iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000028098.13	ENSMUST00000029740.13	ENSMUSP00000029740.9
ENSMUSG00000028098.13	ENSMUST00000199051.4	ENSMUSP00000143321.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.00e-08	36.7	229	270

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C+ed+  ++ ++ lpC+H+fh +C+  w         +++CP+Cr
   Q: 229  CPVCKEDYtvEEKVRQLPCNHFFHSSCIVPW------LELHDTCPVCR 270
           ********99566******************......**********8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.

Protein Sequence
(Fasta)

MAEASAAGAD AGSAVAAHRF FCHFCKGEVN PKLPEYICPR CDSGFIEEVT DDSSFLGGGG 60
SRTDNSTATH FAELWDHLDH TMFLQDFRPF LSSNPLDQDN RANERGHQTH TDFWGPSRPP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGACTCAC GTGACCCTTG CGGGCCTCGG AGCGGCGGGC CGCCCAGAGG AGGCGGCGAC 60
GGCGGTGGCG ACCGCAGCAC GGGAGGTAGC GGCCTGGGGA GGGACCGCCG GCCGCCCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

mmu:67845

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000079	Aegilops tauschii	29.96	6.00e-26	111.00
IUUC-Aml-002035	Ailuropoda melanoleuca	95.14	6.00e-158	549.00
IUUC-Apl-003694	Anas platyrhynchos	69.90	3.00e-90	324.00
IUUC-Aca-004365	Anolis carolinensis	77.98	1.00e-43	167.00
IUUC-Aly-006495	Arabidopsis lyrata	29.89	2.00e-21	96.30
IUUC-Ath-006961	Arabidopsis thaliana	30.50	1.00e-22	100.00
IUUC-Ate-010398	Aspergillus terreus	38.66	4.00e-18	86.30
IUUC-Ame-011898	Astyanax mexicanus	53.52	3.00e-76	278.00
IUUC-Bta-013190	Bos taurus	82.64	9.00e-131	459.00
IUUC-Bci-013958	Botrytis cinerea	36.19	3.00e-17	83.60
IUUC-Bdi-014806	Brachypodium distachyon	26.60	5.00e-24	105.00
IUUC-Bol-016085	Brassica oleracea	32.27	2.00e-29	123.00
IUUC-Bra-016939	Brassica rapa	31.67	4.00e-29	121.00
IUUC-Cja-020001	Callithrix jacchus	90.97	6.00e-151	526.00
IUUC-Cfa-020882	Canis familiaris	95.12	4.00e-157	547.00
IUUC-Cpo-021690	Cavia porcellus	87.18	6.00e-117	413.00
IUUC-Csa-024004	Chlorocebus sabaeus	93.75	6.00e-148	516.00
IUUC-Cho-024643	Choloepus hoffmanni	92.55	6.00e-80	290.00
IUUC-Cin-025452	Ciona intestinalis	41.18	3.00e-19	87.40
IUUC-Csv-025892	Ciona savignyi	38.10	7.00e-22	96.30
IUUC-Dre-027515	Danio rerio	58.68	7.00e-85	306.00
IUUC-Dno-029010	Dasypus novemcinctus	94.79	2.00e-157	548.00
IUUC-Dor-030147	Dipodomys ordii	85.24	1.00e-135	475.00
IUUC-Dse-031376	Dothistroma septosporum	34.53	2.00e-17	84.30
IUUC-Dme-031601	Drosophila melanogaster	55.56	2.00e-35	142.00
IUUC-Ete-032392	Echinops telfairi	91.30	7.00e-79	286.00
IUUC-Eca-033803	Equus caballus	95.57	2.00e-146	511.00
IUUC-Eeu-034831	Erinaceus europaeus	76.79	2.00e-99	355.00
IUUC-Fca-036192	Felis catus	94.10	7.00e-165	572.00
IUUC-Gmo-039513	Gadus morhua	59.12	8.00e-92	330.00
IUUC-Gga-040282	Gallus gallus	77.35	9.00e-78	282.00
IUUC-Gac-041784	Gasterosteus aculeatus	59.43	2.00e-91	328.00
IUUC-Ggo-044873	Gorilla gorilla	93.40	3.00e-147	514.00
IUUC-Hsa-045780	Homo sapiens	93.06	3.00e-147	514.00
IUUC-Hvu-047180	Hordeum vulgare	47.17	2.00e-21	96.70
IUUC-Itr-048142	Ictidomys tridecemlineatus	93.36	7.00e-141	492.00
IUUC-Lch-050673	Latimeria chalumnae	77.85	4.00e-133	467.00
IUUC-Laf-054384	Loxodonta africana	92.71	5.00e-142	496.00
IUUC-Mcc-055137	Macaca mulatta	93.75	6.00e-148	516.00
IUUC-Meu-056635	Macropus eugenii	88.19	4.00e-118	417.00
IUUC-Mtr-058295	Medicago truncatula	41.94	2.00e-21	96.30
IUUC-Mla-058832	Melampsora laricipopulina	45.57	2.00e-14	72.00
IUUC-Mmr-060631	Microcebus murinus	96.88	3.00e-169	587.00
IUUC-Mdo-062489	Monodelphis domestica	89.24	8.00e-133	466.00
IUUC-Mpu-066575	Mustela putorius furo	95.14	5.00e-166	576.00
IUUC-Mlu-067024	Myotis lucifugus	88.93	1.00e-145	508.00
IUUC-Ncr-068908	Neurospora crassa	31.51	5.00e-18	85.90
IUUC-Nle-069348	Nomascus leucogenys	92.01	1.00e-143	502.00
IUUC-Opr-070812	Ochotona princeps	87.15	3.00e-150	524.00
IUUC-Ont-072555	Oreochromis niloticus	61.01	1.00e-87	316.00
IUUC-Ocu-074691	Oryctolagus cuniculus	95.49	7.00e-155	539.00
IUUC-Ola-087047	Oryzias latipes	62.41	1.00e-99	355.00
IUUC-Oga-089111	Otolemur garnettii	94.81	2.00e-150	524.00
IUUC-Oar-089999	Ovis aries	82.99	2.00e-131	462.00
IUUC-Ptr-091473	Pan troglodytes	93.06	6.00e-147	513.00
IUUC-Pan-092618	Papio anubis	81.25	8.00e-120	422.00
IUUC-Psi-093930	Pelodiscus sinensis	82.76	1.00e-118	419.00
IUUC-Pma-094530	Petromyzon marinus	50.94	9.00e-65	239.00
IUUC-Pno-094903	Phaeosphaeria nodorum	41.03	7.00e-18	85.10
IUUC-Pfo-096461	Poecilia formosa	69.70	3.00e-65	241.00
IUUC-Pab-098466	Pongo abelii	93.75	3.00e-148	517.00
IUUC-Pop-100026	Populus trichocarpa	30.23	2.00e-25	109.00
IUUC-Pca-100550	Procavia capensis	76.39	5.00e-117	413.00
IUUC-Pva-102881	Pteropus vampyrus	92.36	3.00e-153	534.00
IUUC-Rno-104914	Rattus norvegicus	99.65	3.00e-174	603.00
IUUC-Sha-107616	Sarcophilus harrisii	89.30	3.00e-120	424.00
IUUC-Sja-107922	Schizosaccharomyces japonicus	45.19	5.00e-23	102.00
IUUC-Spo-108354	Schizosaccharomyces pombe	34.18	8.00e-25	108.00
IUUC-Smo-109522	Selaginella moellendorffii	51.43	5.00e-20	88.60
IUUC-Sly-111262	Solanum lycopersicum	29.84	2.00e-25	109.00
IUUC-Stu-112897	Solanum tuberosum	30.23	1.00e-24	106.00
IUUC-Sar-113319	Sorex araneus	72.22	1.00e-62	233.00
IUUC-Sre-115230	Sporisorium reilianum	38.79	5.00e-18	85.90
IUUC-Ssc-115917	Sus scrofa	84.38	5.00e-137	480.00
IUUC-Tgu-117105	Taeniopygia guttata	90.55	2.00e-67	246.00
IUUC-Tsy-119630	Tarsius syrichta	85.26	1.00e-141	495.00
IUUC-Tni-120265	Tetraodon nigroviridis	64.48	8.00e-105	373.00
IUUC-Tca-120938	Theobroma cacao	40.65	7.00e-21	94.70
IUUC-Tae-122764	Triticum aestivum	46.23	5.00e-21	95.10
IUUC-Tur-125986	Triticum urartu	29.57	2.00e-24	107.00
IUUC-Tme-127143	Tuber melanosporum	46.85	4.00e-28	118.00
IUUC-Tbe-127794	Tupaia belangeri	73.71	4.00e-104	370.00
IUUC-Ttr-129117	Tursiops truncatus	82.64	1.00e-125	442.00
IUUC-Uma-129414	Ustilago maydis	35.83	2.00e-17	84.30
IUUC-Vpa-130755	Vicugna pacos	80.81	4.00e-118	417.00
IUUC-Xtr-132520	Xenopus tropicalis	75.18	1.00e-100	358.00
IUUC-Xma-133074	Xiphophorus maculatus	69.09	8.00e-65	240.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence