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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046174
UUCD1 version UUC-HoS-01150
Ensembl Protein ID ENSP00000402527.2
UniProt Accession Q9GZR1; A6NNY9; O94891; Q5VUL3; Q5VUL4; Q8TBY4; Q9UJV5; SENP6_HUMAN
Genbank Protein ID AAF04852.1; AAG29831.1; AAG30253.1; BAA34517.2; CAH72480.1; CAH72480.1; CAH72480.1; CAH72480.1; CAH72481.1; CAH72481.1; CAH72481.1; CAH74168.1; CAH74168.1; CAH74168.1; CAH74168.1; CAH74170.1; CAH74170.1; CAH74170.1; CAI19523.1; CAI19523.1; CAI19523.1; CAI19523.1; CAI23575.1; CAI23575.1; CAI23575.1; CAI23575.1; CAI23576.1; CAI23576.1; CAI23576.1; EAW48734.1; AAH28583.1; BAC04794.1
Protein Name Sentrin-specific protease 6; SUMO-1-specific protease 1; Sentrin/SUMO-specific protease SENP6
Genbank Nucleotide ID AF196304; AF307849; AF306508; AB018340; AL589656; AL109897; AL355797; AL356057; AL589656; AL355797; AL356057; AL356057; AL109897; AL355797; AL589656; AL356057; AL355797; AL589656; AL109897; AL355797; AL356057; AL589656; AL355797; AL109897; AL356057; AL589656; AL355797; AL356057; AL589656; CH471051; BC028583; AK096455
Gene Name SENP6; KIAA0797; SSP1; SUSP1; FKSG6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000112701.17 ENST00000370010.6 ENSP00000359027.2
ENSG00000112701.17 ENST00000447266.6 ENSP00000402527.2
ENSG00000112701.17 ENST00000493959.6 ENSP00000425624.1
ENSG00000112701.17 ENST00000483859.6 ENSP00000426480.1
ENSG00000112701.17 ENST00000503501.1 ENSP00000422576.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtPHOSIDABioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/ULP ULP 19850744
Classification
Family E-value Score Start End
DUB/ULP 5.80e-79 265.8 666 1041
Active Site
Position(s) Description Evidence
765 N/A {ECO:0000250}
917 {ECO:0000250}
1030 {ECO:0000250}
Domain Profile

   DUB/ULP
   S: 1    isvtnedlkcLeegeflnDviidfylkylvleklkkekverihifssffykklkqkerr...............rvktwtrkvdlfekdl 75
           isvtnedl+cL+egeflnDviidfylkylvleklkke+++rihifssffyk+l+q+err               rvktwtr+vd+fekd+
   Q: 666  ISVTNEDLHCLNEGEFLNDVIIDFYLKYLVLEKLKKEDADRIHIFSSFFYKRLNQRERRnhettnlsiqqkrhgRVKTWTRHVDIFEKDF 755
           689******************************************************999****************************** PP
   S: 76   ifvpineaaHWslavvcf........................................................................ 93
           ifvp+neaaHW+lavvcf                                                                        
   Q: 756  IFVPLNEAAHWFLAVVCFpglekpkyepnphyhenaviqkcstvedscisssasemescsqnssakpvikkmlnkkhciavidsnpgqee 845
           ****************************************************************************************** PP
   S: 94   .......................................................................................... 93
                                                                                                     
   Q: 846  sdprykrnicsvkysvkkinhtaseneefnkgestsqkvadrtksenglqneslssthhtdglskirlnysdespeagkmledelvdfse 935
           ****************************************************************************************** PP
   S: 94   .................................kkksilllDSlrgasksnvvkklreylev..evkkkskrefskeklkgsnpkvpqQk 148
                                            k+++ill+DSlrg+s+snvvk+lreylev  evkk+skr+fsk+++kgsnpkvpqQ+
   Q: 936  dqdnqddssddgfladdncsseigqwhlkpticKQPCILLMDSLRGPSRSNVVKILREYLEVewEVKKGSKRSFSKDVMKGSNPKVPQQN 1025
           **************************************************************999************************* PP
   S: 149  NssDCGvyvlqyvesl 164
           N+sDCGvyvlqyves+
   Q: 1026 NFSDCGVYVLQYVESF 1041
           **************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
 Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
Protein Sequence
(Fasta)
MAAGKSGGSA GEITFLEALA RSESKRDGGF KNNWSFDHEE ESEGDTDKDG TNLLSVDEDE 60
DSETSKGKKL NRRSEIVANS SGEFILKTYV RRNKSESFKT LKGNPIGLNM LSNNKKLSEN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046174|DUB,ULP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTACCTTTT CTCTTCGGTT GGCTGTAGTT TAAATTCTAA GGTCTCCTCA AGAAATGACA 60
TTTTCACATT TCTTAGGCAT CTGTGGTGCC AGAGGAGCAA ACCCATCGCA CACGCCAGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046174|DUB,ULP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR003653--Peptidase_C48_C
PROSITE

PS50600--ULP_PROTEASE
Pfam

PF02902--Peptidase_C48
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0016929--F:SUMO-specific protease activity
GO:0016926--P:protein desumoylation
GO:0070646--P:protein modification by small protein removal
GO:0016925--P:protein sumoylation
GO:0090234--P:regulation of kinetochore assembly
GO:0090169--P:regulation of spindle assembly
KEGG hsa:26054
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001034 Aegilops tauschii 36.36 2.00e-11 65.10
IUUC-Aml-002399 Ailuropoda melanoleuca 85.31 0.00e+00 1568.00
IUUC-Apl-003445 Anas platyrhynchos 66.01 0.00e+00 1231.00
IUUC-Aca-005366 Anolis carolinensis 59.02 0.00e+00 1145.00
IUUC-Afu-008974 Aspergillus fumigatus 38.62 2.00e-21 97.40
IUUC-Aor-010192 Aspergillus oryzae 39.66 4.00e-14 74.70
IUUC-Ame-011689 Astyanax mexicanus 50.00 3.00e-126 446.00
IUUC-Bta-012617 Bos taurus 82.36 0.00e+00 1731.00
IUUC-Bci-013906 Botrytis cinerea 38.40 3.00e-19 92.00
IUUC-Cja-018851 Callithrix jacchus 96.05 0.00e+00 2045.00
IUUC-Cfa-021097 Canis familiaris 85.25 0.00e+00 1800.00
IUUC-Csa-023037 Chlorocebus sabaeus 97.21 0.00e+00 2026.00
IUUC-Cho-024845 Choloepus hoffmanni 83.15 0.00e+00 817.00
IUUC-Csv-025934 Ciona savignyi 58.65 8.00e-42 164.00
IUUC-Cme-027337 Cyanidioschyzon merolae 32.73 1.00e-16 81.60
IUUC-Dre-027712 Danio rerio 38.63 4.00e-74 272.00
IUUC-Dno-029934 Dasypus novemcinctus 87.86 0.00e+00 1863.00
IUUC-Dor-031007 Dipodomys ordii 78.23 0.00e+00 721.00
IUUC-Ete-032953 Echinops telfairi 82.49 0.00e+00 1362.00
IUUC-Eca-033904 Equus caballus 80.72 0.00e+00 1654.00
IUUC-Eeu-034776 Erinaceus europaeus 80.34 0.00e+00 1543.00
IUUC-Fca-035504 Felis catus 86.65 0.00e+00 1770.00
IUUC-Fal-037063 Ficedula albicollis 62.00 0.00e+00 1189.00
IUUC-Ggr-039780 Gaeumannomyces graminis 38.36 7.00e-21 96.70
IUUC-Gga-040954 Gallus gallus 64.43 0.00e+00 1224.00
IUUC-Ggo-045397 Gorilla gorilla 99.46 0.00e+00 2053.00
IUUC-Itr-047947 Ictidomys tridecemlineatus 86.05 0.00e+00 1825.00
IUUC-Lch-050305 Latimeria chalumnae 55.36 0.00e+00 937.00
IUUC-Loc-052813 Lepisosteus oculatus 44.79 0.00e+00 737.00
IUUC-Laf-053816 Loxodonta africana 86.30 0.00e+00 1807.00
IUUC-Mcc-054959 Macaca mulatta 96.85 0.00e+00 2018.00
IUUC-Meu-056793 Macropus eugenii 64.49 5.00e-180 625.00
IUUC-Mor-057033 Magnaporthe oryzae 42.11 3.00e-19 91.30
IUUC-Mpo-057440 Magnaporthe poae 36.97 5.00e-22 99.80
IUUC-Mga-059770 Meleagris gallopavo 71.74 1.00e-179 624.00
IUUC-Mvi-060469 Microbotryum violaceum 36.76 6.00e-19 90.90
IUUC-Mmr-061189 Microcebus murinus 90.39 0.00e+00 1838.00
IUUC-Mdo-062682 Monodelphis domestica 71.96 0.00e+00 1218.00
IUUC-Mmu-063813 Mus musculus 79.24 0.00e+00 1683.00
IUUC-Mpu-066838 Mustela putorius furo 85.25 0.00e+00 1760.00
IUUC-Mlu-067624 Myotis lucifugus 81.11 0.00e+00 1635.00
IUUC-Ncr-068866 Neurospora crassa 34.17 4.00e-16 81.30
IUUC-Nle-069333 Nomascus leucogenys 98.02 0.00e+00 2023.00
IUUC-Ont-072443 Oreochromis niloticus 48.33 1.00e-109 390.00
IUUC-Oan-073177 Ornithorhynchus anatinus 65.95 0.00e+00 1335.00
IUUC-Ocu-073836 Oryctolagus cuniculus 86.93 0.00e+00 1583.00
IUUC-Ola-086425 Oryzias latipes 41.56 7.00e-114 404.00
IUUC-Oga-088060 Otolemur garnettii 85.46 0.00e+00 1483.00
IUUC-Oar-090281 Ovis aries 82.02 0.00e+00 1657.00
IUUC-Ptr-091047 Pan troglodytes 99.37 0.00e+00 2053.00
IUUC-Psi-093754 Pelodiscus sinensis 65.24 0.00e+00 1296.00
IUUC-Ppa-095733 Physcomitrella patens 40.31 2.00e-25 110.00
IUUC-Pfo-096310 Poecilia formosa 47.47 6.00e-159 554.00
IUUC-Pab-097538 Pongo abelii 98.02 0.00e+00 2022.00
IUUC-Pca-100735 Procavia capensis 74.64 0.00e+00 1172.00
IUUC-Pva-103196 Pteropus vampyrus 83.17 0.00e+00 1694.00
IUUC-Pgr-103328 Puccinia graminis 34.23 3.00e-18 88.20
IUUC-Pyt-104790 Pyrenophora triticirepentis 37.86 2.00e-15 77.40
IUUC-Rno-106077 Rattus norvegicus 80.53 0.00e+00 1704.00
IUUC-Sha-106934 Sarcophilus harrisii 71.24 0.00e+00 1310.00
IUUC-Sar-113339 Sorex araneus 75.17 0.00e+00 1351.00
IUUC-Ssc-116084 Sus scrofa 83.21 0.00e+00 1447.00
IUUC-Tgu-116654 Taeniopygia guttata 65.74 0.00e+00 1090.00
IUUC-Tru-118136 Takifugu rubripes 44.44 1.00e-112 400.00
IUUC-Tsy-118994 Tarsius syrichta 84.49 0.00e+00 1758.00
IUUC-Tni-119699 Tetraodon nigroviridis 78.36 6.00e-55 205.00
IUUC-Tbe-127562 Tupaia belangeri 89.57 0.00e+00 1543.00
IUUC-Ttr-128531 Tursiops truncatus 80.38 0.00e+00 1581.00
IUUC-Uma-129452 Ustilago maydis 32.80 2.00e-16 82.00
IUUC-Vpa-130776 Vicugna pacos 83.50 0.00e+00 936.00
IUUC-Xtr-132523 Xenopus tropicalis 51.21 0.00e+00 891.00
Created Date 25-Jun-2017

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