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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-032092
Ensembl Protein ID FBpp0084267
UniProt Accession Q9VBP9; C9QPJ1; E1JIX5; H8F4R9; Q8IMS6; Q95U63; NPL4_DROME
Genbank Protein ID AAF56480.3; AAN14058.2; ACZ95025.1; AAL13515.1; ACX70078.1; AFD10756.1
Protein Name Nuclear protein localization protein 4 homolog
Genbank Nucleotide ID AE014297; AE014297; AE014297; AY058286; BT100105; BT133309
Gene Name Npl4; CG4673
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0039348 FBtr0084892 FBpp0084266
FBgn0039348 FBtr0084893 FBpp0084267
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/ZnF/Other 36.08 2.00e-88 321.00 IUUC-Sce-106145
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome.
 May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome.
Protein Sequence
(Fasta)
MACAPLLLEQ FIYKKRNFAY AFVRHRLFVL CKQSLIRVQS AEGIKRIEIS PKSNLKHLYD 60
SVQNALKVDG FGLFKERNFL TELQASGSQL VGTSLRHGDM VYLKQMAGTS SRRTSTTVLD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032092|UBD,UBD/ZnF/Other|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGGGCAGACT ATCGCCATCC CCACAGCTGT GCGACAGAGA CAGAGACAAA ATTACAATGC 60
CAAATGACAA AATTGTAAGT AAATTGTTGA TAAAAAATTA AAAAGTGCAT TTAGGGTGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032092|UBD,UBD/ZnF/Other|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016563--Npl4
IPR007717--NPL4_C
IPR024682--Npl4_Ub-like_dom
IPR007716--NPL4_Zn-bd_put
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2
PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
Pfam

PF05021--NPL4
PF11543--UN_NPL4
PF05020--zf-NPL4
SMART

SM00547--ZnF_RBZ
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0098586--P:cellular response to virus
GO:0022008--P:neurogenesis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0019233--P:sensory perception of pain
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG dme:Dmel_CG4673
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000460 Aegilops tauschii 28.52 3.00e-16 79.00
IUUC-Aml-002268 Ailuropoda melanoleuca 48.00 4.00e-172 597.00
IUUC-Atr-002939 Amborella trichopoda 25.41 9.00e-15 73.90
IUUC-Apl-003496 Anas platyrhynchos 51.88 1.00e-166 578.00
IUUC-Aca-005230 Anolis carolinensis 47.83 5.00e-175 607.00
IUUC-Aly-006056 Arabidopsis lyrata 25.67 5.00e-17 81.30
IUUC-Ath-006993 Arabidopsis thaliana 24.78 3.00e-15 75.10
IUUC-Ago-007954 Ashbya gossypii 32.88 7.00e-73 267.00
IUUC-Acl-008208 Aspergillus clavatus 34.88 1.00e-86 313.00
IUUC-Afl-008574 Aspergillus flavus 34.54 1.00e-90 326.00
IUUC-Afu-008825 Aspergillus fumigatus 33.94 2.00e-93 335.00
IUUC-Ani-009495 Aspergillus nidulans 33.83 9.00e-94 337.00
IUUC-Ang-009762 Aspergillus niger 33.22 8.00e-86 310.00
IUUC-Aor-010199 Aspergillus oryzae 34.54 2.00e-89 322.00
IUUC-Ate-010592 Aspergillus terreus 34.81 3.00e-90 325.00
IUUC-Ame-011438 Astyanax mexicanus 58.11 2.00e-52 196.00
IUUC-Bgr-012124 Blumeria graminis 39.32 2.00e-89 322.00
IUUC-Bta-013312 Bos taurus 48.25 5.00e-176 610.00
IUUC-Bci-013648 Botrytis cinerea 33.50 1.00e-92 332.00
IUUC-Bdi-014326 Brachypodium distachyon 28.21 1.00e-15 76.60
IUUC-Bol-016294 Brassica oleracea 24.32 5.00e-16 78.20
IUUC-Bra-017023 Brassica rapa 23.49 2.00e-16 79.70
IUUC-Cel-018713 Caenorhabditis elegans 41.70 1.00e-116 412.00
IUUC-Cja-018869 Callithrix jacchus 47.62 4.00e-175 607.00
IUUC-Cfa-020757 Canis familiaris 48.16 4.00e-174 603.00
IUUC-Cpo-022390 Cavia porcellus 48.33 5.00e-174 603.00
IUUC-Csa-023366 Chlorocebus sabaeus 47.62 2.00e-176 611.00
IUUC-Cho-024455 Choloepus hoffmanni 49.07 4.00e-123 434.00
IUUC-Cin-025638 Ciona intestinalis 45.63 6.00e-141 493.00
IUUC-Csv-026310 Ciona savignyi 46.10 2.00e-135 474.00
IUUC-Cgl-026685 Colletotrichum gloeosporioides 35.49 2.00e-83 302.00
IUUC-Cne-026794 Cryptococcus neoformans 27.19 2.00e-65 243.00
IUUC-Cme-027248 Cyanidioschyzon merolae 27.47 1.00e-13 70.50
IUUC-Dre-027689 Danio rerio 47.46 4.00e-172 597.00
IUUC-Dno-030004 Dasypus novemcinctus 47.78 2.00e-174 604.00
IUUC-Dor-030585 Dipodomys ordii 53.71 2.00e-161 561.00
IUUC-Dse-031202 Dothistroma septosporum 33.64 7.00e-82 297.00
IUUC-Ete-033009 Echinops telfairi 58.14 3.00e-60 224.00
IUUC-Eca-034001 Equus caballus 48.25 9.00e-178 615.00
IUUC-Eeu-034485 Erinaceus europaeus 41.48 1.00e-114 406.00
IUUC-Fca-036128 Felis catus 47.67 2.00e-170 591.00
IUUC-Fal-037523 Ficedula albicollis 49.44 5.00e-179 620.00
IUUC-Fox-037802 Fusarium oxysporum 33.11 3.00e-90 325.00
IUUC-Fso-038152 Fusarium solani 33.44 3.00e-91 328.00
IUUC-Gmo-038486 Gadus morhua 46.21 1.00e-162 565.00
IUUC-Ggr-039916 Gaeumannomyces graminis 31.97 3.00e-86 311.00
IUUC-Gga-041208 Gallus gallus 49.44 5.00e-180 623.00
IUUC-Gac-042304 Gasterosteus aculeatus 47.44 8.00e-166 576.00
IUUC-Gma-044007 Glycine max 23.70 2.00e-10 59.30
IUUC-Ggo-045236 Gorilla gorilla 46.59 9.00e-168 582.00
IUUC-Hsa-046334 Homo sapiens 47.78 3.00e-176 610.00
IUUC-Hvu-047323 Hordeum vulgare 23.79 4.00e-08 50.10
IUUC-Itr-047878 Ictidomys tridecemlineatus 48.56 2.00e-107 380.00
IUUC-Lch-050302 Latimeria chalumnae 46.49 2.00e-166 578.00
IUUC-Lpe-051362 Leersia perrieri 29.09 6.00e-17 81.30
IUUC-Loc-052548 Lepisosteus oculatus 47.69 1.00e-171 595.00
IUUC-Lma-053092 Leptosphaeria maculans 36.27 8.00e-88 317.00
IUUC-Laf-053911 Loxodonta africana 48.25 2.00e-177 614.00
IUUC-Mcc-055830 Macaca mulatta 47.73 2.00e-173 601.00
IUUC-Meu-056460 Macropus eugenii 29.46 3.00e-59 221.00
IUUC-Mor-057189 Magnaporthe oryzae 32.52 2.00e-87 315.00
IUUC-Mpo-057366 Magnaporthe poae 33.82 1.00e-89 322.00
IUUC-Mtr-057834 Medicago truncatula 23.35 5.00e-10 58.20
IUUC-Mla-059190 Melampsora laricipopulina 34.21 1.00e-73 270.00
IUUC-Mga-060036 Meleagris gallopavo 49.28 2.00e-179 621.00
IUUC-Mvi-060275 Microbotryum violaceum 35.11 6.00e-78 284.00
IUUC-Mmr-061300 Microcebus murinus 48.96 3.00e-177 614.00
IUUC-Mdo-062911 Monodelphis domestica 50.47 8.00e-163 565.00
IUUC-Mmu-063916 Mus musculus 47.94 1.00e-174 605.00
IUUC-Mac-065601 Musa acuminata 27.07 1.00e-09 57.00
IUUC-Mpu-065912 Mustela putorius furo 48.25 4.00e-174 603.00
IUUC-Mlu-067965 Myotis lucifugus 47.94 3.00e-173 601.00
IUUC-Nfi-068465 Neosartorya fischeri 33.72 2.00e-92 332.00
IUUC-Ncr-068936 Neurospora crassa 34.14 4.00e-83 301.00
IUUC-Nle-069570 Nomascus leucogenys 47.78 7.00e-176 609.00
IUUC-Opr-071097 Ochotona princeps 52.76 1.00e-146 511.00
IUUC-Ont-071430 Oreochromis niloticus 48.89 4.00e-175 607.00
IUUC-Oan-073709 Ornithorhynchus anatinus 43.56 6.00e-118 416.00
IUUC-Ocu-074875 Oryctolagus cuniculus 46.57 2.00e-165 575.00
IUUC-Oba-075214 Oryza barthii 28.36 2.00e-16 79.30
IUUC-Obr-076758 Oryza brachyantha 28.21 3.00e-16 78.20
IUUC-Ogl-077665 Oryza glaberrima 28.36 2.00e-16 79.30
IUUC-Ogu-078899 Oryza glumaepatula 28.36 2.00e-16 79.30
IUUC-Oin-079167 Oryza indica 28.36 2.00e-16 79.30
IUUC-Olo-080451 Oryza longistaminata 28.36 2.00e-16 79.00
IUUC-Ome-081836 Oryza meridionalis 28.36 2.00e-16 79.70
IUUC-Oni-083019 Oryza nivara 28.36 2.00e-16 79.30
IUUC-Opu-083122 Oryza punctata 28.57 2.00e-16 79.70
IUUC-Oru-084900 Oryza rufipogon 28.36 2.00e-16 79.30
IUUC-Osa-086054 Oryza sativa 28.36 2.00e-16 79.30
IUUC-Ola-087077 Oryzias latipes 41.34 1.00e-137 482.00
IUUC-Olu-087601 Ostreococcus lucimarinus 26.10 6.00e-05 41.20
IUUC-Oga-088049 Otolemur garnettii 39.84 5.00e-139 487.00
IUUC-Oar-089678 Ovis aries 48.64 6.00e-176 609.00
IUUC-Ptr-091380 Pan troglodytes 49.82 4.00e-169 587.00
IUUC-Pan-092821 Papio anubis 47.37 7.00e-173 599.00
IUUC-Psi-093074 Pelodiscus sinensis 49.20 5.00e-177 613.00
IUUC-Pma-094102 Petromyzon marinus 47.43 4.00e-174 603.00
IUUC-Pno-094987 Phaeosphaeria nodorum 32.67 3.00e-90 326.00
IUUC-Ppa-095368 Physcomitrella patens 23.65 7.00e-14 70.50
IUUC-Pfo-097245 Poecilia formosa 48.87 6.00e-174 603.00
IUUC-Pab-098763 Pongo abelii 48.02 9.00e-178 615.00
IUUC-Pop-099355 Populus trichocarpa 24.87 2.00e-10 59.30
IUUC-Ppe-101990 Prunus persica 23.12 4.00e-13 68.20
IUUC-Pva-102308 Pteropus vampyrus 46.40 2.00e-140 491.00
IUUC-Pgr-103626 Puccinia graminis 35.18 1.00e-71 263.00
IUUC-Pte-104100 Pyrenophora teres 33.58 2.00e-84 305.00
IUUC-Pyt-104482 Pyrenophora triticirepentis 37.64 8.00e-85 307.00
IUUC-Rno-105582 Rattus norvegicus 47.94 3.00e-174 604.00
IUUC-Sce-106145 Saccharomyces cerevisiae 36.43 4.00e-87 314.00
IUUC-Sha-106647 Sarcophilus harrisii 48.31 4.00e-172 597.00
IUUC-Sja-107972 Schizosaccharomyces japonicus 33.51 7.00e-85 307.00
IUUC-Spo-108281 Schizosaccharomyces pombe 35.58 2.00e-89 322.00
IUUC-Ssl-108617 Sclerotinia sclerotiorum 39.53 5.00e-93 334.00
IUUC-Smo-108933 Selaginella moellendorffii 24.39 1.00e-13 70.10
IUUC-Sit-110083 Setaria italica 28.32 7.00e-17 80.90
IUUC-Sly-111645 Solanum lycopersicum 25.00 1.00e-13 70.10
IUUC-Stu-112422 Solanum tuberosum 25.00 1.00e-13 70.10
IUUC-Sbi-113987 Sorghum bicolor 27.42 5.00e-16 78.20
IUUC-Sre-115095 Sporisorium reilianum 37.31 9.00e-76 277.00
IUUC-Ssc-116141 Sus scrofa 50.80 4.00e-170 590.00
IUUC-Tgu-117492 Taeniopygia guttata 52.56 2.00e-146 511.00
IUUC-Tru-118463 Takifugu rubripes 48.10 3.00e-172 597.00
IUUC-Tsy-118993 Tarsius syrichta 45.74 6.00e-144 503.00
IUUC-Tni-119896 Tetraodon nigroviridis 48.71 1.00e-174 605.00
IUUC-Tca-121169 Theobroma cacao 25.08 1.00e-15 76.60
IUUC-Tre-122046 Trichoderma reesei 32.73 2.00e-83 302.00
IUUC-Tvi-122415 Trichoderma virens 33.28 9.00e-88 317.00
IUUC-Tae-123514 Triticum aestivum 28.52 3.00e-16 79.00
IUUC-Tme-127123 Tuber melanosporum 36.27 3.00e-91 328.00
IUUC-Tbe-127629 Tupaia belangeri 43.77 6.00e-73 267.00
IUUC-Ttr-128476 Tursiops truncatus 44.33 8.00e-141 493.00
IUUC-Uma-129492 Ustilago maydis 35.48 2.00e-75 275.00
IUUC-Vda-129702 Verticillium dahliae 33.27 2.00e-82 299.00
IUUC-Vvi-131090 Vitis vinifera 22.68 1.00e-10 60.10
IUUC-Xtr-131786 Xenopus tropicalis 47.93 4.00e-175 607.00
IUUC-Xma-133997 Xiphophorus maculatus 48.03 1.00e-172 599.00
IUUC-Yli-134537 Yarrowia lipolytica 33.91 1.00e-76 279.00
IUUC-Zma-134847 Zea mays 28.43 1.00e-17 83.60
Created Date 25-Jun-2017

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