iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	Circ2Traits	miRTarBase	microRNA
TRANSFAC	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	HINT	InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/ATG8	6.60e-47	159.6	15	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/ATG8

   S: 1    krkeevekirdkfpdkiPvivekakkeki.peldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnn.slvsvsatlaeiyeeekded 90
           +r+e+v+ ir+++p+kiPvi+e++k+ek+ p+ldk+k+lvP+++++++l+kiir+rlql+a++a+fllvn  s+vsvs++++e+ye+ekded
   Q: 15   QRVEDVRLIREQHPTKIPVIIERYKGEKQlPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGhSMVSVSTPISEVYESEKDED 106
           699*************************99****************************************99******************** PP
   S: 91   gflyvayaseetfG 104
           gfly++ as+etfG
   Q: 107  GFLYMVCASQETFG 120
           *************9 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).

Protein Sequence
(Fasta)

MPSEKTFKQR RTFEQRVEDV RLIREQHPTK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM 60
SELIKIIRRR LQLNANQAFF LLVNGHSMVS VSTPISEVYE SEKDEDGFLY MVCASQETFG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATACCTAAC TGCAAGAACT GCCGCATCCC TGGTGGTCTG ACCTTGTCTC TGAGCTAAGC 60
AGCAGATTTC AGCCACAGCG TCTGACTCTC AGGCAGACAC ATCCTGTCCA AGGACTGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0493--Microtubule
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0000421--C:autophagosome membrane
GO:0031410--C:cytoplasmic vesicle
GO:0012505--C:endomembrane system
GO:0005874--C:microtubule
GO:0006914--P:autophagy

KEGG

hsa:643246

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence