iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064171

UUCD1 version

UUC-MuM-01121

Ensembl Protein ID

ENSMUSP00000080791.4

UniProt Accession

Q6ZPJ3; A2A7X3; Q60800; Q6PCR9; Q7TPN2; Q8BLE8; UBE2O_MOUSE

Genbank Protein ID

BAC98241.1; CAM17106.1; CAM17106.1; CAM20507.1; CAM20507.1; AAA69916.1; AAH59193.1; BAC32345.1

Protein Name

(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O; E2/E3 hybrid ubiquitin-protein ligase UBE2O; Ubiquitin carrier protein O; Ubiquitin-conjugating enzyme E2 O; Ubiquitin-conjugating enzyme E2 of 230 kDa; Ubiquitin-protein ligase O

Genbank Nucleotide ID

AK129431; AL645851; AL607039; AL607039; AL645851; U20780; BC059193; AK045398

Gene Name

Ube2o; Kiaa1734

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000020802.8	ENSMUST00000082152.4	ENSMUSP00000080791.4

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.30e-29	103.8	955	1099

Active Site

Position(s)	Description	Evidence
1037	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk...ifhPnvyenGkvClsi 85
           ++ke++ l+++ p+gi++k+ ++  ++ +++li Gp++tpYe+g++ ++i++p+ YP+ PP++++l++   +++Pn+y+nGkvC+s+
   Q: 955  VRKEMALLATSLPDGIMVKTFED-RMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFCYLSQcsgRLNPNLYDNGKVCVSL 1040
           589********************.5*******************************************999**************** PP
   S: 86   lk.....eeekWspalsvesvllsiqsll..aepnpesplneeaa...ellkknreeykk 135
           l+      +e+W++++s+ +vl+siq l+  +ep+++++  ++ +   e ++++r+ y++
   Q: 1041 LGtwigkGTERWTSKSSLLQVLISIQGLIlvNEPYYNEAGFDSDRglqEGYENSRC-YNE 1099
           *66666699******************9999*******998887655456666665.666 PP

Organism

Mus musculus

Functional Description
(View)

E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly.

Protein Sequence
(Fasta)

MADPAAPAPA QAQAAAAPTP AAAPAAAAPP PAPATDSASG PSSDSGPEAG SQRLLFSHDL 60
VSGRYRGSVH FGLVRLIHGE DSDSEGDDDG RGSSGCSEAG GAGHEEGRAS PLRRGYVRVQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCTGCCGCC GCCCGAGACT CGCGCAGAGC AGTTATGGCG GATCCCGCAG CGCCCGCACC 60
CGCCCAGGCC CAGGCCGCCG CCGCCCCGAC CCCGGCCGCA GCCCCCGCCG CCGCCGCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0003723--F:RNA binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030513--P:positive regulation of BMP signaling pathway
GO:0070534--P:protein K63-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0042147--P:retrograde transport, endosome to Golgi

KEGG

mmu:217342

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000412	Aegilops tauschii	42.17	1.00e-45	178.00
IUUC-Aml-001463	Ailuropoda melanoleuca	94.21	0.00e+00	1945.00
IUUC-Atr-002469	Amborella trichopoda	43.94	2.00e-41	165.00
IUUC-Apl-004084	Anas platyrhynchos	77.73	0.00e+00	1593.00
IUUC-Aca-004435	Anolis carolinensis	72.75	0.00e+00	1609.00
IUUC-Aly-005970	Arabidopsis lyrata	29.21	1.00e-58	221.00
IUUC-Ath-007320	Arabidopsis thaliana	29.59	9.00e-59	222.00
IUUC-Acl-008031	Aspergillus clavatus	44.23	7.00e-33	136.00
IUUC-Afl-008480	Aspergillus flavus	37.31	2.00e-35	145.00
IUUC-Afu-009040	Aspergillus fumigatus	40.31	1.00e-33	139.00
IUUC-Ani-009341	Aspergillus nidulans	41.77	2.00e-23	105.00
IUUC-Ang-009816	Aspergillus niger	39.51	3.00e-32	134.00
IUUC-Aor-010121	Aspergillus oryzae	38.25	1.00e-30	128.00
IUUC-Ate-010487	Aspergillus terreus	36.06	9.00e-35	142.00
IUUC-Ame-010604	Astyanax mexicanus	63.50	0.00e+00	1311.00
IUUC-Bta-013234	Bos taurus	93.70	0.00e+00	2029.00
IUUC-Bdi-015067	Brachypodium distachyon	38.84	7.00e-42	166.00
IUUC-Bol-016468	Brassica oleracea	45.16	4.00e-46	180.00
IUUC-Bra-016796	Brassica rapa	30.35	2.00e-58	221.00
IUUC-Cja-018812	Callithrix jacchus	94.02	0.00e+00	1980.00
IUUC-Cfa-020448	Canis familiaris	93.85	0.00e+00	1910.00
IUUC-Cpo-021316	Cavia porcellus	95.25	0.00e+00	2078.00
IUUC-Csa-023869	Chlorocebus sabaeus	94.10	0.00e+00	1970.00
IUUC-Cin-025614	Ciona intestinalis	36.46	2.00e-44	172.00
IUUC-Cne-026812	Cryptococcus neoformans	45.07	1.00e-44	174.00
IUUC-Dre-028814	Danio rerio	66.63	0.00e+00	882.00
IUUC-Dno-029590	Dasypus novemcinctus	94.18	0.00e+00	1432.00
IUUC-Dor-030644	Dipodomys ordii	82.31	0.00e+00	1118.00
IUUC-Dse-031508	Dothistroma septosporum	36.89	4.00e-34	140.00
IUUC-Dme-032211	Drosophila melanogaster	47.60	3.00e-65	244.00
IUUC-Eca-033413	Equus caballus	89.84	0.00e+00	1813.00
IUUC-Eeu-035035	Erinaceus europaeus	89.56	0.00e+00	1387.00
IUUC-Fca-035610	Felis catus	93.90	0.00e+00	2002.00
IUUC-Fal-036879	Ficedula albicollis	76.51	0.00e+00	1571.00
IUUC-Gmo-039262	Gadus morhua	64.87	0.00e+00	956.00
IUUC-Gga-040958	Gallus gallus	75.79	0.00e+00	1675.00
IUUC-Gac-041730	Gasterosteus aculeatus	63.15	0.00e+00	1375.00
IUUC-Gma-044191	Glycine max	30.08	4.00e-54	206.00
IUUC-Ggo-045316	Gorilla gorilla	94.26	0.00e+00	1978.00
IUUC-Hsa-046126	Homo sapiens	94.10	0.00e+00	1972.00
IUUC-Hvu-047713	Hordeum vulgare	40.45	2.00e-42	168.00
IUUC-Itr-048048	Ictidomys tridecemlineatus	94.55	0.00e+00	1946.00
IUUC-Lch-050531	Latimeria chalumnae	64.80	0.00e+00	1414.00
IUUC-Lpe-051268	Leersia perrieri	47.60	2.00e-39	157.00
IUUC-Loc-052209	Lepisosteus oculatus	66.61	0.00e+00	1444.00
IUUC-Lma-053064	Leptosphaeria maculans	44.14	4.00e-35	143.00
IUUC-Laf-053567	Loxodonta africana	92.00	2.00e-123	434.00
IUUC-Mcc-055722	Macaca mulatta	94.18	0.00e+00	1974.00
IUUC-Meu-056834	Macropus eugenii	89.04	2.00e-178	619.00
IUUC-Mtr-057804	Medicago truncatula	30.18	3.00e-59	224.00
IUUC-Mla-059114	Melampsora laricipopulina	29.63	6.00e-19	89.70
IUUC-Mga-059571	Meleagris gallopavo	78.21	0.00e+00	1582.00
IUUC-Mvi-060389	Microbotryum violaceum	43.33	8.00e-44	172.00
IUUC-Mmr-061535	Microcebus murinus	94.35	0.00e+00	1941.00
IUUC-Mdo-062111	Monodelphis domestica	87.00	0.00e+00	1857.00
IUUC-Mac-065585	Musa acuminata	40.76	1.00e-41	165.00
IUUC-Mpu-065697	Mustela putorius furo	94.12	0.00e+00	1858.00
IUUC-Mlu-068177	Myotis lucifugus	92.06	0.00e+00	1852.00
IUUC-Nfi-068366	Neosartorya fischeri	46.30	1.00e-33	139.00
IUUC-Nle-069704	Nomascus leucogenys	94.20	0.00e+00	1898.00
IUUC-Opr-070982	Ochotona princeps	91.74	0.00e+00	1911.00
IUUC-Ont-072115	Oreochromis niloticus	59.62	0.00e+00	1321.00
IUUC-Oan-072991	Ornithorhynchus anatinus	85.50	0.00e+00	793.00
IUUC-Ocu-073994	Oryctolagus cuniculus	93.00	0.00e+00	1890.00
IUUC-Oba-075236	Oryza barthii	39.73	5.00e-42	166.00
IUUC-Obr-076363	Oryza brachyantha	39.73	6.00e-43	169.00
IUUC-Ogl-077340	Oryza glaberrima	39.73	5.00e-42	166.00
IUUC-Ogu-078661	Oryza glumaepatula	43.44	2.00e-42	168.00
IUUC-Oin-080044	Oryza indica	46.15	2.00e-44	173.00
IUUC-Olo-080524	Oryza longistaminata	46.15	1.00e-44	173.00
IUUC-Ome-081767	Oryza meridionalis	39.73	3.00e-42	167.00
IUUC-Oni-082897	Oryza nivara	39.73	5.00e-42	166.00
IUUC-Opu-083143	Oryza punctata	40.18	2.00e-42	168.00
IUUC-Oru-084813	Oryza rufipogon	39.73	5.00e-42	166.00
IUUC-Osa-085536	Oryza sativa	39.73	6.00e-42	166.00
IUUC-Ola-087200	Oryzias latipes	63.99	0.00e+00	1253.00
IUUC-Oga-088737	Otolemur garnettii	93.90	0.00e+00	1982.00
IUUC-Oar-090259	Ovis aries	88.08	0.00e+00	1800.00
IUUC-Ptr-091146	Pan troglodytes	95.35	0.00e+00	1731.00
IUUC-Pan-091743	Papio anubis	94.18	0.00e+00	1974.00
IUUC-Psi-093231	Pelodiscus sinensis	78.58	0.00e+00	1647.00
IUUC-Pma-094499	Petromyzon marinus	66.03	3.00e-136	479.00
IUUC-Pno-095065	Phaeosphaeria nodorum	45.71	4.00e-31	130.00
IUUC-Ppa-095324	Physcomitrella patens	44.03	6.00e-55	209.00
IUUC-Pfo-096799	Poecilia formosa	64.45	0.00e+00	910.00
IUUC-Pab-098220	Pongo abelii	94.10	0.00e+00	1968.00
IUUC-Pop-099156	Populus trichocarpa	42.99	1.00e-42	169.00
IUUC-Pca-100963	Procavia capensis	88.37	0.00e+00	1797.00
IUUC-Ppe-101372	Prunus persica	29.51	1.00e-58	222.00
IUUC-Pva-102384	Pteropus vampyrus	92.97	0.00e+00	1954.00
IUUC-Pte-104381	Pyrenophora teres	42.93	7.00e-37	149.00
IUUC-Pyt-104607	Pyrenophora triticirepentis	42.42	1.00e-36	149.00
IUUC-Rno-105947	Rattus norvegicus	97.63	0.00e+00	2034.00
IUUC-Sha-106642	Sarcophilus harrisii	87.02	0.00e+00	1760.00
IUUC-Smo-109361	Selaginella moellendorffii	40.79	7.00e-54	205.00
IUUC-Sit-110041	Setaria italica	40.18	3.00e-43	171.00
IUUC-Sly-111922	Solanum lycopersicum	44.60	2.00e-44	174.00
IUUC-Stu-112339	Solanum tuberosum	40.38	1.00e-44	175.00
IUUC-Sbi-114493	Sorghum bicolor	28.59	2.00e-62	234.00
IUUC-Sre-114954	Sporisorium reilianum	44.71	1.00e-45	178.00
IUUC-Ssc-115901	Sus scrofa	86.90	0.00e+00	1895.00
IUUC-Tgu-116873	Taeniopygia guttata	79.46	0.00e+00	1584.00
IUUC-Tru-118710	Takifugu rubripes	55.90	0.00e+00	794.00
IUUC-Tsy-119256	Tarsius syrichta	83.65	0.00e+00	649.00
IUUC-Tni-120839	Tetraodon nigroviridis	63.64	0.00e+00	866.00
IUUC-Tca-121665	Theobroma cacao	29.31	2.00e-60	227.00
IUUC-Tae-125159	Triticum aestivum	40.59	5.00e-51	196.00
IUUC-Tur-126696	Triticum urartu	38.74	4.00e-42	166.00
IUUC-Tme-127207	Tuber melanosporum	42.79	5.00e-35	143.00
IUUC-Ttr-128990	Tursiops truncatus	93.94	0.00e+00	2019.00
IUUC-Uma-129323	Ustilago maydis	43.48	4.00e-47	183.00
IUUC-Vvi-131411	Vitis vinifera	42.86	5.00e-44	173.00
IUUC-Xtr-132000	Xenopus tropicalis	67.39	0.00e+00	664.00
IUUC-Xma-133380	Xiphophorus maculatus	66.15	0.00e+00	1269.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence