iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19648646

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00045	22.3	199	237

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCP 43
           CaiCle++++g     lpC  ++h+ C+  w         + +CP
   Q: 199  CAICLEELQQGdtIARLPCLCIYHKGCIDEW------FEVNRSCP 237
           ********44443666***************......66666677 PP

Organism

Homo sapiens

Functional Description
(View)

May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MGAKQSGPAA ANGRTRAYSG SDLPSSSSGG ANGTAGGGGG ARAAAAGRFP AQVPSAHQPS 60
ASGGAAAAAA APAAPAAPRS RSLGGAVGSV ASGARAAQSP FSIPNSSSGP YGSQDSVHSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGGCCACG TGCGGGAGGA GGGGCCGCCT TCTGGTTGGC GCCCGGTGTC CGTTCCTCCT 60
ATCGGCGTAG GCCCCGCGAG GAAGACAAGG GCGCGCCCTG GCTGGGAGGG CGTGGCCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0967--Endosome
KW-0449--Lipoprotein
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0519--Myristate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0770--Synapse
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005829--C:cytosol
GO:0010008--C:endosome membrane
GO:0005765--C:lysosomal membrane
GO:0005886--C:plasma membrane
GO:0042734--C:presynaptic membrane
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:223082

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002006	Ailuropoda melanoleuca	99.05	9.00e-62	227.00
IUUC-Apl-003883	Anas platyrhynchos	96.63	1.00e-49	187.00
IUUC-Aca-004497	Anolis carolinensis	71.37	5.00e-69	253.00
IUUC-Acl-008261	Aspergillus clavatus	46.30	3.00e-10	60.10
IUUC-Afl-008724	Aspergillus flavus	51.85	1.00e-11	64.70
IUUC-Afu-008835	Aspergillus fumigatus	47.17	3.00e-10	60.50
IUUC-Ang-009666	Aspergillus niger	48.15	2.00e-11	64.30
IUUC-Ate-010331	Aspergillus terreus	29.86	1.00e-10	61.20
IUUC-Ame-011041	Astyanax mexicanus	86.79	2.00e-55	208.00
IUUC-Bgr-012049	Blumeria graminis	45.95	4.00e-07	50.10
IUUC-Bta-013206	Bos taurus	87.30	7.00e-93	333.00
IUUC-Cel-018347	Caenorhabditis elegans	55.56	9.00e-35	139.00
IUUC-Cja-019912	Callithrix jacchus	98.51	2.00e-61	228.00
IUUC-Cpo-021391	Cavia porcellus	97.73	4.00e-49	185.00
IUUC-Csa-023094	Chlorocebus sabaeus	90.08	4.00e-69	254.00
IUUC-Cin-025162	Ciona intestinalis	47.59	2.00e-35	142.00
IUUC-Csv-026373	Ciona savignyi	53.39	6.00e-36	144.00
IUUC-Dre-027399	Danio rerio	60.71	5.00e-47	180.00
IUUC-Dno-029420	Dasypus novemcinctus	88.66	9.00e-67	246.00
IUUC-Dme-031584	Drosophila melanogaster	73.47	8.00e-41	160.00
IUUC-Eca-034068	Equus caballus	98.84	3.00e-50	189.00
IUUC-Fca-035770	Felis catus	96.59	8.00e-51	191.00
IUUC-Gmo-039148	Gadus morhua	73.20	8.00e-65	239.00
IUUC-Gga-041010	Gallus gallus	89.44	3.00e-63	234.00
IUUC-Gac-041711	Gasterosteus aculeatus	87.60	3.00e-59	221.00
IUUC-Lch-049870	Latimeria chalumnae	93.02	3.00e-45	174.00
IUUC-Loc-052877	Lepisosteus oculatus	91.43	2.00e-56	211.00
IUUC-Laf-054451	Loxodonta africana	89.24	5.00e-65	240.00
IUUC-Mcc-055078	Macaca mulatta	86.01	8.00e-71	259.00
IUUC-Mmr-061658	Microcebus murinus	97.73	4.00e-49	185.00
IUUC-Mdo-062052	Monodelphis domestica	82.55	2.00e-65	242.00
IUUC-Mmu-063964	Mus musculus	88.36	3.00e-63	234.00
IUUC-Mlu-067009	Myotis lucifugus	92.66	8.00e-58	214.00
IUUC-Nfi-068593	Neosartorya fischeri	47.17	2.00e-10	60.80
IUUC-Ncr-068662	Neurospora crassa	48.98	6.00e-09	56.20
IUUC-Nle-069306	Nomascus leucogenys	88.57	4.00e-69	254.00
IUUC-Oga-088009	Otolemur garnettii	93.39	1.00e-75	276.00
IUUC-Ptr-091609	Pan troglodytes	94.21	1.00e-72	266.00
IUUC-Pan-092598	Papio anubis	86.01	8.00e-71	259.00
IUUC-Psi-093749	Pelodiscus sinensis	98.82	3.00e-50	189.00
IUUC-Pma-094361	Petromyzon marinus	77.01	6.00e-40	154.00
IUUC-Pfo-096340	Poecilia formosa	91.43	2.00e-57	214.00
IUUC-Pab-097603	Pongo abelii	85.19	2.00e-67	248.00
IUUC-Pva-102216	Pteropus vampyrus	98.82	5.00e-48	184.00
IUUC-Pyt-104423	Pyrenophora triticirepentis	37.70	2.00e-08	54.30
IUUC-Rno-104829	Rattus norvegicus	93.13	1.00e-60	226.00
IUUC-Ssl-108602	Sclerotinia sclerotiorum	46.00	6.00e-08	52.40
IUUC-Ssc-116023	Sus scrofa	96.59	8.00e-49	184.00
IUUC-Tru-117571	Takifugu rubripes	75.86	4.00e-61	227.00
IUUC-Tni-120337	Tetraodon nigroviridis	87.50	2.00e-54	205.00
IUUC-Tbe-127983	Tupaia belangeri	97.01	5.00e-64	237.00
IUUC-Ttr-129090	Tursiops truncatus	84.77	4.00e-72	264.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence