iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/CUE	CUE	12628920

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/CUE	3.70e-08	31.7	100	140

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 4    taleqLkeiFPnldysviqvvLeantgsleaavnnLLegse 44
           + l++Lk+ FPnl +  i++v +a++g l++a+n+LL +s+
   Q: 100  PILQELKDAFPNLEEKYIKAVIIASQGVLSPAFNALLFLSD 140
           6799*********************************9885 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 adapter and thus mediating autophagic clearance of ubiquitin conjugates under starvation conditions. The CUE5-dependent selective autophagy pathway plays an important role in clearance of cytotoxic protein aggregates. Not required for cytoplasmic to vacuole pathway (cvt), mitophagy, pexophagy, or ribophagy.

Protein Sequence
(Fasta)

MEEKEGIKDS SLLEKSNVPE SINEDISKTT DVDLNSDGKK DNDTSAKDGT PKVEEKVNKS 60
SGIDEDEVVT PAEDAKEEEE EHPPLPARRK SEEEPSKENP ILQELKDAFP NLEEKYIKAV 120

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Nucleotide Sequence
(Fasta)

ATGGAAGAAA AGGAAGGTAT CAAGGATTCT TCTCTCCTTG AGAAGAGTAA TGTTCCGGAA 60
TCAATTAATG AGGATATTTC AAAGACGACG GATGTGGATC TAAATTCCGA TGGGAAAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR003892--CUE
IPR009060--UBA-like

PROSITE

PS51140--CUE

Pfam

PF02845--CUE

SMART

SM00546--CUE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0030674--F:protein binding, bridging
GO:0043130--F:ubiquitin binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0006914--P:autophagy
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

sce:YOR042W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001566	Ailuropoda melanoleuca	37.14	4.30e-02	29.60
IUUC-Aca-004943	Anolis carolinensis	37.14	1.50e-01	27.70
IUUC-Ath-007530	Arabidopsis thaliana	59.09	1.20e-01	29.30
IUUC-Ago-007859	Ashbya gossypii	38.91	1.00e-39	154.00
IUUC-Acl-008029	Aspergillus clavatus	33.13	2.00e-14	71.60
IUUC-Afl-008434	Aspergillus flavus	32.91	2.00e-14	71.20
IUUC-Afu-008861	Aspergillus fumigatus	32.32	1.00e-12	65.50
IUUC-Ani-009472	Aspergillus nidulans	35.22	4.00e-11	60.50
IUUC-Ang-009558	Aspergillus niger	32.28	7.00e-14	69.70
IUUC-Aor-010068	Aspergillus oryzae	32.91	2.00e-14	71.20
IUUC-Ate-010415	Aspergillus terreus	32.73	3.00e-14	70.90
IUUC-Ame-011082	Astyanax mexicanus	45.71	7.00e-03	32.30
IUUC-Bgr-011976	Blumeria graminis	28.44	2.00e-19	87.80
IUUC-Bta-013259	Bos taurus	35.42	2.00e-02	30.80
IUUC-Bci-013731	Botrytis cinerea	30.13	2.00e-17	81.30
IUUC-Bol-015361	Brassica oleracea	52.17	8.90e-01	26.60
IUUC-Cja-019277	Callithrix jacchus	33.33	4.60e-02	32.30
IUUC-Csa-023623	Chlorocebus sabaeus	35.42	2.50e-02	30.40
IUUC-Cgl-026515	Colletotrichum gloeosporioides	31.90	4.00e-15	73.60
IUUC-Cne-027075	Cryptococcus neoformans	37.21	3.70e-02	30.80
IUUC-Dre-028691	Danio rerio	45.71	6.00e-03	32.70
IUUC-Dse-031448	Dothistroma septosporum	35.06	1.00e-12	65.50
IUUC-Fox-037953	Fusarium oxysporum	30.05	3.00e-12	64.30
IUUC-Fso-038189	Fusarium solani	28.35	6.00e-18	83.20
IUUC-Ggr-039754	Gaeumannomyces graminis	32.75	1.00e-12	65.50
IUUC-Ggo-044809	Gorilla gorilla	34.21	4.50e-01	26.60
IUUC-Hsa-046654	Homo sapiens	35.42	2.50e-02	30.40
IUUC-Itr-048968	Ictidomys tridecemlineatus	34.43	8.00e-03	33.10
IUUC-Kpa-049266	Komagataella pastoris	49.41	1.00e-16	78.60
IUUC-Lma-053222	Leptosphaeria maculans	32.91	1.00e-12	65.90
IUUC-Laf-053390	Loxodonta africana	37.14	2.50e-02	30.40
IUUC-Mor-057041	Magnaporthe oryzae	28.65	6.00e-13	66.60
IUUC-Mpo-057516	Magnaporthe poae	31.69	3.00e-13	67.40
IUUC-Mvi-060363	Microbotryum violaceum	27.06	1.20e-01	28.50
IUUC-Mdo-062537	Monodelphis domestica	42.31	2.30e-02	30.80
IUUC-Mpu-066005	Mustela putorius furo	37.14	4.00e-02	29.60
IUUC-Mlu-068095	Myotis lucifugus	28.07	4.80e-01	28.10
IUUC-Nfi-068594	Neosartorya fischeri	32.28	1.00e-14	72.00
IUUC-Ncr-068740	Neurospora crassa	31.18	5.00e-10	57.00
IUUC-Nle-069520	Nomascus leucogenys	35.42	2.50e-02	30.40
IUUC-Ont-071379	Oreochromis niloticus	42.86	1.00e-02	32.00
IUUC-Oru-085248	Oryza rufipogon	25.00	1.70e-02	32.70
IUUC-Ola-086417	Oryzias latipes	42.86	1.30e-02	31.60
IUUC-Oar-089528	Ovis aries	37.14	1.70e-02	31.20
IUUC-Pan-091998	Papio anubis	35.42	2.50e-02	30.40
IUUC-Pma-094505	Petromyzon marinus	38.46	2.10e-02	30.80
IUUC-Pno-094817	Phaeosphaeria nodorum	31.65	2.00e-13	67.80
IUUC-Pfo-096152	Poecilia formosa	41.03	3.00e-03	33.50
IUUC-Pab-098651	Pongo abelii	29.55	2.30e-01	29.30
IUUC-Pca-100823	Procavia capensis	34.21	5.00e-01	26.20
IUUC-Pgr-103669	Puccinia graminis	32.08	5.00e-03	33.90
IUUC-Pte-104307	Pyrenophora teres	27.48	1.00e-12	65.10
IUUC-Pyt-104628	Pyrenophora triticirepentis	26.58	1.00e-11	62.40
IUUC-Sja-107739	Schizosaccharomyces japonicus	38.98	9.00e-05	39.70
IUUC-Spo-108260	Schizosaccharomyces pombe	33.33	2.00e-15	75.50
IUUC-Ssl-108621	Sclerotinia sclerotiorum	32.02	1.00e-16	79.00
IUUC-Tru-118257	Takifugu rubripes	40.00	2.30e-02	30.40
IUUC-Tni-120576	Tetraodon nigroviridis	33.33	1.80e-02	30.80
IUUC-Tre-121981	Trichoderma reesei	32.68	1.00e-10	58.90
IUUC-Tvi-122320	Trichoderma virens	30.39	9.00e-12	62.40
IUUC-Tme-127166	Tuber melanosporum	31.12	2.00e-15	74.70
IUUC-Ttr-128957	Tursiops truncatus	30.95	7.60e-01	25.80
IUUC-Vda-129734	Verticillium dahliae	36.42	5.00e-17	80.50
IUUC-Vvi-131569	Vitis vinifera	57.89	3.30e+00	24.30
IUUC-Xma-133353	Xiphophorus maculatus	38.46	1.00e-03	33.90
IUUC-Yli-134593	Yarrowia lipolytica	31.25	2.00e-10	58.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence