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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063409
Ensembl Protein ID ENSMUSP00000110648.1
UniProt Accession Q8K3K8; A2ASP3; OPTN_MOUSE
Genbank Protein ID AAL61853.1; AAQ21118.1; AAQ21118.1; AAQ21118.1; AAQ21118.1; AAQ21118.1; AAQ21118.1; AAQ21118.1; AAQ21118.1; AAQ21118.1; AAQ21118.1; AAQ21118.1; AAQ21118.1; AAQ21118.1; CAM22578.1; AAH61185.1
Protein Name Optineurin
Genbank Nucleotide ID AY071834; AY340635; AY340623; AY340624; AY340625; AY340626; AY340627; AY340628; AY340629; AY340630; AY340631; AY340632; AY340633; AY340634; AL928662; BC061185
Gene Name Optn
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026672.11 ENSMUST00000114996.7 ENSMUSP00000110648.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBAN UBAN 17702576
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBAN 1.50e-22 80.4 457 513
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBAN
   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndsl 57
           +ee+let+ vL++Q+e+Y++DF+aERa+RE+++eeke+L+ q++ l+k+++  ++++
   Q: 457  QEEDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKENNDIEEGG 513
           79************************************************9988765 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52 (By similarity).
 Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52 (By similarity).
Protein Sequence
(Fasta)
MSHQPLSCLT EKGDSPCETP GNGPSNMVHP SLDTFTPEEL LQQMKELLVE NHQLKEAMKL 60
NNQAMKGRFE ELSAWTEKQK EERLLFEMQS KEVKERLKAL THENERLKEE LGKFKEKSEK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063409|UBD,UBAN|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCTGGCGGG TCGCGAGGCC GCGCGTCACC GTCCAGCTGC CCGGTCGCCG CCCCCCGGCT 60
GGTCCCTGGC GGGCGTCGGC ATCCAGAGCT TTGGGACAAA ATACCAACGA AGCAGTGACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063409|UBD,UBAN|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA
PROSITE

PS51801--ZF_CCHC_NOA
Pfam

PF16516--CC2-LZ
PF11577--NEMO
Gene Ontology

GO:0005776--C:autophagosome
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0055037--C:recycling endosome
GO:0005802--C:trans-Golgi network
GO:0042802--F:identical protein binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0031593--F:polyubiquitin binding
GO:0030674--F:protein binding, bridging
GO:0008022--F:protein C-terminus binding
GO:0017137--F:Rab GTPase binding
GO:0034613--P:cellular protein localization
GO:0050829--P:defense response to Gram-negative bacterium
GO:0007030--P:Golgi organization
GO:0090161--P:Golgi ribbon formation
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0016236--P:macroautophagy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0001920--P:negative regulation of receptor recycling
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1904417--P:positive regulation of xenophagy
GO:0000042--P:protein targeting to Golgi
GO:0098792--P:xenophagy
KEGG mmu:71648
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002037 Ailuropoda melanoleuca 74.30 0.00e+00 736.00
IUUC-Apl-003812 Anas platyrhynchos 52.58 3.00e-137 482.00
IUUC-Aca-004625 Anolis carolinensis 52.70 2.00e-139 489.00
IUUC-Aly-005781 Arabidopsis lyrata 32.86 6.00e-03 35.40
IUUC-Ani-009255 Aspergillus nidulans 24.32 8.60e-02 31.60
IUUC-Ame-011116 Astyanax mexicanus 36.77 4.00e-63 236.00
IUUC-Bta-013240 Bos taurus 77.61 0.00e+00 855.00
IUUC-Cja-019911 Callithrix jacchus 76.82 0.00e+00 781.00
IUUC-Cfa-020330 Canis familiaris 77.78 0.00e+00 787.00
IUUC-Cpo-021753 Cavia porcellus 73.94 0.00e+00 767.00
IUUC-Csa-023662 Chlorocebus sabaeus 76.99 0.00e+00 786.00
IUUC-Cho-024574 Choloepus hoffmanni 62.12 7.00e-117 414.00
IUUC-Cme-027299 Cyanidioschyzon merolae 37.08 1.40e-02 34.70
IUUC-Dre-027720 Danio rerio 40.04 1.00e-88 320.00
IUUC-Dno-029079 Dasypus novemcinctus 73.68 0.00e+00 724.00
IUUC-Dor-030890 Dipodomys ordii 74.75 0.00e+00 801.00
IUUC-Dme-032072 Drosophila melanogaster 26.51 2.00e-05 43.10
IUUC-Ete-032568 Echinops telfairi 74.63 0.00e+00 673.00
IUUC-Eca-033528 Equus caballus 76.51 0.00e+00 795.00
IUUC-Eeu-035219 Erinaceus europaeus 67.52 0.00e+00 717.00
IUUC-Fca-035852 Felis catus 76.88 0.00e+00 791.00
IUUC-Fal-036862 Ficedula albicollis 54.26 2.00e-134 472.00
IUUC-Gmo-038735 Gadus morhua 37.97 2.00e-70 259.00
IUUC-Gga-040939 Gallus gallus 53.00 3.00e-137 482.00
IUUC-Gac-041580 Gasterosteus aculeatus 42.40 1.00e-91 330.00
IUUC-Gma-044378 Glycine max 30.77 8.00e-03 35.00
IUUC-Ggo-045034 Gorilla gorilla 69.23 0.00e+00 713.00
IUUC-Hsa-046624 Homo sapiens 76.99 0.00e+00 796.00
IUUC-Itr-048288 Ictidomys tridecemlineatus 70.66 0.00e+00 748.00
IUUC-Lch-049720 Latimeria chalumnae 47.48 7.00e-80 291.00
IUUC-Lpe-051390 Leersia perrieri 40.48 4.40e-02 30.80
IUUC-Loc-052185 Lepisosteus oculatus 43.15 9.00e-100 357.00
IUUC-Laf-054079 Loxodonta africana 77.40 0.00e+00 769.00
IUUC-Mcc-055674 Macaca mulatta 77.78 0.00e+00 786.00
IUUC-Meu-056769 Macropus eugenii 81.07 2.00e-68 253.00
IUUC-Mga-060203 Meleagris gallopavo 52.22 7.00e-128 451.00
IUUC-Mmr-061492 Microcebus murinus 77.26 0.00e+00 769.00
IUUC-Mdo-063051 Monodelphis domestica 70.25 0.00e+00 744.00
IUUC-Mpu-065907 Mustela putorius furo 71.95 0.00e+00 769.00
IUUC-Mlu-066957 Myotis lucifugus 75.04 0.00e+00 723.00
IUUC-Nle-069973 Nomascus leucogenys 76.65 0.00e+00 786.00
IUUC-Opr-071049 Ochotona princeps 71.36 0.00e+00 681.00
IUUC-Ont-071915 Oreochromis niloticus 41.83 4.00e-86 312.00
IUUC-Oan-072965 Ornithorhynchus anatinus 68.43 0.00e+00 728.00
IUUC-Ocu-074029 Oryctolagus cuniculus 69.49 0.00e+00 626.00
IUUC-Ome-081532 Oryza meridionalis 42.50 1.90e-02 32.00
IUUC-Ola-087019 Oryzias latipes 40.90 2.00e-89 323.00
IUUC-Oga-088613 Otolemur garnettii 76.52 0.00e+00 785.00
IUUC-Oar-090386 Ovis aries 77.44 0.00e+00 854.00
IUUC-Ptr-091619 Pan troglodytes 76.65 0.00e+00 791.00
IUUC-Pan-092178 Papio anubis 76.43 0.00e+00 772.00
IUUC-Psi-093214 Pelodiscus sinensis 57.44 5.00e-152 531.00
IUUC-Pfo-096901 Poecilia formosa 39.47 5.00e-78 285.00
IUUC-Pab-097560 Pongo abelii 78.26 2.00e-150 525.00
IUUC-Pca-100853 Procavia capensis 65.79 1.00e-105 377.00
IUUC-Pva-102255 Pteropus vampyrus 72.40 0.00e+00 701.00
IUUC-Rno-105812 Rattus norvegicus 89.57 0.00e+00 992.00
IUUC-Sce-106301 Saccharomyces cerevisiae 25.37 5.30e-02 32.70
IUUC-Sha-107225 Sarcophilus harrisii 76.78 9.00e-148 516.00
IUUC-Sit-110549 Setaria italica 30.30 2.20e-02 33.50
IUUC-Sar-113736 Sorex araneus 69.27 1.00e-121 430.00
IUUC-Ssc-115422 Sus scrofa 77.61 0.00e+00 829.00
IUUC-Tgu-116924 Taeniopygia guttata 53.56 1.00e-133 470.00
IUUC-Tru-117695 Takifugu rubripes 38.54 2.00e-86 313.00
IUUC-Tsy-119090 Tarsius syrichta 71.66 4.00e-136 478.00
IUUC-Tni-120645 Tetraodon nigroviridis 40.94 2.00e-89 323.00
IUUC-Tae-123839 Triticum aestivum 25.45 2.30e-02 35.40
IUUC-Tbe-127970 Tupaia belangeri 84.32 5.00e-119 421.00
IUUC-Ttr-129244 Tursiops truncatus 75.72 0.00e+00 759.00
IUUC-Vpa-130313 Vicugna pacos 73.59 0.00e+00 736.00
IUUC-Xtr-132115 Xenopus tropicalis 44.09 3.00e-96 345.00
IUUC-Xma-133867 Xiphophorus maculatus 39.08 4.00e-80 291.00
Created Date 25-Jun-2017

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