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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063656
UUCD1 version UUC-MuM-00878
Ensembl Protein ID ENSMUSP00000031414.8
UniProt Accession Q99MP8; Q8CC00; Q8CHX1; Q99MP7; Q9CXX8; BRAP_MOUSE
Genbank Protein ID AAK28079.1; AAK28080.1; AAH38490.1; BAB29036.1; BAC28633.1
Protein Name BRCA1-associated protein; BRAP2; Impedes mitogenic signal propagation; RING-type E3 ubiquitin transferase BRAP2
Genbank Nucleotide ID AF321920; AF321921; BC038490; AK013885; AK034212
Gene Name Brap
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029458.14 ENSMUST00000031414.14 ENSMUSP00000031414.8
ENSMUSG00000029458.14 ENSMUST00000140996.5 ENSMUSP00000122536.1
ENSMUSG00000029458.14 ENSMUST00000195952.4 ENSMUSP00000143350.1
ENSMUSG00000029458.14 ENSMUST00000142701.2 ENSMUSP00000143043.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 1.10e-06 30.1 263 303
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg...plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +Cle++++     l++ C+H fh +Clq+w           +CP+Cr
   Q: 263  CTVCLERMDESvngILTTLCNHSFHSQCLQRW--------DDTTCPVCR 303
           9*******77333366777*************........8889****8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport (By similarity).
 Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport (By similarity).
Protein Sequence
(Fasta)
MSVSLVVIRL ELAGHSPVPT DFGFSAAAGE MSDEEIKKKT LASAVACLEG KSAGEKAAII 60
HQHLGRREMT DVIIETMKAR ADEVRDTVEE KKPSAAPVSA QRSREQSESV NTAPESPSKQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063656|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGTCAGAGA CGGCGGCCGA CAGGCGGAAG CGGAGGTTGT TGTGGCTCGG CAGGCTGCGC 60
GCGACGGGGG CTGCCGCTGC TGAGGCGGCG GCCGCGGCTT CTGAGGCGGT GGCGGCGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063656|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011422--BRAP2
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50089--ZF_RING_2
PS50271--ZF_UBP
Pfam

PF07576--BRAP2
PF13639--zf-RING_2
PF02148--zf-UBP
SMART

SM00184--RING
SM00290--ZnF_UBP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031965--C:nuclear membrane
GO:0000151--C:ubiquitin ligase complex
GO:0042802--F:identical protein binding
GO:0008139--F:nuclear localization sequence binding
GO:0003676--F:nucleic acid binding
GO:0000166--F:nucleotide binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000165--P:MAPK cascade
GO:0009968--P:negative regulation of signal transduction
GO:0007265--P:Ras protein signal transduction
KEGG mmu:72399
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000519 Aegilops tauschii 30.58 2.00e-51 196.00
IUUC-Aml-002229 Ailuropoda melanoleuca 91.33 0.00e+00 1053.00
IUUC-Atr-002785 Amborella trichopoda 38.20 4.00e-89 322.00
IUUC-Apl-004048 Anas platyrhynchos 89.73 0.00e+00 900.00
IUUC-Aca-005133 Anolis carolinensis 84.83 0.00e+00 947.00
IUUC-Aly-006306 Arabidopsis lyrata 35.71 6.00e-78 285.00
IUUC-Ath-007604 Arabidopsis thaliana 35.47 5.00e-80 291.00
IUUC-Ago-007905 Ashbya gossypii 36.49 6.00e-71 261.00
IUUC-Acl-008310 Aspergillus clavatus 32.11 4.00e-66 246.00
IUUC-Afl-008497 Aspergillus flavus 31.39 2.00e-59 223.00
IUUC-Afu-008830 Aspergillus fumigatus 38.35 1.00e-63 238.00
IUUC-Ani-009485 Aspergillus nidulans 31.20 5.00e-67 248.00
IUUC-Ang-009603 Aspergillus niger 37.27 2.00e-64 240.00
IUUC-Aor-009935 Aspergillus oryzae 31.88 7.00e-63 234.00
IUUC-Ate-010485 Aspergillus terreus 30.77 1.00e-67 250.00
IUUC-Ame-011516 Astyanax mexicanus 85.65 0.00e+00 747.00
IUUC-Bgr-011985 Blumeria graminis 30.41 2.00e-44 174.00
IUUC-Bta-013203 Bos taurus 92.40 0.00e+00 1077.00
IUUC-Bci-013788 Botrytis cinerea 33.23 7.00e-53 202.00
IUUC-Bdi-014763 Brachypodium distachyon 35.83 3.00e-80 292.00
IUUC-Bol-015518 Brassica oleracea 33.40 5.00e-77 283.00
IUUC-Bra-017435 Brassica rapa 35.96 4.00e-77 282.00
IUUC-Cel-018194 Caenorhabditis elegans 36.90 2.00e-109 390.00
IUUC-Cja-018948 Callithrix jacchus 89.12 0.00e+00 1053.00
IUUC-Cfa-020377 Canis familiaris 91.22 0.00e+00 1092.00
IUUC-Cpo-021930 Cavia porcellus 92.40 0.00e+00 1067.00
IUUC-Cre-022571 Chlamydomonas reinhardtii 42.35 7.00e-58 217.00
IUUC-Csa-023554 Chlorocebus sabaeus 92.37 0.00e+00 922.00
IUUC-Cho-025045 Choloepus hoffmanni 87.55 8.00e-128 450.00
IUUC-Cin-025326 Ciona intestinalis 42.65 2.00e-111 395.00
IUUC-Csv-026232 Ciona savignyi 42.64 7.00e-112 397.00
IUUC-Cgl-026587 Colletotrichum gloeosporioides 30.10 6.00e-58 219.00
IUUC-Cne-026980 Cryptococcus neoformans 35.36 7.00e-50 192.00
IUUC-Cme-027262 Cyanidioschyzon merolae 35.20 1.00e-60 228.00
IUUC-Dre-028521 Danio rerio 76.56 0.00e+00 907.00
IUUC-Dno-029291 Dasypus novemcinctus 90.22 0.00e+00 1050.00
IUUC-Dor-030231 Dipodomys ordii 84.80 0.00e+00 982.00
IUUC-Dse-031234 Dothistroma septosporum 33.19 3.00e-55 210.00
IUUC-Dme-032095 Drosophila melanogaster 42.86 8.00e-119 420.00
IUUC-Ete-032227 Echinops telfairi 80.00 3.00e-177 615.00
IUUC-Eca-034404 Equus caballus 92.76 0.00e+00 1081.00
IUUC-Eeu-035030 Erinaceus europaeus 73.58 6.00e-125 441.00
IUUC-Fca-035428 Felis catus 92.21 0.00e+00 1072.00
IUUC-Fal-037435 Ficedula albicollis 88.63 0.00e+00 943.00
IUUC-Fox-037733 Fusarium oxysporum 33.02 1.00e-60 228.00
IUUC-Fso-038427 Fusarium solani 35.41 8.00e-60 225.00
IUUC-Gmo-038817 Gadus morhua 74.46 0.00e+00 851.00
IUUC-Ggr-039949 Gaeumannomyces graminis 28.54 3.00e-55 209.00
IUUC-Gga-040929 Gallus gallus 88.48 0.00e+00 956.00
IUUC-Gac-041893 Gasterosteus aculeatus 76.65 0.00e+00 870.00
IUUC-Gma-043119 Glycine max 35.92 1.00e-80 293.00
IUUC-Ggo-045106 Gorilla gorilla 92.94 0.00e+00 865.00
IUUC-Hsa-045685 Homo sapiens 90.88 0.00e+00 1089.00
IUUC-Hvu-047475 Hordeum vulgare 32.97 3.00e-34 138.00
IUUC-Itr-048406 Ictidomys tridecemlineatus 93.13 0.00e+00 1079.00
IUUC-Kpa-049175 Komagataella pastoris 37.72 4.00e-64 239.00
IUUC-Lch-050408 Latimeria chalumnae 80.43 0.00e+00 994.00
IUUC-Lpe-050777 Leersia perrieri 33.82 3.00e-65 243.00
IUUC-Loc-052160 Lepisosteus oculatus 65.92 0.00e+00 729.00
IUUC-Lma-053095 Leptosphaeria maculans 33.66 5.00e-76 279.00
IUUC-Laf-053497 Loxodonta africana 91.25 0.00e+00 1078.00
IUUC-Mcc-055381 Macaca mulatta 91.70 0.00e+00 1075.00
IUUC-Meu-056402 Macropus eugenii 67.95 0.00e+00 645.00
IUUC-Mor-057002 Magnaporthe oryzae 29.94 3.00e-60 226.00
IUUC-Mpo-057508 Magnaporthe poae 31.05 1.00e-53 204.00
IUUC-Mtr-058619 Medicago truncatula 40.12 2.00e-68 253.00
IUUC-Mla-058901 Melampsora laricipopulina 33.46 2.00e-70 260.00
IUUC-Mga-059667 Meleagris gallopavo 87.10 0.00e+00 890.00
IUUC-Mvi-060229 Microbotryum violaceum 29.48 7.00e-63 235.00
IUUC-Mmr-060881 Microcebus murinus 84.68 0.00e+00 948.00
IUUC-Mdo-062573 Monodelphis domestica 88.54 0.00e+00 989.00
IUUC-Mac-065512 Musa acuminata 37.61 3.00e-79 289.00
IUUC-Mpu-065816 Mustela putorius furo 92.09 0.00e+00 1077.00
IUUC-Mlu-067225 Myotis lucifugus 90.85 0.00e+00 1080.00
IUUC-Nfi-068534 Neosartorya fischeri 30.94 1.00e-64 241.00
IUUC-Ncr-068801 Neurospora crassa 28.14 1.00e-58 221.00
IUUC-Nle-069258 Nomascus leucogenys 91.17 0.00e+00 983.00
IUUC-Opr-070877 Ochotona princeps 78.73 0.00e+00 871.00
IUUC-Ont-072141 Oreochromis niloticus 76.76 0.00e+00 875.00
IUUC-Oan-072961 Ornithorhynchus anatinus 87.02 0.00e+00 999.00
IUUC-Ocu-074020 Oryctolagus cuniculus 92.36 0.00e+00 933.00
IUUC-Oba-075084 Oryza barthii 29.96 8.00e-66 244.00
IUUC-Obr-076840 Oryza brachyantha 35.52 2.00e-78 286.00
IUUC-Ogl-077880 Oryza glaberrima 44.98 2.00e-79 289.00
IUUC-Ogu-078968 Oryza glumaepatula 29.96 5.00e-66 245.00
IUUC-Oin-079200 Oryza indica 44.98 3.00e-79 289.00
IUUC-Olo-080753 Oryza longistaminata 33.24 3.00e-58 219.00
IUUC-Ome-081756 Oryza meridionalis 29.96 9.00e-66 244.00
IUUC-Oni-082434 Oryza nivara 30.74 9.00e-66 244.00
IUUC-Opu-083262 Oryza punctata 30.37 3.00e-65 243.00
IUUC-Oru-084381 Oryza rufipogon 29.96 5.00e-66 245.00
IUUC-Osa-085760 Oryza sativa 48.31 2.00e-71 262.00
IUUC-Ola-087390 Oryzias latipes 74.82 0.00e+00 827.00
IUUC-Olu-087694 Ostreococcus lucimarinus 32.54 1.00e-58 220.00
IUUC-Oga-088612 Otolemur garnettii 92.62 0.00e+00 1077.00
IUUC-Oar-089988 Ovis aries 92.04 0.00e+00 1064.00
IUUC-Ptr-090637 Pan troglodytes 91.05 0.00e+00 1092.00
IUUC-Pan-092506 Papio anubis 91.70 0.00e+00 1073.00
IUUC-Psi-093026 Pelodiscus sinensis 86.88 0.00e+00 928.00
IUUC-Pno-094779 Phaeosphaeria nodorum 31.49 3.00e-54 206.00
IUUC-Ppa-095731 Physcomitrella patens 38.37 9.00e-96 343.00
IUUC-Pfo-096725 Poecilia formosa 78.01 0.00e+00 866.00
IUUC-Pab-098413 Pongo abelii 92.27 0.00e+00 724.00
IUUC-Pop-099538 Populus trichocarpa 38.10 2.00e-80 293.00
IUUC-Pca-100130 Procavia capensis 78.91 0.00e+00 900.00
IUUC-Ppe-101843 Prunus persica 37.23 5.00e-85 308.00
IUUC-Pva-102752 Pteropus vampyrus 86.99 0.00e+00 1009.00
IUUC-Pgr-103478 Puccinia graminis 37.07 1.00e-75 277.00
IUUC-Ptt-103921 Puccinia triticina 36.90 6.00e-69 255.00
IUUC-Pte-104032 Pyrenophora teres 33.53 5.00e-73 269.00
IUUC-Pyt-104480 Pyrenophora triticirepentis 31.77 2.00e-71 263.00
IUUC-Rno-106037 Rattus norvegicus 82.37 0.00e+00 928.00
IUUC-Sce-106310 Saccharomyces cerevisiae 32.07 2.00e-58 220.00
IUUC-Sha-106752 Sarcophilus harrisii 86.25 0.00e+00 1010.00
IUUC-Sja-107665 Schizosaccharomyces japonicus 36.44 2.00e-81 296.00
IUUC-Spo-108042 Schizosaccharomyces pombe 34.27 1.00e-71 264.00
IUUC-Ssl-108504 Sclerotinia sclerotiorum 31.89 2.00e-52 200.00
IUUC-Smo-109399 Selaginella moellendorffii 38.28 2.00e-89 323.00
IUUC-Sit-110251 Setaria italica 38.26 7.00e-88 317.00
IUUC-Sly-111563 Solanum lycopersicum 44.14 9.00e-76 277.00
IUUC-Stu-112294 Solanum tuberosum 38.44 4.00e-79 288.00
IUUC-Sar-113080 Sorex araneus 78.03 4.00e-145 507.00
IUUC-Sbi-113915 Sorghum bicolor 36.91 1.00e-85 310.00
IUUC-Sre-114897 Sporisorium reilianum 36.21 3.00e-58 220.00
IUUC-Ssc-115369 Sus scrofa 98.91 4.00e-113 399.00
IUUC-Tgu-116710 Taeniopygia guttata 85.49 0.00e+00 986.00
IUUC-Tru-117941 Takifugu rubripes 76.20 0.00e+00 862.00
IUUC-Tsy-118902 Tarsius syrichta 79.33 2.00e-98 352.00
IUUC-Tni-120587 Tetraodon nigroviridis 75.97 0.00e+00 892.00
IUUC-Tca-121425 Theobroma cacao 38.24 5.00e-88 318.00
IUUC-Tre-121874 Trichoderma reesei 34.96 4.00e-58 219.00
IUUC-Tvi-122266 Trichoderma virens 35.82 4.00e-60 226.00
IUUC-Tae-123517 Triticum aestivum 35.70 2.00e-79 289.00
IUUC-Tur-126467 Triticum urartu 32.62 1.00e-51 197.00
IUUC-Tme-127096 Tuber melanosporum 35.17 1.00e-57 217.00
IUUC-Tbe-128012 Tupaia belangeri 85.95 0.00e+00 849.00
IUUC-Ttr-128388 Tursiops truncatus 92.58 0.00e+00 1081.00
IUUC-Uma-129610 Ustilago maydis 31.37 4.00e-56 213.00
IUUC-Vda-129830 Verticillium dahliae 28.98 1.00e-56 214.00
IUUC-Vpa-130171 Vicugna pacos 92.06 0.00e+00 1088.00
IUUC-Vvi-131063 Vitis vinifera 42.86 6.00e-82 298.00
IUUC-Xtr-132313 Xenopus tropicalis 80.74 0.00e+00 969.00
IUUC-Xma-133303 Xiphophorus maculatus 77.03 0.00e+00 862.00
IUUC-Yli-134669 Yarrowia lipolytica 32.00 6.00e-63 234.00
IUUC-Zma-135783 Zea mays 37.39 2.00e-82 299.00
Created Date 25-Jun-2017

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