iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	12215542
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	12215542

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.20e-52	171.8	626	664
UBD/Beta-Prp	1.10e-105	353.1	448	699

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           Ht++v+++af +d ++l+sGs D+ +++W++ tg l++s
   Q: 626  HTEPVYSVAFsPDgKHLASGSFDKCVHIWSTQTGQLVHS 664
           ***********999********************99875 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp 104
           g+hk++i ++k+ + ++++++++ d+t+++wd++tg++ +++  h+a+  +v+++ ++  ++++s+D+ i+v  l  ++++ t+kgh+++v +++++p
   Q: 448  GQHKGPIFALKWNKCGNYILSAGVDKTTIIWDASTGQCTQQFAFHSAPALDVDWQTNQ-AFASCSTDQRIHVCRLGVNEPIKTFKGHTNEVNAIKWCP 544
           689999***************************************************8.9************************************** PP
   S: 105  sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpd........g.nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngk 193
           +g+ l+s s+d t+++w ++ + c +  l+ h++ + +++++p+        +  +l+s+s D+tvrlWd+++g++++tlt+ ht++vys++f+++gk
   Q: 545  QGQLLASCSDDMTLKIWSMNRDRCCH-DLQAHSKEIYTIKWSPTgpgtnnpnTnLILASASFDSTVRLWDVERGSCIHTLTK-HTEPVYSVAFSPDGK 640
           **************************.77777777777777654222221114358999*********************99.*************** PP
   S: 194  elvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrs 253
           +l+sgs d+ v +w+ qtg+ v++++g    + +   s+ ++  +s+s Dgs+++ dlr+
   Q: 641  HLASGSFDKCVHIWSTQTGQLVHSYKGTGGIFEVCWNSKGTKVGASAS-DGSVFVLDLRK 699
           ***************************999999888886666666665.9***9999986 PP

Organism

Drosophila melanogaster

Functional Description
(View)

F-box-like component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, cone cell development and neuronal cell cycle control. E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins. Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation. Required to block the S phase entry in the peripheral nervous system and central nervous system in a process that does not involve the degradation of ttk. Involved in cone cell development by preventing the transcriptional repression mediated by Su(H) on Dl, probably by participating in a E3 complex that contains sno and mediates the ubiquitination and subsequent proteasomal degradation of some component of the Su(H) repressor complex.

Protein Sequence
(Fasta)

MSFSSDEVNF LVYRYLQESG FLHSAYVFGI ESHISQSNIN GALVPPAALL TILQKGLLYT 60
EVEWSVGEDG EVARPIEGLS LIDAVMPEVK PLKPIVKTEP GKPGAVDSSA PAGGNQNNNA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTACTCCGCC ATTTTTTTGC GCGTTTCAGA AACGCGTTTT CGATCCCTCG GTTTTATTTG 60
TGGAAAAAAT ATGTGAAGTG CTCTTGCGGC AAGCAGCAAA CTGGCAGAAT TGAAAACACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0716--Sensory transduction
KW-0833--Ubl conjugation pathway
KW-0844--Vision
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005634--C:nucleus
GO:0005700--C:polytene chromosome
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0005525--F:GTP binding
GO:0070491--F:repressing transcription factor binding
GO:0007049--P:cell cycle
GO:0071482--P:cellular response to light stimulus
GO:0022416--P:chaeta development
GO:0042676--P:compound eye cone cell fate commitment
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0008587--P:imaginal disc-derived wing margin morphogenesis
GO:0046329--P:negative regulation of JNK cascade
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0070050--P:neuron cellular homeostasis
GO:0007219--P:Notch signaling pathway
GO:0042461--P:photoreceptor cell development
GO:0031065--P:positive regulation of histone deacetylation
GO:0045572--P:positive regulation of imaginal disc growth
GO:0045747--P:positive regulation of Notch signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042058--P:regulation of epidermal growth factor receptor signaling pathway
GO:0030162--P:regulation of proteolysis
GO:0006979--P:response to oxidative stress
GO:0007601--P:visual perception
GO:0035220--P:wing disc development

