iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-063051

Ensembl Protein ID

ENSMODP00000021019.3

UniProt Accession

F6R1Z3; F6R1Z3_MONDO

Protein Name

Uncharacterized protein

Gene Name

OPTN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000016841.3	ENSMODT00000021389.3	ENSMODP00000021019.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	1.50e-23	82.7	514	570

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndsl 57
           +ee+let+ +L++Q+e+Y++DF+aERa+RE+++eeke+L+ q++ l+k+++ ++d+ 
   Q: 514  QEEDLETMSILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAFLLKENNVFEDGS 570
           79****************************************************974 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MEMTHRKEAR PSRSTGRGFQ APLPFSLPLP QKPHSASTSP SCGGCNRNPR MRAPEQGSTT 60
MSHQPLGDSA ENGECSKGST GNGPQNLAHP DLDTFTPEEM LKQMKELLIE NHQLKEAMKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAAATGA CGCACAGAAA AGAAGCGAGG CCATCCCGCT CAACAGGGCG GGGTTTCCAG 60
GCTCCCCTAC CTTTCTCTCT CCCGCTCCCA CAGAAGCCCC ACAGCGCCTC CACCTCACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005802--C:trans-Golgi network
GO:0070530--F:K63-linked polyubiquitin binding
GO:0050829--P:defense response to Gram-negative bacterium
GO:0090161--P:Golgi ribbon formation
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0016236--P:macroautophagy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0001920--P:negative regulation of receptor recycling
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1904417--P:positive regulation of xenophagy
GO:0000042--P:protein targeting to Golgi
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	71.48	0.00e+00	679.00
IUUC-Apl-003812	Anas platyrhynchos	56.37	1.00e-151	529.00
IUUC-Aca-004625	Anolis carolinensis	55.31	8.00e-150	523.00
IUUC-Aly-005781	Arabidopsis lyrata	50.00	2.80e-02	33.10
IUUC-Ame-011116	Astyanax mexicanus	47.95	2.00e-53	203.00
IUUC-Bta-013240	Bos taurus	74.19	0.00e+00	795.00
IUUC-Cja-019911	Callithrix jacchus	75.30	0.00e+00	755.00
IUUC-Cfa-020330	Canis familiaris	74.87	0.00e+00	745.00
IUUC-Cpo-021753	Cavia porcellus	72.74	0.00e+00	737.00
IUUC-Csa-023662	Chlorocebus sabaeus	75.47	0.00e+00	758.00
IUUC-Cho-024574	Choloepus hoffmanni	63.28	5.00e-114	404.00
IUUC-Dre-027720	Danio rerio	39.86	9.00e-91	327.00
IUUC-Dno-029079	Dasypus novemcinctus	72.09	0.00e+00	684.00
IUUC-Dor-030890	Dipodomys ordii	71.50	0.00e+00	740.00
IUUC-Dme-032072	Drosophila melanogaster	27.75	2.00e-04	40.40
IUUC-Ete-032568	Echinops telfairi	72.88	0.00e+00	647.00
IUUC-Eca-033528	Equus caballus	73.49	0.00e+00	735.00
IUUC-Eeu-035219	Erinaceus europaeus	65.81	0.00e+00	676.00
IUUC-Fca-035852	Felis catus	74.71	0.00e+00	742.00
IUUC-Fal-036862	Ficedula albicollis	57.19	2.00e-147	515.00
IUUC-Gmo-038735	Gadus morhua	36.94	4.00e-69	255.00
IUUC-Gga-040939	Gallus gallus	56.34	7.00e-153	533.00
IUUC-Gac-041580	Gasterosteus aculeatus	40.91	1.00e-88	320.00
IUUC-Ggo-045034	Gorilla gorilla	66.67	0.00e+00	667.00
IUUC-Hsa-046624	Homo sapiens	75.38	0.00e+00	765.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	70.14	0.00e+00	728.00
IUUC-Lch-049720	Latimeria chalumnae	49.49	2.00e-85	309.00
IUUC-Loc-052185	Lepisosteus oculatus	44.81	3.00e-106	379.00
IUUC-Laf-054079	Loxodonta africana	73.46	0.00e+00	721.00
IUUC-Mcc-055674	Macaca mulatta	75.55	0.00e+00	756.00
IUUC-Meu-056769	Macropus eugenii	92.94	6.00e-79	288.00
IUUC-Mla-059036	Melampsora laricipopulina	39.39	6.90e-01	28.90
IUUC-Mga-060203	Meleagris gallopavo	56.14	6.00e-144	504.00
IUUC-Mmr-061492	Microcebus murinus	75.04	0.00e+00	748.00
IUUC-Mmu-063409	Mus musculus	70.25	0.00e+00	764.00
IUUC-Mpu-065907	Mustela putorius furo	69.45	0.00e+00	722.00
IUUC-Mlu-066957	Myotis lucifugus	72.82	0.00e+00	686.00
IUUC-Nle-069973	Nomascus leucogenys	74.79	0.00e+00	756.00
IUUC-Opr-071049	Ochotona princeps	68.72	0.00e+00	645.00
IUUC-Ont-071915	Oreochromis niloticus	42.42	2.00e-90	326.00
IUUC-Oan-072965	Ornithorhynchus anatinus	75.56	0.00e+00	792.00
IUUC-Ocu-074029	Oryctolagus cuniculus	66.91	1.00e-169	588.00
IUUC-Ola-087019	Oryzias latipes	39.86	3.00e-84	306.00
IUUC-Oga-088613	Otolemur garnettii	74.87	0.00e+00	747.00
IUUC-Oar-090386	Ovis aries	74.02	0.00e+00	790.00
IUUC-Ptr-091619	Pan troglodytes	74.87	0.00e+00	759.00
IUUC-Pan-092178	Papio anubis	75.64	0.00e+00	754.00
IUUC-Psi-093214	Pelodiscus sinensis	63.18	1.00e-172	599.00
IUUC-Pfo-096901	Poecilia formosa	40.07	2.00e-82	300.00
IUUC-Pab-097560	Pongo abelii	68.32	0.00e+00	660.00
IUUC-Pca-100853	Procavia capensis	65.17	1.00e-104	374.00
IUUC-Pva-102255	Pteropus vampyrus	72.99	0.00e+00	681.00
IUUC-Rno-105812	Rattus norvegicus	71.31	0.00e+00	757.00
IUUC-Sha-107225	Sarcophilus harrisii	93.09	0.00e+00	635.00
IUUC-Sar-113736	Sorex araneus	68.36	3.00e-119	422.00
IUUC-Sbi-114619	Sorghum bicolor	35.14	1.30e+00	27.70
IUUC-Ssc-115422	Sus scrofa	74.02	0.00e+00	775.00
IUUC-Tgu-116924	Taeniopygia guttata	56.54	8.00e-142	497.00
IUUC-Tru-117695	Takifugu rubripes	37.52	2.00e-76	280.00
IUUC-Tsy-119090	Tarsius syrichta	73.82	3.00e-135	475.00
IUUC-Tni-120645	Tetraodon nigroviridis	40.57	8.00e-86	311.00
IUUC-Tbe-127970	Tupaia belangeri	66.17	3.00e-121	428.00
IUUC-Ttr-129244	Tursiops truncatus	72.99	0.00e+00	720.00
IUUC-Vpa-130313	Vicugna pacos	72.48	0.00e+00	700.00
IUUC-Xtr-132115	Xenopus tropicalis	44.58	4.00e-98	352.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence