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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018495
UUCD1 version UUC-CaE-00044
Ensembl Protein ID F55B12.3a
UniProt Accession Q93794; O44083; Q95ZT0; SEL10_CAEEL
Genbank Protein ID AAC47809.1; CAB02129.2; CAC42307.1
Protein Name F-box/WD repeat-containing protein sel-10; Egg laying defective protein 41; Suppressor/enhancer of lin-12 protein 10
Genbank Nucleotide ID AF020788; Z79757; Z79757
Gene Name sel-10; egl-41; F55B12.3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00004767 F55B12.3a F55B12.3a
WBGene00004767 F55B12.3b.1 F55B12.3b.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 18718460; 17050737
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 18718460
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.0041 17.5 121 167
E3 adaptor/Cullin RING/DCX/DWD 5.60e-52 171.7 501 536
UBD/Beta-Prp 8.10e-78 261.9 250 512
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 100  aglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           ++ l+ lp e+ ++il++l++ +ll++a+v+++w+ +++ +++wk++
   Q: 121  RDFLSCLPVELGMKILHNLTGYDLLKVAQVSKNWKLISEIDKIWKSL 167
           567789********************************999999975 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvl 35
           gH + +t+l++    ++++++sdDgt+k+WD+ +g l
   Q: 501  GHRSAITSLQWfgR-NMVATSSDDGTVKLWDIERGAL 536
           8**********653.9***************988765 PP
   

   UBD/Beta-Prp
   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfs 103
           +l+gh+++vitc+++  ++++l+tgs+d+t+kvw +++g ++ +l gh+++v++ ++s+ g ++v+gs+Drt+kvw+  +g+ +htl+gh+++v+++++ 
   Q: 250  VLRGHEDHVITCMQI--HDDVLVTGSDDNTLKVWCIDKGEVMYTLVGHTGGVWTSQISQCGRYIVSGSTDRTVKVWSTVDGSLLHTLQGHTSTVRCMAMA 347
           689************..**********************************************************************************9 PP
   S: 104  psgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgt 203
              + lv+Gs+d t+rvwd+e+g  l  tl gh+++v+cv++++    +vsG++D tv++W+  tg+++rtltg h+++vysl f+s++  + sgsld++
   Q: 348  G--SILVTGSRDTTLRVWDVESGRHLA-TLHGHHAAVRCVQFDG--TTVVSGGYDFTVKIWNAHTGRCIRTLTG-HNNRVYSLLFESERSIVCSGSLDTS 441
           9..************************.****************..9**************************9.************************* PP
   S: 204  vklwdlq...tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsf 275
           +++wd+     +ecv  l+ght+ ++ +++   +++lvs+++D  +r+Wd+  g+++++l++h+s ++s +   f
   Q: 442  IRVWDFTrpeGQECVALLQGHTSLTSGMQLR--GNILVSCNADSHVRVWDIHEGTCVHMLSGHRSAITSLQW--F 512
           *******898889******************..**********************************99987..4 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Probable substrate recognition component of SCF (SKP1-CUL-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquination and subsequent proteasomal degradation of target proteins (PubMed:17626846). Regulates synapse elimination in early development in the motor neuron HSNL (PubMed:17626846). Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis (PubMed:9389650). May target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation (PubMed:9389650). Involved in sex determination by promoting female development (PubMed:15306688, PubMed:18718460). Potential regulator of presenilin (PubMed:9861048). May have a role in egg laying (PubMed:8293978, PubMed:15306688). Regulates zyg-1 levels (possibly redundantly with lin-23) to control centrosome duplication during mitosis (PubMed:22623721). Negatively regulates lin-45 activity and protein stability, probably by targeting it for ubiquitination and proteasomal degradation (PubMed:23154983).
 Probable substrate recognition component of SCF (SKP1-CUL-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquination and subsequent proteasomal degradation of target proteins (PubMed:17626846). Regulates synapse elimination in early development in the motor neuron HSNL (PubMed:17626846). Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis (PubMed:9389650). May target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation (PubMed:9389650). Involved in sex determination by promoting female development (PubMed:15306688, PubMed:18718460). Potential regulator of presenilin (PubMed:9861048). May have a role in egg laying (PubMed:8293978, PubMed:15306688). Regulates zyg-1 levels (possibly redundantly with lin-23) to control centrosome duplication during mitosis (PubMed:22623721). Negatively regulates lin-45 activity and protein stability, probably by targeting it for ubiquitination and proteasomal degradation (PubMed:23154983).
Protein Sequence
(Fasta)
MWPRNDVHMD DGSMTPEDQE PVTDNDMEYN DNGEESSYSN GSSSSYNADK LSSSRPLQHK 60
LDLSASPSRN NDLNPRVEHL IALFKDLSSA EQMDAFTRLL QESNMTNIRQ LRAIIEPHFQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018495|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAAAAGTGTT GGAAATTGTG GCTCCTCCTG AAGTCGAACA ATCGGAATTT CCGTTTTCAG 60
AGAATGTAGG CTATTTCAAA TAATCGTATT TTTCGGTTTT GTGCAATTTC TAGCATATTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018495|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-1185--Reference proteome
KW-0677--Repeat
KW-0726--Sexual differentiation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR023302--Pept_S9A_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12937--F-box-like
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:0030424--C:axon
GO:0005737--C:cytoplasm
GO:0042803--F:protein homodimerization activity
GO:0019901--F:protein kinase binding
GO:0030154--P:cell differentiation
GO:0046660--P:female sex differentiation
GO:0010826--P:negative regulation of centrosome duplication
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0008593--P:regulation of Notch signaling pathway
GO:0031647--P:regulation of protein stability
GO:0040028--P:regulation of vulval development
KEGG cel:CELE_F55B12.3
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002406 Ailuropoda melanoleuca 48.53 3.00e-131 461.00
IUUC-Apl-003489 Anas platyrhynchos 48.73 2.00e-131 461.00
IUUC-Aca-005318 Anolis carolinensis 48.73 2.00e-131 461.00
IUUC-Ago-007888 Ashbya gossypii 30.09 1.00e-54 206.00
IUUC-Acl-008123 Aspergillus clavatus 31.29 1.00e-63 236.00
IUUC-Afl-008730 Aspergillus flavus 31.57 1.00e-63 236.00
IUUC-Afu-009014 Aspergillus fumigatus 31.08 4.00e-65 241.00
IUUC-Ani-009332 Aspergillus nidulans 30.74 7.00e-63 233.00
IUUC-Ang-009790 Aspergillus niger 32.49 2.00e-66 245.00
IUUC-Aor-010215 Aspergillus oryzae 31.40 4.00e-63 234.00
IUUC-Ate-010535 Aspergillus terreus 31.01 2.00e-64 239.00
IUUC-Ame-010898 Astyanax mexicanus 48.53 1.00e-130 459.00
IUUC-Bgr-012075 Blumeria graminis 34.21 7.00e-74 270.00
IUUC-Bta-012391 Bos taurus 48.73 4.00e-131 460.00
IUUC-Bci-013725 Botrytis cinerea 33.14 2.00e-68 252.00
IUUC-Cja-018902 Callithrix jacchus 48.73 9.00e-132 462.00
IUUC-Cfa-020237 Canis familiaris 48.73 1.00e-131 462.00
IUUC-Cpo-022234 Cavia porcellus 48.73 2.00e-131 461.00
IUUC-Csa-023532 Chlorocebus sabaeus 48.73 9.00e-132 462.00
IUUC-Cho-025026 Choloepus hoffmanni 44.99 9.00e-80 290.00
IUUC-Cin-025516 Ciona intestinalis 40.00 1.00e-74 271.00
IUUC-Csv-026312 Ciona savignyi 47.71 6.00e-127 446.00
IUUC-Cgl-026492 Colletotrichum gloeosporioides 32.77 3.00e-70 258.00
IUUC-Cne-027018 Cryptococcus neoformans 30.48 8.00e-66 244.00
IUUC-Dre-028303 Danio rerio 49.02 5.00e-131 460.00
IUUC-Dno-029576 Dasypus novemcinctus 47.16 8.00e-126 443.00
IUUC-Dor-030196 Dipodomys ordii 48.53 1.00e-130 459.00
IUUC-Dse-031558 Dothistroma septosporum 32.52 1.00e-67 249.00
IUUC-Dme-031702 Drosophila melanogaster 49.71 3.00e-135 475.00
IUUC-Ete-032791 Echinops telfairi 49.60 1.00e-129 456.00
IUUC-Eca-033424 Equus caballus 48.73 3.00e-131 461.00
IUUC-Eeu-034996 Erinaceus europaeus 48.14 2.00e-129 454.00
IUUC-Fca-036422 Felis catus 48.73 8.00e-132 462.00
IUUC-Fal-037267 Ficedula albicollis 48.34 2.00e-130 458.00
IUUC-Fox-037800 Fusarium oxysporum 33.47 2.00e-71 262.00
IUUC-Fso-038258 Fusarium solani 33.47 9.00e-71 259.00
IUUC-Gmo-039478 Gadus morhua 60.53 9.00e-109 385.00
IUUC-Ggr-039781 Gaeumannomyces graminis 32.18 3.00e-66 244.00
IUUC-Gga-040667 Gallus gallus 48.73 8.00e-132 462.00
IUUC-Gac-042423 Gasterosteus aculeatus 48.76 1.00e-122 431.00
IUUC-Ggo-044422 Gorilla gorilla 48.73 9.00e-132 462.00
IUUC-Hsa-045898 Homo sapiens 48.73 1.00e-131 462.00
IUUC-Itr-048241 Ictidomys tridecemlineatus 49.31 9.00e-131 458.00
IUUC-Kpa-049097 Komagataella pastoris 29.60 4.00e-66 244.00
IUUC-Lch-050414 Latimeria chalumnae 48.53 2.00e-131 461.00
IUUC-Loc-052348 Lepisosteus oculatus 48.53 6.00e-131 459.00
IUUC-Lma-053185 Leptosphaeria maculans 31.88 1.00e-63 236.00
IUUC-Laf-054054 Loxodonta africana 48.73 7.00e-132 463.00
IUUC-Mcc-055056 Macaca mulatta 48.73 9.00e-132 462.00
IUUC-Meu-056778 Macropus eugenii 38.89 2.00e-49 189.00
IUUC-Mor-057076 Magnaporthe oryzae 33.93 1.00e-65 243.00
IUUC-Mpo-057423 Magnaporthe poae 39.77 3.00e-61 228.00
IUUC-Mla-059081 Melampsora laricipopulina 32.13 2.00e-62 232.00
IUUC-Mga-059255 Meleagris gallopavo 48.73 1.00e-131 462.00
IUUC-Mvi-060490 Microbotryum violaceum 35.19 8.00e-53 201.00
IUUC-Mmr-061292 Microcebus murinus 48.73 1.00e-131 462.00
IUUC-Mdo-062304 Monodelphis domestica 48.73 4.00e-132 464.00
IUUC-Mmu-063610 Mus musculus 48.73 5.00e-132 463.00
IUUC-Mpu-065931 Mustela putorius furo 48.73 1.00e-131 462.00
IUUC-Mlu-066976 Myotis lucifugus 48.73 7.00e-132 462.00
IUUC-Nfi-068428 Neosartorya fischeri 31.08 2.00e-65 242.00
IUUC-Ncr-068688 Neurospora crassa 34.16 2.00e-70 258.00
IUUC-Nle-070174 Nomascus leucogenys 48.73 1.00e-131 462.00
IUUC-Opr-070851 Ochotona princeps 45.92 1.00e-66 246.00
IUUC-Ont-071997 Oreochromis niloticus 47.75 2.00e-128 451.00
IUUC-Oan-072936 Ornithorhynchus anatinus 48.73 1.00e-131 462.00
IUUC-Ocu-074742 Oryctolagus cuniculus 48.73 7.00e-132 463.00
IUUC-Ola-087098 Oryzias latipes 48.51 2.00e-129 454.00
IUUC-Olu-087837 Ostreococcus lucimarinus 34.20 8.00e-33 132.00
IUUC-Oga-088884 Otolemur garnettii 57.49 3.00e-114 403.00
IUUC-Oar-090220 Ovis aries 36.53 2.00e-94 338.00
IUUC-Ptr-090492 Pan troglodytes 48.73 1.00e-131 462.00
IUUC-Pan-091770 Papio anubis 48.73 1.00e-131 462.00
IUUC-Psi-093207 Pelodiscus sinensis 48.73 2.00e-131 461.00
IUUC-Pma-094749 Petromyzon marinus 49.30 3.00e-123 434.00
IUUC-Pno-095026 Phaeosphaeria nodorum 36.69 2.00e-60 226.00
IUUC-Pfo-096493 Poecilia formosa 48.53 4.00e-131 460.00
IUUC-Pab-098141 Pongo abelii 48.73 3.00e-131 460.00
IUUC-Pca-100571 Procavia capensis 43.97 2.00e-79 288.00
IUUC-Pva-102988 Pteropus vampyrus 48.73 8.00e-132 462.00
IUUC-Pgr-103612 Puccinia graminis 34.00 2.00e-54 206.00
IUUC-Ptt-103698 Puccinia triticina 33.22 5.00e-38 151.00
IUUC-Pte-104275 Pyrenophora teres 31.24 2.00e-67 249.00
IUUC-Pyt-104438 Pyrenophora triticirepentis 31.97 4.00e-68 251.00
IUUC-Rno-105706 Rattus norvegicus 48.73 8.00e-132 462.00
IUUC-Sce-106314 Saccharomyces cerevisiae 28.17 5.00e-60 224.00
IUUC-Sha-107653 Sarcophilus harrisii 48.73 1.00e-131 462.00
IUUC-Sja-107840 Schizosaccharomyces japonicus 29.66 3.00e-62 231.00
IUUC-Spo-108063 Schizosaccharomyces pombe 30.21 1.00e-53 203.00
IUUC-Sar-113600 Sorex araneus 45.40 9.00e-117 412.00
IUUC-Sre-114901 Sporisorium reilianum 44.83 4.00e-53 202.00
IUUC-Ssc-115787 Sus scrofa 48.14 6.00e-128 450.00
IUUC-Tgu-117510 Taeniopygia guttata 48.73 1.00e-131 462.00
IUUC-Tru-117819 Takifugu rubripes 47.95 3.00e-130 457.00
IUUC-Tsy-118828 Tarsius syrichta 48.73 1.00e-131 462.00
IUUC-Tni-120468 Tetraodon nigroviridis 48.14 3.00e-130 457.00
IUUC-Tre-122193 Trichoderma reesei 33.89 1.00e-70 259.00
IUUC-Tvi-122615 Trichoderma virens 33.33 2.00e-71 262.00
IUUC-Tme-127021 Tuber melanosporum 33.47 2.00e-69 255.00
IUUC-Tbe-127925 Tupaia belangeri 48.73 2.00e-131 461.00
IUUC-Ttr-128899 Tursiops truncatus 48.53 2.00e-131 461.00
IUUC-Uma-129449 Ustilago maydis 45.69 2.00e-53 203.00
IUUC-Vda-129802 Verticillium dahliae 33.27 1.00e-69 256.00
IUUC-Vpa-130082 Vicugna pacos 46.10 2.00e-100 358.00
IUUC-Xtr-132213 Xenopus tropicalis 48.34 2.00e-131 461.00
IUUC-Xma-133646 Xiphophorus maculatus 48.44 8.00e-130 456.00
IUUC-Yli-134429 Yarrowia lipolytica 34.40 1.00e-70 259.00
Created Date 25-Jun-2017

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