KEGG

dme:Dmel_CG4063

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000916	Aegilops tauschii	57.86	1.00e-53	200.00
IUUC-Aml-001450	Ailuropoda melanoleuca	81.74	0.00e+00	641.00
IUUC-Atr-002514	Amborella trichopoda	61.87	1.00e-136	479.00
IUUC-Apl-003232	Anas platyrhynchos	81.47	0.00e+00	641.00
IUUC-Aca-005035	Anolis carolinensis	80.93	0.00e+00	637.00
IUUC-Aly-005622	Arabidopsis lyrata	55.70	3.00e-115	407.00
IUUC-Ath-007137	Arabidopsis thaliana	55.97	2.00e-116	412.00
IUUC-Ago-007869	Ashbya gossypii	26.88	3.00e-35	142.00
IUUC-Ame-011601	Astyanax mexicanus	80.87	8.00e-176	609.00
IUUC-Bta-013202	Bos taurus	81.47	0.00e+00	639.00
IUUC-Bdi-014315	Brachypodium distachyon	58.76	4.00e-130	457.00
IUUC-Bol-016277	Brassica oleracea	55.56	1.00e-119	422.00
IUUC-Bra-016944	Brassica rapa	55.82	5.00e-120	424.00
IUUC-Cja-019281	Callithrix jacchus	80.11	0.00e+00	630.00
IUUC-Cfa-020929	Canis familiaris	81.74	0.00e+00	641.00
IUUC-Cpo-021682	Cavia porcellus	82.02	0.00e+00	640.00
IUUC-Cre-022979	Chlamydomonas reinhardtii	60.38	2.00e-127	448.00
IUUC-Csa-023943	Chlorocebus sabaeus	79.84	0.00e+00	631.00
IUUC-Cho-024872	Choloepus hoffmanni	78.02	2.00e-36	145.00
IUUC-Cin-025704	Ciona intestinalis	76.05	3.00e-178	617.00
IUUC-Csv-026257	Ciona savignyi	77.03	2.00e-176	610.00
IUUC-Cne-026946	Cryptococcus neoformans	36.49	9.00e-31	127.00
IUUC-Cme-027258	Cyanidioschyzon merolae	42.21	1.00e-86	313.00
IUUC-Dre-027906	Danio rerio	81.69	6.00e-177	612.00
IUUC-Dno-029196	Dasypus novemcinctus	81.42	2.00e-176	610.00
IUUC-Dor-030732	Dipodomys ordii	81.34	6.00e-172	596.00
IUUC-Ete-033150	Echinops telfairi	81.68	2.00e-153	534.00
IUUC-Eca-033897	Equus caballus	81.74	0.00e+00	641.00
IUUC-Eeu-034952	Erinaceus europaeus	70.72	5.00e-143	500.00
IUUC-Fca-036462	Felis catus	81.47	0.00e+00	640.00
IUUC-Fal-037388	Ficedula albicollis	81.74	0.00e+00	643.00
IUUC-Gmo-038870	Gadus morhua	80.87	0.00e+00	634.00
IUUC-Gga-040671	Gallus gallus	81.74	0.00e+00	643.00
IUUC-Gac-041844	Gasterosteus aculeatus	81.97	0.00e+00	641.00
IUUC-Gma-044208	Glycine max	58.62	3.00e-132	464.00
IUUC-Ggo-045373	Gorilla gorilla	80.38	0.00e+00	635.00
IUUC-Hsa-045841	Homo sapiens	80.38	0.00e+00	635.00
IUUC-Itr-048236	Ictidomys tridecemlineatus	81.74	0.00e+00	636.00
IUUC-Kpa-049338	Komagataella pastoris	29.69	4.00e-33	135.00
IUUC-Lch-050535	Latimeria chalumnae	80.60	0.00e+00	633.00
IUUC-Lpe-051084	Leersia perrieri	58.18	3.00e-129	454.00
IUUC-Loc-052030	Lepisosteus oculatus	81.15	0.00e+00	635.00
IUUC-Laf-054071	Loxodonta africana	81.20	0.00e+00	637.00
IUUC-Mcc-055203	Macaca mulatta	81.42	5.00e-176	609.00
IUUC-Meu-056563	Macropus eugenii	82.70	7.00e-113	399.00
IUUC-Mtr-058624	Medicago truncatula	57.55	1.00e-124	439.00
IUUC-Mga-059895	Meleagris gallopavo	81.74	0.00e+00	643.00
IUUC-Mvi-060557	Microbotryum violaceum	35.88	4.00e-69	255.00
IUUC-Mmr-061286	Microcebus murinus	81.47	0.00e+00	640.00
IUUC-Mdo-062078	Monodelphis domestica	81.15	1.00e-175	608.00
IUUC-Mmu-063447	Mus musculus	82.02	0.00e+00	643.00
IUUC-Mac-065508	Musa acuminata	59.47	4.00e-89	320.00
IUUC-Mpu-066741	Mustela putorius furo	81.42	3.00e-176	610.00
IUUC-Mlu-067852	Myotis lucifugus	81.74	0.00e+00	638.00
IUUC-Nle-069151	Nomascus leucogenys	80.38	0.00e+00	635.00
IUUC-Opr-070277	Ochotona princeps	68.80	1.00e-137	482.00
IUUC-Ont-072252	Oreochromis niloticus	82.51	0.00e+00	643.00
IUUC-Oan-073562	Ornithorhynchus anatinus	82.02	0.00e+00	643.00
IUUC-Ocu-074280	Oryctolagus cuniculus	81.42	3.00e-176	610.00
IUUC-Oba-075618	Oryza barthii	56.03	1.00e-119	422.00
IUUC-Obr-076718	Oryza brachyantha	58.71	5.00e-130	457.00
IUUC-Ogl-077302	Oryza glaberrima	58.45	2.00e-130	458.00
IUUC-Ogu-078718	Oryza glumaepatula	58.45	2.00e-130	458.00
IUUC-Oin-079515	Oryza indica	51.92	1.00e-69	257.00
IUUC-Olo-080427	Oryza longistaminata	59.31	6.00e-125	440.00
IUUC-Ome-081696	Oryza meridionalis	56.84	5.00e-125	440.00
IUUC-Oni-082137	Oryza nivara	58.45	2.00e-130	458.00
IUUC-Opu-083505	Oryza punctata	56.03	6.00e-120	423.00
IUUC-Oru-085276	Oryza rufipogon	58.45	2.00e-130	458.00
IUUC-Osa-085791	Oryza sativa	58.45	2.00e-130	458.00
IUUC-Ola-087365	Oryzias latipes	81.42	0.00e+00	638.00
IUUC-Olu-087589	Ostreococcus lucimarinus	58.55	1.00e-134	472.00
IUUC-Oga-088357	Otolemur garnettii	78.14	1.00e-164	572.00
IUUC-Oar-089506	Ovis aries	81.74	0.00e+00	640.00
IUUC-Ptr-091532	Pan troglodytes	81.42	3.00e-176	610.00
IUUC-Pan-091927	Papio anubis	81.42	3.00e-176	610.00
IUUC-Psi-093358	Pelodiscus sinensis	82.02	0.00e+00	642.00
IUUC-Pma-094105	Petromyzon marinus	75.94	2.00e-55	208.00
IUUC-Ppa-095868	Physcomitrella patens	63.26	1.00e-132	465.00
IUUC-Pfo-096158	Poecilia formosa	81.42	0.00e+00	638.00
IUUC-Pab-098705	Pongo abelii	81.42	3.00e-176	610.00
IUUC-Pop-098989	Populus trichocarpa	58.09	1.00e-122	432.00
IUUC-Pca-100256	Procavia capensis	80.89	7.00e-173	599.00
IUUC-Ppe-101572	Prunus persica	63.76	5.00e-126	443.00
IUUC-Pva-102616	Pteropus vampyrus	81.34	5.00e-173	600.00
IUUC-Rno-105857	Rattus norvegicus	82.02	0.00e+00	643.00
IUUC-Sce-106132	Saccharomyces cerevisiae	25.26	3.00e-29	122.00
IUUC-Sha-107326	Sarcophilus harrisii	81.74	0.00e+00	642.00
IUUC-Smo-109301	Selaginella moellendorffii	60.38	3.00e-134	471.00
IUUC-Sit-110710	Setaria italica	58.98	2.00e-135	475.00
IUUC-Sly-111042	Solanum lycopersicum	60.22	2.00e-132	464.00
IUUC-Stu-112786	Solanum tuberosum	55.87	9.00e-123	432.00
IUUC-Sar-112971	Sorex araneus	72.38	4.00e-157	547.00
IUUC-Sbi-114420	Sorghum bicolor	59.52	1.00e-136	479.00
IUUC-Sre-115175	Sporisorium reilianum	40.23	7.00e-54	204.00
IUUC-Ssc-115646	Sus scrofa	81.74	0.00e+00	642.00
IUUC-Tgu-116898	Taeniopygia guttata	81.74	0.00e+00	643.00
IUUC-Tru-118254	Takifugu rubripes	81.42	0.00e+00	637.00
IUUC-Tsy-118853	Tarsius syrichta	70.77	7.00e-136	476.00
IUUC-Tni-120861	Tetraodon nigroviridis	81.47	0.00e+00	635.00
IUUC-Tca-121739	Theobroma cacao	53.75	4.00e-121	427.00
IUUC-Tae-125368	Triticum aestivum	58.49	1.00e-130	459.00
IUUC-Tur-126856	Triticum urartu	56.52	3.00e-59	221.00
IUUC-Tme-127126	Tuber melanosporum	36.36	7.00e-55	207.00
IUUC-Tbe-127767	Tupaia belangeri	80.39	3.00e-152	530.00
IUUC-Ttr-128826	Tursiops truncatus	81.85	2.00e-164	571.00
IUUC-Uma-129469	Ustilago maydis	38.72	2.00e-52	199.00
IUUC-Vpa-130768	Vicugna pacos	80.89	9.00e-173	598.00
IUUC-Vvi-131193	Vitis vinifera	58.36	7.00e-126	443.00
IUUC-Xtr-132842	Xenopus tropicalis	77.60	4.00e-166	577.00
IUUC-Xma-134020	Xiphophorus maculatus	81.42	0.00e+00	638.00
IUUC-Yli-134648	Yarrowia lipolytica	27.85	2.00e-39	155.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence