iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020191

Ensembl Protein ID

ENSCAFP00000017168.3

UniProt Accession

E2R0T3; E2R0T3_CANLF

Genbank Protein ID

ENSCAFP00000017168

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03011046

Gene Name

OTUD7B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000011671.3	ENSCAFT00000018535.3	ENSCAFP00000017168.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.90e-37	128.5	184	365
UBD/ZnF/ZnF_A20	1.10e-16	60.7	796	830

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek...........edekefcqklvepe.... 74
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al+  + + +++++ k+++++++++++k           ++e++++ kl+++e    
   Q: 184  LPLATTGDGNCLLHAASLGMWGFHDRDLmLRKALYALMEKGAEKEALKRRWRWQQTQQNKesglvytedewQKEWNELIKLASSEprmh 272
           6899********************************************************************************98887 PP
   S: 75   ...akg.................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYd 133
                g                 ee+h+f+La++L+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H++
   Q: 273  lgtN-GancggvespeepvyeslEEFHVFVLAHVLRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPASQcHRSPLVLAYDQAHFS 360
           7650.255579****************************************************************************** PP
   S: 134  aLval 138
           aLv++
   Q: 361  ALVSM 365
           **986 PP

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           +p++++Ck+ +C+fYG+petn++CS+Cyreelrrr
   Q: 796  PPTQTKCKQpNCSFYGHPETNNFCSCCYREELRRR 830
           59********************************9 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MTLDMDAVLS DFVRSTGAEP GLARDLLEGK NWDVSAALSD FEQLRQVHAG NLPPPFSEGS 60
GGSRTPEKGF SDRESARPPR PTLQRQDDVI QEKRLSRGIS HASSSIVSLA RSHVSSNGGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGGTCGGG GCGGGGCCGG GCGGGCGGAG GCCTGGGGGC GGCTGGGGTG TCACCACCAA 60
CCCGCTCCGG CCGGAAACTG GCGCTAGTTT CCGGCCGGAC GGCCGAAAGC CACCGATCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006955--P:immune response
GO:0002385--P:mucosal immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032717--P:negative regulation of interleukin-8 production
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

KEGG

cfa:483178

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002119	Ailuropoda melanoleuca	95.87	0.00e+00	1482.00
IUUC-Apl-003567	Anas platyrhynchos	65.07	0.00e+00	936.00
IUUC-Bta-013398	Bos taurus	95.02	0.00e+00	1432.00
IUUC-Cel-018468	Caenorhabditis elegans	50.16	5.00e-85	308.00
IUUC-Cja-019965	Callithrix jacchus	91.72	0.00e+00	1357.00
IUUC-Cpo-022232	Cavia porcellus	90.95	0.00e+00	1342.00
IUUC-Csa-023593	Chlorocebus sabaeus	93.71	0.00e+00	1456.00
IUUC-Cho-024729	Choloepus hoffmanni	85.17	4.00e-174	605.00
IUUC-Csv-026177	Ciona savignyi	30.56	4.00e-03	34.70
IUUC-Dno-029900	Dasypus novemcinctus	93.32	0.00e+00	1406.00
IUUC-Dor-031121	Dipodomys ordii	85.38	0.00e+00	691.00
IUUC-Ete-032473	Echinops telfairi	88.33	0.00e+00	1051.00
IUUC-Eca-033946	Equus caballus	96.14	0.00e+00	1072.00
IUUC-Eeu-034670	Erinaceus europaeus	92.76	0.00e+00	1378.00
IUUC-Fca-035871	Felis catus	95.97	0.00e+00	1380.00
IUUC-Fso-038203	Fusarium solani	30.93	1.90e-02	34.70
IUUC-Gmo-039373	Gadus morhua	77.25	0.00e+00	676.00
IUUC-Gga-041105	Gallus gallus	66.22	0.00e+00	969.00
IUUC-Gac-041806	Gasterosteus aculeatus	56.55	0.00e+00	813.00
IUUC-Ggo-045472	Gorilla gorilla	93.59	0.00e+00	1414.00
IUUC-Hsa-046473	Homo sapiens	93.36	0.00e+00	1415.00
IUUC-Itr-048841	Ictidomys tridecemlineatus	94.54	0.00e+00	1427.00
IUUC-Lch-050432	Latimeria chalumnae	63.81	0.00e+00	949.00
IUUC-Mcc-055261	Macaca mulatta	93.48	0.00e+00	1458.00
IUUC-Meu-056477	Macropus eugenii	79.97	0.00e+00	941.00
IUUC-Mga-059533	Meleagris gallopavo	68.06	0.00e+00	972.00
IUUC-Mdo-062847	Monodelphis domestica	82.94	0.00e+00	1150.00
IUUC-Mmu-064260	Mus musculus	88.74	0.00e+00	1307.00
IUUC-Mpu-066876	Mustela putorius furo	91.01	0.00e+00	1370.00
IUUC-Mlu-068039	Myotis lucifugus	93.84	0.00e+00	1425.00
IUUC-Nle-069260	Nomascus leucogenys	93.12	0.00e+00	1414.00
IUUC-Opr-070564	Ochotona princeps	91.84	0.00e+00	789.00
IUUC-Ocu-073824	Oryctolagus cuniculus	94.34	0.00e+00	954.00
IUUC-Ola-086490	Oryzias latipes	57.36	0.00e+00	763.00
IUUC-Oga-088124	Otolemur garnettii	93.96	0.00e+00	1417.00
IUUC-Oar-090086	Ovis aries	95.49	0.00e+00	1436.00
IUUC-Ptr-091622	Pan troglodytes	94.96	0.00e+00	1107.00
IUUC-Pan-092724	Papio anubis	93.36	0.00e+00	1452.00
IUUC-Psi-093333	Pelodiscus sinensis	63.93	0.00e+00	932.00
IUUC-Pab-098667	Pongo abelii	93.12	0.00e+00	1392.00
IUUC-Pca-100701	Procavia capensis	90.81	0.00e+00	731.00
IUUC-Pva-102136	Pteropus vampyrus	93.59	0.00e+00	1422.00
IUUC-Rno-105546	Rattus norvegicus	89.34	0.00e+00	1330.00
IUUC-Sha-106732	Sarcophilus harrisii	81.39	0.00e+00	1062.00
IUUC-Sar-113562	Sorex araneus	82.23	0.00e+00	1161.00
IUUC-Ssc-116191	Sus scrofa	95.14	0.00e+00	1425.00
IUUC-Tgu-116942	Taeniopygia guttata	76.81	0.00e+00	793.00
IUUC-Tsy-119343	Tarsius syrichta	85.73	0.00e+00	1239.00
IUUC-Tbe-127283	Tupaia belangeri	94.34	0.00e+00	769.00
IUUC-Ttr-128692	Tursiops truncatus	91.70	0.00e+00	1322.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence