iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	miRTarBase	microRNA	TRANSFAC
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.80e-06	29.9	41	82

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmv 43
           +Dv+l  gg+ f++h++ L+a S +F++lf  + +e+     v
   Q: 41   TDVVLRAGGRDFPCHRAALSAGSAYFRSLFAAGRPERG-PAVV 82
           7*****************************99999985.4444 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MRQGHAPEES EPGCEAPCAG PCHAQRVLQA LNAYRRSGTL TDVVLRAGGR DFPCHRAALS 60
AGSAYFRSLF AAGRPERGPA VVPVVPVAPE APGTSPAGAA AALAVVLDYV YGAGVRLRAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGGCAAG GCCATGCGCC GGAGGAGTCG GAGCCGGGCT GCGAAGCGCC GTGCGCGGGT 60
CCGTGCCACG CGCAGCGCGT GCTGCAGGCC CTGAACGCCT ACCGGCGGAG CGGCACCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030601--KLHL35
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016567--P:protein ubiquitination

KEGG

hsa:283212

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003919	Anas platyrhynchos	57.95	0.00e+00	701.00
IUUC-Aca-004292	Anolis carolinensis	54.61	0.00e+00	639.00
IUUC-Bta-012754	Bos taurus	89.54	0.00e+00	879.00
IUUC-Cja-019390	Callithrix jacchus	94.80	0.00e+00	776.00
IUUC-Cfa-021181	Canis familiaris	88.85	0.00e+00	867.00
IUUC-Dno-028982	Dasypus novemcinctus	89.40	0.00e+00	884.00
IUUC-Fca-035405	Felis catus	91.29	0.00e+00	733.00
IUUC-Gga-041027	Gallus gallus	57.77	0.00e+00	698.00
IUUC-Ggo-045055	Gorilla gorilla	98.97	0.00e+00	953.00
IUUC-Itr-048569	Ictidomys tridecemlineatus	92.38	0.00e+00	837.00
IUUC-Lch-050580	Latimeria chalumnae	49.64	4.00e-178	617.00
IUUC-Loc-052921	Lepisosteus oculatus	48.94	6.00e-153	534.00
IUUC-Laf-053674	Loxodonta africana	82.16	0.00e+00	848.00
IUUC-Mga-059938	Meleagris gallopavo	57.60	0.00e+00	691.00
IUUC-Mdo-062790	Monodelphis domestica	63.27	0.00e+00	677.00
IUUC-Mmu-064185	Mus musculus	89.44	0.00e+00	869.00
IUUC-Mpu-065712	Mustela putorius furo	89.10	0.00e+00	921.00
IUUC-Ocu-074956	Oryctolagus cuniculus	88.34	0.00e+00	991.00
IUUC-Oga-088752	Otolemur garnettii	90.33	0.00e+00	879.00
IUUC-Oar-089426	Ovis aries	89.15	0.00e+00	653.00
IUUC-Ptr-091651	Pan troglodytes	99.14	0.00e+00	941.00
IUUC-Psi-093093	Pelodiscus sinensis	58.48	0.00e+00	701.00
IUUC-Rno-105037	Rattus norvegicus	86.96	0.00e+00	874.00
IUUC-Sha-106719	Sarcophilus harrisii	59.90	0.00e+00	656.00
IUUC-Ssc-116393	Sus scrofa	88.34	0.00e+00	918.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence