iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/Cullin	Cullin_N_terminal	18698375

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	1.10e-241	803.8	20	744

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesv.kkeyeelytavynlclsk..vgaklYkklkevleefikqvkkkveesedeq.lLktynreWekfreqlkvlrkifayldrt.. 93
           +r++v k+lrq++v ++e+++l+++v+++cl++  ++ak+Y++l+++++efi+q++++v+++++eq lL+ty++eW+kf++q+++l+ +f++l+++  
   Q: 20   KRRIVLKLLRQDTVsQREWQDLFFGVHFVCLWDekGAAKIYDCLQQDIVEFIVQAQSQVQAQRGEQaLLATYIVEWRKFFTQSNYLPLPFRQLEQSpq 117
           689*****************************9999************************************************************87 PP
   S: 94   .......................................................yvkk............................skkv......s 102
                                                                                                  s  +      s
   Q: 118  vkpsssgssssasvsasgastsaaaaaaatscsgqagksgastsaaagastsaaaA--AastsastssaaaaaaasgsgssssststS--KknptedS 211
           77777777777777777777777777777777776666655555555555555550..055555555566666666666666655431..1345667* PP
   S: 103  evrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLslnk...laiykesFEakfleatqefykaesaeflqenevdeYl 197
           +vrkL+ld+w+k+i++dik+rl+e+++k+++aeR+g+a+d++l++gv+es+v+Ls+n+   l+iy+e+FE+++l+at efy+ +sae++qen+v +Y+
   Q: 212  PVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAedkLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYM 309
           *********************************************************9999************************************* PP
   S: 198  kkvearlneeeeraaryleestetkLlevvekeliakhlesllaelvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaalt..ae 291
           k+++++l+eee ra+ryle+s+++ L+++++++li++hl+s++ae++al+rd++te+l++m++L++rv++  g+e+++++l++hi+++g+a++   +e
   Q: 310  KYADSKLREEEVRAKRYLEPSSFSILTYTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLMDRVMHgvGVEPMMGDLQRHIMSAGLADMLsaSE 407
           **********************************************************************999********************99999 PP
   S: 292  ekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlka.................akspEllAryiDqlLrks..skgltee 370
           ++++d++kyVerllel+nk+++lv++aFn+d++Fl+a+d af+t+vn++sv+k+                 +k+pEllA+y+D+lLr++  sk+lt+e
   Q: 408  VITQDSEKYVERLLELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMelptsianrgvkytapeSKCPELLANYCDMLLRRTplSKRLTSE 505
           ************************************************************************************************** PP
   S: 371  eleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeec.gaeftskLerMfqdlkvSedlnrqFkeekenteesesvels 467
           +++a+l++vllv+ky+++kdvF++y+k hL++RL++g+sa+se+Ee+++e+L+e++ +a+++++L+rMfqd+kvSedln+qF+     t++s++++++
   Q: 506  QIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWLREVGmPADYVNRLARMFQDIKVSEDLNTQFR-----TSISRHDAIN 598
           ***********************************************************************************.....********** PP
   S: 468  vlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnns..ekvsveelkkatel 563
           +++L+agaW+++se+++vsLP ele++i+++eefY++khsgRkLqW+h+++++++++++++g+y+l+V+tfQmavL+a+n++  +k+s+e+l+ atel
   Q: 599  IKILNAGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITFVNNFGRYDLDVTTFQMAVLFAWNQRqhDKISYENLRLATEL 696
           *********************************************************************************999************** PP
   S: 564  peeeLrrtlqsLvs.sk..kqvlkkepeske....ieeedlfsvNqef 604
           p++eLrrtl+sLv+ +k  kq+l +ep++ +    ++e+++f++Nqef
   Q: 697  PDPELRRTLWSLVAfPKikKQILLMEPAAISspkdFAENTMFYINQEF 744
           **************99999********99444777************9 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MLRAIGKRDR DIFEEVWPDK RRIVLKLLRQ DTVSQREWQD LFFGVHFVCL WDEKGAAKIY 60
DCLQQDIVEF IVQAQSQVQA QRGEQALLAT YIVEWRKFFT QSNYLPLPFR QLEQSPQVKP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATCGTATCG CCTAATTACA AAAAATAAAT ATAAATGAAG TGAAGCGGAC GCAGCAACAA 60
AAACAAAGAG ATTGCTACGA TCAAAATGCT ACGGGTAAGT GACCTGATCG GCGATGAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007281--P:germ cell development
GO:0007293--P:germarium-derived egg chamber formation
GO:0007295--P:growth of a germarium-derived egg chamber
GO:0008285--P:negative regulation of cell proliferation
GO:0007528--P:neuromuscular junction development
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051726--P:regulation of cell cycle
GO:0008582--P:regulation of synaptic growth at neuromuscular junction
GO:0016360--P:sensory organ precursor cell fate determination

KEGG

dme:Dmel_CG1401

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002082	Ailuropoda melanoleuca	68.13	0.00e+00	888.00
IUUC-Apl-003564	Anas platyrhynchos	68.13	0.00e+00	889.00
IUUC-Aca-004319	Anolis carolinensis	68.13	0.00e+00	888.00
IUUC-Ame-011742	Astyanax mexicanus	67.32	0.00e+00	883.00
IUUC-Bta-012515	Bos taurus	68.13	0.00e+00	890.00
IUUC-Cel-018522	Caenorhabditis elegans	52.20	0.00e+00	668.00
IUUC-Cja-018785	Callithrix jacchus	68.13	0.00e+00	889.00
IUUC-Cfa-020932	Canis familiaris	68.13	0.00e+00	890.00
IUUC-Cpo-022317	Cavia porcellus	68.29	0.00e+00	890.00
IUUC-Csa-023949	Chlorocebus sabaeus	68.13	0.00e+00	889.00
IUUC-Cin-025540	Ciona intestinalis	69.95	7.00e-145	505.00
IUUC-Csv-025978	Ciona savignyi	62.33	0.00e+00	785.00
IUUC-Dre-028114	Danio rerio	66.12	0.00e+00	873.00
IUUC-Dno-029195	Dasypus novemcinctus	68.13	0.00e+00	888.00
IUUC-Dor-030573	Dipodomys ordii	62.07	3.00e-121	428.00
IUUC-Ete-032428	Echinops telfairi	59.97	0.00e+00	731.00
IUUC-Eca-033232	Equus caballus	68.13	0.00e+00	889.00
IUUC-Eeu-035348	Erinaceus europaeus	73.45	1.00e-162	566.00
IUUC-Fca-035401	Felis catus	67.98	0.00e+00	875.00
IUUC-Fal-037514	Ficedula albicollis	68.13	0.00e+00	887.00
IUUC-Gmo-038577	Gadus morhua	67.87	0.00e+00	885.00
IUUC-Gga-041096	Gallus gallus	68.13	0.00e+00	888.00
IUUC-Gac-042108	Gasterosteus aculeatus	67.42	0.00e+00	881.00
IUUC-Ggo-045313	Gorilla gorilla	68.13	0.00e+00	888.00
IUUC-Hsa-045974	Homo sapiens	68.13	0.00e+00	889.00
IUUC-Itr-049009	Ictidomys tridecemlineatus	68.13	0.00e+00	887.00
IUUC-Lch-050615	Latimeria chalumnae	67.98	0.00e+00	887.00
IUUC-Loc-051807	Lepisosteus oculatus	68.18	0.00e+00	891.00
IUUC-Laf-053601	Loxodonta africana	68.13	0.00e+00	889.00
IUUC-Mcc-055260	Macaca mulatta	68.13	0.00e+00	887.00
IUUC-Meu-056632	Macropus eugenii	65.46	3.00e-125	441.00
IUUC-Mga-059658	Meleagris gallopavo	68.03	0.00e+00	884.00
IUUC-Mmr-061424	Microcebus murinus	59.69	0.00e+00	722.00
IUUC-Mdo-061836	Monodelphis domestica	68.29	0.00e+00	889.00
IUUC-Mmu-063757	Mus musculus	67.68	0.00e+00	882.00
IUUC-Mpu-065823	Mustela putorius furo	68.13	0.00e+00	889.00
IUUC-Mlu-066969	Myotis lucifugus	67.98	0.00e+00	887.00
IUUC-Nle-069943	Nomascus leucogenys	68.13	0.00e+00	889.00
IUUC-Opr-070820	Ochotona princeps	65.46	2.00e-125	442.00
IUUC-Ont-072527	Oreochromis niloticus	68.33	0.00e+00	895.00
IUUC-Oan-072743	Ornithorhynchus anatinus	68.13	0.00e+00	889.00
IUUC-Ocu-074586	Oryctolagus cuniculus	68.13	0.00e+00	889.00
IUUC-Ola-087526	Oryzias latipes	67.73	0.00e+00	885.00
IUUC-Oga-088425	Otolemur garnettii	64.09	0.00e+00	851.00
IUUC-Oar-089785	Ovis aries	68.13	0.00e+00	889.00
IUUC-Ptr-091242	Pan troglodytes	68.13	0.00e+00	889.00
IUUC-Pan-092246	Papio anubis	68.13	0.00e+00	889.00
IUUC-Psi-094081	Pelodiscus sinensis	68.13	0.00e+00	888.00
IUUC-Pma-094735	Petromyzon marinus	62.30	7.00e-108	383.00
IUUC-Pfo-096357	Poecilia formosa	68.18	0.00e+00	893.00
IUUC-Pab-098248	Pongo abelii	67.78	0.00e+00	800.00
IUUC-Pca-100756	Procavia capensis	60.88	8.00e-174	603.00
IUUC-Pva-102990	Pteropus vampyrus	53.66	2.00e-115	409.00
IUUC-Rno-105887	Rattus norvegicus	67.83	0.00e+00	882.00
IUUC-Sha-107016	Sarcophilus harrisii	68.29	0.00e+00	889.00
IUUC-Sar-113558	Sorex araneus	63.18	0.00e+00	829.00
IUUC-Ssc-115414	Sus scrofa	68.13	0.00e+00	889.00
IUUC-Tgu-116801	Taeniopygia guttata	67.58	0.00e+00	874.00
IUUC-Tru-117565	Takifugu rubripes	68.33	0.00e+00	893.00
IUUC-Tsy-119292	Tarsius syrichta	67.43	0.00e+00	816.00
IUUC-Tni-120471	Tetraodon nigroviridis	67.93	0.00e+00	886.00
IUUC-Tbe-127838	Tupaia belangeri	63.03	0.00e+00	828.00
IUUC-Ttr-128345	Tursiops truncatus	68.13	0.00e+00	888.00
IUUC-Vpa-130191	Vicugna pacos	57.94	2.00e-102	366.00
IUUC-Xtr-132810	Xenopus tropicalis	67.98	0.00e+00	887.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence