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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063904
UUCD1 version UUC-MuM-00735
Ensembl Protein ID ENSMUSP00000059211.8
UniProt Accession Q8CFD5; Q3U066; Q8VDC4; Q9CWK7; ERCC8_MOUSE
Genbank Protein ID CAD20255.1; BAB27039.1; BAE33989.1; AAH37200.1
Protein Name DNA excision repair protein ERCC-8; Cockayne syndrome WD repeat protein CSA homolog
Genbank Nucleotide ID AJ427222; AK010576; AK157175; BC037200
Gene Name Ercc8; Ckn1; Csa
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000021694.18 ENSMUST00000054835.14 ENSMUSP00000059211.8
ENSMUSG00000021694.18 ENSMUST00000120672.7 ENSMUSP00000112746.1
ENSMUSG00000021694.18 ENSMUST00000142931.7 ENSMUSP00000118154.1
ENSMUSG00000021694.18 ENSMUST00000123138.1 ENSMUSP00000119212.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.70e-30 103.0 184 218
UBD/Beta-Prp 1.80e-47 163.1 102 361
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrt 32
           gH  ++ ++++   +d +l+++s D  +k+WD+r+
   Q: 184  GHRQEILAVSWsprHDYILATASADSRVKLWDVRR 218
           8***********8666889*************986 PP
   

   UBD/Beta-Prp
   S: 13   itcvkf.spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk...ilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           +  v++   d+ +++++s d+t+kvwd+ t ++ + + + e++v++  +sp +    + + g +   +++ dl++g+c h+l+gh +++
   Q: 102  VETVQWyPHDTGMFTSSSFDKTLKVWDTNTLQA-ADVFNFEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEI 189
           444555334444555566666666666666444.5555555566666666666556566666666666666666666666666666666 PP
   S: 98   lslsfsp.sgdklvsGshdrtirvwdletgq.clee..............tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk 170
           l++s+sp  ++ l+++s+d+ +++wd++  + cl +               ++ h+g vn++++ +dg  l + ++D+ +rlW++++g+
   Q: 190  LAVSWSPrHDYILATASADSRVKLWDVRRASgCLLTldqhngkksqaaesANTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSSSGD 278
           66666663335556666666666666665432555566666666666666666666666666666666666666666666666665544 PP
   S: 171  llrtl.tgghtdsvyslsfdsng...kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
                  +  +ds + l+f  +     e+v + + +t+ ++ +++ge +  l+gh + v +  f pn + l+sgs D  i  W
   Q: 279  NTLVNyGKVCNDSRKGLQFAVSCgcsSEFVFVPHGSTIAVYAVHSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAW 361
           32222222234444444433322333666666666666666666666666666666666666666666666666666666666 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Involved in transcription-coupled nucleotide excision repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. It is the substrate-recognition component of the CSA complex (DCX(ERCC8) complex) which promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair.
 Involved in transcription-coupled nucleotide excision repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. It is the substrate-recognition component of the CSA complex (DCX(ERCC8) complex) which promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair.
Protein Sequence
(Fasta)
MLSFLSARQS GLEDPLRLRR AQSTRRVLGL ELNKDRDVER IHGSGVNTLD IEPVEGRYML 60
SGGSDGVVVL YDLENASRQP HYTCKAVCSV GRSHPDVHKY SVETVQWYPH DTGMFTSSSF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063904|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATCCCCCAGT TCCCCGGTCT GTCATGGCAG CGCCCAGGCC TCCAGCCGGT GTGTGGACCC 60
GAGATGTTGA GCTTTTTGTC CGCTCGACAG TCGGGTTTGG AGGACCCTCT TCGCTTGCGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063904|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0016363--C:nuclear matrix
GO:0000109--C:nucleotide-excision repair complex
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0032403--F:protein complex binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006289--P:nucleotide-excision repair
GO:0045739--P:positive regulation of DNA repair
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006979--P:response to oxidative stress
GO:0009411--P:response to UV
GO:0010165--P:response to X-ray
GO:0006283--P:transcription-coupled nucleotide-excision repair
KEGG mmu:71991
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001170 Aegilops tauschii 32.00 6.00e-37 149.00
IUUC-Aml-002201 Ailuropoda melanoleuca 89.67 0.00e+00 754.00
IUUC-Atr-002784 Amborella trichopoda 36.64 3.00e-40 159.00
IUUC-Apl-003202 Anas platyrhynchos 81.05 0.00e+00 655.00
IUUC-Aca-004708 Anolis carolinensis 80.46 1.00e-175 608.00
IUUC-Aly-006144 Arabidopsis lyrata 33.99 2.00e-64 239.00
IUUC-Ath-006673 Arabidopsis thaliana 41.15 6.00e-46 178.00
IUUC-Acl-008195 Aspergillus clavatus 39.77 6.00e-43 168.00
IUUC-Afl-008406 Aspergillus flavus 37.65 2.00e-38 152.00
IUUC-Afu-008759 Aspergillus fumigatus 33.73 1.00e-39 157.00
IUUC-Ani-009380 Aspergillus nidulans 37.20 9.00e-41 161.00
IUUC-Ang-009820 Aspergillus niger 37.15 1.00e-38 153.00
IUUC-Aor-010092 Aspergillus oryzae 38.26 2.00e-43 169.00
IUUC-Ate-010491 Aspergillus terreus 34.83 2.00e-44 173.00
IUUC-Bta-012825 Bos taurus 90.43 0.00e+00 758.00
IUUC-Bci-013856 Botrytis cinerea 32.69 9.00e-53 201.00
IUUC-Bdi-014899 Brachypodium distachyon 34.52 4.00e-65 242.00
IUUC-Bol-015337 Brassica oleracea 38.79 8.00e-45 174.00
IUUC-Bra-018089 Brassica rapa 32.89 1.00e-66 247.00
IUUC-Cja-018725 Callithrix jacchus 89.42 0.00e+00 755.00
IUUC-Cfa-021162 Canis familiaris 90.18 0.00e+00 756.00
IUUC-Cpo-022190 Cavia porcellus 89.17 0.00e+00 754.00
IUUC-Cre-022960 Chlamydomonas reinhardtii 36.09 2.00e-38 154.00
IUUC-Csa-023610 Chlorocebus sabaeus 89.67 0.00e+00 760.00
IUUC-Cho-024689 Choloepus hoffmanni 88.41 0.00e+00 693.00
IUUC-Cin-025324 Ciona intestinalis 38.28 3.00e-80 292.00
IUUC-Csv-026059 Ciona savignyi 38.13 2.00e-73 269.00
IUUC-Cgl-026384 Colletotrichum gloeosporioides 35.44 2.00e-39 156.00
IUUC-Cme-027182 Cyanidioschyzon merolae 28.66 5.00e-14 73.20
IUUC-Dre-028696 Danio rerio 71.82 7.00e-176 609.00
IUUC-Dno-029102 Dasypus novemcinctus 89.42 0.00e+00 754.00
IUUC-Dor-030361 Dipodomys ordii 73.55 2.00e-170 591.00
IUUC-Dse-031167 Dothistroma septosporum 31.47 8.00e-48 184.00
IUUC-Ete-032856 Echinops telfairi 74.06 2.00e-173 601.00
IUUC-Eca-033611 Equus caballus 90.27 0.00e+00 650.00
IUUC-Eeu-034583 Erinaceus europaeus 68.26 4.00e-154 537.00
IUUC-Fca-036481 Felis catus 89.67 0.00e+00 753.00
IUUC-Fal-037327 Ficedula albicollis 78.53 9.00e-166 575.00
IUUC-Fox-037684 Fusarium oxysporum 33.78 5.00e-43 168.00
IUUC-Fso-038306 Fusarium solani 34.75 1.00e-53 203.00
IUUC-Gmo-039043 Gadus morhua 68.18 6.00e-165 573.00
IUUC-Ggr-039783 Gaeumannomyces graminis 31.03 1.00e-37 151.00
IUUC-Gga-041085 Gallus gallus 83.91 0.00e+00 632.00
IUUC-Gac-042328 Gasterosteus aculeatus 69.65 2.00e-161 561.00
IUUC-Gma-043004 Glycine max 33.18 7.00e-55 207.00
IUUC-Ggo-045627 Gorilla gorilla 81.59 0.00e+00 687.00
IUUC-Hsa-046028 Homo sapiens 89.67 0.00e+00 760.00
IUUC-Hvu-047678 Hordeum vulgare 30.10 1.00e-29 123.00
IUUC-Itr-048648 Ictidomys tridecemlineatus 89.42 0.00e+00 758.00
IUUC-Kpa-049386 Komagataella pastoris 29.78 1.00e-43 170.00
IUUC-Lch-050590 Latimeria chalumnae 76.72 2.00e-157 548.00
IUUC-Lpe-051725 Leersia perrieri 34.07 2.00e-36 146.00
IUUC-Loc-051788 Lepisosteus oculatus 75.26 0.00e+00 627.00
IUUC-Lma-053082 Leptosphaeria maculans 33.71 2.00e-53 202.00
IUUC-Laf-053809 Loxodonta africana 90.18 0.00e+00 768.00
IUUC-Mcc-054998 Macaca mulatta 93.24 2.00e-160 558.00
IUUC-Meu-055929 Macropus eugenii 74.62 2.00e-179 621.00
IUUC-Mor-057003 Magnaporthe oryzae 35.12 2.00e-48 187.00
IUUC-Mtr-057921 Medicago truncatula 33.26 3.00e-56 212.00
IUUC-Mga-059449 Meleagris gallopavo 63.93 1.00e-122 432.00
IUUC-Mmr-061609 Microcebus murinus 86.48 0.00e+00 701.00
IUUC-Mdo-062564 Monodelphis domestica 83.17 0.00e+00 709.00
IUUC-Mac-064716 Musa acuminata 31.42 3.00e-52 199.00
IUUC-Mpu-066617 Mustela putorius furo 89.67 0.00e+00 753.00
IUUC-Mlu-067054 Myotis lucifugus 87.66 0.00e+00 735.00
IUUC-Nfi-068467 Neosartorya fischeri 36.44 1.00e-33 137.00
IUUC-Nle-069731 Nomascus leucogenys 89.67 0.00e+00 760.00
IUUC-Opr-070297 Ochotona princeps 66.11 3.00e-85 308.00
IUUC-Ont-072558 Oreochromis niloticus 70.79 1.00e-164 572.00
IUUC-Oan-072864 Ornithorhynchus anatinus 87.72 2.00e-26 110.00
IUUC-Ocu-074415 Oryctolagus cuniculus 90.68 0.00e+00 763.00
IUUC-Oba-075735 Oryza barthii 41.05 3.00e-40 159.00
IUUC-Obr-076387 Oryza brachyantha 39.34 8.00e-45 174.00
IUUC-Ogl-077924 Oryza glaberrima 42.86 5.00e-18 84.00
IUUC-Ogu-078186 Oryza glumaepatula 36.31 1.00e-62 233.00
IUUC-Oin-079389 Oryza indica 35.71 9.00e-47 181.00
IUUC-Olo-080916 Oryza longistaminata 28.92 5.00e-16 77.00
IUUC-Ome-081471 Oryza meridionalis 41.05 2.00e-40 160.00
IUUC-Oni-082315 Oryza nivara 41.05 3.00e-40 159.00
IUUC-Opu-083210 Oryza punctata 33.75 3.00e-57 216.00
IUUC-Oru-085159 Oryza rufipogon 42.11 2.00e-43 170.00
IUUC-Osa-085926 Oryza sativa 42.57 7.00e-33 133.00
IUUC-Ola-087084 Oryzias latipes 68.84 4.00e-167 580.00
IUUC-Olu-087853 Ostreococcus lucimarinus 30.32 6.00e-41 161.00
IUUC-Oga-089008 Otolemur garnettii 88.22 0.00e+00 744.00
IUUC-Oar-089259 Ovis aries 89.67 0.00e+00 754.00
IUUC-Ptr-091112 Pan troglodytes 89.09 0.00e+00 751.00
IUUC-Pan-092303 Papio anubis 82.95 2.00e-63 233.00
IUUC-Psi-093050 Pelodiscus sinensis 81.20 0.00e+00 690.00
IUUC-Pma-094259 Petromyzon marinus 56.93 7.00e-129 453.00
IUUC-Pno-094798 Phaeosphaeria nodorum 32.58 2.00e-51 196.00
IUUC-Ppa-095477 Physcomitrella patens 32.03 4.00e-54 205.00
IUUC-Pfo-096855 Poecilia formosa 68.49 9.00e-165 572.00
IUUC-Pab-098096 Pongo abelii 89.17 0.00e+00 756.00
IUUC-Pop-098800 Populus trichocarpa 36.84 3.00e-45 176.00
IUUC-Pca-100187 Procavia capensis 91.75 9.00e-113 400.00
IUUC-Ppe-101759 Prunus persica 37.07 6.00e-44 171.00
IUUC-Pva-102438 Pteropus vampyrus 77.07 1.00e-90 327.00
IUUC-Pte-104197 Pyrenophora teres 33.62 4.00e-50 192.00
IUUC-Pyt-104421 Pyrenophora triticirepentis 34.46 2.00e-50 192.00
IUUC-Rno-106087 Rattus norvegicus 94.96 0.00e+00 790.00
IUUC-Sce-106276 Saccharomyces cerevisiae 26.80 3.00e-13 70.10
IUUC-Sha-106831 Sarcophilus harrisii 80.15 0.00e+00 682.00
IUUC-Sja-107681 Schizosaccharomyces japonicus 33.50 3.00e-57 215.00
IUUC-Spo-108294 Schizosaccharomyces pombe 36.94 2.00e-65 243.00
IUUC-Ssl-108613 Sclerotinia sclerotiorum 33.24 5.00e-52 198.00
IUUC-Smo-109008 Selaginella moellendorffii 39.05 5.00e-73 268.00
IUUC-Sit-110300 Setaria italica 31.21 2.00e-43 169.00
IUUC-Sly-111441 Solanum lycopersicum 30.30 1.00e-46 180.00
IUUC-Stu-111995 Solanum tuberosum 30.23 5.00e-46 178.00
IUUC-Sar-113196 Sorex araneus 79.09 1.00e-122 433.00
IUUC-Sbi-113790 Sorghum bicolor 40.00 3.00e-42 166.00
IUUC-Ssc-115609 Sus scrofa 90.18 0.00e+00 760.00
IUUC-Tgu-116927 Taeniopygia guttata 79.45 0.00e+00 664.00
IUUC-Tru-118164 Takifugu rubripes 70.15 8.00e-173 599.00
IUUC-Tsy-119151 Tarsius syrichta 83.63 0.00e+00 698.00
IUUC-Tni-120896 Tetraodon nigroviridis 69.58 9.00e-164 569.00
IUUC-Tca-121592 Theobroma cacao 37.50 5.00e-45 175.00
IUUC-Tre-122023 Trichoderma reesei 35.45 4.00e-50 192.00
IUUC-Tvi-122507 Trichoderma virens 35.85 9.00e-50 191.00
IUUC-Tae-125730 Triticum aestivum 41.33 1.00e-42 167.00
IUUC-Tur-126092 Triticum urartu 32.27 6.00e-35 141.00
IUUC-Tbe-127422 Tupaia belangeri 68.73 1.00e-144 505.00
IUUC-Ttr-129097 Tursiops truncatus 86.90 0.00e+00 733.00
IUUC-Vda-130014 Verticillium dahliae 37.54 7.00e-50 191.00
IUUC-Vpa-130782 Vicugna pacos 89.67 0.00e+00 761.00
IUUC-Vvi-131494 Vitis vinifera 28.70 9.00e-51 194.00
IUUC-Xtr-132165 Xenopus tropicalis 75.41 2.00e-177 615.00
IUUC-Xma-133205 Xiphophorus maculatus 69.15 2.00e-168 585.00
IUUC-Yli-134614 Yarrowia lipolytica 34.60 1.00e-58 220.00
IUUC-Zma-135861 Zea mays 35.77 9.00e-62 231.00
Created Date 25-Jun-2017

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