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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045931
Ensembl Protein ID ENSP00000483570.1
UniProt Accession Q06187; B2RAW1; Q32ML5; BTK_HUMAN
Genbank Protein ID CAA41728.1; AAB60639.1; AAB60639.1; AAB60639.1; AAB60639.1; AAA61479.1; AAA61479.1; AAA61479.1; AAA61479.1; AAA61479.1; AAA61479.1; AAA61479.1; AAA61479.1; AAA61479.1; AAA61479.1; AAA61479.1; AAA61479.1; AAA61479.1; AAA61479.1; AAC51347.1; AAC51347.1; AAC51347.1; AAC51347.1; AAC51347.1; AAC51347.1; AAC51347.1; AAC51347.1; AAC51347.1; AAC51347.1; AAC51347.1; AAC51347.1; AAC51347.1; AAC51347.1; AAC51347.1; AAC51347.1; AAC51347.1; AAC51347.1; AAB64205.1; BAG37008.1; CAB55876.1; AAI09080.1; AAI09081.1
Protein Name Tyrosine-protein kinase BTK; Agammaglobulinemia tyrosine kinase; B-cell progenitor kinase; Bruton tyrosine kinase
Genbank Nucleotide ID X58957; U10087; U10084; U10085; U10086; L31572; L31557; L31558; L31559; L31561; L31563; L31564; L31565; L31566; L31567; L31568; L31569; L31570; L31571; U13433; U13410; U13412; U13413; U13414; U13415; U13416; U13417; U13422; U13423; U13424; U13425; U13427; U13428; U13429; U13430; U13431; U13432; U78027; AK314382; AL035422; BC109079; BC109080
Gene Name BTK; AGMX1; ATK; BPK
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000010671.15 ENST00000621635.4 ENSP00000483570.1
ENSG00000010671.15 ENST00000372880.5 ENSP00000361971.1
ENSG00000010671.15 ENST00000618050.4 ENSP00000479125.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbGWAS CentralOMIM
Drug and target
TTDKPIDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 3.10e-13 51.1 250 307
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++kv +lydy++ n ++L+l+kGd  +++  ee +  W+++ ++ +g++G +P+n+v+++e
   Q: 250  LKKVVALYDYMPMNANDLQLRKGDEYFIL--EESNLPWWRA-RDKNGQEGYIPSNYVTEAE 307
           689*************************9..9999******.6***************987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
 Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
Protein Sequence
(Fasta)
MASWSIQQMV IGCPLCGRHC SGGEHTGELQ KEEAMAAVIL ESIFLKRSQQ KKKTSPLNFK 60
KRLFLLTVHK LSYYEYDFER GRRGSKKGSI DVEKITCVET VVPEKNPPPE RQIPRRGEES 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045931|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTCGTCACTT TATCTCTTTT GGTGGACTCT GCTACGTAGT GGCGTTCAGT GAAGGGAGCA 60
GTGTTTTTCC CAGATCCTCT GGCCTCCCCG TCCCCGAGGG AAGCCAGGAC TAGGGTCGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045931|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-1064--Adaptive immunity
KW-0877--Alternative promoter usage
KW-0053--Apoptosis
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0391--Immunity
KW-0399--Innate immunity
KW-0418--Kinase
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011009--Kinase-like_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR001562--Znf_Btk_motif
PROSITE

PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
PS51113--ZF_BTK
Pfam

PF00779--BTK
PF00169--PH
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00402--TECBTKDOMAIN
PR00109--TYRKINASE
SMART

SM00107--BTK
SM00233--PH
SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0042629--C:mast cell granule
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0002250--P:adaptive immune response
GO:0097190--P:apoptotic signaling pathway
GO:0042113--P:B cell activation
GO:0002344--P:B cell affinity maturation
GO:0050853--P:B cell receptor signaling pathway
GO:0019722--P:calcium-mediated signaling
GO:0048469--P:cell maturation
GO:0098761--P:cellular response to interleukin-7
GO:0071226--P:cellular response to molecule of fungal origin
GO:0034614--P:cellular response to reactive oxygen species
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0002553--P:histamine secretion by mast cell
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0045087--P:innate immune response
GO:0035556--P:intracellular signal transduction
GO:0007498--P:mesoderm development
GO:0002755--P:MyD88-dependent toll-like receptor signaling pathway
GO:0030889--P:negative regulation of B cell proliferation
GO:0001818--P:negative regulation of cytokine production
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0045579--P:positive regulation of B cell differentiation
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0001812--P:positive regulation of type I hypersensitivity
GO:0001805--P:positive regulation of type III hypersensitivity
GO:0006468--P:protein phosphorylation
GO:0002902--P:regulation of B cell apoptotic process
GO:0002721--P:regulation of B cell cytokine production
GO:0042127--P:regulation of cell proliferation
GO:0006351--P:transcription, DNA-templated
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG hsa:695
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001365 Ailuropoda melanoleuca 99.09 0.00e+00 1286.00
IUUC-Apl-003907 Anas platyrhynchos 86.41 0.00e+00 1129.00
IUUC-Aca-004978 Anolis carolinensis 76.85 0.00e+00 1056.00
IUUC-Ame-010694 Astyanax mexicanus 55.70 6.00e-151 527.00
IUUC-Bta-012467 Bos taurus 98.63 0.00e+00 1282.00
IUUC-Cja-018841 Callithrix jacchus 98.79 0.00e+00 1283.00
IUUC-Cfa-020983 Canis familiaris 98.94 0.00e+00 1272.00
IUUC-Cpo-021307 Cavia porcellus 98.79 0.00e+00 1286.00
IUUC-Csa-023508 Chlorocebus sabaeus 100.00 0.00e+00 983.00
IUUC-Dre-028544 Danio rerio 57.96 6.00e-148 516.00
IUUC-Dno-029828 Dasypus novemcinctus 96.56 0.00e+00 1261.00
IUUC-Dor-030102 Dipodomys ordii 91.18 0.00e+00 1064.00
IUUC-Ete-032981 Echinops telfairi 90.14 0.00e+00 1146.00
IUUC-Eca-033594 Equus caballus 99.39 0.00e+00 1290.00
IUUC-Eeu-035281 Erinaceus europaeus 93.74 0.00e+00 1008.00
IUUC-Fca-035495 Felis catus 98.48 0.00e+00 1266.00
IUUC-Fal-036719 Ficedula albicollis 85.89 0.00e+00 1156.00
IUUC-Gga-041193 Gallus gallus 81.91 0.00e+00 1134.00
IUUC-Gac-042383 Gasterosteus aculeatus 45.65 3.00e-127 448.00
IUUC-Itr-048061 Ictidomys tridecemlineatus 98.79 0.00e+00 1283.00
IUUC-Lch-049868 Latimeria chalumnae 74.54 0.00e+00 983.00
IUUC-Loc-052730 Lepisosteus oculatus 57.75 1.00e-163 570.00
IUUC-Laf-053516 Loxodonta africana 98.18 0.00e+00 1303.00
IUUC-Mcc-054795 Macaca mulatta 98.85 0.00e+00 1342.00
IUUC-Meu-056157 Macropus eugenii 85.13 0.00e+00 1102.00
IUUC-Mga-059529 Meleagris gallopavo 85.45 0.00e+00 958.00
IUUC-Mmr-060824 Microcebus murinus 92.85 0.00e+00 1227.00
IUUC-Mdo-063036 Monodelphis domestica 94.99 0.00e+00 1236.00
IUUC-Mmu-064047 Mus musculus 98.33 0.00e+00 1284.00
IUUC-Mpu-066810 Mustela putorius furo 98.79 0.00e+00 1286.00
IUUC-Mlu-067671 Myotis lucifugus 98.04 0.00e+00 1276.00
IUUC-Nle-069108 Nomascus leucogenys 100.00 0.00e+00 1290.00
IUUC-Opr-070505 Ochotona princeps 75.00 0.00e+00 672.00
IUUC-Ont-072585 Oreochromis niloticus 58.37 7.00e-161 560.00
IUUC-Oan-073495 Ornithorhynchus anatinus 93.02 0.00e+00 1243.00
IUUC-Ocu-074416 Oryctolagus cuniculus 98.94 0.00e+00 1286.00
IUUC-Ola-086938 Oryzias latipes 59.07 2.00e-156 545.00
IUUC-Oga-088995 Otolemur garnettii 97.58 0.00e+00 1267.00
IUUC-Oar-089632 Ovis aries 97.57 0.00e+00 1257.00
IUUC-Ptr-090941 Pan troglodytes 99.85 0.00e+00 1289.00
IUUC-Pan-091900 Papio anubis 96.97 0.00e+00 1239.00
IUUC-Psi-093048 Pelodiscus sinensis 81.93 0.00e+00 1109.00
IUUC-Pfo-096955 Poecilia formosa 60.05 2.00e-163 568.00
IUUC-Pab-097587 Pongo abelii 99.85 0.00e+00 1290.00
IUUC-Pca-100374 Procavia capensis 88.93 2.00e-147 516.00
IUUC-Pva-102583 Pteropus vampyrus 98.79 0.00e+00 1259.00
IUUC-Rno-104868 Rattus norvegicus 93.66 0.00e+00 1200.00
IUUC-Sha-106744 Sarcophilus harrisii 93.63 0.00e+00 1258.00
IUUC-Sar-113041 Sorex araneus 98.47 0.00e+00 1127.00
IUUC-Ssc-115294 Sus scrofa 99.09 0.00e+00 1287.00
IUUC-Tgu-116458 Taeniopygia guttata 53.09 0.00e+00 716.00
IUUC-Tsy-118945 Tarsius syrichta 97.65 0.00e+00 869.00
IUUC-Ttr-128769 Tursiops truncatus 89.38 0.00e+00 1149.00
IUUC-Vpa-130517 Vicugna pacos 93.11 0.00e+00 711.00
Created Date 25-Jun-2017

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