iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Protein 3D Structure
PDB	MMDB
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
PhosphoBase
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-12	47.9	55	111

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + v +l+dy a+nd +L+  kG++++v+      ++W+ + +  +g++G +P+nFv+ +e
   Q: 55   RFVVALFDYAAVNDRDLQVLKGEKLQVL---RSTGDWWLARSLVTGREGYVPSNFVAPVE 111
           6789************************...9999*********************9986 PP

Organism

Mus musculus

Functional Description
(View)

Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptor FCGR2. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.

Protein Sequence
(Fasta)

MGLLSSKRQV SEKGKGWSPV KIRTQDKAPP PLPPLVVFNH LAPPSPNQDP DEEERFVVAL 60
FDYAAVNDRD LQVLKGEKLQ VLRSTGDWWL ARSLVTGREG YVPSNFVAPV ETLEVEKWFF 120

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Nucleotide Sequence
(Fasta)

GGGAAACACC AGCCGTGTGG TGAACCAAAA CCCATGAGAA AACTTTGGGG TGGCAGAGGG 60
GCATCATGAC CAGCCTGGCT GAAGGTCAGG TGCCCATGAA ACTTCCTCAG AAACACCTCC 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0050853--P:B cell receptor signaling pathway
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0032024--P:positive regulation of insulin secretion
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

mmu:12143

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	88.20	0.00e+00	885.00
IUUC-Apl-003307	Anas platyrhynchos	75.67	0.00e+00	739.00
IUUC-Aca-004357	Anolis carolinensis	69.30	0.00e+00	669.00
IUUC-Ame-010642	Astyanax mexicanus	70.22	0.00e+00	685.00
IUUC-Bta-012400	Bos taurus	86.43	0.00e+00	880.00
IUUC-Cja-019717	Callithrix jacchus	84.83	0.00e+00	687.00
IUUC-Cfa-021056	Canis familiaris	87.20	0.00e+00	897.00
IUUC-Cpo-021779	Cavia porcellus	87.58	0.00e+00	889.00
IUUC-Csa-023557	Chlorocebus sabaeus	88.82	0.00e+00	891.00
IUUC-Dre-027517	Danio rerio	69.48	0.00e+00	699.00
IUUC-Eca-034218	Equus caballus	86.75	0.00e+00	864.00
IUUC-Eeu-035095	Erinaceus europaeus	65.60	0.00e+00	638.00
IUUC-Fca-036015	Felis catus	87.20	0.00e+00	905.00
IUUC-Fal-036946	Ficedula albicollis	75.96	0.00e+00	732.00
IUUC-Gga-040822	Gallus gallus	70.60	0.00e+00	745.00
IUUC-Ggo-044608	Gorilla gorilla	89.44	0.00e+00	811.00
IUUC-Hsa-046719	Homo sapiens	87.99	0.00e+00	882.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	88.98	0.00e+00	895.00
IUUC-Lch-050114	Latimeria chalumnae	74.04	0.00e+00	703.00
IUUC-Loc-052326	Lepisosteus oculatus	72.08	0.00e+00	711.00
IUUC-Laf-053387	Loxodonta africana	85.00	0.00e+00	871.00
IUUC-Mcc-055026	Macaca mulatta	89.03	0.00e+00	893.00
IUUC-Mga-059427	Meleagris gallopavo	74.83	0.00e+00	731.00
IUUC-Mmr-061660	Microcebus murinus	87.80	0.00e+00	886.00
IUUC-Mdo-062318	Monodelphis domestica	76.89	0.00e+00	798.00
IUUC-Mpu-066582	Mustela putorius furo	88.61	0.00e+00	887.00
IUUC-Nle-069624	Nomascus leucogenys	88.80	0.00e+00	869.00
IUUC-Opr-070656	Ochotona princeps	81.76	0.00e+00	810.00
IUUC-Ont-072266	Oreochromis niloticus	69.05	0.00e+00	679.00
IUUC-Ocu-073907	Oryctolagus cuniculus	85.40	0.00e+00	863.00
IUUC-Oga-088057	Otolemur garnettii	86.03	0.00e+00	876.00
IUUC-Oar-089332	Ovis aries	82.44	0.00e+00	839.00
IUUC-Ptr-091551	Pan troglodytes	86.64	0.00e+00	840.00
IUUC-Pan-092173	Papio anubis	89.23	0.00e+00	877.00
IUUC-Psi-093895	Pelodiscus sinensis	73.44	0.00e+00	724.00
IUUC-Pab-097598	Pongo abelii	88.20	0.00e+00	858.00
IUUC-Pva-102135	Pteropus vampyrus	87.88	0.00e+00	865.00
IUUC-Rno-104891	Rattus norvegicus	96.39	0.00e+00	967.00
IUUC-Sha-107192	Sarcophilus harrisii	77.73	0.00e+00	815.00
IUUC-Ssc-115696	Sus scrofa	87.23	0.00e+00	896.00
IUUC-Tgu-117056	Taeniopygia guttata	74.77	0.00e+00	726.00
IUUC-Tru-117621	Takifugu rubripes	68.15	0.00e+00	652.00
IUUC-Tbe-127520	Tupaia belangeri	86.81	0.00e+00	664.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence