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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-032192
UUCD1 version UUC-DrM-00006
Ensembl Protein ID FBpp0081568
UniProt Accession P51592; Q9VH88; HYD_DROME
Genbank Protein ID AAB88625.1; AAF54431.2
Protein Name E3 ubiquitin-protein ligase hyd; HECT-type E3 ubiquitin transferase hyd; Protein hyperplastic discs
Genbank Nucleotide ID L14644; AE014297
Gene Name hyd; l(3)C43; CG9484
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0002431 FBtr0082090 FBpp0081568
FBgn0002431 FBtr0339599 FBpp0308671
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 12421709; 20604743
UBD/Alpha-Helix/UBA UBA 12421709; 24854243
Classification
Family E-value Score Start End
E3 activity/HECT 1.00e-68 232.2 2585 2884
UBD/Alpha-Helix/UBA 0.0049 17.0 168 195
Active Site
Position(s) Description Evidence
2854 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 38   npdlglflysen..dketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllgkklsledleevdpelykslkeikena... 128
           + + +lf ys++  + +t +   +    + e+++ F+ +Grl+g++l +++ll+l+l+++++k +lg+k++++dl+ +dp ly+s  +i +na   
   Q: 2585 DDNEPLF-YSPGkrGFYTPRQGFA----SFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAqtk 2675
           4444455.2222013333222222....3399*****************************************************77766666455 PP
   S: 129  esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeei 224
           e + +   ++l f ++  + + + ++eL+pgG+++ Vt +N  eYv++++eyrl ++ ++ +ea+++G  +v+p +++  +t+e+l+ll++G  +i
   Q: 2676 EGEETINRMELCFVIDLMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDI 2771
           446666778888888999999*************************************************************************** PP
   S: 225  dvedlkketkykggytedspai....qwFwevleefsseerkafLqFvTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYs 314
           +v++l + t+++++ +e   ++    +wFw+++e+++  er++++ F+Tgs+ lP+  +Gf++l+  +++ir  a+d++lP++nTC+++L +P Ys
   Q: 2772 NVSTLISYTTFNDESSEGPDKLlkfkKWFWSIVEKMNIMERQDLVYFWTGSPALPAseEGFQPLP--SVTIRP-ADDSHLPTANTCISRLYIPLYS 2864
           ***********8888887777778899*****************************99*******..799999.99******************** PP
   S: 315  skeilkekLlyAieetkgFel 335
           sk+il++k+l+Ai++ k+F++
   Q: 2865 SKSILRSKMLMAIKS-KNFGF 2884
           ***************.99875 PP
   

   UBD/Alpha-Helix/UBA
   S: 13   MGFdreealqaLraannnleaAveyLld 40
           +G +r++++++L+++n +++ Av++Ll+
   Q: 168  QGKSRNLIIRELQRTNLDVNLAVNNLLS 195
           577***********************97 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Required for regulation of cell proliferation in imaginal disks and germ cells. Acts as a negative regulator of hh, ci and dpp expression in the anterior of the eye disk.
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Required for regulation of cell proliferation in imaginal disks and germ cells. Acts as a negative regulator of hh, ci and dpp expression in the anterior of the eye disk.
Protein Sequence
(Fasta)
MVSMQFVLQP LPGSDDQFIE RIREVSDKVN RFGYGSHRIF EQLKIPVKEV VIGPAHIGVL 60
LEDGKAFRVS FSINSEKLDL TKSDAKCSTS GGSGTASASK APSSSRPMAR SRARLLRATG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032192|E3,HECT;UBD,UBA|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCAGTACGG TCACTCTGAA AGTCTCTCAA CGTTTTGTGA CATGAAAATT CAACGAGGAC 60
ACTGTGTACA TGAATAGTTG AAAAATTAAA ATGGTTTCCA TGCAATTTGT TTTGCAACCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032192|E3,HECT;UBD,UBA|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR015940--UBA
IPR003126--Znf_UBR
PROSITE

PS50237--HECT
PS51309--PABC
PS50030--UBA
PS51157--ZF_UBR
Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP
SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0043130--F:ubiquitin binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0048749--P:compound eye development
GO:0007455--P:eye-antennal disc morphogenesis
GO:0008585--P:female gonad development
GO:0007444--P:imaginal disc development
GO:0007446--P:imaginal disc growth
GO:0007112--P:male meiosis cytokinesis
GO:0045879--P:negative regulation of smoothened signaling pathway
GO:0000209--P:protein polyubiquitination
GO:0030162--P:regulation of proteolysis
GO:0007289--P:spermatid nucleus differentiation
GO:0007283--P:spermatogenesis
KEGG dme:Dmel_CG9484
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002217 Ailuropoda melanoleuca 40.35 8.00e-176 611.00
IUUC-Apl-004165 Anas platyrhynchos 39.38 2.00e-172 600.00
IUUC-Aca-004577 Anolis carolinensis 39.06 1.00e-171 597.00
IUUC-Ame-010702 Astyanax mexicanus 52.24 4.00e-168 586.00
IUUC-Bta-012313 Bos taurus 40.35 6.00e-176 612.00
IUUC-Cel-018165 Caenorhabditis elegans 30.86 2.00e-82 301.00
IUUC-Cja-019858 Callithrix jacchus 40.35 4.00e-176 612.00
IUUC-Cfa-020973 Canis familiaris 40.35 1.00e-175 611.00
IUUC-Cpo-022065 Cavia porcellus 51.97 5.00e-161 560.00
IUUC-Csa-023985 Chlorocebus sabaeus 40.35 4.00e-176 612.00
IUUC-Cho-025034 Choloepus hoffmanni 63.88 8.00e-113 402.00
IUUC-Cin-025715 Ciona intestinalis 45.71 8.00e-150 525.00
IUUC-Csv-026131 Ciona savignyi 48.45 9.00e-142 496.00
IUUC-Dre-027730 Danio rerio 39.26 8.00e-175 608.00
IUUC-Dno-029123 Dasypus novemcinctus 39.09 4.00e-167 583.00
IUUC-Dor-030757 Dipodomys ordii 42.20 4.00e-148 519.00
IUUC-Ete-032292 Echinops telfairi 52.28 2.00e-124 441.00
IUUC-Eca-034347 Equus caballus 40.16 3.00e-173 603.00
IUUC-Eeu-034873 Erinaceus europaeus 40.35 5.00e-176 612.00
IUUC-Fca-036485 Felis catus 50.80 2.00e-162 567.00
IUUC-Fal-037071 Ficedula albicollis 39.30 3.00e-172 600.00
IUUC-Gmo-039589 Gadus morhua 51.92 3.00e-169 589.00
IUUC-Gga-041195 Gallus gallus 51.44 1.00e-165 577.00
IUUC-Gac-042538 Gasterosteus aculeatus 52.48 1.00e-169 590.00
IUUC-Ggo-045351 Gorilla gorilla 40.35 5.00e-176 612.00
IUUC-Hsa-045941 Homo sapiens 40.35 6.00e-176 612.00
IUUC-Itr-048635 Ictidomys tridecemlineatus 40.45 2.00e-176 613.00
IUUC-Lch-050480 Latimeria chalumnae 38.73 3.00e-170 593.00
IUUC-Loc-052664 Lepisosteus oculatus 52.88 1.00e-167 584.00
IUUC-Laf-053960 Loxodonta africana 51.83 2.00e-168 585.00
IUUC-Mcc-054703 Macaca mulatta 40.35 4.00e-176 612.00
IUUC-Meu-056431 Macropus eugenii 62.03 7.00e-83 303.00
IUUC-Mga-059289 Meleagris gallopavo 40.19 6.00e-177 615.00
IUUC-Mmr-061737 Microcebus murinus 40.35 1.00e-176 614.00
IUUC-Mdo-062499 Monodelphis domestica 40.16 2.00e-169 590.00
IUUC-Mmu-063273 Mus musculus 51.60 9.00e-167 581.00
IUUC-Mpu-066907 Mustela putorius furo 40.35 1.00e-175 611.00
IUUC-Mlu-067942 Myotis lucifugus 41.13 4.00e-180 625.00
IUUC-Nle-069527 Nomascus leucogenys 40.35 2.00e-176 614.00
IUUC-Opr-070626 Ochotona princeps 50.53 5.00e-91 330.00
IUUC-Ont-071951 Oreochromis niloticus 52.61 8.00e-170 592.00
IUUC-Oan-072958 Ornithorhynchus anatinus 39.92 4.00e-169 589.00
IUUC-Ocu-074503 Oryctolagus cuniculus 39.77 4.00e-178 619.00
IUUC-Ola-086757 Oryzias latipes 52.19 5.00e-173 602.00
IUUC-Oga-088781 Otolemur garnettii 40.25 2.00e-173 603.00
IUUC-Oar-089274 Ovis aries 40.35 6.00e-176 612.00
IUUC-Ptr-090669 Pan troglodytes 40.25 3.00e-175 609.00
IUUC-Pan-092226 Papio anubis 40.35 3.00e-176 613.00
IUUC-Psi-093502 Pelodiscus sinensis 39.38 1.00e-171 597.00
IUUC-Pma-094454 Petromyzon marinus 51.40 9.00e-115 407.00
IUUC-Pfo-096173 Poecilia formosa 37.74 1.00e-170 594.00
IUUC-Pab-098355 Pongo abelii 40.35 9.00e-176 611.00
IUUC-Pca-100570 Procavia capensis 47.60 1.00e-125 445.00
IUUC-Pva-102572 Pteropus vampyrus 53.04 8.00e-118 419.00
IUUC-Rno-104916 Rattus norvegicus 51.28 2.00e-166 580.00
IUUC-Sha-106653 Sarcophilus harrisii 40.02 2.00e-169 590.00
IUUC-Sar-113517 Sorex araneus 49.13 3.00e-109 390.00
IUUC-Ssc-115470 Sus scrofa 51.60 3.00e-166 579.00
IUUC-Tgu-116932 Taeniopygia guttata 39.13 4.00e-170 592.00
IUUC-Tru-117682 Takifugu rubripes 51.99 1.00e-166 580.00
IUUC-Tsy-119417 Tarsius syrichta 50.96 2.00e-161 564.00
IUUC-Tni-120442 Tetraodon nigroviridis 37.25 4.00e-162 566.00
IUUC-Tbe-127456 Tupaia belangeri 32.74 3.00e-93 337.00
IUUC-Ttr-128606 Tursiops truncatus 52.71 5.00e-127 449.00
IUUC-Vpa-130112 Vicugna pacos 52.71 4.00e-127 449.00
IUUC-Xtr-131929 Xenopus tropicalis 38.61 3.00e-174 606.00
Created Date 25-Jun-2017

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