iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066876

Ensembl Protein ID

ENSMPUP00000005365.1

UniProt Accession

M3Y214; M3Y214_MUSPF

Genbank Protein ID

ENSMPUP00000005365

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01089789

Gene Name

OTUD7B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000005404.1	ENSMPUT00000005454.1	ENSMPUP00000005365.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.00e-35	122.2	286	467
UBD/ZnF/ZnF_A20	1.10e-16	60.5	899	933

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieekedekefcqklvepeakg............ 77
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al+  + + +++++ k+++++++++++ke+e  f ++ +++e ++            
   Q: 286  LPLATTGDGNCLLHAASLGMWGFHDRDLmLRKALYALMEKGAEKEALKRRWRWQQTQQNKEQEVVFTESSASKELHAkrilegkrgava 374
           6899**********************************************************************443445666666999 PP
   S: 78   ......................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYda 134
                                 ee+h+f+La++L+rpi+vv++++l++         ++ggi+lpl++p ++ +++p+vL+Y+++H++a
   Q: 375  riqkgvrmswvesseepvyeslEEFHVFVLAHVLRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPVSQcHRSPLVLAYDQAHFSA 463
           99999************************************************************************************ PP
   S: 135  Lval 138
           Lv++
   Q: 464  LVSM 467
           *986 PP

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           +p++++Ck+ +C+fYG+petn++CS+Cyreelrrr
   Q: 899  PPTQTKCKQpNCSFYGHPETNNFCSCCYREELRRR 933
           59********************************9 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

RGVEQAKNHW GRPVLISAVW LQLLILCGAT AAVAVSATAS ASIVVGGGAS RTPGSQPRNE 60
ERRPGPALRP GLGPCPGSRE GGGLNFDLCP PYLSCLKVLN DHMTLDMDAV LSDFVRSTGA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGGTGTGG AGCAGGCAAA AAACCACTGG GGGAGGCCAG TCCTGATCAG TGCCGTCTGG 60
CTCCAGCTCC TGATCCTGTG CGGAGCAACA GCCGCGGTCG CAGTCTCCGC CACCGCCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0732--Signal

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0002385--P:mucosal immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032717--P:negative regulation of interleukin-8 production
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0035871--P:protein K11-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002119	Ailuropoda melanoleuca	91.45	0.00e+00	1402.00
IUUC-Apl-003567	Anas platyrhynchos	62.74	0.00e+00	866.00
IUUC-Bta-013398	Bos taurus	90.65	0.00e+00	1344.00
IUUC-Cja-019965	Callithrix jacchus	87.49	0.00e+00	1269.00
IUUC-Cfa-020191	Canis familiaris	91.60	0.00e+00	1359.00
IUUC-Cpo-022232	Cavia porcellus	86.71	0.00e+00	1258.00
IUUC-Csa-023593	Chlorocebus sabaeus	89.11	0.00e+00	1360.00
IUUC-Cho-024729	Choloepus hoffmanni	82.74	1.00e-168	587.00
IUUC-Csv-026177	Ciona savignyi	30.56	7.00e-03	33.90
IUUC-Dno-029900	Dasypus novemcinctus	87.57	0.00e+00	1351.00
IUUC-Dor-031121	Dipodomys ordii	78.19	5.00e-176	610.00
IUUC-Ete-032473	Echinops telfairi	81.19	0.00e+00	968.00
IUUC-Eca-033946	Equus caballus	89.89	0.00e+00	982.00
IUUC-Eeu-034670	Erinaceus europaeus	88.06	0.00e+00	1305.00
IUUC-Fca-035871	Felis catus	91.12	0.00e+00	1290.00
IUUC-Fso-038203	Fusarium solani	29.90	1.50e-01	32.00
IUUC-Gmo-039373	Gadus morhua	71.67	6.00e-176	611.00
IUUC-Gga-041105	Gallus gallus	65.05	0.00e+00	915.00
IUUC-Ggo-045472	Gorilla gorilla	88.45	0.00e+00	1332.00
IUUC-Hsa-046473	Homo sapiens	88.52	0.00e+00	1318.00
IUUC-Itr-048841	Ictidomys tridecemlineatus	90.18	0.00e+00	1338.00
IUUC-Lch-050432	Latimeria chalumnae	60.70	0.00e+00	872.00
IUUC-Mcc-055261	Macaca mulatta	88.88	0.00e+00	1361.00
IUUC-Meu-056477	Macropus eugenii	75.69	0.00e+00	842.00
IUUC-Mga-059533	Meleagris gallopavo	65.19	0.00e+00	915.00
IUUC-Mdo-062847	Monodelphis domestica	78.97	0.00e+00	1065.00
IUUC-Mmu-064260	Mus musculus	85.80	0.00e+00	1240.00
IUUC-Mlu-068039	Myotis lucifugus	89.13	0.00e+00	1332.00
IUUC-Nle-069260	Nomascus leucogenys	88.17	0.00e+00	1316.00
IUUC-Opr-070564	Ochotona princeps	84.58	0.00e+00	705.00
IUUC-Ocu-073824	Oryctolagus cuniculus	87.16	0.00e+00	863.00
IUUC-Oga-088124	Otolemur garnettii	89.13	0.00e+00	1326.00
IUUC-Oar-090086	Ovis aries	91.24	0.00e+00	1350.00
IUUC-Ptr-091622	Pan troglodytes	88.38	0.00e+00	1012.00
IUUC-Pan-092724	Papio anubis	88.88	0.00e+00	1357.00
IUUC-Psi-093333	Pelodiscus sinensis	60.78	0.00e+00	892.00
IUUC-Pab-098667	Pongo abelii	88.28	0.00e+00	1294.00
IUUC-Pca-100701	Procavia capensis	89.98	0.00e+00	723.00
IUUC-Pva-102136	Pteropus vampyrus	88.52	0.00e+00	1316.00
IUUC-Rno-105546	Rattus norvegicus	86.39	0.00e+00	1254.00
IUUC-Sha-106732	Sarcophilus harrisii	79.22	0.00e+00	982.00
IUUC-Sar-113562	Sorex araneus	78.75	0.00e+00	1078.00
IUUC-Ssc-116191	Sus scrofa	90.30	0.00e+00	1332.00
IUUC-Tsy-119343	Tarsius syrichta	84.63	0.00e+00	1062.00
IUUC-Tbe-127283	Tupaia belangeri	77.22	0.00e+00	720.00
IUUC-Ttr-128692	Tursiops truncatus	91.01	0.00e+00	1307.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence