iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.60e-13	48.8	55	111

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + v +l+dy a+nd +L+  kG++++v+   +  ++W+ + +  +g++G +P+nFv+ +e
   Q: 55   RFVVALFDYAAVNDRDLQVLKGEKLQVL---KSTGDWWLARSLVTGREGYVPSNFVAPVE 111
           6789************************...8999*********************9986 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MGLLSSKRQI SEKSKSWSPV KARAQGKVPP PLPPLVVFNH LPPPSPNQHP DEEERFVVAL 60
FDYAAVNDRD LQVLKGEKLQ VLKSTGDWWL ARSLVTGREG YVPSNFVAPV ETLEVEKWFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAACAAACCA ATGGAGGGAA AACACCAGCC ACGTGGTAAA CCAAAACCCA TGAGAAAACT 60
CTGGGGTACC AGAGGGGCAA TATGACCAGC ATGGCTGAAC GTCAGGTGCC CACGGAACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0050853--P:B cell receptor signaling pathway
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0032024--P:positive regulation of insulin secretion
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

rno:364403

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	88.41	0.00e+00	884.00
IUUC-Apl-003307	Anas platyrhynchos	75.45	0.00e+00	738.00
IUUC-Aca-004357	Anolis carolinensis	69.30	0.00e+00	669.00
IUUC-Ame-010642	Astyanax mexicanus	70.44	0.00e+00	688.00
IUUC-Bta-012400	Bos taurus	85.23	0.00e+00	870.00
IUUC-Cja-019717	Callithrix jacchus	84.83	0.00e+00	688.00
IUUC-Cfa-021056	Canis familiaris	87.40	0.00e+00	897.00
IUUC-Cpo-021779	Cavia porcellus	88.38	0.00e+00	891.00
IUUC-Csa-023557	Chlorocebus sabaeus	86.93	0.00e+00	891.00
IUUC-Dre-027517	Danio rerio	69.48	0.00e+00	701.00
IUUC-Eca-034218	Equus caballus	87.37	0.00e+00	871.00
IUUC-Eeu-035095	Erinaceus europaeus	65.40	0.00e+00	634.00
IUUC-Fca-036015	Felis catus	86.40	0.00e+00	894.00
IUUC-Fal-036946	Ficedula albicollis	70.72	0.00e+00	733.00
IUUC-Gga-040822	Gallus gallus	70.38	0.00e+00	747.00
IUUC-Ggo-044608	Gorilla gorilla	90.14	0.00e+00	818.00
IUUC-Hsa-046719	Homo sapiens	86.53	0.00e+00	888.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	89.38	0.00e+00	896.00
IUUC-Lch-050114	Latimeria chalumnae	74.27	0.00e+00	706.00
IUUC-Loc-052326	Lepisosteus oculatus	71.49	0.00e+00	711.00
IUUC-Laf-053387	Loxodonta africana	84.00	0.00e+00	863.00
IUUC-Mcc-055026	Macaca mulatta	87.13	0.00e+00	894.00
IUUC-Mga-059427	Meleagris gallopavo	74.83	0.00e+00	732.00
IUUC-Mmr-061660	Microcebus murinus	88.00	0.00e+00	882.00
IUUC-Mdo-062318	Monodelphis domestica	75.90	0.00e+00	788.00
IUUC-Mmu-063325	Mus musculus	96.39	0.00e+00	980.00
IUUC-Mpu-066582	Mustela putorius furo	88.82	0.00e+00	885.00
IUUC-Nle-069624	Nomascus leucogenys	88.59	0.00e+00	864.00
IUUC-Opr-070656	Ochotona princeps	81.76	0.00e+00	805.00
IUUC-Ont-072266	Oreochromis niloticus	68.83	0.00e+00	681.00
IUUC-Ocu-073907	Oryctolagus cuniculus	85.60	0.00e+00	863.00
IUUC-Oga-088057	Otolemur garnettii	85.43	0.00e+00	868.00
IUUC-Oar-089332	Ovis aries	81.24	0.00e+00	828.00
IUUC-Ptr-091551	Pan troglodytes	85.19	0.00e+00	847.00
IUUC-Pan-092173	Papio anubis	87.33	0.00e+00	875.00
IUUC-Psi-093895	Pelodiscus sinensis	73.66	0.00e+00	725.00
IUUC-Pab-097598	Pongo abelii	86.73	0.00e+00	862.00
IUUC-Pva-102135	Pteropus vampyrus	88.53	0.00e+00	869.00
IUUC-Sha-107192	Sarcophilus harrisii	77.34	0.00e+00	811.00
IUUC-Ssc-115696	Sus scrofa	86.83	0.00e+00	890.00
IUUC-Tgu-117056	Taeniopygia guttata	74.77	0.00e+00	725.00
IUUC-Tru-117621	Takifugu rubripes	68.37	0.00e+00	654.00
IUUC-Tbe-127520	Tupaia belangeri	87.07	0.00e+00	666.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence