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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018422
UUCD1 version UUC-CaE-00039
Ensembl Protein ID F55A11.3
UniProt Accession Q20798; HRD1_CAEEL
Genbank Protein ID CAA96657.1
Protein Name E3 ubiquitin-protein ligase hrd-1; RING-type E3 ubiquitin transferase hrd-1; Suppressor/enhancer of lin-12
Genbank Nucleotide ID Z72511
Gene Name sel-11; hrd-1; F55A11.3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00004768 F55A11.3 F55A11.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 15530417
Classification
Family E-value Score Start End
E3 activity/RING/RING 3.10e-09 37.5 292 333
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC+e++  +  p+ lpC Hvfha+Cl  w       +++++CP+Cr
   Q: 292  CIICREEMtvDASPKRLPCSHVFHAHCLRSW------FQRQQTCPTCR 333
           ********9877799****************......**********8 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Thought to play a role together with hsp-3 in developmental growth and function of intestinal cells and to play a role together with hsp-4 in gonad formation.
 Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Thought to play a role together with hsp-3 in developmental growth and function of intestinal cells and to play a role together with hsp-4 in gonad formation.
Protein Sequence
(Fasta)
MRVSAGLMIG GSCVATAATI LNAFLINKQF YPSIVYLSKS NASMAVIYVQ GIVLVYLMFQ 60
LLKSILFGDL RAAEAEHLSE RTWHAVLETC LAFTVFRDDF SAIFVMQFIG LLFIKCFHWL 120
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Protein Fasta Sequence


>IUUC-Cel-018422|E3,RING|Caenorhabditis elegans
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Nucleotide Sequence
(Fasta)
ATCCCTCGGA ATTCAGATGA GGGTATCAGC TGGACTAATG ATTGGTGGCT CGTGTGTGGC 60
GACTGCGGCC ACCATACTCA ACGCGTTCCT GATCAACAAA CAGTTCTATC CATCAATCGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018422|E3,RING|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032832--E3_lig_synoviolin/Hrd1
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0000836--C:Hrd1p ubiquitin ligase complex
GO:0016021--C:integral component of membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:1990381--F:ubiquitin-specific protease binding
GO:0051082--F:unfolded protein binding
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0035264--P:multicellular organism growth
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0010468--P:regulation of gene expression
GO:0008593--P:regulation of Notch signaling pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG cel:CELE_F55A11.3
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000344 Aegilops tauschii 36.20 4.00e-46 177.00
IUUC-Aml-001539 Ailuropoda melanoleuca 57.19 7.00e-117 413.00
IUUC-Atr-002892 Amborella trichopoda 40.06 5.00e-70 257.00
IUUC-Apl-004003 Anas platyrhynchos 52.54 2.00e-34 136.00
IUUC-Aca-004799 Anolis carolinensis 59.42 5.00e-115 407.00
IUUC-Aly-006352 Arabidopsis lyrata 39.82 8.00e-66 243.00
IUUC-Ath-006702 Arabidopsis thaliana 38.92 7.00e-65 239.00
IUUC-Ago-007894 Ashbya gossypii 25.91 4.00e-16 78.60
IUUC-Acl-008041 Aspergillus clavatus 28.21 2.00e-46 179.00
IUUC-Afl-008427 Aspergillus flavus 28.29 4.00e-41 161.00
IUUC-Afu-009023 Aspergillus fumigatus 27.60 2.00e-45 176.00
IUUC-Ani-009133 Aspergillus nidulans 28.72 8.00e-43 167.00
IUUC-Ang-009612 Aspergillus niger 30.32 3.00e-48 185.00
IUUC-Aor-010045 Aspergillus oryzae 28.04 5.00e-46 177.00
IUUC-Ate-010533 Aspergillus terreus 28.79 2.00e-46 179.00
IUUC-Ame-011083 Astyanax mexicanus 58.41 4.00e-112 397.00
IUUC-Bgr-012122 Blumeria graminis 26.70 2.00e-41 162.00
IUUC-Bta-013375 Bos taurus 57.70 8.00e-117 412.00
IUUC-Bci-013675 Botrytis cinerea 31.44 9.00e-24 104.00
IUUC-Bdi-015070 Brachypodium distachyon 39.57 1.00e-61 229.00
IUUC-Bol-015593 Brassica oleracea 39.69 1.00e-64 239.00
IUUC-Bra-017516 Brassica rapa 40.00 3.00e-65 241.00
IUUC-Cja-019779 Callithrix jacchus 55.42 8.00e-107 379.00
IUUC-Cfa-020189 Canis familiaris 57.70 3.00e-117 414.00
IUUC-Cpo-022209 Cavia porcellus 57.19 3.00e-117 414.00
IUUC-Cre-022743 Chlamydomonas reinhardtii 40.38 9.00e-62 229.00
IUUC-Csa-023571 Chlorocebus sabaeus 57.70 5.00e-117 413.00
IUUC-Cho-024889 Choloepus hoffmanni 51.36 9.00e-101 359.00
IUUC-Csv-026160 Ciona savignyi 49.85 7.00e-95 339.00
IUUC-Cgl-026601 Colletotrichum gloeosporioides 34.57 3.00e-10 58.90
IUUC-Cne-027002 Cryptococcus neoformans 35.43 6.00e-61 227.00
IUUC-Cme-027285 Cyanidioschyzon merolae 34.80 2.00e-42 165.00
IUUC-Dre-027999 Danio rerio 59.05 2.00e-114 405.00
IUUC-Dno-029250 Dasypus novemcinctus 57.88 9.00e-117 412.00
IUUC-Dor-030718 Dipodomys ordii 54.19 1.00e-108 385.00
IUUC-Dse-031498 Dothistroma septosporum 34.48 8.00e-21 94.40
IUUC-Dme-031969 Drosophila melanogaster 53.17 2.00e-103 368.00
IUUC-Ete-032962 Echinops telfairi 25.90 1.00e-27 116.00
IUUC-Eca-033258 Equus caballus 57.19 5.00e-117 413.00
IUUC-Fca-035980 Felis catus 56.89 1.00e-116 412.00
IUUC-Fal-037554 Ficedula albicollis 46.13 6.00e-56 210.00
IUUC-Fox-037902 Fusarium oxysporum 33.83 1.00e-26 113.00
IUUC-Fso-038418 Fusarium solani 28.64 3.00e-43 169.00
IUUC-Gmo-039288 Gadus morhua 57.45 1.00e-112 399.00
IUUC-Ggr-040076 Gaeumannomyces graminis 30.89 1.00e-47 183.00
IUUC-Gga-040347 Gallus gallus 57.64 8.00e-46 174.00
IUUC-Gac-042347 Gasterosteus aculeatus 58.41 5.00e-113 400.00
IUUC-Gma-044123 Glycine max 40.62 1.00e-66 246.00
IUUC-Ggo-044858 Gorilla gorilla 57.70 7.00e-117 413.00
IUUC-Hsa-046412 Homo sapiens 57.19 7.00e-117 413.00
IUUC-Hvu-047279 Hordeum vulgare 38.65 2.00e-60 224.00
IUUC-Itr-048924 Ictidomys tridecemlineatus 57.70 1.00e-116 412.00
IUUC-Kpa-049117 Komagataella pastoris 25.60 1.00e-23 102.00
IUUC-Lch-049533 Latimeria chalumnae 31.56 2.00e-38 152.00
IUUC-Lpe-051229 Leersia perrieri 34.86 3.00e-21 94.70
IUUC-Loc-052843 Lepisosteus oculatus 57.89 2.00e-70 257.00
IUUC-Lma-052997 Leptosphaeria maculans 27.25 1.00e-43 170.00
IUUC-Laf-053482 Loxodonta africana 57.70 1.00e-116 412.00
IUUC-Mcc-055075 Macaca mulatta 57.19 6.00e-117 413.00
IUUC-Meu-056683 Macropus eugenii 61.54 6.00e-94 336.00
IUUC-Mor-057082 Magnaporthe oryzae 29.77 1.00e-48 187.00
IUUC-Mpo-057573 Magnaporthe poae 29.26 5.00e-43 167.00
IUUC-Mtr-058601 Medicago truncatula 40.31 1.00e-70 259.00
IUUC-Mla-059168 Melampsora laricipopulina 37.85 3.00e-70 258.00
IUUC-Mvi-060515 Microbotryum violaceum 38.70 6.00e-58 217.00
IUUC-Mmr-060922 Microcebus murinus 57.19 9.00e-117 412.00
IUUC-Mdo-062491 Monodelphis domestica 57.70 5.00e-115 407.00
IUUC-Mmu-063770 Mus musculus 57.19 8.00e-117 412.00
IUUC-Mac-064789 Musa acuminata 39.69 2.00e-69 255.00
IUUC-Mpu-066107 Mustela putorius furo 57.19 1.00e-116 412.00
IUUC-Mlu-067918 Myotis lucifugus 57.88 3.00e-109 387.00
IUUC-Nfi-068389 Neosartorya fischeri 27.34 2.00e-45 176.00
IUUC-Ncr-068742 Neurospora crassa 28.79 2.00e-37 149.00
IUUC-Nle-069139 Nomascus leucogenys 57.19 7.00e-117 413.00
IUUC-Opr-070898 Ochotona princeps 56.44 7.00e-68 250.00
IUUC-Ont-071991 Oreochromis niloticus 57.85 7.00e-116 409.00
IUUC-Ocu-074065 Oryctolagus cuniculus 57.19 3.00e-116 410.00
IUUC-Oba-075221 Oryza barthii 38.15 7.00e-60 223.00
IUUC-Obr-076914 Oryza brachyantha 39.14 1.00e-56 213.00
IUUC-Ogu-078124 Oryza glumaepatula 38.15 6.00e-60 223.00
IUUC-Oin-080013 Oryza indica 37.23 7.00e-57 213.00
IUUC-Olo-080247 Oryza longistaminata 37.65 7.00e-55 206.00
IUUC-Ome-081769 Oryza meridionalis 39.57 3.00e-62 231.00
IUUC-Oni-082946 Oryza nivara 38.15 7.00e-60 223.00
IUUC-Opu-083268 Oryza punctata 34.06 1.00e-42 166.00
IUUC-Oru-085114 Oryza rufipogon 38.15 6.00e-60 223.00
IUUC-Osa-085829 Oryza sativa 39.57 4.00e-62 231.00
IUUC-Ola-087449 Oryzias latipes 59.68 9.00e-115 405.00
IUUC-Olu-087894 Ostreococcus lucimarinus 39.21 2.00e-63 234.00
IUUC-Oga-089036 Otolemur garnettii 57.70 5.00e-117 413.00
IUUC-Oar-089715 Ovis aries 57.70 8.00e-117 412.00
IUUC-Ptr-091000 Pan troglodytes 57.70 1.00e-116 412.00
IUUC-Pan-092187 Papio anubis 57.19 4.00e-117 413.00
IUUC-Psi-093377 Pelodiscus sinensis 59.11 4.00e-110 390.00
IUUC-Pma-094759 Petromyzon marinus 61.59 2.00e-51 194.00
IUUC-Pno-094883 Phaeosphaeria nodorum 27.76 1.00e-40 160.00
IUUC-Ppa-095684 Physcomitrella patens 40.42 1.00e-64 239.00
IUUC-Pfo-096861 Poecilia formosa 57.78 9.00e-113 399.00
IUUC-Pab-098030 Pongo abelii 57.19 8.00e-117 412.00
IUUC-Pop-099245 Populus trichocarpa 39.01 4.00e-69 254.00
IUUC-Pca-100191 Procavia capensis 55.89 5.00e-110 390.00
IUUC-Ppe-101829 Prunus persica 41.23 6.00e-71 260.00
IUUC-Pva-102689 Pteropus vampyrus 57.19 8.00e-117 412.00
IUUC-Pgr-103286 Puccinia graminis 34.92 6.00e-63 234.00
IUUC-Ptt-103919 Puccinia triticina 35.83 1.00e-60 226.00
IUUC-Pte-104372 Pyrenophora teres 29.52 9.00e-48 184.00
IUUC-Pyt-104456 Pyrenophora triticirepentis 29.26 2.00e-45 176.00
IUUC-Rno-105723 Rattus norvegicus 57.70 9.00e-117 412.00
IUUC-Sce-106348 Saccharomyces cerevisiae 23.12 1.00e-18 86.70
IUUC-Sha-107300 Sarcophilus harrisii 61.30 7.00e-95 339.00
IUUC-Sja-107685 Schizosaccharomyces japonicus 29.75 4.00e-34 138.00
IUUC-Spo-108308 Schizosaccharomyces pombe 30.37 7.00e-41 160.00
IUUC-Ssl-108558 Sclerotinia sclerotiorum 31.29 7.00e-21 94.70
IUUC-Smo-109123 Selaginella moellendorffii 43.35 6.00e-68 249.00
IUUC-Sit-110276 Setaria italica 40.18 2.00e-63 235.00
IUUC-Sly-111819 Solanum lycopersicum 40.86 1.00e-64 239.00
IUUC-Stu-112048 Solanum tuberosum 37.69 9.00e-66 243.00
IUUC-Sbi-114027 Sorghum bicolor 40.49 2.00e-70 258.00
IUUC-Sre-115212 Sporisorium reilianum 34.50 3.00e-59 221.00
IUUC-Ssc-116323 Sus scrofa 58.01 3.00e-117 414.00
IUUC-Tru-118045 Takifugu rubripes 57.19 8.00e-115 406.00
IUUC-Tsy-118823 Tarsius syrichta 48.58 1.00e-85 308.00
IUUC-Tni-120106 Tetraodon nigroviridis 60.63 2.00e-82 298.00
IUUC-Tca-121462 Theobroma cacao 41.02 3.00e-70 258.00
IUUC-Tre-122204 Trichoderma reesei 30.20 2.00e-48 186.00
IUUC-Tvi-122550 Trichoderma virens 33.17 4.00e-26 112.00
IUUC-Tae-124064 Triticum aestivum 40.18 5.00e-63 233.00
IUUC-Tur-126538 Triticum urartu 35.51 7.00e-44 171.00
IUUC-Tme-127197 Tuber melanosporum 37.61 2.00e-57 216.00
IUUC-Tbe-127385 Tupaia belangeri 51.96 4.00e-102 363.00
IUUC-Ttr-128795 Tursiops truncatus 57.70 9.00e-117 412.00
IUUC-Uma-129401 Ustilago maydis 33.71 3.00e-48 185.00
IUUC-Vda-129968 Verticillium dahliae 33.15 2.00e-23 103.00
IUUC-Vpa-130483 Vicugna pacos 24.84 2.00e-27 115.00
IUUC-Vvi-130944 Vitis vinifera 41.54 7.00e-70 256.00
IUUC-Xtr-131884 Xenopus tropicalis 57.31 5.00e-117 413.00
IUUC-Xma-133488 Xiphophorus maculatus 57.78 2.00e-113 401.00
IUUC-Yli-134552 Yarrowia lipolytica 28.45 4.00e-38 150.00
IUUC-Zma-135530 Zea mays 40.32 2.00e-61 228.00
Created Date 25-Jun-2017

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