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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046906
Ensembl Protein ID ENSP00000351908.4
UniProt Accession Q99683; A6NIA0; B4DGB2; Q5THN3; Q99461; M3K5_HUMAN
Genbank Protein ID AAC50894.1; BAA12684.2; BAG57723.1; CAI20176.1; CAI20176.1; CAI15470.1; CAI15470.1; AAH54503.1; AAH88829.1
Protein Name Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; MAPK/ERK kinase kinase 5
Genbank Nucleotide ID U67156; D84476; AK294507; AL024508; AL121933; AL121933; AL024508; BC054503; BC088829
Gene Name MAP3K5; ASK1; MAPKKK5; MEKK5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000197442.9 ENST00000359015.4 ENSP00000351908.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
TTDKPIDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UBQ/UBQ_Other UBQ_Other 24286022
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
 Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
Protein Sequence
(Fasta)
MSTEADEGIT FSVPPFAPSG FCTIPEGGIC RRGGAAAVGE GEEHQLPPPP PGSFWNVESA 60
AAPGIGCPAA TSSSSATRGR GSSVGGGSRR TTVAYVINEA SQGQLVVAES EALQSLREAC 120
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Protein Fasta Sequence


>IUUC-Hsa-046906|ULD,UBQ_Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
CGAGCGCGGC GCCCTTGAGC TGCACCGCGG CGCAGGTTTG CGAGCCGACT TGTCAGCCGG 60
CCAAGAAAAG GAAGCTCCGT CCCTTCCCGC TCACCCGGCT TCCCCACCCC TTGTACTCTA 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046906|ULD,UBQ_Other|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0945--Host-virus interaction
KW-0391--Immunity
KW-0399--Innate immunity
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0346--Stress response
KW-0808--Transferase
KW-0832--Ubl conjugation
Interpro

IPR025136--DUF4071
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR013761--SAM/pointed
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF13281--DUF4071
PF00069--Pkinase
SMART

SM00220--S_TKc
Gene Ontology

GO:0005829--C:cytosol
GO:0009897--C:external side of plasma membrane
GO:1990604--C:IRE1-TRAF2-ASK1 complex
GO:1902911--C:protein kinase complex
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004709--F:MAP kinase kinase kinase activity
GO:0042803--F:protein homodimerization activity
GO:0004672--F:protein kinase activity
GO:0019903--F:protein phosphatase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0007257--P:activation of JUN kinase activity
GO:0000186--P:activation of MAPKK activity
GO:0097190--P:apoptotic signaling pathway
GO:0070301--P:cellular response to hydrogen peroxide
GO:1902170--P:cellular response to reactive nitrogen species
GO:0071356--P:cellular response to tumor necrosis factor
GO:0072577--P:endothelial cell apoptotic process
GO:0045087--P:innate immune response
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0008631--P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254--P:JNK cascade
GO:0000165--P:MAPK cascade
GO:0038066--P:p38MAPK cascade
GO:0043065--P:positive regulation of apoptotic process
GO:0010666--P:positive regulation of cardiac muscle cell apoptotic process
GO:0043280--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046330--P:positive regulation of JNK cascade
GO:0043507--P:positive regulation of JUN kinase activity
GO:0045663--P:positive regulation of myoblast differentiation
GO:1901216--P:positive regulation of neuron death
GO:1900745--P:positive regulation of p38MAPK cascade
GO:1904707--P:positive regulation of vascular smooth muscle cell proliferation
GO:0097300--P:programmed necrotic cell death
GO:0006468--P:protein phosphorylation
GO:0034976--P:response to endoplasmic reticulum stress
GO:0002931--P:response to ischemia
GO:0016032--P:viral process
GO:0042060--P:wound healing
KEGG hsa:4217
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002318 Ailuropoda melanoleuca 97.04 0.00e+00 2360.00
IUUC-Apl-003713 Anas platyrhynchos 89.16 0.00e+00 2080.00
IUUC-Aca-005331 Anolis carolinensis 87.79 0.00e+00 2094.00
IUUC-Ame-011158 Astyanax mexicanus 74.14 0.00e+00 1856.00
IUUC-Bta-012770 Bos taurus 95.12 0.00e+00 2466.00
IUUC-Cja-019656 Callithrix jacchus 98.54 0.00e+00 2565.00
IUUC-Cfa-020488 Canis familiaris 96.07 0.00e+00 2458.00
IUUC-Cpo-022516 Cavia porcellus 94.95 0.00e+00 2339.00
IUUC-Csa-023104 Chlorocebus sabaeus 99.51 0.00e+00 2359.00
IUUC-Cho-024379 Choloepus hoffmanni 89.99 0.00e+00 1234.00
IUUC-Dre-028836 Danio rerio 75.48 0.00e+00 1888.00
IUUC-Dno-029842 Dasypus novemcinctus 94.30 0.00e+00 2207.00
IUUC-Dor-030990 Dipodomys ordii 95.50 0.00e+00 1939.00
IUUC-Ete-032693 Echinops telfairi 85.11 0.00e+00 2000.00
IUUC-Eca-033337 Equus caballus 95.77 0.00e+00 2322.00
IUUC-Eeu-034602 Erinaceus europaeus 80.28 0.00e+00 2060.00
IUUC-Fca-035954 Felis catus 96.48 0.00e+00 1939.00
IUUC-Fal-037358 Ficedula albicollis 88.65 0.00e+00 2108.00
IUUC-Gmo-038836 Gadus morhua 78.53 0.00e+00 1764.00
IUUC-Gga-040443 Gallus gallus 86.73 0.00e+00 2241.00
IUUC-Gac-041634 Gasterosteus aculeatus 75.06 0.00e+00 1939.00
IUUC-Ggo-045263 Gorilla gorilla 97.90 0.00e+00 2519.00
IUUC-Itr-048449 Ictidomys tridecemlineatus 95.66 0.00e+00 1107.00
IUUC-Lch-050213 Latimeria chalumnae 78.70 0.00e+00 1810.00
IUUC-Loc-051829 Lepisosteus oculatus 72.01 0.00e+00 1881.00
IUUC-Laf-053538 Loxodonta africana 95.55 0.00e+00 2501.00
IUUC-Mcc-054776 Macaca mulatta 99.27 0.00e+00 2617.00
IUUC-Mga-059636 Meleagris gallopavo 88.61 0.00e+00 2138.00
IUUC-Mmr-061323 Microcebus murinus 97.16 0.00e+00 2490.00
IUUC-Mdo-062146 Monodelphis domestica 91.36 0.00e+00 2338.00
IUUC-Mmu-064022 Mus musculus 94.13 0.00e+00 2430.00
IUUC-Mpu-066531 Mustela putorius furo 93.18 0.00e+00 2473.00
IUUC-Mlu-068181 Myotis lucifugus 90.97 0.00e+00 2400.00
IUUC-Nle-069758 Nomascus leucogenys 99.67 0.00e+00 2361.00
IUUC-Opr-070531 Ochotona princeps 88.02 0.00e+00 1468.00
IUUC-Ont-072014 Oreochromis niloticus 77.57 0.00e+00 1915.00
IUUC-Oan-073169 Ornithorhynchus anatinus 93.56 0.00e+00 2250.00
IUUC-Ocu-074050 Oryctolagus cuniculus 92.65 0.00e+00 2169.00
IUUC-Ola-086941 Oryzias latipes 80.34 0.00e+00 1553.00
IUUC-Oga-088796 Otolemur garnettii 96.22 0.00e+00 2476.00
IUUC-Oar-090445 Ovis aries 96.89 0.00e+00 2303.00
IUUC-Ptr-090846 Pan troglodytes 99.56 0.00e+00 2620.00
IUUC-Pan-091986 Papio anubis 99.34 0.00e+00 2620.00
IUUC-Psi-093805 Pelodiscus sinensis 89.09 0.00e+00 2241.00
IUUC-Pfo-097301 Poecilia formosa 73.99 0.00e+00 1934.00
IUUC-Pab-097662 Pongo abelii 99.55 0.00e+00 2517.00
IUUC-Pca-100755 Procavia capensis 95.88 0.00e+00 729.00
IUUC-Pva-102280 Pteropus vampyrus 86.89 0.00e+00 2269.00
IUUC-Rno-105547 Rattus norvegicus 92.89 0.00e+00 2414.00
IUUC-Sha-106859 Sarcophilus harrisii 90.83 0.00e+00 2289.00
IUUC-Sar-113714 Sorex araneus 84.30 0.00e+00 1944.00
IUUC-Tgu-117116 Taeniopygia guttata 87.32 0.00e+00 2179.00
IUUC-Tru-118088 Takifugu rubripes 76.63 0.00e+00 1949.00
IUUC-Tsy-119616 Tarsius syrichta 91.79 0.00e+00 2014.00
IUUC-Tni-120284 Tetraodon nigroviridis 75.54 0.00e+00 1904.00
IUUC-Tbe-127900 Tupaia belangeri 95.12 0.00e+00 851.00
IUUC-Ttr-128294 Tursiops truncatus 85.31 0.00e+00 2147.00
IUUC-Vpa-130470 Vicugna pacos 87.52 0.00e+00 2066.00
IUUC-Xtr-132396 Xenopus tropicalis 75.67 0.00e+00 1979.00
Created Date 25-Jun-2017

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