iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mlu-068039

Ensembl Protein ID

ENSMLUP00000009878.2

UniProt Accession

G1PGU8; G1PGU8_MYOLU

Genbank Protein ID

ENSMLUP00000009878

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02030075

Gene Name

OTUD7B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000010828.2	ENSMLUT00000010836.2	ENSMLUP00000009878.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	7.10e-36	123.7	183	365
UBD/ZnF/ZnF_A20	7.60e-16	57.8	798	830

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs.llgvfddds.lsdalveaLreltseylqkesdffsefieek...........edekefcqklvepe... 74
           l+l+t+gDGnCLl+A+s + ++g++d+d+ l++al+  + + +++++ k+++++++++++k           ++e++++ kl+++e   
   Q: 183  LPLATTGDGNCLLHAASLAgMWGFHDRDLmLRKALYALMEKGAEKEALKRRWRWQQTQQNKesglvytedewQKEWNELIKLASSEprm 271
           6899************9766*****************************************************************9898 PP
   S: 75   ....akg.................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHY 132
                 g                 ee+h+f+La++L+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H+
   Q: 272  hlgtN-GancsgvesseepvyeslEEFHVFVLAHVLRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPASQcHRSPLVLAYDQAHF 359
           87650.255577***************************************************************************** PP
   S: 133  daLval 138
           +aLv++
   Q: 360  SALVSM 365
           ***986 PP

UBD/ZnF/ZnF_A20

   S: 3    skllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           ++++Ck+ +C+fYG+petn++CS+Cyreelrr+
   Q: 798  TQTKCKQpNCSFYGHPETNNFCSCCYREELRRK 830
           799****************************97 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MTLDMDAVLS DFVRSTGAEP GLARDLLEGK NWDVSAALSD FEQLRQVHAG ILPQSFSEGS 60
GASRNPEKGF SDRECTRPPR PTLQRQDDIV QEKRLSRGIS HASSSIVSLA RSHVSNGGGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTACATCC ATTGCCTGAC AGTACTTAAT GATCACATGA CCCTGGACAT GGATGCTGTC 60
CTGTCAGATT TTGTTCGTTC CACAGGAGCC GAGCCAGGGC TGGCCCGAGA TCTCCTGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0002385--P:mucosal immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032717--P:negative regulation of interleukin-8 production
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0035871--P:protein K11-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002119	Ailuropoda melanoleuca	93.81	0.00e+00	1444.00
IUUC-Apl-003567	Anas platyrhynchos	65.72	0.00e+00	945.00
IUUC-Aca-004392	Anolis carolinensis	55.05	0.00e+00	809.00
IUUC-Ame-011052	Astyanax mexicanus	64.52	0.00e+00	768.00
IUUC-Bta-013398	Bos taurus	94.79	0.00e+00	1422.00
IUUC-Cel-018468	Caenorhabditis elegans	50.65	2.00e-85	310.00
IUUC-Cja-019965	Callithrix jacchus	92.20	0.00e+00	1361.00
IUUC-Cfa-020191	Canis familiaris	93.84	0.00e+00	1417.00
IUUC-Cpo-022232	Cavia porcellus	90.60	0.00e+00	1328.00
IUUC-Csa-023593	Chlorocebus sabaeus	93.96	0.00e+00	1451.00
IUUC-Cho-024729	Choloepus hoffmanni	85.84	6.00e-172	597.00
IUUC-Csv-026177	Ciona savignyi	30.51	7.00e-03	33.90
IUUC-Dre-028617	Danio rerio	62.61	0.00e+00	763.00
IUUC-Dno-029900	Dasypus novemcinctus	93.20	0.00e+00	1392.00
IUUC-Dor-031121	Dipodomys ordii	83.80	0.00e+00	687.00
IUUC-Ete-032473	Echinops telfairi	88.65	0.00e+00	1047.00
IUUC-Eca-033946	Equus caballus	96.14	0.00e+00	1052.00
IUUC-Eeu-034670	Erinaceus europaeus	92.42	0.00e+00	1365.00
IUUC-Fca-035871	Felis catus	94.19	0.00e+00	1345.00
IUUC-Fal-037145	Ficedula albicollis	65.01	0.00e+00	786.00
IUUC-Gmo-039373	Gadus morhua	77.25	0.00e+00	684.00
IUUC-Gga-041105	Gallus gallus	67.61	0.00e+00	982.00
IUUC-Gac-041806	Gasterosteus aculeatus	56.74	0.00e+00	820.00
IUUC-Ggo-045472	Gorilla gorilla	93.84	0.00e+00	1400.00
IUUC-Hsa-046473	Homo sapiens	93.72	0.00e+00	1408.00
IUUC-Itr-048841	Ictidomys tridecemlineatus	94.31	0.00e+00	1416.00
IUUC-Lch-050432	Latimeria chalumnae	64.94	0.00e+00	963.00
IUUC-Loc-052841	Lepisosteus oculatus	74.71	0.00e+00	741.00
IUUC-Laf-053437	Loxodonta africana	62.20	0.00e+00	731.00
IUUC-Mcc-055261	Macaca mulatta	93.84	0.00e+00	1455.00
IUUC-Meu-056477	Macropus eugenii	80.39	0.00e+00	949.00
IUUC-Mga-059533	Meleagris gallopavo	69.65	0.00e+00	986.00
IUUC-Mmr-061437	Microcebus murinus	64.04	0.00e+00	777.00
IUUC-Mdo-062847	Monodelphis domestica	82.61	0.00e+00	1146.00
IUUC-Mmu-064260	Mus musculus	87.69	0.00e+00	1290.00
IUUC-Mpu-066876	Mustela putorius furo	89.01	0.00e+00	1331.00
IUUC-Nle-069260	Nomascus leucogenys	93.48	0.00e+00	1407.00
IUUC-Opr-070564	Ochotona princeps	90.05	0.00e+00	771.00
IUUC-Ont-072431	Oreochromis niloticus	73.54	0.00e+00	715.00
IUUC-Oan-073235	Ornithorhynchus anatinus	56.43	0.00e+00	755.00
IUUC-Ocu-073824	Oryctolagus cuniculus	94.17	0.00e+00	944.00
IUUC-Ola-087026	Oryzias latipes	63.27	0.00e+00	768.00
IUUC-Oga-088124	Otolemur garnettii	93.37	0.00e+00	1394.00
IUUC-Oar-090086	Ovis aries	95.38	0.00e+00	1425.00
IUUC-Ptr-091622	Pan troglodytes	95.44	0.00e+00	1102.00
IUUC-Pan-092724	Papio anubis	93.60	0.00e+00	1443.00
IUUC-Psi-093333	Pelodiscus sinensis	63.69	0.00e+00	945.00
IUUC-Pfo-096785	Poecilia formosa	73.63	0.00e+00	728.00
IUUC-Pab-098667	Pongo abelii	93.72	0.00e+00	1386.00
IUUC-Pca-100701	Procavia capensis	93.22	0.00e+00	741.00
IUUC-Pva-102136	Pteropus vampyrus	93.01	0.00e+00	1405.00
IUUC-Rno-105546	Rattus norvegicus	88.40	0.00e+00	1314.00
IUUC-Sha-106732	Sarcophilus harrisii	82.14	0.00e+00	1052.00
IUUC-Sar-113562	Sorex araneus	81.30	0.00e+00	1154.00
IUUC-Ssc-116191	Sus scrofa	95.02	0.00e+00	1414.00
IUUC-Tgu-116942	Taeniopygia guttata	75.50	0.00e+00	796.00
IUUC-Tru-118720	Takifugu rubripes	70.43	0.00e+00	676.00
IUUC-Tsy-119343	Tarsius syrichta	85.14	0.00e+00	1229.00
IUUC-Tni-120795	Tetraodon nigroviridis	72.57	0.00e+00	698.00
IUUC-Tbe-127283	Tupaia belangeri	94.35	0.00e+00	768.00
IUUC-Ttr-128692	Tursiops truncatus	91.59	0.00e+00	1306.00
IUUC-Xtr-132888	Xenopus tropicalis	62.95	0.00e+00	909.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence