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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045873
Ensembl Protein ID ENSP00000297661.4
UniProt Accession Q9NZ09; B7Z348; B7Z8N9; D3DRL7; F5GXE2; F5H0J8; Q4V759; Q53FP7; Q5T7B3; Q6FI75; Q8NC52; Q8NCG6; Q8NCH9; UBAP1_HUMAN
Genbank Protein ID AAF37827.2; CAB66667.1; BAC11162.1; BAC11176.1; BAC11224.1; BAC11323.1; BAC11342.1; BAH12084.1; BAH14025.1; CAG38582.1; BAD96955.1; CAI15914.1; CAI15915.1; EAW58467.1; EAW58468.1; EAW58469.1; EAW58470.1; AAH20950.1; AAH98141.1; AAH98316.1; AAH99726.1; AAI00669.1
Protein Name Ubiquitin-associated protein 1; Nasopharyngeal carcinoma-associated gene 20 protein
Genbank Nucleotide ID AF222043; AL136733; AK074724; AK074745; AK074812; AK074969; AK074995; AK295482; AK303711; CR533551; AK223235; AL353662; AL353662; CH471071; CH471071; CH471071; CH471071; BC020950; BC098141; BC098316; BC099726; BC100668
Gene Name UBAP1; NAG20
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000165006.13 ENST00000625521.2 ENSP00000486574.1
ENSG00000165006.13 ENST00000297661.8 ENSP00000297661.4
ENSG00000165006.13 ENST00000379186.8 ENSP00000368484.3
ENSG00000165006.13 ENST00000626262.2 ENSP00000487222.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 11599797; 21757351; 22405001
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 3.70e-14 54.0 459 496
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLl 39
           e+ +++ +++eMGF+ +++++ L+ +nn+ + A+e+L+
   Q: 459  EFLQLMSKFKEMGFELKDIKEVLLLHNNDQDNALEDLM 496
           667899******************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2.
 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2.
Protein Sequence
(Fasta)
MASKKLGADF HGTFSYLDDV PFKTGDKFKT PAKVGLPIGF SLPDCLQVVR EVQYDFSLEK 60
KTIEWAEEIK KIEEAEREAE CKIAEAEAKV NSKSGPEGDS KMSFSKTHST ATMPPPINPI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045873|UBD,UBA|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGACGCCCAA ATGAGTGGGG CGGTGAGGGG AAGGAGGAGG GAAGTAGGAC TTCAACATGG 60
CGGCTGCGGC ACTGGCGGTG GCTACGGTGA CGGCCTGGCC CGGAGCGGGC AGAGTTGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045873|UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR023340--UMA
PROSITE

PS50030--UBA
PS51497--UMA
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000813--C:ESCRT I complex
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0043130--F:ubiquitin binding
GO:0015031--P:protein transport
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
KEGG hsa:51271
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001255 Ailuropoda melanoleuca 93.85 0.00e+00 880.00
IUUC-Atr-003026 Amborella trichopoda 29.17 3.00e-04 38.90
IUUC-Apl-003392 Anas platyrhynchos 74.56 0.00e+00 674.00
IUUC-Aca-004360 Anolis carolinensis 67.45 0.00e+00 628.00
IUUC-Aly-006147 Arabidopsis lyrata 26.15 5.00e-04 37.70
IUUC-Ame-010979 Astyanax mexicanus 43.16 8.00e-82 297.00
IUUC-Bta-012720 Bos taurus 92.03 0.00e+00 847.00
IUUC-Bdi-014208 Brachypodium distachyon 33.33 9.00e-04 37.40
IUUC-Bra-016839 Brassica rapa 40.48 4.00e-02 33.10
IUUC-Cja-019955 Callithrix jacchus 98.57 0.00e+00 939.00
IUUC-Cfa-020433 Canis familiaris 92.68 2.00e-153 535.00
IUUC-Cpo-022043 Cavia porcellus 91.63 0.00e+00 901.00
IUUC-Csa-023905 Chlorocebus sabaeus 99.60 0.00e+00 917.00
IUUC-Cho-025098 Choloepus hoffmanni 92.84 0.00e+00 895.00
IUUC-Cin-025370 Ciona intestinalis 30.37 2.00e-08 53.90
IUUC-Dre-027667 Danio rerio 48.76 7.00e-49 188.00
IUUC-Dno-028980 Dasypus novemcinctus 93.64 0.00e+00 923.00
IUUC-Dor-030380 Dipodomys ordii 93.43 0.00e+00 904.00
IUUC-Dme-031880 Drosophila melanogaster 40.30 1.10e-02 35.00
IUUC-Ete-032657 Echinops telfairi 83.33 0.00e+00 788.00
IUUC-Eca-034094 Equus caballus 94.27 0.00e+00 899.00
IUUC-Eeu-034842 Erinaceus europaeus 91.30 0.00e+00 839.00
IUUC-Fca-036237 Felis catus 94.91 0.00e+00 877.00
IUUC-Fal-037011 Ficedula albicollis 73.42 0.00e+00 682.00
IUUC-Gmo-038530 Gadus morhua 73.91 4.00e-49 189.00
IUUC-Gga-040947 Gallus gallus 73.02 0.00e+00 672.00
IUUC-Gac-042101 Gasterosteus aculeatus 41.45 4.00e-86 311.00
IUUC-Gma-043886 Glycine max 28.12 4.00e-04 38.10
IUUC-Ggo-045459 Gorilla gorilla 98.99 0.00e+00 893.00
IUUC-Itr-048313 Ictidomys tridecemlineatus 95.82 0.00e+00 907.00
IUUC-Lch-050450 Latimeria chalumnae 54.05 1.00e-137 483.00
IUUC-Loc-052519 Lepisosteus oculatus 42.80 7.00e-84 304.00
IUUC-Laf-054397 Loxodonta africana 94.84 0.00e+00 902.00
IUUC-Mcc-055651 Macaca mulatta 98.68 0.00e+00 841.00
IUUC-Meu-056233 Macropus eugenii 85.83 0.00e+00 838.00
IUUC-Mor-057162 Magnaporthe oryzae 27.96 1.20e-01 31.60
IUUC-Mtr-058776 Medicago truncatula 25.77 6.00e-04 37.40
IUUC-Mga-059888 Meleagris gallopavo 72.13 0.00e+00 660.00
IUUC-Mmr-061166 Microcebus murinus 96.54 0.00e+00 926.00
IUUC-Mdo-062565 Monodelphis domestica 83.94 0.00e+00 772.00
IUUC-Mmu-063850 Mus musculus 91.04 0.00e+00 861.00
IUUC-Mac-065028 Musa acuminata 34.15 1.00e-03 36.60
IUUC-Mpu-066241 Mustela putorius furo 95.26 0.00e+00 899.00
IUUC-Mlu-068065 Myotis lucifugus 92.73 0.00e+00 887.00
IUUC-Nle-069682 Nomascus leucogenys 99.60 0.00e+00 918.00
IUUC-Opr-070846 Ochotona princeps 91.63 0.00e+00 897.00
IUUC-Ont-071429 Oreochromis niloticus 43.23 1.00e-79 290.00
IUUC-Oan-073014 Ornithorhynchus anatinus 96.15 2.00e-24 103.00
IUUC-Ocu-073955 Oryctolagus cuniculus 91.83 0.00e+00 902.00
IUUC-Obr-076832 Oryza brachyantha 34.09 8.00e-04 37.40
IUUC-Oin-080129 Oryza indica 33.33 1.00e-03 37.00
IUUC-Ola-087056 Oryzias latipes 40.55 1.00e-76 280.00
IUUC-Oga-088447 Otolemur garnettii 94.42 0.00e+00 892.00
IUUC-Oar-089849 Ovis aries 92.03 0.00e+00 851.00
IUUC-Ptr-091574 Pan troglodytes 99.39 0.00e+00 891.00
IUUC-Pan-092584 Papio anubis 99.20 0.00e+00 944.00
IUUC-Psi-093796 Pelodiscus sinensis 70.80 0.00e+00 684.00
IUUC-Pfo-096166 Poecilia formosa 40.70 1.00e-77 283.00
IUUC-Pab-098347 Pongo abelii 99.04 7.00e-160 556.00
IUUC-Pop-098804 Populus trichocarpa 25.58 2.00e-03 36.20
IUUC-Pca-100709 Procavia capensis 90.87 2.00e-118 419.00
IUUC-Pva-102428 Pteropus vampyrus 94.27 0.00e+00 925.00
IUUC-Rno-105514 Rattus norvegicus 91.24 0.00e+00 871.00
IUUC-Sha-107555 Sarcophilus harrisii 86.81 0.00e+00 828.00
IUUC-Stu-112785 Solanum tuberosum 26.47 3.00e-04 38.90
IUUC-Sar-113282 Sorex araneus 78.95 0.00e+00 648.00
IUUC-Ssc-116069 Sus scrofa 87.44 0.00e+00 741.00
IUUC-Tgu-116700 Taeniopygia guttata 73.92 0.00e+00 663.00
IUUC-Tru-117901 Takifugu rubripes 40.90 2.00e-76 280.00
IUUC-Tsy-119084 Tarsius syrichta 92.31 0.00e+00 676.00
IUUC-Tni-120603 Tetraodon nigroviridis 36.19 2.00e-59 223.00
IUUC-Tbe-127397 Tupaia belangeri 73.93 0.00e+00 644.00
IUUC-Ttr-128728 Tursiops truncatus 93.43 0.00e+00 851.00
IUUC-Vpa-130555 Vicugna pacos 93.04 0.00e+00 768.00
IUUC-Vvi-131340 Vitis vinifera 31.37 3.00e-04 38.90
IUUC-Xtr-132412 Xenopus tropicalis 59.57 3.00e-148 518.00
IUUC-Xma-133280 Xiphophorus maculatus 37.94 5.00e-59 221.00
Created Date 25-Jun-2017

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