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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046549
UUCD1 version UUC-HoS-01256
Ensembl Protein ID ENSP00000452871.1
UniProt Accession Q04726; B4DPT0; E9PD64; F8W964; Q6PI57; Q8IVV6; Q8WVR2; Q9HCM5; TLE3_HUMAN
Genbank Protein ID AAA61194.1; BAB13373.1; BAG60692.1; AAH41831.1; AAH43247.1
Protein Name Transducin-like enhancer protein 3; Enhancer of split groucho-like protein 3
Genbank Nucleotide ID M99438; AB046767; AK315058; AC026583; BC043247
Gene Name TLE3; KIAA1547
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000140332.15 ENST00000558939.5 ENSP00000452871.1
ENSG00000140332.15 ENST00000317509.12 ENSP00000319233.8
ENSG00000140332.15 ENST00000557919.5 ENSP00000452803.1
ENSG00000140332.15 ENST00000560525.5 ENSP00000453219.1
ENSG00000140332.15 ENST00000559929.5 ENSP00000453081.1
ENSG00000140332.15 ENST00000559048.5 ENSP00000453760.1
ENSG00000140332.15 ENST00000560939.5 ENSP00000452933.1
ENSG00000140332.15 ENST00000557997.5 ENSP00000453083.1
ENSG00000140332.15 ENST00000561453.5 ENSP00000453373.1
ENSG00000140332.15 ENST00000539550.5 ENSP00000442594.1
ENSG00000140332.15 ENST00000558201.5 ENSP00000452881.1
ENSG00000140332.15 ENST00000440567.7 ENSP00000415057.3
ENSG00000140332.15 ENST00000558379.5 ENSP00000453435.1
ENSG00000140332.15 ENST00000451782.6 ENSP00000394717.2
ENSG00000140332.15 ENST00000557984.5 ENSP00000452809.1
ENSG00000140332.15 ENST00000537387.2 ENSP00000456178.1
ENSG00000140332.15 ENST00000627388.2 ENSP00000485965.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPMSZDB
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17041588; 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.80e-21 76.4 616 654
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 616  GHTDGASCIDIsHDgTKLWTGGLDNTVRSWDLREGRQLQ 654
           8**********9888*********************998 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
 Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
Protein Sequence
(Fasta)
MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 60
YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046549|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TATAATATAT ATCTATTTAT TATATGTCTT TCGGTTAATT CCTGATCTGA GGAGCGCTGT 60
TTTTCACTCC CATGCGAAAG TCACCAGCGG GTAGGGCCTG ATTGCTACTT TTCATGCATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046549|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat
KW-0879--Wnt signaling pathway
Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF03920--TLE_N
PF00400--WD40
PRINTS

PR01850--GROUCHOFAMLY
SMART

SM00320--WD40
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0009887--P:animal organ morphogenesis
GO:1904837--P:beta-catenin-TCF complex assembly
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007165--P:signal transduction
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway
KEGG hsa:7090
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002200 Ailuropoda melanoleuca 98.70 0.00e+00 1377.00
IUUC-Aca-005074 Anolis carolinensis 92.98 0.00e+00 1050.00
IUUC-Ame-010724 Astyanax mexicanus 87.81 0.00e+00 1258.00
IUUC-Bta-013189 Bos taurus 99.09 0.00e+00 1393.00
IUUC-Cja-018781 Callithrix jacchus 99.87 0.00e+00 1407.00
IUUC-Cfa-021016 Canis familiaris 98.47 0.00e+00 1304.00
IUUC-Cpo-021793 Cavia porcellus 96.76 0.00e+00 1366.00
IUUC-Csa-023928 Chlorocebus sabaeus 99.48 0.00e+00 1397.00
IUUC-Cin-025767 Ciona intestinalis 57.75 2.00e-169 589.00
IUUC-Dre-028595 Danio rerio 89.64 0.00e+00 1254.00
IUUC-Dno-029736 Dasypus novemcinctus 93.23 0.00e+00 1242.00
IUUC-Dor-030787 Dipodomys ordii 92.71 0.00e+00 1060.00
IUUC-Ete-032685 Echinops telfairi 96.34 0.00e+00 1310.00
IUUC-Eca-033249 Equus caballus 97.93 0.00e+00 1363.00
IUUC-Fca-036239 Felis catus 98.87 0.00e+00 1275.00
IUUC-Gmo-039000 Gadus morhua 83.89 0.00e+00 1136.00
IUUC-Gac-041924 Gasterosteus aculeatus 89.18 0.00e+00 1236.00
IUUC-Ggo-044458 Gorilla gorilla 98.69 0.00e+00 1412.00
IUUC-Itr-048755 Ictidomys tridecemlineatus 98.59 0.00e+00 1203.00
IUUC-Lch-050110 Latimeria chalumnae 92.76 0.00e+00 1253.00
IUUC-Loc-052165 Lepisosteus oculatus 92.26 0.00e+00 1281.00
IUUC-Laf-053817 Loxodonta africana 97.80 0.00e+00 1405.00
IUUC-Mcc-055673 Macaca mulatta 97.57 0.00e+00 1407.00
IUUC-Meu-056601 Macropus eugenii 95.98 0.00e+00 1375.00
IUUC-Mga-059792 Meleagris gallopavo 84.64 0.00e+00 1028.00
IUUC-Mmr-060904 Microcebus murinus 97.31 0.00e+00 1399.00
IUUC-Mdo-061897 Monodelphis domestica 93.34 0.00e+00 1334.00
IUUC-Mmu-063702 Mus musculus 97.06 0.00e+00 1366.00
IUUC-Mpu-066618 Mustela putorius furo 99.22 0.00e+00 1393.00
IUUC-Mlu-067934 Myotis lucifugus 98.19 0.00e+00 1370.00
IUUC-Nle-069452 Nomascus leucogenys 99.48 0.00e+00 1396.00
IUUC-Opr-070854 Ochotona princeps 92.88 0.00e+00 1206.00
IUUC-Ont-071865 Oreochromis niloticus 89.55 0.00e+00 1268.00
IUUC-Ocu-074091 Oryctolagus cuniculus 98.44 0.00e+00 1351.00
IUUC-Ola-086424 Oryzias latipes 89.69 0.00e+00 1256.00
IUUC-Oga-088548 Otolemur garnettii 96.67 0.00e+00 1378.00
IUUC-Oar-089856 Ovis aries 97.15 0.00e+00 1362.00
IUUC-Ptr-090848 Pan troglodytes 99.48 0.00e+00 1395.00
IUUC-Pan-092288 Papio anubis 98.83 0.00e+00 1379.00
IUUC-Psi-093427 Pelodiscus sinensis 94.83 0.00e+00 1321.00
IUUC-Pfo-096613 Poecilia formosa 89.59 0.00e+00 1268.00
IUUC-Pab-098175 Pongo abelii 99.61 0.00e+00 1399.00
IUUC-Pca-100321 Procavia capensis 97.67 0.00e+00 1391.00
IUUC-Pva-102741 Pteropus vampyrus 92.88 0.00e+00 1288.00
IUUC-Rno-104864 Rattus norvegicus 98.19 0.00e+00 1362.00
IUUC-Sha-106568 Sarcophilus harrisii 94.76 0.00e+00 1338.00
IUUC-Sar-113414 Sorex araneus 93.56 0.00e+00 632.00
IUUC-Ssc-116160 Sus scrofa 97.79 0.00e+00 1380.00
IUUC-Tru-117982 Takifugu rubripes 84.12 0.00e+00 1253.00
IUUC-Tni-120823 Tetraodon nigroviridis 90.31 0.00e+00 1274.00
IUUC-Ttr-128845 Tursiops truncatus 98.83 0.00e+00 1415.00
Created Date 25-Jun-2017

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