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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046131
UUCD1 version UUC-HoS-00326
Ensembl Protein ID ENSP00000430872.1
UniProt Accession Q99619; B7Z4W1; D3DUT0; SPSB2_HUMAN
Genbank Protein ID AAL57346.1; BAH12697.1; AAB51328.1; EAW88719.1; EAW88720.1; AAH02983.1; AAH71933.1
Protein Name SPRY domain-containing SOCS box protein 2; Gene-rich cluster protein C9
Genbank Nucleotide ID AF403027; AK297963; U47924; CH471116; CH471116; BC002983; BC071933
Gene Name SPSB2; GRCC9; SSB2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000111671.9 ENST00000523102.5 ENSP00000430872.1
ENSG00000111671.9 ENST00000519357.1 ENSP00000431037.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpressTCGAICGCCOSMIC
THPA
DNA & RNA Element
UTRdbcircBaseCircNetTRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 20603330
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 1.50e-15 58.4 219 263
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 6    llrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           ++r ep+SL hL+Rl++r+ lg++rl ++++LPLP+++k+YLly+
   Q: 219  ERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPLPPAMKRYLLYQ 263
           7899****************************************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MGQTALAGGS SSTPTPQALY PDLSCPEGLE ELLSAPPPDL GAQRRHGWNP KDCSENIEVK 60
EGGLYFERRP VAQSTDGARG KRGYSRGLHA WEISWPLEQR GTHAVVGVAT ALAPLQTDHY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046131|E3,SOCS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCAAAAAAAA GAAAAATTAC TGGTGAAAAG GCCATCTTCC AGAATACCAT GAGGTTAGTG 60
GTTGCTATCT TCTGGGGAAA GATGCCCAAC TGCATTTAAT ATTTCCAAAC TAGAAACACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046131|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR001496--SOCS_box
IPR003877--SPRY_dom
PROSITE

PS50188--B302_SPRY
PS50225--SOCS
Pfam

PF07525--SOCS_box
PF00622--SPRY
SMART

SM00253--SOCS
SM00969--SOCS_box
SM00449--SPRY
Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination
KEGG hsa:84727
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001366 Ailuropoda melanoleuca 94.68 9.00e-133 466.00
IUUC-Cja-019350 Callithrix jacchus 96.96 3.00e-147 513.00
IUUC-Cfa-020542 Canis familiaris 95.44 5.00e-144 503.00
IUUC-Cpo-021754 Cavia porcellus 92.78 1.00e-139 488.00
IUUC-Cho-024374 Choloepus hoffmanni 91.37 1.00e-66 244.00
IUUC-Dno-029997 Dasypus novemcinctus 94.30 8.00e-116 409.00
IUUC-Eeu-034632 Erinaceus europaeus 90.87 1.00e-134 471.00
IUUC-Fca-035539 Felis catus 94.51 1.00e-126 445.00
IUUC-Gma-042785 Glycine max 43.33 5.30e-02 29.30
IUUC-Ggo-044949 Gorilla gorilla 99.62 1.00e-151 528.00
IUUC-Itr-048113 Ictidomys tridecemlineatus 95.45 2.00e-143 501.00
IUUC-Laf-053755 Loxodonta africana 95.82 2.00e-137 481.00
IUUC-Mcc-055467 Macaca mulatta 85.55 1.00e-122 432.00
IUUC-Meu-056625 Macropus eugenii 85.28 2.00e-114 404.00
IUUC-Mmr-061190 Microcebus murinus 97.34 1.00e-138 485.00
IUUC-Mmu-063210 Mus musculus 90.53 9.00e-136 475.00
IUUC-Mpu-066662 Mustela putorius furo 94.30 2.00e-142 497.00
IUUC-Nle-069267 Nomascus leucogenys 98.86 8.00e-151 525.00
IUUC-Opr-070650 Ochotona princeps 84.79 3.00e-111 394.00
IUUC-Ocu-073993 Oryctolagus cuniculus 95.06 3.00e-143 500.00
IUUC-Oga-089049 Otolemur garnettii 94.30 5.00e-135 473.00
IUUC-Pab-098113 Pongo abelii 99.24 4.00e-151 526.00
IUUC-Pca-100149 Procavia capensis 96.83 2.00e-122 431.00
IUUC-Pva-102664 Pteropus vampyrus 95.44 5.00e-135 473.00
IUUC-Rno-105741 Rattus norvegicus 91.29 6.00e-126 443.00
IUUC-Sha-107519 Sarcophilus harrisii 84.21 2.00e-111 394.00
IUUC-Ssc-115687 Sus scrofa 94.68 2.00e-142 498.00
IUUC-Tsy-119519 Tarsius syrichta 69.07 1.00e-82 299.00
IUUC-Tur-126737 Triticum urartu 26.14 4.00e-01 29.30
Created Date 25-Jun-2017

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