• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063200
UUCD1 version UUC-MuM-00095
Ensembl Protein ID ENSMUSP00000095433.3
UniProt Accession A2AN08; A2AN07; A2AN09; A2AN10; A2AN11; Q52KI4; Q6PB49; Q6PFC7; Q80Y11; Q8BGB9; Q8C3E8; Q8C4W5; Q8C8X7; Q8CGE0; Q8CHF3; UBR4_MOUSE
Genbank Protein ID BAC31850.1; BAC37944.1; BAC38442.2; BAC38980.2; BAC39609.1; CAM22428.1; CAM22429.1; CAM22430.1; CAM22431.1; BAC41426.2; AAH40468.1; AAH51096.1; AAH57625.1; AAH59890.1; AAH94329.1
Protein Name E3 ubiquitin-protein ligase UBR4; N-recognin-4; RING-type E3 ubiquitin transferase UBR4; Zinc finger UBR1-type protein 1; p600
Genbank Nucleotide ID AK044277; AK080556; AK082231; AK083644; AK086097; AL807833; AL807833; AL807833; AL807833; AB093242; BC040468; BC051096; BC057625; BC059890; BC094329
Gene Name Ubr4; Kiaa0462; Zubr1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000066036.14 ENSMUST00000097822.9 ENSMUSP00000095433.3
ENSMUSG00000066036.14 ENSMUST00000129949.7 ENSMUSP00000115711.1
ENSMUSG00000066036.14 ENSMUST00000129779.1 ENSMUSP00000114947.1
ENSMUSG00000066036.14 ENSMUST00000165860.7 ENSMUSP00000125800.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemiRTarBasemicroRNATRANSFAC
RAID2
Protein-protein Interaction
IIDiRefIndexHINT
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/N-recognin/UBR-box 96.92 0.00e+00 9455.00 IUUC-Hsa-046955
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
Protein Sequence
(Fasta)
MATSGGEEAA AAAPAPGAPA TGQDTTPGWE VAVRPLLSAS YSAFEMKELP QLVASVIESE 60
SEILHHEKQY EPFYSSFVAL STHYITTVCS LIPRNQLQSV AAACKVLIEF SLLRLENPDE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063200|E3,UBR-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGCTTCAAT CATGGCGGTC GCGGTGGCGT CTGGGTTCTG GATCTGGGCT GCTGTGCTGC 60
TCGTCCCTGC GGCCGCGGTC TACGAAGACC AAGTGGGCAA GTTTGACTGG TGCGTACAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063200|E3,UBR-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0112--Calmodulin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025704--E3_Ub_ligase_UBR4
IPR017986--WD40_repeat_dom
IPR003126--Znf_UBR
PROSITE

PS51157--ZF_UBR
Pfam

PF13764--E3_UbLigase_R4
PF02207--zf-UBR
SMART

SM00396--ZnF_UBR1
Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG mmu:69116
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000915 Aegilops tauschii 33.81 0.00e+00 898.00
IUUC-Aml-001346 Ailuropoda melanoleuca 96.48 0.00e+00 9517.00
IUUC-Atr-002587 Amborella trichopoda 31.37 5.00e-170 594.00
IUUC-Apl-003678 Anas platyrhynchos 90.80 0.00e+00 5673.00
IUUC-Aca-004517 Anolis carolinensis 90.77 0.00e+00 926.00
IUUC-Aly-006117 Arabidopsis lyrata 31.91 0.00e+00 890.00
IUUC-Ath-007289 Arabidopsis thaliana 33.74 0.00e+00 818.00
IUUC-Ame-011965 Astyanax mexicanus 82.18 0.00e+00 4759.00
IUUC-Bta-012498 Bos taurus 95.76 0.00e+00 9426.00
IUUC-Bdi-014555 Brachypodium distachyon 32.06 0.00e+00 902.00
IUUC-Bol-015522 Brassica oleracea 33.37 0.00e+00 832.00
IUUC-Bra-017090 Brassica rapa 33.39 0.00e+00 767.00
IUUC-Cel-018504 Caenorhabditis elegans 27.20 2.00e-156 548.00
IUUC-Cja-018983 Callithrix jacchus 96.90 0.00e+00 9548.00
IUUC-Cfa-020612 Canis familiaris 96.65 0.00e+00 9575.00
IUUC-Cpo-021700 Cavia porcellus 96.57 0.00e+00 9565.00
IUUC-Csa-023771 Chlorocebus sabaeus 96.98 0.00e+00 9502.00
IUUC-Cho-024474 Choloepus hoffmanni 89.92 0.00e+00 4760.00
IUUC-Cin-025247 Ciona intestinalis 57.82 0.00e+00 1028.00
IUUC-Csv-026255 Ciona savignyi 57.69 0.00e+00 1050.00
IUUC-Dre-028796 Danio rerio 84.13 0.00e+00 5119.00
IUUC-Dno-030056 Dasypus novemcinctus 96.14 0.00e+00 9497.00
IUUC-Dor-030711 Dipodomys ordii 93.86 0.00e+00 6870.00
IUUC-Dme-032113 Drosophila melanogaster 48.22 0.00e+00 1726.00
IUUC-Ete-032334 Echinops telfairi 94.26 0.00e+00 4027.00
IUUC-Eca-033327 Equus caballus 96.74 0.00e+00 9598.00
IUUC-Eeu-034698 Erinaceus europaeus 85.19 0.00e+00 1212.00
IUUC-Fca-035430 Felis catus 96.02 0.00e+00 9430.00
IUUC-Fal-037566 Ficedula albicollis 90.40 0.00e+00 5614.00
IUUC-Gmo-038674 Gadus morhua 83.21 0.00e+00 8063.00
IUUC-Gga-040641 Gallus gallus 92.10 0.00e+00 9245.00
IUUC-Gac-041870 Gasterosteus aculeatus 83.52 0.00e+00 8351.00
IUUC-Gma-042722 Glycine max 34.26 0.00e+00 864.00
IUUC-Ggo-045360 Gorilla gorilla 96.56 0.00e+00 9529.00
IUUC-Hsa-046955 Homo sapiens 96.92 0.00e+00 9542.00
IUUC-Hvu-047255 Hordeum vulgare 33.75 0.00e+00 895.00
IUUC-Itr-048714 Ictidomys tridecemlineatus 94.21 0.00e+00 3890.00
IUUC-Lch-049893 Latimeria chalumnae 80.55 0.00e+00 5013.00
IUUC-Lpe-050948 Leersia perrieri 33.35 0.00e+00 821.00
IUUC-Loc-052019 Lepisosteus oculatus 83.47 0.00e+00 8196.00
IUUC-Laf-054238 Loxodonta africana 95.69 0.00e+00 9443.00
IUUC-Mcc-054905 Macaca mulatta 96.97 0.00e+00 9542.00
IUUC-Meu-056297 Macropus eugenii 87.30 0.00e+00 8451.00
IUUC-Mtr-058169 Medicago truncatula 31.71 0.00e+00 926.00
IUUC-Mga-059621 Meleagris gallopavo 92.05 0.00e+00 9212.00
IUUC-Mmr-061395 Microcebus murinus 98.66 0.00e+00 2984.00
IUUC-Mdo-063037 Monodelphis domestica 91.54 0.00e+00 4625.00
IUUC-Mac-065267 Musa acuminata 32.92 0.00e+00 785.00
IUUC-Mpu-066639 Mustela putorius furo 96.74 0.00e+00 9544.00
IUUC-Mlu-067172 Myotis lucifugus 96.53 0.00e+00 9562.00
IUUC-Ncr-068935 Neurospora crassa 31.11 3.70e-01 30.40
IUUC-Nle-069162 Nomascus leucogenys 96.77 0.00e+00 8327.00
IUUC-Opr-070567 Ochotona princeps 93.26 0.00e+00 3488.00
IUUC-Ont-072364 Oreochromis niloticus 81.78 0.00e+00 5013.00
IUUC-Oan-072804 Ornithorhynchus anatinus 83.57 0.00e+00 2004.00
IUUC-Ocu-074637 Oryctolagus cuniculus 96.31 0.00e+00 9498.00
IUUC-Oba-075215 Oryza barthii 33.67 0.00e+00 821.00
IUUC-Obr-076704 Oryza brachyantha 34.07 0.00e+00 870.00
IUUC-Ogl-077593 Oryza glaberrima 35.51 0.00e+00 648.00
IUUC-Ogu-078732 Oryza glumaepatula 33.59 0.00e+00 823.00
IUUC-Oin-079805 Oryza indica 32.43 0.00e+00 731.00
IUUC-Olo-080261 Oryza longistaminata 33.65 0.00e+00 825.00
IUUC-Ome-081392 Oryza meridionalis 33.56 0.00e+00 863.00
IUUC-Oni-082086 Oryza nivara 33.65 0.00e+00 824.00
IUUC-Opu-083535 Oryza punctata 33.71 0.00e+00 830.00
IUUC-Oru-084735 Oryza rufipogon 33.65 0.00e+00 824.00
IUUC-Ola-086799 Oryzias latipes 83.37 0.00e+00 8254.00
IUUC-Olu-087777 Ostreococcus lucimarinus 27.22 1.00e-83 306.00
IUUC-Oga-088126 Otolemur garnettii 94.25 0.00e+00 1542.00
IUUC-Oar-090428 Ovis aries 94.41 0.00e+00 9239.00
IUUC-Ptr-091407 Pan troglodytes 96.95 0.00e+00 9543.00
IUUC-Pan-091777 Papio anubis 96.51 0.00e+00 9515.00
IUUC-Psi-093587 Pelodiscus sinensis 92.13 0.00e+00 9282.00
IUUC-Ppa-095781 Physcomitrella patens 33.37 0.00e+00 916.00
IUUC-Pfo-097449 Poecilia formosa 83.79 0.00e+00 8357.00
IUUC-Pab-098450 Pongo abelii 95.71 0.00e+00 9404.00
IUUC-Pop-100041 Populus trichocarpa 31.76 0.00e+00 894.00
IUUC-Pca-100663 Procavia capensis 89.71 0.00e+00 2846.00
IUUC-Ppe-101386 Prunus persica 33.83 0.00e+00 813.00
IUUC-Pva-102701 Pteropus vampyrus 96.88 0.00e+00 4059.00
IUUC-Rno-105367 Rattus norvegicus 97.94 0.00e+00 5946.00
IUUC-Sha-107490 Sarcophilus harrisii 91.91 0.00e+00 5696.00
IUUC-Smo-109103 Selaginella moellendorffii 33.06 0.00e+00 906.00
IUUC-Sit-110670 Setaria italica 34.09 0.00e+00 885.00
IUUC-Sly-110952 Solanum lycopersicum 32.23 0.00e+00 893.00
IUUC-Stu-112624 Solanum tuberosum 35.60 1.00e-130 461.00
IUUC-Sar-113180 Sorex araneus 88.93 0.00e+00 4180.00
IUUC-Sbi-114596 Sorghum bicolor 31.55 0.00e+00 929.00
IUUC-Ssc-115377 Sus scrofa 98.45 0.00e+00 2979.00
IUUC-Tgu-117330 Taeniopygia guttata 89.48 0.00e+00 5600.00
IUUC-Tru-117635 Takifugu rubripes 82.84 0.00e+00 8286.00
IUUC-Tsy-119551 Tarsius syrichta 89.51 0.00e+00 4564.00
IUUC-Tni-119727 Tetraodon nigroviridis 82.56 0.00e+00 8253.00
IUUC-Tca-121017 Theobroma cacao 32.00 0.00e+00 939.00
IUUC-Tae-122892 Triticum aestivum 35.37 2.00e-25 109.00
IUUC-Tur-126292 Triticum urartu 33.81 0.00e+00 897.00
IUUC-Ttr-128332 Tursiops truncatus 95.36 0.00e+00 8411.00
IUUC-Vpa-130615 Vicugna pacos 93.55 0.00e+00 2586.00
IUUC-Vvi-131435 Vitis vinifera 33.87 0.00e+00 815.00
IUUC-Xtr-132130 Xenopus tropicalis 90.03 0.00e+00 2103.00
IUUC-Xma-133859 Xiphophorus maculatus 81.82 0.00e+00 5075.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved