iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000229346.8	ENST00000428611.6	ENSP00000412370.2
ENSG00000229346.8	ENST00000448645.2	ENSP00000399446.2

Annotation

Cancer Mutation
TCGA	COSMIC	CGAP	IntOGen
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAF	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.30e-06	29.3	11	79
E3 activity/RING/RING	1.50e-07	33.5	16	61

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 3    peeflCpIslelMrdPvvlpsGitydrssIekwlasggk......tcPvtrqplteedlvPnltlrrli 65
            +e +CpI     r+Pv++ +G+ + r+++ ++ +  g       tcP++++p+++ ++ Pn  l +++
   Q: 11   ADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGPdleespTCPLCKEPFRPGSFRPNWQLANVV 79
           57899*****************************444444555579****************9987776 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw...pglknssskefrCPlCr 46
           C+iC+  +++ p++ +CgH f++ Cl ++   pg+      + +CPlC+
   Q: 16   CPICQGTLRE-PVTIDCGHNFCRACLTRYceiPGPD--LEESPTCPLCK 61
           ********99.*******************987777..889999****7 PP

Organism

Homo sapiens

Functional Description
(View)

Seems to play an important role in erythropoiesis.

Protein Sequence
(Fasta)

MASAASVTSL ADEVNCPICQ GTLREPVTID CGHNFCRACL TRYCEIPGPD LEESPTCPLC 60
KEPFRPGSFR PNWQLANVVE NIERLQLVST LGLGEEDVCQ EHGEKIYFFC EDDEMQLCVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGTGTGTGA CCCAGCCCTT CCCCCGTGGC CAAGCAGAGA GAGTGGCCTT GAGGAAGCCA 60
TAGCAGCAGG ACCAGCATGG CCTCTGCTGC CTCTGTGACC AGCCTGGCAG ATGAAGTCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0008270--F:zinc ion binding
GO:0030218--P:erythrocyte differentiation
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell

KEGG

hsa:10107

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002355	Ailuropoda melanoleuca	84.41	0.00e+00	812.00
IUUC-Bta-012587	Bos taurus	85.86	0.00e+00	828.00
IUUC-Cja-018721	Callithrix jacchus	95.63	0.00e+00	921.00
IUUC-Cfa-020759	Canis familiaris	82.56	0.00e+00	780.00
IUUC-Cpo-022485	Cavia porcellus	72.75	0.00e+00	688.00
IUUC-Csa-023679	Chlorocebus sabaeus	97.09	0.00e+00	936.00
IUUC-Cho-024918	Choloepus hoffmanni	70.00	3.00e-96	344.00
IUUC-Dno-028912	Dasypus novemcinctus	75.52	0.00e+00	751.00
IUUC-Dor-030459	Dipodomys ordii	78.05	0.00e+00	775.00
IUUC-Ete-032226	Echinops telfairi	84.32	2.00e-169	588.00
IUUC-Eca-034379	Equus caballus	86.28	0.00e+00	867.00
IUUC-Eeu-035312	Erinaceus europaeus	80.46	0.00e+00	798.00
IUUC-Fca-036106	Felis catus	80.04	0.00e+00	764.00
IUUC-Ggo-045433	Gorilla gorilla	98.96	0.00e+00	981.00
IUUC-Itr-048465	Ictidomys tridecemlineatus	83.50	0.00e+00	777.00
IUUC-Laf-054405	Loxodonta africana	87.71	0.00e+00	876.00
IUUC-Mcc-055599	Macaca mulatta	97.30	0.00e+00	939.00
IUUC-Meu-056471	Macropus eugenii	64.20	3.00e-125	441.00
IUUC-Mmr-061779	Microcebus murinus	78.96	0.00e+00	754.00
IUUC-Mdo-062384	Monodelphis domestica	75.00	0.00e+00	725.00
IUUC-Mmu-063430	Mus musculus	84.38	0.00e+00	814.00
IUUC-Mpu-066787	Mustela putorius furo	82.10	0.00e+00	783.00
IUUC-Mlu-067590	Myotis lucifugus	73.46	2.00e-123	434.00
IUUC-Nle-069295	Nomascus leucogenys	98.75	0.00e+00	953.00
IUUC-Opr-071186	Ochotona princeps	88.37	3.00e-88	318.00
IUUC-Oan-072904	Ornithorhynchus anatinus	40.93	4.00e-83	302.00
IUUC-Ocu-074896	Oryctolagus cuniculus	85.98	0.00e+00	663.00
IUUC-Oga-088589	Otolemur garnettii	89.17	0.00e+00	858.00
IUUC-Oar-089521	Ovis aries	85.17	0.00e+00	806.00
IUUC-Ptr-090905	Pan troglodytes	98.34	0.00e+00	971.00
IUUC-Pan-092682	Papio anubis	97.30	0.00e+00	912.00
IUUC-Pab-098559	Pongo abelii	97.83	0.00e+00	716.00
IUUC-Pca-100591	Procavia capensis	75.52	0.00e+00	729.00
IUUC-Pva-103067	Pteropus vampyrus	85.65	0.00e+00	803.00
IUUC-Rno-105824	Rattus norvegicus	83.33	0.00e+00	835.00
IUUC-Sha-107385	Sarcophilus harrisii	76.25	0.00e+00	758.00
IUUC-Sar-113541	Sorex araneus	87.58	1.00e-159	555.00
IUUC-Ssc-115893	Sus scrofa	85.48	0.00e+00	850.00
IUUC-Tsy-119290	Tarsius syrichta	90.24	2.00e-172	597.00
IUUC-Tbe-127565	Tupaia belangeri	82.97	5.00e-111	394.00
IUUC-Ttr-128456	Tursiops truncatus	84.62	0.00e+00	812.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence