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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046176
UUCD1 version UUC-HoS-00119
Ensembl Protein ID ENSP00000252108.3
UniProt Accession Q14139; B0YJB6; Q2M1H0; Q6P5T4; Q7Z639; UBE4A_HUMAN
Genbank Protein ID BAA09475.2; ACA06094.1; EAW67371.1; AAH52643.1; AAH62695.1; AAI11418.1; AAI12368.1
Protein Name Ubiquitin conjugation factor E4 A; RING-type E3 ubiquitin transferase E4 A
Genbank Nucleotide ID D50916; EF445042; CH471065; BC052643; BC062695; BC111417; BC112367
Gene Name UBE4A; KIAA0126
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000110344.9 ENST00000252108.7 ENSP00000252108.3
ENSG00000110344.9 ENST00000431736.6 ENSP00000387362.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/U-box U-box 18069675
Classification
Family E-value Score Start End
E3 activity/RING/U-box 9.90e-22 78.5 988 1059
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 2    vpeeflCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceens 73
            ++efl+pI+ +lM+dPvvlp s++t+drs+I+++l s+++ +P++r+plt +++ Pn++l++ iq+w++e++
   Q: 988  ACDEFLDPIMSTLMCDPVVLPsSRVTVDRSTIARHLLSDQT-DPFNRSPLTMDQIRPNTELKEKIQRWLAERK 1059
           579******************9******************9.***************************9976 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.
 Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.
Protein Sequence
(Fasta)
MTDQENNNNI SSNPFAALFG SLADAKQFAA IQKEQLKQQS DELPASPDDS DNSVSESLDE 60
FDYSVAEISR SFRSQQEICE QLNINHMIQR IFLITLDNSD PSLKSGNGIP SRCVYLEEMA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046176|E3,U-box|Homo sapiens
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Nucleotide Sequence
(Fasta)
TAACTTCCGG TTGCTGTGCT GAGTCGGAAG TGGGAACCCT TCGGCCGCTG AGATTCTGTC 60
GTGTCGTCGC TGCTGGCACT TCAGGCTCTG GTAAGACAGG CAATAGCTTC AGGGGACGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046176|E3,U-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR011989--ARM-like
IPR019474--Ub_conjug_fac_E4_core
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51698--U_BOX
Pfam

PF04564--U-box
PF10408--Ufd2P_core
SMART

SM00504--Ubox
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0000209--P:protein polyubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:9354
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001281 Ailuropoda melanoleuca 98.04 0.00e+00 2085.00
IUUC-Apl-003514 Anas platyrhynchos 89.41 0.00e+00 1897.00
IUUC-Aca-005167 Anolis carolinensis 85.90 0.00e+00 1761.00
IUUC-Ame-010905 Astyanax mexicanus 67.86 0.00e+00 711.00
IUUC-Bta-012413 Bos taurus 96.91 0.00e+00 2088.00
IUUC-Cja-019715 Callithrix jacchus 98.79 0.00e+00 2129.00
IUUC-Cfa-021185 Canis familiaris 98.69 0.00e+00 2149.00
IUUC-Cpo-021516 Cavia porcellus 98.50 0.00e+00 2119.00
IUUC-Csa-023765 Chlorocebus sabaeus 99.72 0.00e+00 2118.00
IUUC-Cho-024614 Choloepus hoffmanni 98.41 0.00e+00 867.00
IUUC-Cin-025532 Ciona intestinalis 36.81 3.00e-164 572.00
IUUC-Csv-025834 Ciona savignyi 52.26 2.00e-48 184.00
IUUC-Dre-028223 Danio rerio 77.24 0.00e+00 1615.00
IUUC-Dno-029785 Dasypus novemcinctus 97.47 0.00e+00 2097.00
IUUC-Dor-030421 Dipodomys ordii 94.23 0.00e+00 1981.00
IUUC-Dme-031715 Drosophila melanogaster 35.46 6.00e-134 471.00
IUUC-Ete-032767 Echinops telfairi 95.45 0.00e+00 1323.00
IUUC-Eca-033587 Equus caballus 98.41 0.00e+00 2110.00
IUUC-Fca-035622 Felis catus 97.86 0.00e+00 2136.00
IUUC-Fal-037262 Ficedula albicollis 87.66 0.00e+00 1896.00
IUUC-Gmo-038686 Gadus morhua 73.12 0.00e+00 1578.00
IUUC-Gga-041222 Gallus gallus 88.22 0.00e+00 1942.00
IUUC-Gac-042637 Gasterosteus aculeatus 74.05 0.00e+00 1571.00
IUUC-Ggo-044685 Gorilla gorilla 99.07 0.00e+00 2135.00
IUUC-Itr-048469 Ictidomys tridecemlineatus 98.70 0.00e+00 1064.00
IUUC-Lch-049630 Latimeria chalumnae 81.11 0.00e+00 1744.00
IUUC-Loc-052727 Lepisosteus oculatus 76.63 0.00e+00 1645.00
IUUC-Laf-054041 Loxodonta africana 95.67 0.00e+00 2102.00
IUUC-Mcc-055099 Macaca mulatta 98.52 0.00e+00 2135.00
IUUC-Meu-055991 Macropus eugenii 90.23 0.00e+00 1948.00
IUUC-Mga-059596 Meleagris gallopavo 88.28 0.00e+00 1780.00
IUUC-Mmr-061244 Microcebus murinus 97.42 0.00e+00 1749.00
IUUC-Mdo-062335 Monodelphis domestica 90.64 0.00e+00 1927.00
IUUC-Mmu-063572 Mus musculus 95.67 0.00e+00 2082.00
IUUC-Mpu-066444 Mustela putorius furo 93.93 0.00e+00 2030.00
IUUC-Mlu-068232 Myotis lucifugus 96.44 0.00e+00 2085.00
IUUC-Nle-070036 Nomascus leucogenys 98.97 0.00e+00 2131.00
IUUC-Opr-070503 Ochotona princeps 92.37 0.00e+00 1371.00
IUUC-Ont-072389 Oreochromis niloticus 75.72 0.00e+00 1606.00
IUUC-Oan-073114 Ornithorhynchus anatinus 88.28 0.00e+00 1719.00
IUUC-Ocu-074370 Oryctolagus cuniculus 97.58 0.00e+00 1839.00
IUUC-Ola-086562 Oryzias latipes 73.23 0.00e+00 1587.00
IUUC-Oga-088146 Otolemur garnettii 97.18 0.00e+00 2083.00
IUUC-Oar-089190 Ovis aries 96.90 0.00e+00 2060.00
IUUC-Ptr-090592 Pan troglodytes 98.97 0.00e+00 2135.00
IUUC-Pan-092271 Papio anubis 99.72 0.00e+00 2143.00
IUUC-Psi-093730 Pelodiscus sinensis 86.41 0.00e+00 1908.00
IUUC-Pma-094120 Petromyzon marinus 77.05 6.00e-132 463.00
IUUC-Pfo-097077 Poecilia formosa 72.91 0.00e+00 1555.00
IUUC-Pab-098069 Pongo abelii 98.70 0.00e+00 2096.00
IUUC-Pca-100762 Procavia capensis 93.95 0.00e+00 1954.00
IUUC-Pva-103149 Pteropus vampyrus 97.30 0.00e+00 2099.00
IUUC-Rno-105342 Rattus norvegicus 95.39 0.00e+00 2080.00
IUUC-Sha-106555 Sarcophilus harrisii 91.29 0.00e+00 1972.00
IUUC-Sly-110848 Solanum lycopersicum 38.98 1.00e-76 280.00
IUUC-Sar-113131 Sorex araneus 90.95 0.00e+00 1192.00
IUUC-Ssc-115841 Sus scrofa 97.66 0.00e+00 2098.00
IUUC-Tgu-116823 Taeniopygia guttata 86.74 0.00e+00 1868.00
IUUC-Tru-118249 Takifugu rubripes 73.25 0.00e+00 1568.00
IUUC-Tsy-119112 Tarsius syrichta 99.74 0.00e+00 753.00
IUUC-Tni-119848 Tetraodon nigroviridis 73.58 0.00e+00 1543.00
IUUC-Tbe-127889 Tupaia belangeri 84.88 0.00e+00 866.00
IUUC-Ttr-129300 Tursiops truncatus 88.46 0.00e+00 1175.00
IUUC-Vpa-130215 Vicugna pacos 96.74 0.00e+00 2073.00
IUUC-Xtr-132107 Xenopus tropicalis 80.81 0.00e+00 1702.00
Created Date 25-Jun-2017

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