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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046988
Ensembl Protein ID ENSP00000398837.1
UniProt Accession Q9UMN6; O15022; O95836; Q96GP2; Q96IP3; Q9UK25; Q9Y668; Q9Y669; KMT2B_HUMAN
Genbank Protein ID CAB45385.1; AAD56420.1; BAA20763.3; AAH09337.2; AAH07353.3; AAD17932.1; AAD26113.1; AAD26112.1
Protein Name Histone-lysine N-methyltransferase 2B; Myeloid/lymphoid or mixed-lineage leukemia protein 4; Trithorax homolog 2; WW domain-binding protein 7
Genbank Nucleotide ID AJ007041; AD000671; AB002302; BC009337; BC007353; AF104918; AF105279; AF105280
Gene Name KMT2B; HRX2; KIAA0304; MLL2; MLL4; TRX2; WBP7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000272333.5 ENST00000420124.2 ENSP00000398837.1
Annotation
Cancer Mutation
ICGCIntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanSomamiRRAID2
Protein-protein Interaction
IIDiRefIndexMenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/PHD PHD 23129768; 24291127
Classification
Family E-value Score Start End
E3 activity/RING/PHD 2.50e-29 102.9 1250 1303
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++g+++k+l+eCe+Cr+++HpaCl++s ++++ ++++  wiC+ C ++
   Q: 1250 KFCHVCGRKGRGSKHLLECERCRHAYHPACLGPS-YPTRATRKRrhWICSACVRC 1303
           58********************************.88888877777******876 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.
 Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.
Protein Sequence
(Fasta)
MAAAAGGGSC PGPGSARGRF PGRPRGAGGG GGRGGRGNGA ERVRVALRRG GGATGPGGAE 60
PGEDTALLRL LGLRRGLRRL RRLWAGPRVQ RGRGRGRGRG WGPSRGCVPE EESSDGESDE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046988|E3,PHD|Homo sapiens
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Nucleotide Sequence
(Fasta)
ATGGCGGCGG CGGCGGGCGG CGGCAGTTGC CCCGGGCCTG GCTCCGCGCG GGGCCGCTTC 60
CCGGGCCGGC CGCGGGGCGC CGGCGGGGGC GGGGGCCGCG GCGGACGGGG CAACGGGGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046988|E3,PHD|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC
SMART

SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET
Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0048096--P:chromatin-mediated maintenance of transcription
GO:0016458--P:gene silencing
GO:0051568--P:histone H3-K4 methylation
GO:0080182--P:histone H3-K4 trimethylation
GO:0007613--P:memory
GO:0009994--P:oocyte differentiation
GO:0001541--P:ovarian follicle development
GO:0030728--P:ovulation
GO:0051569--P:regulation of histone H3-K4 methylation
GO:0006351--P:transcription, DNA-templated
KEGG hsa:9757
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002367 Ailuropoda melanoleuca 91.95 0.00e+00 3215.00
IUUC-Aca-004718 Anolis carolinensis 63.85 0.00e+00 1380.00
IUUC-Ame-011927 Astyanax mexicanus 44.56 0.00e+00 855.00
IUUC-Bta-013578 Bos taurus 93.57 0.00e+00 2937.00
IUUC-Bdi-014882 Brachypodium distachyon 33.50 2.00e-27 117.00
IUUC-Bra-017422 Brassica rapa 33.50 1.00e-27 118.00
IUUC-Cja-019138 Callithrix jacchus 94.29 0.00e+00 3360.00
IUUC-Cfa-020020 Canis familiaris 93.10 0.00e+00 3152.00
IUUC-Cpo-021552 Cavia porcellus 89.02 0.00e+00 3214.00
IUUC-Csa-024216 Chlorocebus sabaeus 98.26 0.00e+00 3513.00
IUUC-Cho-024565 Choloepus hoffmanni 77.16 6.00e-165 576.00
IUUC-Dre-027440 Danio rerio 44.14 0.00e+00 892.00
IUUC-Dno-029583 Dasypus novemcinctus 93.84 0.00e+00 3052.00
IUUC-Dor-030903 Dipodomys ordii 86.78 0.00e+00 2167.00
IUUC-Dme-032023 Drosophila melanogaster 47.56 3.00e-93 338.00
IUUC-Eca-034026 Equus caballus 94.24 0.00e+00 1950.00
IUUC-Eeu-034687 Erinaceus europaeus 92.46 0.00e+00 1139.00
IUUC-Fca-036311 Felis catus 91.91 0.00e+00 3258.00
IUUC-Gmo-039265 Gadus morhua 45.13 0.00e+00 816.00
IUUC-Gac-042202 Gasterosteus aculeatus 47.89 0.00e+00 743.00
IUUC-Ggo-044791 Gorilla gorilla 98.76 0.00e+00 2243.00
IUUC-Hvu-047762 Hordeum vulgare 36.57 4.00e-20 93.20
IUUC-Itr-048907 Ictidomys tridecemlineatus 91.23 0.00e+00 3363.00
IUUC-Lpe-051476 Leersia perrieri 31.51 3.00e-24 107.00
IUUC-Loc-052252 Lepisosteus oculatus 53.59 0.00e+00 779.00
IUUC-Laf-053703 Loxodonta africana 92.18 0.00e+00 2184.00
IUUC-Mcc-054782 Macaca mulatta 97.11 0.00e+00 2757.00
IUUC-Meu-056046 Macropus eugenii 80.35 0.00e+00 1899.00
IUUC-Mmr-061316 Microcebus murinus 91.43 0.00e+00 2857.00
IUUC-Mdo-062648 Monodelphis domestica 79.84 0.00e+00 2034.00
IUUC-Mmu-063579 Mus musculus 90.39 0.00e+00 3268.00
IUUC-Mac-064935 Musa acuminata 32.64 8.00e-30 125.00
IUUC-Mpu-066710 Mustela putorius furo 92.93 0.00e+00 3233.00
IUUC-Mlu-067559 Myotis lucifugus 90.80 0.00e+00 3220.00
IUUC-Nle-070085 Nomascus leucogenys 96.44 0.00e+00 2292.00
IUUC-Opr-071148 Ochotona princeps 88.59 0.00e+00 3222.00
IUUC-Ont-071626 Oreochromis niloticus 48.48 0.00e+00 783.00
IUUC-Ocu-074475 Oryctolagus cuniculus 90.89 0.00e+00 3148.00
IUUC-Obr-076458 Oryza brachyantha 34.48 4.00e-28 119.00
IUUC-Ogl-077851 Oryza glaberrima 36.26 3.00e-28 120.00
IUUC-Ogu-078706 Oryza glumaepatula 36.26 2.00e-28 121.00
IUUC-Oin-079802 Oryza indica 31.43 3.00e-23 103.00
IUUC-Osa-085421 Oryza sativa 36.26 4.00e-28 119.00
IUUC-Ola-086609 Oryzias latipes 48.89 0.00e+00 756.00
IUUC-Oga-088140 Otolemur garnettii 93.35 0.00e+00 3245.00
IUUC-Oar-089447 Ovis aries 91.84 0.00e+00 2040.00
IUUC-Ptr-090902 Pan troglodytes 99.56 0.00e+00 3389.00
IUUC-Pan-091930 Papio anubis 98.67 0.00e+00 3440.00
IUUC-Ppa-095221 Physcomitrella patens 36.54 8.00e-31 129.00
IUUC-Pfo-096884 Poecilia formosa 50.19 0.00e+00 788.00
IUUC-Pab-098404 Pongo abelii 86.94 0.00e+00 2518.00
IUUC-Pop-099585 Populus trichocarpa 33.50 1.00e-26 115.00
IUUC-Pca-100949 Procavia capensis 84.77 0.00e+00 1248.00
IUUC-Ppe-101920 Prunus persica 33.01 1.00e-27 119.00
IUUC-Pva-102634 Pteropus vampyrus 91.75 0.00e+00 3286.00
IUUC-Rno-105870 Rattus norvegicus 90.00 0.00e+00 3344.00
IUUC-Sit-110552 Setaria italica 34.33 8.00e-29 122.00
IUUC-Sar-113289 Sorex araneus 89.76 0.00e+00 1757.00
IUUC-Ssc-115509 Sus scrofa 92.78 0.00e+00 3227.00
IUUC-Tru-117736 Takifugu rubripes 45.35 0.00e+00 830.00
IUUC-Tca-121624 Theobroma cacao 32.67 9.00e-28 119.00
IUUC-Tae-125629 Triticum aestivum 36.57 3.00e-20 93.60
IUUC-Tbe-127825 Tupaia belangeri 87.92 0.00e+00 1586.00
IUUC-Ttr-128754 Tursiops truncatus 94.02 0.00e+00 1246.00
IUUC-Xtr-132838 Xenopus tropicalis 49.06 0.00e+00 1011.00
IUUC-Xma-133119 Xiphophorus maculatus 43.09 0.00e+00 977.00
Created Date 25-Jun-2017

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