iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UBL/SUMO	SUMO	11806825

Classification

Family	E-value	Score	Start	End
ULD/UBL/SUMO	2.90e-26	92.3	11	90
ULD/UDP/UBQ/UBQ_Other	4.20e-06	26.9	24	87

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/SUMO

   S: 5    fkapvslkvagqdGsevlfklklsaqlkklmeavYvkrinldensvrfvfngqkireqetpeelevededkiellcqksGG 85
           +++++++kv gqd++ev+f++k+ +++ kl+++ Y++r+++ +ns+rf+f+g++i++++tp++le+ed+d+ie+++++ GG
   Q: 11   NAEYIKIKVVGQDSNEVHFRVKYGTSMAKLKKS-YADRTGVAVNSLRFLFDGRRINDDDTPKTLEMEDDDVIEVYQEQLGG 90
           899******************************.**********************************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 11   s.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekk 73
           s e  ++v+  ++ a+LK+   +++g+ +++ r +++G+ + dd+t + + + d+++i +++++
   Q: 24   SnEVHFRVKYGTSMAKLKKSYADRTGVAVNSLRFLFDGRRINDDDTPKTLEMEDDDVIEVYQEQ 87
           44666778888999**********************************************9976 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process (PubMed:11806825). Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction (PubMed:11806825, PubMed:25475837). Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17 (PubMed:15107848, PubMed:16701625). Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates (PubMed:15466489, PubMed:15689373, PubMed:15990876, PubMed:24349540). Probably by sumoylating bet-1, prevents muscle myosin depletion in aging adults probably by preventing myoblast growth factor receptor egl-15 overexpression (PubMed:24285704). Plays a role in the attenuation of the let-60/ras pathway (PubMed:24349540, PubMed:24285704).

Protein Sequence
(Fasta)

MADDAAQAGD NAEYIKIKVV GQDSNEVHFR VKYGTSMAKL KKSYADRTGV AVNSLRFLFD 60
GRRINDDDTP KTLEMEDDDV IEVYQEQLGG F 91

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTCAGAGA CTCCCGCTAT AAACGATGGC CGATGATGCA GCTCAAGCAG GCGACAACGC 60
CGAATACATC AAGATCAAGG TCGTTGGACA GGTAATTTGA CTGGAAATTC GCCGCGAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR022617--Rad60/SUMO-like_dom
IPR033950--Sumo
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF11976--Rad60-SLD

SMART

SM00213--UBQ

Gene Ontology

GO:0005694--C:chromosome
GO:0005737--C:cytoplasm
GO:0005815--C:microtubule organizing center
GO:0005634--C:nucleus
GO:0005819--C:spindle
GO:0042802--F:identical protein binding
GO:0031386--F:protein tag
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0007080--P:mitotic metaphase plate congression
GO:0051306--P:mitotic sister chromatid separation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0002119--P:nematode larval development
GO:0034502--P:protein localization to chromosome
GO:0016925--P:protein sumoylation
GO:0070194--P:synaptonemal complex disassembly

KEGG

cel:CELE_K12C11.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001056	Aegilops tauschii	48.61	6.00e-16	74.30
IUUC-Aml-001606	Ailuropoda melanoleuca	65.82	9.00e-29	116.00
IUUC-Atr-002794	Amborella trichopoda	50.62	4.00e-19	84.30
IUUC-Apl-003638	Anas platyrhynchos	65.82	5.00e-29	117.00
IUUC-Aca-004710	Anolis carolinensis	65.82	6.00e-29	117.00
IUUC-Aly-005765	Arabidopsis lyrata	50.62	4.00e-19	84.70
IUUC-Ath-007391	Arabidopsis thaliana	48.81	1.00e-19	85.90
IUUC-Ago-007749	Ashbya gossypii	40.66	1.00e-16	75.90
IUUC-Acl-008286	Aspergillus clavatus	44.09	4.00e-18	80.90
IUUC-Afl-008650	Aspergillus flavus	45.16	1.00e-19	85.90
IUUC-Afu-008969	Aspergillus fumigatus	42.55	3.00e-18	81.60
IUUC-Ani-009300	Aspergillus nidulans	44.09	6.00e-19	84.00
IUUC-Ang-009651	Aspergillus niger	44.83	6.00e-19	83.60
IUUC-Ate-010503	Aspergillus terreus	36.94	2.00e-15	73.20
IUUC-Ame-011662	Astyanax mexicanus	64.20	4.00e-29	117.00
IUUC-Bgr-012250	Blumeria graminis	37.08	1.00e-16	76.60
IUUC-Bta-013491	Bos taurus	65.82	9.00e-29	116.00
IUUC-Bci-013625	Botrytis cinerea	46.84	2.00e-18	82.00
IUUC-Bdi-014847	Brachypodium distachyon	50.00	1.00e-18	82.80
IUUC-Bol-015977	Brassica oleracea	47.62	5.00e-19	84.30
IUUC-Bra-017542	Brassica rapa	48.81	1.00e-19	86.70
IUUC-Cja-019109	Callithrix jacchus	65.82	9.00e-29	116.00
IUUC-Cfa-020657	Canis familiaris	65.82	9.00e-29	116.00
IUUC-Cpo-022508	Cavia porcellus	65.82	8.00e-29	116.00
IUUC-Cre-022970	Chlamydomonas reinhardtii	44.44	7.00e-18	80.10
IUUC-Csa-023026	Chlorocebus sabaeus	67.09	1.00e-20	89.70
IUUC-Cho-024767	Choloepus hoffmanni	64.71	4.00e-23	99.00
IUUC-Cin-025314	Ciona intestinalis	44.44	6.00e-19	84.00
IUUC-Csv-026212	Ciona savignyi	41.67	6.00e-20	87.40
IUUC-Cne-027072	Cryptococcus neoformans	53.03	5.00e-15	71.20
IUUC-Cme-027181	Cyanidioschyzon merolae	48.75	5.00e-17	77.40
IUUC-Dre-028383	Danio rerio	66.25	1.00e-28	116.00
IUUC-Dno-029820	Dasypus novemcinctus	65.82	9.00e-29	116.00
IUUC-Dor-030760	Dipodomys ordii	22.78	4.00e-05	40.80
IUUC-Dse-031390	Dothistroma septosporum	45.92	5.00e-21	90.90
IUUC-Dme-031967	Drosophila melanogaster	47.78	7.00e-22	93.60
IUUC-Ete-032934	Echinops telfairi	37.23	9.00e-16	73.20
IUUC-Eca-033958	Equus caballus	65.82	9.00e-29	116.00
IUUC-Eeu-034822	Erinaceus europaeus	65.82	8.00e-29	116.00
IUUC-Fca-035601	Felis catus	65.82	1.00e-28	116.00
IUUC-Fal-036740	Ficedula albicollis	65.82	8.00e-29	117.00
IUUC-Fox-037950	Fusarium oxysporum	48.81	3.00e-20	88.20
IUUC-Fso-038430	Fusarium solani	49.41	7.00e-21	90.50
IUUC-Gmo-038535	Gadus morhua	46.81	1.00e-23	99.40
IUUC-Ggr-040015	Gaeumannomyces graminis	48.05	2.00e-18	82.80
IUUC-Gga-040129	Gallus gallus	65.82	5.00e-29	117.00
IUUC-Gac-042112	Gasterosteus aculeatus	62.96	3.00e-28	114.00
IUUC-Gma-043091	Glycine max	46.59	5.00e-19	84.70
IUUC-Ggo-045413	Gorilla gorilla	65.82	9.00e-29	116.00
IUUC-Hsa-046108	Homo sapiens	65.82	9.00e-29	116.00
IUUC-Hvu-047514	Hordeum vulgare	46.07	4.00e-18	81.60
IUUC-Itr-047968	Ictidomys tridecemlineatus	65.82	1.00e-28	116.00
IUUC-Kpa-049243	Komagataella pastoris	41.98	2.00e-09	52.00
IUUC-Lch-049881	Latimeria chalumnae	59.34	1.00e-24	102.00
IUUC-Lpe-051684	Leersia perrieri	46.67	4.00e-19	84.70
IUUC-Loc-052189	Lepisosteus oculatus	64.20	8.00e-29	117.00
IUUC-Lma-052968	Leptosphaeria maculans	46.84	4.00e-19	84.70
IUUC-Laf-053478	Loxodonta africana	65.82	1.00e-28	116.00
IUUC-Mcc-054832	Macaca mulatta	48.15	5.00e-21	92.00
IUUC-Meu-056112	Macropus eugenii	66.67	8.00e-29	117.00
IUUC-Mor-057132	Magnaporthe oryzae	48.72	7.00e-19	84.00
IUUC-Mpo-057351	Magnaporthe poae	48.05	2.00e-18	82.40
IUUC-Mtr-057985	Medicago truncatula	51.95	1.00e-18	83.20
IUUC-Mla-059030	Melampsora laricipopulina	45.68	4.00e-10	55.50
IUUC-Mga-060035	Meleagris gallopavo	65.82	5.00e-29	117.00
IUUC-Mvi-060478	Microbotryum violaceum	29.69	4.00e-08	48.10
IUUC-Mmr-060903	Microcebus murinus	65.82	9.00e-29	116.00
IUUC-Mdo-062633	Monodelphis domestica	65.82	6.00e-29	117.00
IUUC-Mmu-063272	Mus musculus	65.82	9.00e-29	116.00
IUUC-Mac-064486	Musa acuminata	47.73	5.00e-21	90.50
IUUC-Mpu-066505	Mustela putorius furo	65.82	1.00e-28	117.00
IUUC-Mlu-067469	Myotis lucifugus	65.82	1.00e-28	116.00
IUUC-Nfi-068364	Neosartorya fischeri	42.39	3.00e-18	81.30
IUUC-Ncr-068663	Neurospora crassa	46.25	6.00e-19	84.00
IUUC-Nle-069344	Nomascus leucogenys	65.22	4.00e-24	100.00
IUUC-Opr-071104	Ochotona princeps	23.53	2.00e-05	42.70
IUUC-Ont-071436	Oreochromis niloticus	62.96	3.00e-28	114.00
IUUC-Oan-073080	Ornithorhynchus anatinus	48.68	4.00e-20	88.20
IUUC-Ocu-074220	Oryctolagus cuniculus	65.00	9.00e-29	116.00
IUUC-Oba-075425	Oryza barthii	51.95	4.00e-19	84.70
IUUC-Obr-076884	Oryza brachyantha	51.95	2.00e-19	85.50
IUUC-Ogl-077346	Oryza glaberrima	51.95	4.00e-19	84.70
IUUC-Ogu-078983	Oryza glumaepatula	50.65	3.00e-18	82.80
IUUC-Oin-079503	Oryza indica	51.95	4.00e-19	84.70
IUUC-Olo-080573	Oryza longistaminata	51.95	4.00e-19	84.70
IUUC-Ome-081885	Oryza meridionalis	51.95	4.00e-19	84.70
IUUC-Oni-082762	Oryza nivara	51.95	4.00e-19	84.70
IUUC-Opu-083431	Oryza punctata	51.95	1.00e-18	84.70
IUUC-Oru-084392	Oryza rufipogon	51.95	4.00e-19	84.70
IUUC-Osa-086070	Oryza sativa	51.95	4.00e-19	84.70
IUUC-Ola-086373	Oryzias latipes	62.96	5.00e-28	114.00
IUUC-Olu-087670	Ostreococcus lucimarinus	45.71	2.00e-16	75.10
IUUC-Oga-088024	Otolemur garnettii	62.50	2.00e-27	112.00
IUUC-Oar-089991	Ovis aries	65.82	1.00e-28	116.00
IUUC-Ptr-090688	Pan troglodytes	65.82	7.00e-29	117.00
IUUC-Pan-092204	Papio anubis	65.82	9.00e-29	116.00
IUUC-Psi-093396	Pelodiscus sinensis	65.82	6.00e-29	117.00
IUUC-Pno-094884	Phaeosphaeria nodorum	46.84	4.00e-19	84.70
IUUC-Ppa-095772	Physcomitrella patens	48.10	2.00e-17	79.30
IUUC-Pfo-096306	Poecilia formosa	62.96	5.00e-28	114.00
IUUC-Pab-098393	Pongo abelii	66.67	2.00e-28	117.00
IUUC-Pop-099655	Populus trichocarpa	47.73	7.00e-20	87.40
IUUC-Pca-100237	Procavia capensis	65.82	3.00e-27	112.00
IUUC-Ppe-102021	Prunus persica	49.41	8.00e-21	90.10
IUUC-Pva-102353	Pteropus vampyrus	64.41	3.00e-20	89.00
IUUC-Pgr-103683	Puccinia graminis	48.10	2.00e-17	79.30
IUUC-Ptt-103986	Puccinia triticina	46.84	7.00e-17	77.40
IUUC-Pte-104358	Pyrenophora teres	46.34	2.00e-19	85.10
IUUC-Pyt-104485	Pyrenophora triticirepentis	46.34	2.00e-19	85.10
IUUC-Rno-105286	Rattus norvegicus	65.82	9.00e-29	116.00
IUUC-Sce-106231	Saccharomyces cerevisiae	45.45	2.00e-16	75.50
IUUC-Sha-106712	Sarcophilus harrisii	64.71	1.00e-23	99.00
IUUC-Sja-107710	Schizosaccharomyces japonicus	50.52	7.00e-22	94.40
IUUC-Spo-108261	Schizosaccharomyces pombe	56.25	2.00e-21	92.80
IUUC-Smo-109051	Selaginella moellendorffii	43.75	2.00e-17	79.30
IUUC-Sit-110664	Setaria italica	33.72	5.00e-08	48.50
IUUC-Sly-111435	Solanum lycopersicum	48.86	8.00e-20	87.00
IUUC-Stu-111935	Solanum tuberosum	47.19	4.00e-19	84.70
IUUC-Sar-113550	Sorex araneus	65.82	9.00e-29	116.00
IUUC-Sbi-114801	Sorghum bicolor	49.41	9.00e-19	83.60
IUUC-Sre-115172	Sporisorium reilianum	55.56	1.00e-20	89.70
IUUC-Ssc-115837	Sus scrofa	63.29	5.00e-28	114.00
IUUC-Tgu-117064	Taeniopygia guttata	65.82	5.00e-29	117.00
IUUC-Tru-117752	Takifugu rubripes	62.96	3.00e-28	114.00
IUUC-Tsy-119358	Tarsius syrichta	63.33	2.00e-20	89.40
IUUC-Tni-120621	Tetraodon nigroviridis	62.96	4.00e-28	114.00
IUUC-Tca-120927	Theobroma cacao	47.73	2.00e-19	86.30
IUUC-Tre-121926	Trichoderma reesei	48.75	1.00e-19	86.30
IUUC-Tvi-122514	Trichoderma virens	45.98	1.00e-19	86.30
IUUC-Tae-124484	Triticum aestivum	48.31	4.00e-19	84.70
IUUC-Tur-126333	Triticum urartu	48.53	2.00e-14	70.10
IUUC-Tme-126902	Tuber melanosporum	48.10	7.00e-19	83.60
IUUC-Tbe-127363	Tupaia belangeri	44.68	6.00e-21	90.50
IUUC-Ttr-128166	Tursiops truncatus	65.82	1.00e-28	117.00
IUUC-Uma-129444	Ustilago maydis	51.69	5.00e-21	90.90
IUUC-Vda-129731	Verticillium dahliae	43.96	2.00e-19	85.90
IUUC-Vpa-130172	Vicugna pacos	65.82	1.00e-28	117.00
IUUC-Vvi-131092	Vitis vinifera	50.62	1.00e-19	86.70
IUUC-Xtr-132473	Xenopus tropicalis	58.43	8.00e-29	117.00
IUUC-Xma-133814	Xiphophorus maculatus	62.96	3.00e-28	114.00
IUUC-Yli-134507	Yarrowia lipolytica	43.33	1.00e-15	72.40
IUUC-Zma-134810	Zea mays	46.43	1.00e-18	82.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence