0.00e+00	1197.00
IUUC-Fal-036948	Ficedula albicollis	83.95	0.00e+00	1262.00
IUUC-Gmo-038842	Gadus morhua	84.13	0.00e+00	976.00
IUUC-Gga-040617	Gallus gallus	82.01	0.00e+00	1293.00
IUUC-Gac-041338	Gasterosteus aculeatus	67.60	0.00e+00	1038.00
IUUC-Ggo-045278	Gorilla gorilla	75.99	0.00e+00	1214.00
IUUC-Hsa-046148	Homo sapiens	75.96	0.00e+00	1215.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	89.35	0.00e+00	995.00
IUUC-Lch-050663	Latimeria chalumnae	69.17	0.00e+00	1110.00
IUUC-Loc-052604	Lepisosteus oculatus	69.02	0.00e+00	1067.00
IUUC-Laf-053944	Loxodonta africana	75.74	0.00e+00	1192.00
IUUC-Mcc-055655	Macaca mulatta	75.74	0.00e+00	1209.00
IUUC-Meu-055953	Macropus eugenii	64.94	0.00e+00	995.00
IUUC-Mga-060190	Meleagris gallopavo	81.64	0.00e+00	1284.00
IUUC-Mmr-060896	Microcebus murinus	75.96	0.00e+00	1186.00
IUUC-Mdo-062536	Monodelphis domestica	76.75	0.00e+00	1229.00
IUUC-Mmu-064017	Mus musculus	75.71	0.00e+00	1176.00
IUUC-Mpu-066608	Mustela putorius furo	73.92	0.00e+00	1128.00
IUUC-Mlu-067623	Myotis lucifugus	73.40	0.00e+00	1137.00
IUUC-Nle-069496	Nomascus leucogenys	73.68	0.00e+00	1162.00
IUUC-Opr-071054	Ochotona princeps	89.58	0.00e+00	1058.00
IUUC-Ont-071279	Oreochromis niloticus	67.32	0.00e+00	1014.00
IUUC-Oan-073512	Ornithorhynchus anatinus	73.16	0.00e+00	1132.00
IUUC-Ocu-074271	Oryctolagus cuniculus	74.54	0.00e+00	1172.00
IUUC-Ola-087237	Oryzias latipes	65.43	0.00e+00	992.00
IUUC-Oga-088164	Otolemur garnettii	76.35	0.00e+00	1191.00
IUUC-Oar-089698	Ovis aries	75.83	0.00e+00	1167.00
IUUC-Ptr-091306	Pan troglodytes	74.51	0.00e+00	1182.00
IUUC-Pan-092814	Papio anubis	79.44	0.00e+00	1136.00
IUUC-Pfo-096709	Poecilia formosa	84.79	0.00e+00	985.00
IUUC-Pab-098494	Pongo abelii	73.77	0.00e+00	1165.00
IUUC-Pca-100596	Procavia capensis	73.26	0.00e+00	972.00
IUUC-Pva-103154	Pteropus vampyrus	80.85	0.00e+00	1058.00
IUUC-Rno-104954	Rattus norvegicus	75.59	0.00e+00	1168.00
IUUC-Sha-106781	Sarcophilus harrisii	76.66	0.00e+00	1241.00
IUUC-Ssc-116307	Sus scrofa	72.30	0.00e+00	1099.00
IUUC-Tbe-127793	Tupaia belangeri	72.42	0.00e+00	997.00
IUUC-Ttr-128275	Tursiops truncatus	89.93	0.00e+00	1073.00
IUUC-Xtr-132866	Xenopus tropicalis	77.85	0.00e+00	1023.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence