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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046052
UUCD1 version UUC-HoS-01169
Ensembl Protein ID ENSP00000280377.5
UniProt Accession Q9Y4E8; Q08AL5; Q9H8G9; Q9HCA6; Q9UNP0; Q9Y5B5; UBP15_HUMAN
Genbank Protein ID AAD52099.1; BAA25455.2; AAD41086.1; BAB14648.1; BAF85026.1; AAH20688.1; AAH63454.1; AAI25124.1; AAG28973.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 15; Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15; Unph-2; Unph4
Genbank Nucleotide ID AF106069; AB011101; AF153604; AK023703; AK292337; AC048342; BC063454; BC125123; AF013990
Gene Name USP15; KIAA0529
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000135655.14 ENST00000353364.7 ENSP00000258123.4
ENSG00000135655.14 ENST00000549523.5 ENSP00000447603.1
ENSG00000135655.14 ENST00000280377.9 ENSP00000280377.5
ENSG00000135655.14 ENST00000312635.10 ENSP00000309240.6
ENSG00000135655.14 ENST00000549237.5 ENSP00000448393.1
ENSG00000135655.14 ENST00000552997.1 ENSP00000447367.1
ENSG00000135655.14 ENST00000549415.1 ENSP00000448372.1
ENSG00000135655.14 ENST00000548620.1 ENSP00000446559.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetTRANSFACRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 21245847; 16005295
Classification
Family E-value Score Start End
DUB/USP 1.20e-119 401.2 289 933
ULD/UDP/UBQ/UBQ_Other 1.80e-09 39.0 147 217
Active Site
Position(s) Description Evidence
298 Nucleophile
891 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqD 91
    +Gl+NlgNtC+mNS++QcLsn+p+l+e++l+ k++e+ln +np ++ ge++ks+++l++++w++k ++v+pr+++++++++a++fsgy+qqD
   Q: 289 CGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNdKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQD 380
    7******************************9************************************************************ PP
   S: 92 aqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
    +qE+laflld+l+e+l++ ++kp+ +++++d ++d+ a+e++ k+n+s+i+d+F+g +ks+++c+ec+++s++++pf++l+lp+p+
   Q: 381 CQELLAFLLDGLHEDLNRIRKKPYIQLKDAD--GRPDKvvaeeAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPM 470
    ***************************9999..5555555777************************************************* PP
   S: 179 keetkke..................................................................................... 185
    k+e+ +e
   Q: 471 KKERTLEvylvrmdpltkpmqykvvvpkignildlctalsalsgipadkmivtdiynhrfhrifamdenlssimerddiyvfeininrtedt 562
    ***9999************************************************************************************* PP
   S: 186 ............................................................................................ 185
   
   Q: 563 ehviipvclrekfrhssythhtgsslfgqpflmavprnntedklynllllrmcryvkisteteetegslhcckdqningngpngiheegsps 654
    ******************************************************************************************** PP
   S: 186 ............................................................................................ 185
   
   Q: 655 emetdepddessqdqelpsenensqsedsvggdndsenglctedtckgqltghkkrlftfqfnnlgntdinyikddtrhirfddrqlrlder 746
    ******************************************************************************************** PP
   S: 186 ........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRf 237
    +l+dc+e ft++e+l e+ +yc++ck++q+a+kkl+l++lP+vL++hLkRf
   Q: 747 sflaldwdpdlkkryfdenaaedfekhesveykppkkpfvKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRF 838
    ******************************************************************************************** PP
   S: 238 sfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg 327
    s+s+ ++r k+++ v+fp++ Ld+s+f+++p+ + +++Y+Liav +H+G++++GHY+a++kn++++ W++fdDs+V++ +e+++++
   Q: 839 SYSR--YMRDKLDTLVDFPINdLDMSEFLINPNAG---PCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGkWYYFDDSSVSTASEDQIVS--- 922
    9977..6999*********************9988...8**************************65555*******************... PP
   S: 328 staYvlfYkrr 338
    + aYvlfY+r+
   Q: 923 KAAYVLFYQRQ 933
    *********96 PP
   


   ULD/UDP/UBQ/UBQ_Other

   S: 12   eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk.....GkiL.eddktLadyglkdgstihllekksg 75
    + t++++++dt+ ++ ++i+k ++ip + + rL++k ++L ++d t++d gl++g+++++++k+++
   Q: 147 VVTRRFSKADTIDTIEKEIRKIFSIPdEKETRLWNKymsntFEPLnKPDSTIQDAGLYQGQVLVIEQKNED 217
    77899*********************999*****998875544569*********************9986 PP
   

Organism Homo sapiens
Functional Description
(View)

Functional Description



     Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.
Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.
Protein Sequence
(Fasta)
MAEGGAADLD TQRSDIATLL KTSLRKGDTW YLVDSRWFKQ WKKYVGFDSW DKYQMGDQNV 60
YPGPIDNSGL LKDGDAQSLK EHLIDELDYI LLPTEGWNKL VSWYTLMEGQ EPIARKVVEQ 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-046052|DUB,USP;ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGGGACGCC ATTCCCATAA TGCTCTGGGG CGTGCCGCCG CCGTCGCTGC CACCTCCCCT 60
ACCGCTAGTG GAAGAAGATG GCGGAAGGCG GAGCGGCGGA TCTGGACACC CAGCGGTCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046052|DUB,USP;ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR013792--RNA3'P_cycl/enolpyr_Trfase_a/b
IPR028135--Ub_USP-typ
IPR029071--Ubiquitin-rel_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH
PF14533--USP7_C2

SMART

SM00695--DUSP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0042802--F:identical protein binding
GO:0046332--F:SMAD binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0005160--F:transforming growth factor beta receptor binding
GO:0061649--F:ubiquitinated histone binding
GO:0030509--P:BMP signaling pathway
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0060389--P:pathway-restricted SMAD protein phosphorylation
GO:0016579--P:protein deubiquitination
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG hsa:9958
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000058 Aegilops tauschii 39.91 3.00e-119 422.00
IUUC-Aml-001852 Ailuropoda melanoleuca 98.88 0.00e+00 1895.00
IUUC-Apl-003249 Anas platyrhynchos 95.07 0.00e+00 1722.00
IUUC-Aca-004261 Anolis carolinensis 93.44 0.00e+00 1736.00
IUUC-Aly-005644 Arabidopsis lyrata 36.08 1.00e-138 488.00
IUUC-Ath-006782 Arabidopsis thaliana 35.77 2.00e-138 486.00
IUUC-Acl-008284 Aspergillus clavatus 35.27 2.00e-55 211.00
IUUC-Afl-008507 Aspergillus flavus 43.30 1.00e-53 205.00
IUUC-Ame-010757 Astyanax mexicanus 78.77 0.00e+00 1262.00
IUUC-Bgr-012277 Blumeria graminis 42.40 3.00e-63 238.00
IUUC-Bta-013128 Bos taurus 95.72 0.00e+00 1860.00
IUUC-Bci-013993 Botrytis cinerea 42.81 6.00e-64 240.00
IUUC-Bol-015570 Brassica oleracea 37.33 4.00e-154 539.00
IUUC-Bra-017029 Brassica rapa 36.15 3.00e-139 489.00
IUUC-Cja-019222 Callithrix jacchus 99.49 0.00e+00 1902.00
IUUC-Cfa-020035 Canis familiaris 98.88 0.00e+00 1893.00
IUUC-Cpo-022071 Cavia porcellus 98.48 0.00e+00 1806.00
IUUC-Csa-023882 Chlorocebus sabaeus 99.90 0.00e+00 1908.00
IUUC-Cin-025292 Ciona intestinalis 44.59 0.00e+00 748.00
IUUC-Csv-026109 Ciona savignyi 47.29 1.00e-148 520.00
IUUC-Cne-026852 Cryptococcus neoformans 46.45 2.00e-71 264.00
IUUC-Cme-027338 Cyanidioschyzon merolae 56.36 5.00e-68 253.00
IUUC-Dno-029025 Dasypus novemcinctus 93.03 0.00e+00 1776.00
IUUC-Dor-030956 Dipodomys ordii 90.10 0.00e+00 1630.00
IUUC-Dse-031432 Dothistroma septosporum 40.43 4.00e-58 221.00
IUUC-Eca-034340 Equus caballus 99.37 0.00e+00 1844.00
IUUC-Eeu-034488 Erinaceus europaeus 89.10 0.00e+00 1266.00
IUUC-Fca-035552 Felis catus 95.82 0.00e+00 1855.00
IUUC-Fal-036618 Ficedula albicollis 94.96 0.00e+00 1717.00
IUUC-Gga-041146 Gallus gallus 93.79 0.00e+00 1760.00
IUUC-Gac-041679 Gasterosteus aculeatus 77.58 0.00e+00 1465.00
IUUC-Gma-043368 Glycine max 40.44 4.00e-120 426.00
IUUC-Ggo-045002 Gorilla gorilla 99.89 0.00e+00 1844.00
IUUC-Hvu-047108 Hordeum vulgare 40.24 7.00e-123 434.00
IUUC-Itr-048306 Ictidomys tridecemlineatus 95.83 0.00e+00 1857.00
IUUC-Lch-050107 Latimeria chalumnae 86.67 0.00e+00 1735.00
IUUC-Lpe-051185 Leersia perrieri 39.88 1.00e-125 444.00
IUUC-Loc-052105 Lepisosteus oculatus 83.80 0.00e+00 1514.00
IUUC-Lma-052981 Leptosphaeria maculans 36.72 6.00e-66 247.00
IUUC-Laf-053645 Loxodonta africana 98.57 0.00e+00 1891.00
IUUC-Mcc-055586 Macaca mulatta 100.00 0.00e+00 1910.00
IUUC-Meu-056764 Macropus eugenii 90.15 0.00e+00 1003.00
IUUC-Mga-060162 Meleagris gallopavo 94.10 0.00e+00 1765.00
IUUC-Mmr-061105 Microcebus murinus 99.29 0.00e+00 1901.00
IUUC-Mdo-062107 Monodelphis domestica 97.15 0.00e+00 1842.00
IUUC-Mmu-063662 Mus musculus 97.66 0.00e+00 1876.00
IUUC-Mac-065239 Musa acuminata 33.23 2.00e-132 467.00
IUUC-Mpu-065868 Mustela putorius furo 96.90 0.00e+00 1885.00
IUUC-Mlu-068000 Myotis lucifugus 92.01 0.00e+00 1677.00
IUUC-Nle-069874 Nomascus leucogenys 99.79 0.00e+00 1880.00
IUUC-Opr-071212 Ochotona princeps 93.50 0.00e+00 1781.00
IUUC-Ont-071834 Oreochromis niloticus 79.68 0.00e+00 1460.00
IUUC-Ocu-074573 Oryctolagus cuniculus 99.39 0.00e+00 1904.00
IUUC-Oba-075427 Oryza barthii 34.63 1.00e-132 467.00
IUUC-Ogl-077583 Oryza glaberrima 40.36 4.00e-128 452.00
IUUC-Ogu-078422 Oryza glumaepatula 34.63 7.00e-133 468.00
IUUC-Oin-079300 Oryza indica 40.51 4.00e-129 455.00
IUUC-Ome-081271 Oryza meridionalis 35.99 2.00e-148 520.00
IUUC-Oni-082834 Oryza nivara 34.74 3.00e-133 469.00
IUUC-Opu-083691 Oryza punctata 35.02 2.00e-145 509.00
IUUC-Oru-084820 Oryza rufipogon 34.63 8.00e-133 468.00
IUUC-Osa-086139 Oryza sativa 36.07 7.00e-148 518.00
IUUC-Oga-089022 Otolemur garnettii 95.51 0.00e+00 1855.00
IUUC-Oar-089767 Ovis aries 98.67 0.00e+00 1893.00
IUUC-Ptr-091319 Pan troglodytes 96.84 0.00e+00 1875.00
IUUC-Pan-091968 Papio anubis 99.90 0.00e+00 1908.00
IUUC-Psi-093849 Pelodiscus sinensis 93.49 0.00e+00 1712.00
IUUC-Pma-094533 Petromyzon marinus 60.27 0.00e+00 1120.00
IUUC-Pno-094890 Phaeosphaeria nodorum 36.39 3.00e-59 224.00
IUUC-Pfo-097110 Poecilia formosa 78.38 0.00e+00 1456.00
IUUC-Pab-098664 Pongo abelii 99.90 0.00e+00 1908.00
IUUC-Pop-099801 Populus trichocarpa 36.99 6.00e-150 525.00
IUUC-Pca-100359 Procavia capensis 80.92 0.00e+00 1337.00
IUUC-Ppe-101587 Prunus persica 36.98 1.00e-148 521.00
IUUC-Pva-102394 Pteropus vampyrus 97.25 0.00e+00 1852.00
IUUC-Pgr-103546 Puccinia graminis 29.56 7.00e-68 253.00
IUUC-Pte-104102 Pyrenophora teres 35.50 7.00e-57 217.00
IUUC-Pyt-104812 Pyrenophora triticirepentis 39.43 2.00e-56 215.00
IUUC-Rno-105383 Rattus norvegicus 95.11 0.00e+00 1852.00
IUUC-Sce-106170 Saccharomyces cerevisiae 36.97 2.00e-60 228.00
IUUC-Sha-107393 Sarcophilus harrisii 97.25 0.00e+00 1847.00
IUUC-Ssl-108461 Sclerotinia sclerotiorum 30.56 1.00e-13 71.60
IUUC-Smo-109356 Selaginella moellendorffii 46.85 2.00e-79 290.00
IUUC-Sly-111726 Solanum lycopersicum 39.93 5.00e-93 335.00
IUUC-Sar-113498 Sorex araneus 98.27 0.00e+00 1884.00
IUUC-Sre-115130 Sporisorium reilianum 43.87 2.00e-77 285.00
IUUC-Ssc-115285 Sus scrofa 99.19 0.00e+00 1896.00
IUUC-Tgu-116529 Taeniopygia guttata 94.51 0.00e+00 1775.00
IUUC-Tru-118298 Takifugu rubripes 78.83 0.00e+00 1466.00
IUUC-Tsy-119117 Tarsius syrichta 89.79 0.00e+00 1157.00
IUUC-Tni-120093 Tetraodon nigroviridis 75.68 0.00e+00 1402.00
IUUC-Tur-126149 Triticum urartu 39.50 6.00e-106 379.00
IUUC-Tme-127062 Tuber melanosporum 31.40 2.00e-77 284.00
IUUC-Tbe-127672 Tupaia belangeri 91.44 0.00e+00 1253.00
IUUC-Ttr-128441 Tursiops truncatus 94.46 0.00e+00 1157.00
IUUC-Vpa-130469 Vicugna pacos 98.95 0.00e+00 1827.00
IUUC-Xtr-132729 Xenopus tropicalis 84.23 0.00e+00 1626.00
Created Date 25-Jun-2017

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