iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000137055.14	ENST00000397292.7	ENSP00000380460.3
ENSG00000137055.14	ENST00000517642.5	ENSP00000430447.1
ENSG00000137055.14	ENST00000487173.5	ENSP00000430734.1
ENSG00000137055.14	ENST00000520884.5	ENSP00000429372.1
ENSG00000137055.14	ENST00000523212.1	ENSP00000428111.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM	SZDB
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/PFU	PFU	19423704; 21070969
UBD/Beta-Prp	Beta-Prp	19423704; 21070969

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-26	93.0	149	179
UBD/Beta-Prp	2.10e-66	225.8	12	302

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gHt+ v++++  ++ +l+++Gs D+t+k+W 
   Q: 149  GHTAAVWAVKIlPEqGLMLTGSADKTVKLWK 179
           8*********99999***************7 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl....lrslsgheaevtavkfspdgk.....ilvtgseDrtikvwdlstgk 85
           ++l+gh+ +v   v+++     +++ srd+t+++w  ++++     ++++sgh+++v++v+++p+++     +++tg++D++i++++l+++ 
   Q: 12   CSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRsfteMHCMSGHSNFVSCVCIIPSSDiyphgLIATGGNDHNICIFSLDSPM 103
           8999************55555699999************99999***********************999999******************* PP
   S: 86   cvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
           ++++lkgh+++v+sls+ +   +l+sGs+d t++vw   +++c+  tl+gh+++v+ v++ p++ l+ +Gs+D+tv+lW  k g++ rt++g
   Q: 104  PLYILKGHKNTVCSLSSGK-FGTLLSGSWDTTAKVW--LNDKCMM-TLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW--KAGRCERTFSG 189
           ******************9.9***************..9******.*********************************..88********9 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
            h+d v+ l++ s+ +e++s+++d +++ w++ tgec++ + ght+ ++s+ ++pn   +v++++D+s+riW  ++g++ +t+ l+++s+++
   Q: 190  -HEDCVRGLAILSE-TEFLSCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWC 276
           .*********9996.8****************.***************************************..9***************** PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkkn 297
           ++v  +++  +v g++d++++++  +++
   Q: 277  CCV--LDNGDIVVGASDGIIRVFTESED 302
           ***..9999*************997766 PP

Organism

Homo sapiens

Functional Description
(View)

Involved in the maintenance of ubiquitin levels.

Protein Sequence
(Fasta)

MTSGATRYRL SCSLRGHELD VRGLVCCAYP PGAFVSVSRD RTTRLWAPDS PNRSFTEMHC 60
MSGHSNFVSC VCIIPSSDIY PHGLIATGGN DHNICIFSLD SPMPLYILKG HKNTVCSLSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACAAACTGT TGGGCCCGGA GTCGGAAGAG ACCCGGGTTT GGGAAGGACC CCAGGGTCAG 60
GCGTCCTGGT GGAAGGGCGG GCCTCTTTCT CTCTTGCTCA GCAGGGAGTC CAGAGCCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR033510--PLAA/Doa1/Lub1
IPR015155--PLAA_fam_Ub-bd_PFU
IPR013535--PUL_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS51394--PFU
PS51396--PUL
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF09070--PFU
PF08324--PUL
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0016005--F:phospholipase A2 activator activity
GO:0043130--F:ubiquitin binding
GO:0006954--P:inflammatory response
GO:0006644--P:phospholipid metabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0007165--P:signal transduction
GO:0010992--P:ubiquitin homeostasis

KEGG

hsa:9373

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000146	Aegilops tauschii	31.30	7.00e-92	331.00
IUUC-Aml-002125	Ailuropoda melanoleuca	95.74	0.00e+00	1583.00
IUUC-Atr-002554	Amborella trichopoda	31.01	3.00e-96	346.00
IUUC-Apl-004094	Anas platyrhynchos	81.42	0.00e+00	1264.00
IUUC-Aca-004726	Anolis carolinensis	80.00	0.00e+00	1325.00
IUUC-Aly-005961	Arabidopsis lyrata	32.58	5.00e-108	385.00
IUUC-Ath-006639	Arabidopsis thaliana	32.52	5.00e-104	372.00
IUUC-Ago-007772	Ashbya gossypii	28.89	2.00e-79	290.00
IUUC-Acl-008316	Aspergillus clavatus	31.39	2.00e-88	320.00
IUUC-Afl-008532	Aspergillus flavus	32.58	2.00e-89	323.00
IUUC-Afu-008950	Aspergillus fumigatus	31.98	2.00e-90	327.00
IUUC-Ani-009186	Aspergillus nidulans	33.37	5.00e-93	335.00
IUUC-Ang-009575	Aspergillus niger	31.11	3.00e-85	310.00
IUUC-Aor-010086	Aspergillus oryzae	32.58	2.00e-89	323.00
IUUC-Ate-010541	Aspergillus terreus	29.97	2.00e-84	307.00
IUUC-Ame-011633	Astyanax mexicanus	67.29	0.00e+00	1115.00
IUUC-Bgr-012292	Blumeria graminis	30.01	7.00e-92	332.00
IUUC-Bta-013218	Bos taurus	93.84	0.00e+00	1572.00
IUUC-Bci-013876	Botrytis cinerea	39.48	1.00e-90	327.00
IUUC-Bdi-014810	Brachypodium distachyon	33.20	7.00e-106	378.00
IUUC-Bol-016006	Brassica oleracea	33.07	4.00e-108	385.00
IUUC-Bra-017593	Brassica rapa	33.46	6.00e-109	388.00
IUUC-Cel-018703	Caenorhabditis elegans	27.41	2.00e-71	264.00
IUUC-Cja-019270	Callithrix jacchus	97.36	0.00e+00	1617.00
IUUC-Cfa-021262	Canis familiaris	95.50	0.00e+00	1574.00
IUUC-Cpo-021449	Cavia porcellus	89.47	0.00e+00	1444.00
IUUC-Csa-024140	Chlorocebus sabaeus	98.87	0.00e+00	1639.00
IUUC-Cho-024923	Choloepus hoffmanni	94.21	0.00e+00	767.00
IUUC-Cin-025373	Ciona intestinalis	40.29	2.00e-175	609.00
IUUC-Csv-026324	Ciona savignyi	42.35	0.00e+00	657.00
IUUC-Cgl-026711	Colletotrichum gloeosporioides	31.37	4.00e-84	306.00
IUUC-Cne-026998	Cryptococcus neoformans	32.26	2.00e-87	317.00
IUUC-Cme-027154	Cyanidioschyzon merolae	29.94	3.00e-58	219.00
IUUC-Dre-028674	Danio rerio	65.33	0.00e+00	1100.00
IUUC-Dno-028966	Dasypus novemcinctus	94.21	0.00e+00	1572.00
IUUC-Dor-030343	Dipodomys ordii	88.71	0.00e+00	914.00
IUUC-Dse-031385	Dothistroma septosporum	31.20	3.00e-83	303.00
IUUC-Dme-032044	Drosophila melanogaster	36.28	2.00e-126	446.00
IUUC-Ete-032506	Echinops telfairi	84.78	0.00e+00	831.00
IUUC-Eca-033547	Equus caballus	95.23	0.00e+00	1580.00
IUUC-Eeu-034462	Erinaceus europaeus	80.09	0.00e+00	671.00
IUUC-Fca-035893	Felis catus	95.10	0.00e+00	1576.00
IUUC-Fal-037235	Ficedula albicollis	81.78	0.00e+00	1371.00
IUUC-Fox-037836	Fusarium oxysporum	31.76	5.00e-96	345.00
IUUC-Fso-038251	Fusarium solani	31.04	2.00e-93	337.00
IUUC-Gmo-038648	Gadus morhua	65.93	0.00e+00	959.00
IUUC-Ggr-039867	Gaeumannomyces graminis	29.73	2.00e-82	300.00
IUUC-Gga-040989	Gallus gallus	79.40	0.00e+00	1316.00
IUUC-Gac-041344	Gasterosteus aculeatus	67.08	0.00e+00	1068.00
IUUC-Gma-043067	Glycine max	31.84	5.00e-105	375.00
IUUC-Ggo-045009	Gorilla gorilla	99.01	0.00e+00	1261.00
IUUC-Itr-048636	Ictidomys tridecemlineatus	95.85	0.00e+00	1594.00
IUUC-Kpa-049134	Komagataella pastoris	43.35	1.00e-89	324.00
IUUC-Lch-049597	Latimeria chalumnae	72.57	0.00e+00	738.00
IUUC-Lpe-050821	Leersia perrieri	31.27	1.00e-98	354.00
IUUC-Loc-051849	Lepisosteus oculatus	72.19	0.00e+00	1195.00
IUUC-Lma-053297	Leptosphaeria maculans	33.58	2.00e-103	370.00
IUUC-Laf-053495	Loxodonta africana	93.74	0.00e+00	1554.00
IUUC-Meu-055983	Macropus eugenii	81.31	0.00e+00	651.00
IUUC-Mor-057006	Magnaporthe oryzae	35.97	4.00e-73	269.00
IUUC-Mpo-057465	Magnaporthe poae	35.48	1.00e-72	268.00
IUUC-Mtr-058374	Medicago truncatula	32.58	7.00e-114	405.00
IUUC-Mla-058895	Melampsora laricipopulina	36.03	1.00e-77	283.00
IUUC-Mvi-060297	Microbotryum violaceum	35.38	8.00e-109	388.00
IUUC-Mmr-060810	Microcebus murinus	90.49	0.00e+00	1474.00
IUUC-Mdo-062671	Monodelphis domestica	87.69	0.00e+00	1442.00
IUUC-Mmu-063536	Mus musculus	94.09	0.00e+00	1538.00
IUUC-Mac-064902	Musa acuminata	32.00	4.00e-100	359.00
IUUC-Mpu-066085	Mustela putorius furo	95.98	0.00e+00	1593.00
IUUC-Mlu-067907	Myotis lucifugus	91.76	0.00e+00	995.00
IUUC-Nfi-068457	Neosartorya fischeri	31.09	1.00e-72	267.00
IUUC-Ncr-068622	Neurospora crassa	30.56	5.00e-97	349.00
IUUC-Nle-069049	Nomascus leucogenys	98.36	0.00e+00	1618.00
IUUC-Opr-071013	Ochotona princeps	74.78	0.00e+00	658.00
IUUC-Ont-071339	Oreochromis niloticus	69.86	0.00e+00	1155.00
IUUC-Oan-073353	Ornithorhynchus anatinus	83.40	1.00e-112	399.00
IUUC-Ocu-074625	Oryctolagus cuniculus	95.85	0.00e+00	1596.00
IUUC-Oba-075226	Oryza barthii	29.15	1.00e-85	310.00
IUUC-Obr-076875	Oryza brachyantha	33.17	1.00e-110	394.00
IUUC-Ogl-077057	Oryza glaberrima	32.29	5.00e-110	392.00
IUUC-Ogu-078156	Oryza glumaepatula	32.16	1.00e-109	390.00
IUUC-Oin-079373	Oryza indica	31.91	2.00e-108	386.00
IUUC-Olo-080849	Oryza longistaminata	29.64	4.00e-75	276.00
IUUC-Ome-081654	Oryza meridionalis	28.64	4.00e-85	309.00
IUUC-Oni-082221	Oryza nivara	29.15	3.00e-87	316.00
IUUC-Opu-084103	Oryza punctata	29.18	3.00e-87	316.00
IUUC-Oru-084751	Oryza rufipogon	28.41	6.00e-84	305.00
IUUC-Osa-085584	Oryza sativa	32.04	3.00e-108	386.00
IUUC-Ola-086974	Oryzias latipes	68.68	0.00e+00	1151.00
IUUC-Oga-088052	Otolemur garnettii	90.95	0.00e+00	1491.00
IUUC-Oar-089509	Ovis aries	93.52	0.00e+00	1560.00
IUUC-Ptr-090911	Pan troglodytes	99.87	0.00e+00	1652.00
IUUC-Pan-092141	Papio anubis	98.37	0.00e+00	1628.00
IUUC-Psi-093543	Pelodiscus sinensis	82.41	0.00e+00	1286.00
IUUC-Pno-094952	Phaeosphaeria nodorum	32.81	1.00e-96	347.00
IUUC-Ppa-095881	Physcomitrella patens	32.76	2.00e-109	390.00
IUUC-Pfo-096739	Poecilia formosa	67.84	0.00e+00	1132.00
IUUC-Pab-098641	Pongo abelii	99.62	0.00e+00	1649.00
IUUC-Pop-099621	Populus trichocarpa	31.14	8.00e-103	368.00
IUUC-Pca-100599	Procavia capensis	85.12	0.00e+00	1306.00
IUUC-Ppe-101874	Prunus persica	32.46	3.00e-110	392.00
IUUC-Pva-103009	Pteropus vampyrus	91.63	0.00e+00	1281.00
IUUC-Pgr-103260	Puccinia graminis	32.31	3.00e-91	329.00
IUUC-Ptt-103711	Puccinia triticina	32.32	5.00e-91	328.00
IUUC-Pte-104337	Pyrenophora teres	32.86	7.00e-94	338.00
IUUC-Pyt-104475	Pyrenophora triticirepentis	33.03	9.00e-95	341.00
IUUC-Rno-105273	Rattus norvegicus	94.59	0.00e+00	1578.00
IUUC-Sce-106351	Saccharomyces cerevisiae	39.22	2.00e-80	293.00
IUUC-Sha-106758	Sarcophilus harrisii	87.23	0.00e+00	1442.00
IUUC-Sja-107687	Schizosaccharomyces japonicus	39.87	3.00e-96	346.00
IUUC-Spo-108093	Schizosaccharomyces pombe	34.08	5.00e-100	358.00
IUUC-Ssl-108623	Sclerotinia sclerotiorum	40.04	1.00e-91	331.00
IUUC-Smo-109368	Selaginella moellendorffii	30.36	1.00e-95	344.00
IUUC-Sit-109699	Setaria italica	33.63	9.00e-111	394.00
IUUC-Sly-111063	Solanum lycopersicum	32.60	1.00e-104	374.00
IUUC-Sar-113199	Sorex araneus	95.99	0.00e+00	821.00
IUUC-Sbi-114745	Sorghum bicolor	33.02	1.00e-102	367.00
IUUC-Sre-115080	Sporisorium reilianum	33.13	1.00e-105	377.00
IUUC-Ssc-115666	Sus scrofa	93.50	0.00e+00	1558.00
IUUC-Tgu-116877	Taeniopygia guttata	80.78	0.00e+00	1356.00
IUUC-Tru-117580	Takifugu rubripes	67.05	0.00e+00	1131.00
IUUC-Tsy-118946	Tarsius syrichta	96.64	0.00e+00	1478.00
IUUC-Tni-119755	Tetraodon nigroviridis	64.51	0.00e+00	1057.00
IUUC-Tca-120977	Theobroma cacao	31.64	1.00e-101	364.00
IUUC-Tre-122217	Trichoderma reesei	31.67	3.00e-96	346.00
IUUC-Tvi-122671	Trichoderma virens	30.83	2.00e-92	333.00
IUUC-Tae-125581	Triticum aestivum	33.20	2.00e-107	383.00
IUUC-Tur-126404	Triticum urartu	24.17	4.00e-22	100.00
IUUC-Tme-126971	Tuber melanosporum	34.44	6.00e-115	408.00
IUUC-Tbe-127858	Tupaia belangeri	77.98	0.00e+00	662.00
IUUC-Ttr-128173	Tursiops truncatus	92.21	0.00e+00	1518.00
IUUC-Uma-129322	Ustilago maydis	33.42	3.00e-106	379.00
IUUC-Vda-129682	Verticillium dahliae	31.08	4.00e-90	325.00
IUUC-Vpa-130607	Vicugna pacos	91.69	0.00e+00	1405.00
IUUC-Vvi-131153	Vitis vinifera	32.73	1.00e-111	397.00
IUUC-Xtr-132208	Xenopus tropicalis	74.81	0.00e+00	1240.00
IUUC-Xma-133098	Xiphophorus maculatus	68.58	0.00e+00	1129.00
IUUC-Yli-134646	Yarrowia lipolytica	39.38	8.00e-97	348.00
IUUC-Zma-135920	Zea mays	31.00	6.00e-93	335.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence