iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088124

Ensembl Protein ID

ENSOGAP00000016541.1

UniProt Accession

H0XKA1; H0XKA1_OTOGA

Genbank Protein ID

ENSOGAP00000016541

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03162481

Gene Name

OTUD7B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000030526.1	ENSOGAT00000034906.1	ENSOGAP00000016541.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	4.50e-37	127.5	185	366
UBD/ZnF/ZnF_A20	9.40e-17	60.7	797	831

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek...........edekefcqklvepe.... 74
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al+  + + +++++ k+++++++++++k           ++e++++ kl+++e    
   Q: 185  LPLATTGDGNCLLHAASLGMWGFHDRDLmLRKALYALMEKGVEKEALKRRWRWQQTQQNKesglvyteeewQKEWNELIKLASSEprmh 273
           6899********************************************************************************98877 PP
   S: 75   ...akg.................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYd 133
                g                 ee+h+f+La++L+rpi+vv++++l++         ++ggi+lpl++p ++ +++p+vL+Y+++H++
   Q: 274  lgtN-GtncggvesseepvyeslEEFHVFVLAHVLRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPVNQcHRSPLVLAYDQAHFS 361
           7540.366688****************************************************************************** PP
   S: 134  aLval 138
           aLv++
   Q: 362  ALVSM 366
           **986 PP

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           +p++++Ck+ +C+fYG+petn++CS+Cyreelrrr
   Q: 797  PPTQTKCKQpNCSFYGHPETNNFCSCCYREELRRR 831
           59********************************9 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MTLDMDAVLS DFVRSTGAEP GLARDLLEGK NWDVSAALSD FEQLRQVHAG NLPPPFSEGS 60
GGSRTSEKGF SDKESTRPPR PVLQRQDDII QAEKRLSRGI SHASSSIVSL ARSHVSSNGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATCCTGGAC CAGCCGCCGT AGTCGGAGTG GCAACCGGGT GTGGAACGGG CAAAAAGCCA 60
CTGGGGGAGG CCAGTCAAGA TCAGTCCCGT CCGGCTTCAG CTCTAGATCC TGTGCGGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0002385--P:mucosal immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032717--P:negative regulation of interleukin-8 production
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0035871--P:protein K11-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002119	Ailuropoda melanoleuca	93.69	0.00e+00	1452.00
IUUC-Apl-003567	Anas platyrhynchos	65.49	0.00e+00	944.00
IUUC-Bta-013398	Bos taurus	94.19	0.00e+00	1411.00
IUUC-Cel-018468	Caenorhabditis elegans	49.67	1.00e-83	304.00
IUUC-Cja-019965	Callithrix jacchus	92.43	0.00e+00	1368.00
IUUC-Cfa-020191	Canis familiaris	93.96	0.00e+00	1423.00
IUUC-Cpo-022232	Cavia porcellus	90.96	0.00e+00	1339.00
IUUC-Csa-023593	Chlorocebus sabaeus	94.08	0.00e+00	1459.00
IUUC-Cho-024729	Choloepus hoffmanni	84.27	2.00e-168	585.00
IUUC-Dno-029900	Dasypus novemcinctus	92.72	0.00e+00	1386.00
IUUC-Dor-031121	Dipodomys ordii	84.03	0.00e+00	684.00
IUUC-Ete-032473	Echinops telfairi	88.35	0.00e+00	1036.00
IUUC-Eca-033946	Equus caballus	94.53	0.00e+00	1046.00
IUUC-Eeu-034670	Erinaceus europaeus	91.35	0.00e+00	1354.00
IUUC-Fca-035871	Felis catus	94.19	0.00e+00	1360.00
IUUC-Fso-038203	Fusarium solani	29.59	1.50e-01	32.00
IUUC-Gmo-039373	Gadus morhua	77.04	0.00e+00	681.00
IUUC-Gga-041105	Gallus gallus	67.68	0.00e+00	976.00
IUUC-Gac-041806	Gasterosteus aculeatus	56.72	0.00e+00	811.00
IUUC-Ggo-045472	Gorilla gorilla	94.19	0.00e+00	1416.00
IUUC-Hsa-046473	Homo sapiens	93.96	0.00e+00	1417.00
IUUC-Itr-048841	Ictidomys tridecemlineatus	95.14	0.00e+00	1427.00
IUUC-Lch-050432	Latimeria chalumnae	63.86	0.00e+00	953.00
IUUC-Mcc-055261	Macaca mulatta	93.84	0.00e+00	1461.00
IUUC-Meu-056477	Macropus eugenii	79.74	0.00e+00	944.00
IUUC-Mga-059533	Meleagris gallopavo	69.03	0.00e+00	982.00
IUUC-Mdo-062847	Monodelphis domestica	82.61	0.00e+00	1144.00
IUUC-Mmu-064260	Mus musculus	88.17	0.00e+00	1299.00
IUUC-Mpu-066876	Mustela putorius furo	89.01	0.00e+00	1340.00
IUUC-Mlu-068039	Myotis lucifugus	93.37	0.00e+00	1408.00
IUUC-Nle-069260	Nomascus leucogenys	93.72	0.00e+00	1415.00
IUUC-Opr-070564	Ochotona princeps	90.72	0.00e+00	781.00
IUUC-Ocu-073824	Oryctolagus cuniculus	94.51	0.00e+00	952.00
IUUC-Ola-086490	Oryzias latipes	75.05	0.00e+00	694.00
IUUC-Oar-090086	Ovis aries	94.55	0.00e+00	1415.00
IUUC-Ptr-091622	Pan troglodytes	94.81	0.00e+00	1095.00
IUUC-Pan-092724	Papio anubis	93.84	0.00e+00	1455.00
IUUC-Psi-093333	Pelodiscus sinensis	64.58	0.00e+00	945.00
IUUC-Pab-098667	Pongo abelii	93.60	0.00e+00	1392.00
IUUC-Pca-100701	Procavia capensis	91.90	0.00e+00	729.00
IUUC-Pva-102136	Pteropus vampyrus	92.65	0.00e+00	1396.00
IUUC-Rno-105546	Rattus norvegicus	88.99	0.00e+00	1322.00
IUUC-Sha-106732	Sarcophilus harrisii	82.14	0.00e+00	1059.00
IUUC-Sar-113562	Sorex araneus	81.07	0.00e+00	1145.00
IUUC-Ssc-116191	Sus scrofa	94.08	0.00e+00	1402.00
IUUC-Tgu-116942	Taeniopygia guttata	76.85	0.00e+00	806.00
IUUC-Tru-117911	Takifugu rubripes	77.56	0.00e+00	722.00
IUUC-Tsy-119343	Tarsius syrichta	85.26	0.00e+00	1233.00
IUUC-Tbe-127283	Tupaia belangeri	95.21	0.00e+00	777.00
IUUC-Ttr-128692	Tursiops truncatus	91.00	0.00e+00	1303.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence