iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000197562.9	ENST00000248139.7	ENSP00000248139.3
ENSG00000197562.9	ENST00000565511.5	ENSP00000457845.1
ENSG00000197562.9	ENST00000509637.6	ENSP00000455232.1
ENSG00000197562.9	ENST00000563109.1	ENSP00000455225.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	15601820

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	5.40e-16	59.9	180	227

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
           ++k+w ++++++SLq+LC++aI++c++ + +   dkLPLP  +k++L+++++
   Q: 180  MEKIW-RPNRVFSLQDLCCRAIVSCTPVHLI---DKLPLPVTIKSHLKSFSM 227
           67899.**********************888...***************976 PP

Organism

Homo sapiens

Functional Description
(View)

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MGSQGSPVKS YDYLLKFLLV GDSDVGKGEI LESLQDGAAE SPYAYSNGID YKTTTILLDG 60
RRVKLELWDT SGQGRFCTIF RSYSRGAQGI LLVYDITNRW SFDGIDRWIK EIDEHAPGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCCGGGGC CACCCCGCCG CTCCCTCCGA GGGTTCTGCG GAAGCAGGCG GCACAGCCTG 60
CGAGGGGCTT TCGTTTCCCG GACTCAGCCG CATCGCCTCG GCTCGGGCGC GCCTGCATCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0342--GTP-binding
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0564--Palmitate
KW-0636--Prenylation
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR027417--P-loop_NTPase
IPR005225--Small_GTP-bd_dom
IPR001806--Small_GTPase
IPR001496--SOCS_box

PROSITE

PS51419--RAB
PS50225--SOCS

Pfam

PF00071--Ras
PF07525--SOCS_box

SMART

SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005768--C:endosome
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0008021--C:synaptic vesicle
GO:0019003--F:GDP binding
GO:0005525--F:GTP binding
GO:0072659--P:protein localization to plasma membrane
GO:0009306--P:protein secretion
GO:0016567--P:protein ubiquitination
GO:0007264--P:small GTPase mediated signal transduction
GO:0006904--P:vesicle docking involved in exocytosis

KEGG

hsa:57799

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001616	Ailuropoda melanoleuca	98.14	2.00e-142	498.00
IUUC-Apl-003799	Anas platyrhynchos	90.20	1.00e-129	455.00
IUUC-Ame-011203	Astyanax mexicanus	93.95	2.00e-152	531.00
IUUC-Bta-013490	Bos taurus	99.64	3.00e-151	527.00
IUUC-Cja-019990	Callithrix jacchus	99.29	4.00e-150	523.00
IUUC-Cpo-022437	Cavia porcellus	98.53	7.00e-143	499.00
IUUC-Csa-024147	Chlorocebus sabaeus	100.00	1.00e-151	528.00
IUUC-Dre-027427	Danio rerio	93.59	3.00e-152	530.00
IUUC-Dno-029998	Dasypus novemcinctus	92.80	4.00e-116	413.00
IUUC-Dor-030584	Dipodomys ordii	89.70	1.00e-108	385.00
IUUC-Dme-031810	Drosophila melanogaster	69.20	3.00e-94	337.00
IUUC-Ete-033080	Echinops telfairi	96.80	9.00e-143	499.00
IUUC-Eca-033423	Equus caballus	99.15	5.00e-126	443.00
IUUC-Eeu-034590	Erinaceus europaeus	89.27	1.00e-111	395.00
IUUC-Fca-035697	Felis catus	99.15	1.00e-121	428.00
IUUC-Fal-037070	Ficedula albicollis	97.51	2.00e-150	525.00
IUUC-Gmo-039605	Gadus morhua	92.53	1.00e-150	525.00
IUUC-Gga-040343	Gallus gallus	97.51	2.00e-150	525.00
IUUC-Gac-041833	Gasterosteus aculeatus	88.81	1.00e-143	501.00
IUUC-Ggo-045131	Gorilla gorilla	92.53	4.00e-134	470.00
IUUC-Itr-048902	Ictidomys tridecemlineatus	98.93	3.00e-151	527.00
IUUC-Lch-050193	Latimeria chalumnae	95.02	3.00e-153	534.00
IUUC-Loc-052243	Lepisosteus oculatus	93.59	2.00e-152	531.00
IUUC-Laf-054435	Loxodonta africana	97.15	5.00e-150	523.00
IUUC-Mcc-055337	Macaca mulatta	99.64	2.00e-150	525.00
IUUC-Meu-056731	Macropus eugenii	97.60	1.00e-80	292.00
IUUC-Mmr-061380	Microcebus murinus	99.28	4.00e-150	523.00
IUUC-Mdo-062438	Monodelphis domestica	97.51	2.00e-150	524.00
IUUC-Mmu-064046	Mus musculus	99.29	3.00e-151	527.00
IUUC-Mpu-066029	Mustela putorius furo	94.44	6.00e-123	432.00
IUUC-Mlu-067741	Myotis lucifugus	99.29	9.00e-151	525.00
IUUC-Nle-069240	Nomascus leucogenys	93.95	1.00e-138	485.00
IUUC-Ont-071248	Oreochromis niloticus	94.31	2.00e-152	531.00
IUUC-Oan-073432	Ornithorhynchus anatinus	97.45	5.00e-122	430.00
IUUC-Olo-080270	Oryza longistaminata	34.41	6.00e-12	65.50
IUUC-Ola-086486	Oryzias latipes	86.36	8.00e-139	486.00
IUUC-Oga-088293	Otolemur garnettii	99.29	3.00e-151	527.00
IUUC-Ptr-090720	Pan troglodytes	100.00	1.00e-151	528.00
IUUC-Pan-091732	Papio anubis	100.00	1.00e-151	528.00
IUUC-Psi-093627	Pelodiscus sinensis	96.09	1.00e-142	498.00
IUUC-Pfo-097105	Poecilia formosa	93.24	6.00e-152	529.00
IUUC-Pab-098054	Pongo abelii	100.00	1.00e-151	528.00
IUUC-Pca-100775	Procavia capensis	97.93	1.00e-89	322.00
IUUC-Pva-102658	Pteropus vampyrus	98.93	4.00e-150	523.00
IUUC-Rno-105303	Rattus norvegicus	99.29	3.00e-151	527.00
IUUC-Sha-106536	Sarcophilus harrisii	97.51	2.00e-150	524.00
IUUC-Tgu-116858	Taeniopygia guttata	98.96	5.00e-114	402.00
IUUC-Tru-118264	Takifugu rubripes	77.08	4.00e-139	487.00
IUUC-Tni-120350	Tetraodon nigroviridis	93.24	4.00e-151	526.00
IUUC-Ttr-129236	Tursiops truncatus	99.29	9.00e-153	532.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence