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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046659
UUCD1 version UUC-HoS-01135
Ensembl Protein ID ENSP00000350512.4
UniProt Accession Q92905; O15386; Q6AW95; Q86WQ4; Q9BQ17; CSN5_HUMAN
Genbank Protein ID AAB16847.1; AAD03468.1; CAG46479.1; AAH01187.1; AAH01859.1; AAH07272.1; CAH10375.1; AAL82571.1
Protein Name COP9 signalosome complex subunit 5; Jun activation domain-binding protein 1
Genbank Nucleotide ID U65928; U70734; CR541678; BC001187; BC001859; BC007272; BX648542; AY078082
Gene Name COPS5; CSN5; JAB1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000121022.13 ENST00000357849.8 ENSP00000350512.4
ENSG00000121022.13 ENST00000517736.5 ENSP00000429774.1
ENSG00000121022.13 ENST00000518374.5 ENSP00000427869.1
ENSG00000121022.13 ENST00000523890.5 ENSP00000427997.1
ENSG00000121022.13 ENST00000517406.1 ENSP00000428124.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/JAMM JAMM 19826004
Classification
Family E-value Score Start End
DUB/JAMM 3.60e-07 31.7 138 151
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/JAMM
   S: 1    HSHPgftcwlSsVD 14
           HSHPg++cwlS++D
   Q: 138  HSHPGYGCWLSGID 151
           *************9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.
 Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.
Protein Sequence
(Fasta)
MAASGSGMAQ KTWELANNMQ EAQSIDEIYK YDKKQQQEIL AAKPWTKDHH YFKYCKISAL 60
ALLKMVMHAR SGGNLEVMGL MLGKVDGETM IIMDSFALPV EGTETRVNAQ AAAYEYMAAY 120
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Protein Fasta Sequence


>IUUC-Hsa-046659|DUB,JAMM|Homo sapiens
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Nucleotide Sequence
(Fasta)
ATTGTGCCAA GGAGTAAAAG ACAACAATGC TGCCAGGATG ATGCCAACAC ACTACCTGCC 60
CATCCAGGAA CAAGCAATTT ACAAATTTAC AAAAAGTGTA AGTTTAAGGT GGCTTTTACT 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046659|DUB,JAMM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0736--Signalosome
KW-0770--Synapse
Interpro

IPR000555--JAMM/MPN+_dom
Pfam

PF01398--JAB
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0030054--C:cell junction
GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0008021--C:synaptic vesicle
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0003743--F:translation initiation factor activity
GO:1990182--P:exosomal secretion
GO:0000715--P:nucleotide-excision repair, DNA damage recognition
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0000338--P:protein deneddylation
GO:0016579--P:protein deubiquitination
GO:0051726--P:regulation of cell cycle
GO:1903894--P:regulation of IRE1-mediated unfolded protein response
GO:0046328--P:regulation of JNK cascade
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0006283--P:transcription-coupled nucleotide-excision repair
GO:0006412--P:translation
KEGG hsa:10987
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000468 Aegilops tauschii 66.57 4.00e-122 431.00
IUUC-Aml-001429 Ailuropoda melanoleuca 100.00 0.00e+00 627.00
IUUC-Atr-003048 Amborella trichopoda 68.34 5.00e-125 440.00
IUUC-Apl-003610 Anas platyrhynchos 90.36 1.00e-163 569.00
IUUC-Aca-004662 Anolis carolinensis 98.62 2.00e-156 545.00
IUUC-Aly-005914 Arabidopsis lyrata 66.76 6.00e-123 433.00
IUUC-Ath-007496 Arabidopsis thaliana 66.86 1.00e-122 432.00
IUUC-Ago-007860 Ashbya gossypii 41.88 2.00e-47 183.00
IUUC-Acl-008155 Aspergillus clavatus 54.88 5.00e-98 350.00
IUUC-Afu-008820 Aspergillus fumigatus 55.18 3.00e-98 351.00
IUUC-Ani-009303 Aspergillus nidulans 54.74 2.00e-96 345.00
IUUC-Ang-009617 Aspergillus niger 54.09 9.00e-94 337.00
IUUC-Aor-009888 Aspergillus oryzae 56.49 1.00e-95 342.00
IUUC-Ate-010575 Aspergillus terreus 56.75 3.00e-100 358.00
IUUC-Ame-010617 Astyanax mexicanus 95.81 4.00e-180 623.00
IUUC-Bgr-012019 Blumeria graminis 55.62 2.00e-100 358.00
IUUC-Bta-013211 Bos taurus 99.70 0.00e+00 644.00
IUUC-Bci-013645 Botrytis cinerea 57.89 2.00e-104 372.00
IUUC-Bdi-014727 Brachypodium distachyon 67.66 9.00e-119 419.00
IUUC-Bol-015205 Brassica oleracea 67.37 6.00e-121 427.00
IUUC-Bra-017649 Brassica rapa 67.37 6.00e-121 427.00
IUUC-Cel-018469 Caenorhabditis elegans 57.23 2.00e-104 372.00
IUUC-Cja-019703 Callithrix jacchus 100.00 0.00e+00 645.00
IUUC-Cfa-020181 Canis familiaris 99.70 0.00e+00 644.00
IUUC-Cpo-021499 Cavia porcellus 100.00 0.00e+00 645.00
IUUC-Cre-022735 Chlamydomonas reinhardtii 60.31 6.00e-112 397.00
IUUC-Csa-024200 Chlorocebus sabaeus 100.00 0.00e+00 645.00
IUUC-Cho-024915 Choloepus hoffmanni 97.12 6.00e-119 420.00
IUUC-Cin-025353 Ciona intestinalis 79.94 7.00e-138 483.00
IUUC-Csv-026118 Ciona savignyi 80.24 9.00e-139 486.00
IUUC-Cgl-026511 Colletotrichum gloeosporioides 52.37 2.00e-95 342.00
IUUC-Cne-026988 Cryptococcus neoformans 49.14 3.00e-85 308.00
IUUC-Dre-028134 Danio rerio 96.37 2.00e-179 621.00
IUUC-Dno-029658 Dasypus novemcinctus 100.00 0.00e+00 645.00
IUUC-Dor-031074 Dipodomys ordii 100.00 0.00e+00 645.00
IUUC-Dse-031497 Dothistroma septosporum 56.68 2.00e-98 352.00
IUUC-Dme-032199 Drosophila melanogaster 74.70 2.00e-143 501.00
IUUC-Ete-032739 Echinops telfairi 98.82 1.00e-86 313.00
IUUC-Eca-034095 Equus caballus 99.70 0.00e+00 644.00
IUUC-Eeu-034934 Erinaceus europaeus 84.43 2.00e-148 518.00
IUUC-Fca-035569 Felis catus 100.00 0.00e+00 645.00
IUUC-Fal-037553 Ficedula albicollis 99.30 3.00e-156 543.00
IUUC-Fox-037945 Fusarium oxysporum 49.85 6.00e-88 317.00
IUUC-Fso-038385 Fusarium solani 54.38 1.00e-94 339.00
IUUC-Gmo-039438 Gadus morhua 95.77 2.00e-175 608.00
IUUC-Ggr-039968 Gaeumannomyces graminis 60.36 3.00e-95 341.00
IUUC-Gga-040344 Gallus gallus 99.08 4.00e-180 623.00
IUUC-Gac-042256 Gasterosteus aculeatus 96.11 8.00e-177 612.00
IUUC-Gma-043226 Glycine max 67.15 2.00e-124 438.00
IUUC-Ggo-044523 Gorilla gorilla 93.01 2.00e-163 568.00
IUUC-Itr-048834 Ictidomys tridecemlineatus 100.00 0.00e+00 641.00
IUUC-Kpa-049139 Komagataella pastoris 58.49 1.00e-52 201.00
IUUC-Lch-049562 Latimeria chalumnae 97.28 0.00e+00 625.00
IUUC-Lpe-050737 Leersia perrieri 67.55 7.00e-128 450.00
IUUC-Loc-051798 Lepisosteus oculatus 97.85 2.00e-175 608.00
IUUC-Lma-052979 Leptosphaeria maculans 52.51 3.00e-93 335.00
IUUC-Laf-053391 Loxodonta africana 100.00 2.00e-121 427.00
IUUC-Mcc-055667 Macaca mulatta 100.00 0.00e+00 645.00
IUUC-Meu-056067 Macropus eugenii 68.60 2.00e-83 301.00
IUUC-Mor-057084 Magnaporthe oryzae 53.31 2.00e-97 348.00
IUUC-Mpo-057347 Magnaporthe poae 54.01 1.00e-97 349.00
IUUC-Mtr-057781 Medicago truncatula 68.79 1.00e-125 442.00
IUUC-Mla-059106 Melampsora laricipopulina 51.56 4.00e-104 371.00
IUUC-Mga-059473 Meleagris gallopavo 99.30 3.00e-156 543.00
IUUC-Mvi-060540 Microbotryum violaceum 54.44 1.00e-108 386.00
IUUC-Mmr-061138 Microcebus murinus 96.41 1.00e-97 348.00
IUUC-Mdo-062893 Monodelphis domestica 99.70 0.00e+00 643.00
IUUC-Mmu-063637 Mus musculus 99.40 0.00e+00 643.00
IUUC-Mac-064683 Musa acuminata 67.16 6.00e-128 450.00
IUUC-Mpu-066096 Mustela putorius furo 86.27 2.00e-151 528.00
IUUC-Mlu-067872 Myotis lucifugus 96.11 2.00e-178 618.00
IUUC-Nfi-068443 Neosartorya fischeri 54.88 5.00e-97 347.00
IUUC-Ncr-068953 Neurospora crassa 52.61 1.00e-90 326.00
IUUC-Nle-068972 Nomascus leucogenys 100.00 0.00e+00 645.00
IUUC-Opr-070215 Ochotona princeps 89.52 2.00e-158 551.00
IUUC-Ont-072538 Oreochromis niloticus 96.68 5.00e-176 610.00
IUUC-Oan-073143 Ornithorhynchus anatinus 99.10 0.00e+00 641.00
IUUC-Ocu-074197 Oryctolagus cuniculus 100.00 0.00e+00 645.00
IUUC-Oba-075884 Oryza barthii 62.43 2.00e-120 425.00
IUUC-Obr-076874 Oryza brachyantha 66.67 8.00e-125 439.00
IUUC-Ogl-077169 Oryza glaberrima 67.36 2.00e-124 438.00
IUUC-Ogu-078258 Oryza glumaepatula 67.36 3.00e-124 437.00
IUUC-Oin-079101 Oryza indica 62.71 1.00e-120 426.00
IUUC-Olo-080708 Oryza longistaminata 55.52 2.00e-96 345.00
IUUC-Ome-081571 Oryza meridionalis 62.71 1.00e-120 426.00
IUUC-Oni-082888 Oryza nivara 62.71 1.00e-120 426.00
IUUC-Opu-083182 Oryza punctata 67.36 2.00e-124 438.00
IUUC-Oru-084895 Oryza rufipogon 62.71 1.00e-120 426.00
IUUC-Osa-085331 Oryza sativa 67.36 2.00e-124 438.00
IUUC-Ola-086850 Oryzias latipes 96.98 7.00e-177 612.00
IUUC-Olu-087607 Ostreococcus lucimarinus 57.69 2.00e-80 292.00
IUUC-Oga-088640 Otolemur garnettii 100.00 0.00e+00 628.00
IUUC-Oar-090299 Ovis aries 99.69 0.00e+00 626.00
IUUC-Ptr-091499 Pan troglodytes 100.00 0.00e+00 645.00
IUUC-Pan-091751 Papio anubis 100.00 2.00e-156 545.00
IUUC-Psi-092978 Pelodiscus sinensis 98.15 9.00e-179 619.00
IUUC-Pma-094634 Petromyzon marinus 93.52 2.00e-170 592.00
IUUC-Pno-095094 Phaeosphaeria nodorum 52.38 2.00e-93 335.00
IUUC-Ppa-095440 Physcomitrella patens 68.91 8.00e-128 450.00
IUUC-Pfo-097332 Poecilia formosa 96.98 1.00e-176 612.00
IUUC-Pab-097998 Pongo abelii 100.00 0.00e+00 645.00
IUUC-Pop-098905 Populus trichocarpa 66.09 5.00e-130 457.00
IUUC-Pca-100521 Procavia capensis 100.00 2.00e-61 229.00
IUUC-Ppe-101309 Prunus persica 67.45 1.00e-130 459.00
IUUC-Pva-102953 Pteropus vampyrus 100.00 0.00e+00 645.00
IUUC-Pgr-103452 Puccinia graminis 60.59 6.00e-91 327.00
IUUC-Ptt-103777 Puccinia triticina 62.65 7.00e-88 317.00
IUUC-Pte-104273 Pyrenophora teres 52.38 4.00e-94 338.00
IUUC-Pyt-104627 Pyrenophora triticirepentis 53.56 7.00e-93 333.00
IUUC-Rno-105666 Rattus norvegicus 99.10 0.00e+00 639.00
IUUC-Sce-106319 Saccharomyces cerevisiae 40.29 3.00e-34 139.00
IUUC-Sha-106602 Sarcophilus harrisii 99.70 0.00e+00 643.00
IUUC-Sja-107822 Schizosaccharomyces japonicus 45.89 1.00e-47 182.00
IUUC-Spo-108318 Schizosaccharomyces pombe 40.58 2.00e-64 239.00
IUUC-Ssl-108428 Sclerotinia sclerotiorum 58.51 1.00e-105 376.00
IUUC-Smo-108821 Selaginella moellendorffii 66.18 1.00e-124 439.00
IUUC-Sit-110526 Setaria italica 66.37 1.00e-117 416.00
IUUC-Sly-111466 Solanum lycopersicum 67.16 5.00e-132 464.00
IUUC-Stu-112776 Solanum tuberosum 67.74 2.00e-132 465.00
IUUC-Sar-113459 Sorex araneus 99.70 0.00e+00 644.00
IUUC-Sbi-114873 Sorghum bicolor 66.86 9.00e-122 429.00
IUUC-Sre-114919 Sporisorium reilianum 64.64 1.00e-92 333.00
IUUC-Ssc-116102 Sus scrofa 100.00 0.00e+00 645.00
IUUC-Tgu-116937 Taeniopygia guttata 99.61 2.00e-139 487.00
IUUC-Tru-118615 Takifugu rubripes 97.28 2.00e-177 614.00
IUUC-Tsy-119173 Tarsius syrichta 99.36 1.00e-172 598.00
IUUC-Tni-120246 Tetraodon nigroviridis 97.00 4.00e-178 617.00
IUUC-Tca-121859 Theobroma cacao 68.17 3.00e-128 451.00
IUUC-Tre-122030 Trichoderma reesei 52.44 1.00e-95 342.00
IUUC-Tvi-122506 Trichoderma virens 53.80 3.00e-100 358.00
IUUC-Tae-125382 Triticum aestivum 66.57 7.00e-122 430.00
IUUC-Tur-126517 Triticum urartu 68.71 5.00e-119 420.00
IUUC-Tme-127122 Tuber melanosporum 55.86 1.00e-101 363.00
IUUC-Tbe-128108 Tupaia belangeri 98.80 0.00e+00 628.00
IUUC-Ttr-128644 Tursiops truncatus 100.00 0.00e+00 645.00
IUUC-Uma-129390 Ustilago maydis 52.23 9.00e-94 337.00
IUUC-Vda-129932 Verticillium dahliae 48.13 3.00e-89 322.00
IUUC-Vpa-130110 Vicugna pacos 100.00 0.00e+00 645.00
IUUC-Vvi-131534 Vitis vinifera 68.25 2.00e-131 462.00
IUUC-Xtr-132739 Xenopus tropicalis 97.01 0.00e+00 630.00
IUUC-Xma-133919 Xiphophorus maculatus 96.98 1.00e-176 612.00
IUUC-Yli-134677 Yarrowia lipolytica 50.15 2.00e-90 326.00
IUUC-Zma-135578 Zea mays 67.46 1.00e-122 432.00
Created Date 25-Jun-2017

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