iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000241322.9	ENST00000472534.1	ENSP00000468137.1
ENSG00000241322.9	ENST00000395906.7	ENSP00000379242.3
ENSG00000241322.9	ENST00000583965.5	ENSP00000462959.1
ENSG00000241322.9	ENST00000571263.2	ENSP00000463684.1
ENSG00000241322.9	ENST00000261644.8	ENSP00000261644.8
ENSG00000241322.9	ENST00000630868.1	ENSP00000486674.1

Annotation

Cancer Mutation
ICGC	COSMIC
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
AREsite	CircNet	microRNA	TRANSFAC
Protein-protein Interaction
IID
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.90e-28	97.4	493	530
UBD/Beta-Prp	1.50e-40	141.0	418	655

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvllks 38
           gH++ +tc+++ + ++lvsG++D+++kvWD++tg++lk+
   Q: 493  GHQGTITCMDL-CkNRLVSGGRDCQVKVWDVDTGKCLKT 530
           8**********.4489********************986 PP

UBD/Beta-Prp

   S: 16   vkfspdksllatgsrdgtikvwdvttgkll.rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsg 106
           +++  +++l+a++s +++i + d+ + k++  ++ gh + v+a+ + +++++l++gs D  i+ wdl++g c++++ gh+ +++++++++  
   Q: 418  IHY-SGGDLIAVSS-NRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK-- 505
           455.6778888887.***********99962567********************************************************.. PP
   S: 107  dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsg 198
           ++lvsG++d  ++vwd++tg+cl+ t+  h++ +  +++++   ++vs++  + v++W +++++l++tl+g h+++v++l fd+   +l+sg
   Q: 506  NRLVSGGRDCQVKVWDVDTGKCLK-TF-RHKDPILATRIND--TYIVSSCERGLVKVWHIAMAQLVKTLSG-HEGAVKCLFFDQ--WHLLSG 590
           ***********************9.55.5777888889988..***************************9.************..8***** PP
   S: 199  sldgtvklwdlq..tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn 264
           s+dg v  w++    ++c+++++  ++   +  ++    r++s+ +Dg iri++  +g+++k+++   
   Q: 591  STDGLVMAWSMVgkYERCLMAFKHPKEVLDVSLLF---LRVISACADGKIRIYNFFNGNCMKVIKANG 655
           ***********988899999998777666655555...89**********************998754 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MENLESRLKN APYFRCEKGT DSIPLCRKCE TRVLAWKIFS TKEWFCRIND ISQRRFLVGI 60
LKQLNSLYLL HYFQNILQTT QGKDFIYNRS RIDLSKKEGK VVKSSLNQML DKTVEQKMKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAAAACC TGGAATCAAG GCTCAAGAAT GCCCCCTATT TTCGTTGTGA GAAGGGAACC 60
GATTCCATCC CTCTATGCCG GAAGTGTGAG ACGCGTGTCT TAGCCTGGAA GATCTTCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

KEGG

hsa:374286

Orthology

iUUCD ID