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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046007
UUCD1 version UUC-HoS-01174
Ensembl Protein ID ENSP00000313454.4
UniProt Accession A0AVT1; A6N8M7; B2RAV3; Q4W5K0; Q6UV21; Q86T78; Q86TC7; Q8N5T3; Q8N9E4; Q9H3T7; Q9NVC9; UBA6_HUMAN
Genbank Protein ID AAQ63403.1; ABR25253.1; BAB19785.1; BAA91824.1; BAC04463.1; BAG37000.1; CAD89908.1; CAD89959.1; AAY40999.1; AAH31637.1; AAI26485.1; AAI26487.1
Protein Name Ubiquitin-like modifier-activating enzyme 6; Monocyte protein 4; Ubiquitin-activating enzyme E1-like protein 2
Genbank Nucleotide ID AY359880; EF623993; AB014773; AK001670; AK094969; AK314371; AL832015; AL832458; AC079880; BC031637; BC126484; BC126486
Gene Name UBA6; MOP4; UBE1L2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000033178.12 ENST00000322244.9 ENSP00000313454.4
ENSG00000033178.12 ENST00000514261.1 ENSP00000425091.1
ENSG00000033178.12 ENST00000505673.2 ENSP00000421984.2
ENSG00000033178.12 ENST00000420827.2 ENSP00000399234.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDHINTInWeb_IM
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E1 E1_ThiF 20075161
Classification
Family E-value Score Start End
E1 4.70e-228 758.9 443 930
Active Site
Position(s) Description Evidence
625 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU10132}
Domain Profile

   E1
   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv......gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnp 86
           YD +++++G++ ++kl++ +++lvG+g++GcE+lKn++l+Gv      g+itv+D d +e+snlnrqFLfr+++++k+K+ +aa+a  ++n+
   Q: 443  YDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVgtskekGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINS 534
           9******************************************************************************************* PP
   S: 87   dvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfct 175
           +++++ah +++++++e+i+   F++k dv+++aldn+earr+v+++cl++ +pl++sgt+G++G+++vi+++lte+y++++dpp+++iPfct
   Q: 535  QIKIDAHLNKVCPTTETIYndeFYTKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFCT 626
           ******************************************************************************************** PP
   S: 176  lketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikq 255
           lk++p+a+ehti+wa            +lfnk++++++++eevl+k++s +++eg+++v  +l s++++n+++++e+a+ +f+k++++++ q
   Q: 627  LKSFPAAIEHTIQWArdkfessfshkpSLFNKFWQTYSSAEEVLQKIQSGHSLEGCFQV-IKLLSRRPRNWSQCVELARLKFEKYFNHKALQ 717
           ***********************************************************.999***************************** PP
   S: 256  llksfecdivtkskspfwv.........................................................sfcsnaealqvpekve 290
           ll++f+ di+ k++s fw+                                                         +f++ ++ +q++e++ 
   Q: 718  LLHCFPLDIRLKDGSLFWQspkrppspikfdlneplhlsflqnaaklyatvycipfaeedlsadallnilsevkiqEFKPSNKVVQTDETAR 809
           ******************************************************************************************** PP
   S: 291  kdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnav 375
           k+ +v  +s++     ++l++++l++ ++k+++++++lsfekddd+  ++d++taa+nlra++++iep +d++++k+iag+iipaiatt+a+
   Q: 810  KPDHVPISSEDernaiFQLEKAILSNEATKSDLQMAVLSFEKDDDHngHIDFITAASNLRAKMYSIEP-ADRFKTKRIAGKIIPAIATTTAT 900
           ******999999********************************************************.*********************** PP
   S: 376  vgGlaaqEviKvvsg.kfeplknfflfdae 404
           v+Gl+a+E+iKv+ g +fe++kn+fl++a+
   Q: 901  VSGLVALEMIKVTGGyPFEAYKNCFLNLAI 930
           **************************9886 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.
 Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.
Protein Sequence
(Fasta)
MEGSEPVAAH QGEEASCSSW GTGSTNKNLP IMSTASVEID DALYSRQRYV LGDTAMQKMA 60
KSHVFLSGMG GLGLEIAKNL VLAGIKAVTI HDTEKCQAWD LGTNFFLSED DVVNKRNRAE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046007|E1,E1_ThiF|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCCCCACGG TCCCGCCCCT TCCTACCTTC CAGTAGCCGG CGGCGGTGTC TCAGGCGGCA 60
ATGGAAGGAT CCGAGCCTGT GGCCGCCCAT CAGGGGGAAG AGGCGTCCTG TTCTTCCTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046007|E1,E1_ThiF|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR000011--UBQ/SUMO-activ_enz_E1-like
Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys
PRINTS

PR01849--UBIQUITINACT
SMART

SM00985--UBA_e1_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0019780--F:FAT10 activating enzyme activity
GO:0004839--F:ubiquitin activating enzyme activity
GO:0021764--P:amygdala development
GO:0060996--P:dendritic spine development
GO:0021766--P:hippocampus development
GO:0007612--P:learning
GO:0007626--P:locomotory behavior
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:55236
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001608 Ailuropoda melanoleuca 92.40 0.00e+00 2037.00
IUUC-Apl-004158 Anas platyrhynchos 79.90 0.00e+00 1736.00
IUUC-Aca-005349 Anolis carolinensis 80.31 0.00e+00 1762.00
IUUC-Bta-012696 Bos taurus 92.11 0.00e+00 2033.00
IUUC-Cja-019563 Callithrix jacchus 97.15 0.00e+00 2097.00
IUUC-Cfa-020951 Canis familiaris 92.02 0.00e+00 2036.00
IUUC-Cpo-022307 Cavia porcellus 88.34 0.00e+00 1927.00
IUUC-Csa-023647 Chlorocebus sabaeus 98.19 0.00e+00 2133.00
IUUC-Cho-024682 Choloepus hoffmanni 77.25 0.00e+00 942.00
IUUC-Dre-028022 Danio rerio 66.73 0.00e+00 1468.00
IUUC-Dno-029796 Dasypus novemcinctus 90.56 0.00e+00 1947.00
IUUC-Dor-030981 Dipodomys ordii 75.89 0.00e+00 1519.00
IUUC-Ete-032514 Echinops telfairi 77.60 0.00e+00 1143.00
IUUC-Eca-033697 Equus caballus 92.61 0.00e+00 2003.00
IUUC-Eeu-035323 Erinaceus europaeus 84.15 0.00e+00 1367.00
IUUC-Fca-035858 Felis catus 93.59 0.00e+00 2021.00
IUUC-Fal-036848 Ficedula albicollis 80.12 0.00e+00 1731.00
IUUC-Gmo-039326 Gadus morhua 65.95 0.00e+00 1384.00
IUUC-Gga-040747 Gallus gallus 80.22 0.00e+00 1718.00
IUUC-Gac-041406 Gasterosteus aculeatus 66.63 0.00e+00 1389.00
IUUC-Ggo-044577 Gorilla gorilla 99.43 0.00e+00 2157.00
IUUC-Itr-048191 Ictidomys tridecemlineatus 95.51 0.00e+00 1074.00
IUUC-Lch-049992 Latimeria chalumnae 73.18 0.00e+00 1541.00
IUUC-Loc-051899 Lepisosteus oculatus 68.33 0.00e+00 1485.00
IUUC-Laf-054413 Loxodonta africana 91.90 0.00e+00 1870.00
IUUC-Mcc-054656 Macaca mulatta 98.38 0.00e+00 2136.00
IUUC-Meu-056463 Macropus eugenii 71.31 0.00e+00 1423.00
IUUC-Mga-059721 Meleagris gallopavo 78.54 0.00e+00 1628.00
IUUC-Mmr-060908 Microcebus murinus 91.35 0.00e+00 2004.00
IUUC-Mdo-062096 Monodelphis domestica 84.30 0.00e+00 1893.00
IUUC-Mmu-064114 Mus musculus 89.07 0.00e+00 1955.00
IUUC-Mpu-066017 Mustela putorius furo 92.21 0.00e+00 2043.00
IUUC-Mlu-068037 Myotis lucifugus 90.17 0.00e+00 1963.00
IUUC-Nle-069494 Nomascus leucogenys 98.29 0.00e+00 2132.00
IUUC-Opr-070910 Ochotona princeps 67.09 2.00e-174 606.00
IUUC-Ont-071592 Oreochromis niloticus 68.27 0.00e+00 1450.00
IUUC-Oan-073268 Ornithorhynchus anatinus 80.59 0.00e+00 1609.00
IUUC-Ocu-074296 Oryctolagus cuniculus 93.06 0.00e+00 2036.00
IUUC-Ola-086376 Oryzias latipes 68.27 0.00e+00 1400.00
IUUC-Oga-088186 Otolemur garnettii 93.44 0.00e+00 2043.00
IUUC-Oar-089307 Ovis aries 92.21 0.00e+00 2033.00
IUUC-Ptr-090609 Pan troglodytes 99.52 0.00e+00 2149.00
IUUC-Pan-092905 Papio anubis 98.22 0.00e+00 2034.00
IUUC-Psi-093489 Pelodiscus sinensis 81.35 0.00e+00 1750.00
IUUC-Pma-094203 Petromyzon marinus 64.86 1.00e-56 211.00
IUUC-Pfo-096670 Poecilia formosa 68.59 0.00e+00 1456.00
IUUC-Pab-098418 Pongo abelii 98.57 0.00e+00 2133.00
IUUC-Pca-100889 Procavia capensis 75.29 0.00e+00 1589.00
IUUC-Pva-103144 Pteropus vampyrus 81.75 0.00e+00 1761.00
IUUC-Rno-105612 Rattus norvegicus 89.35 0.00e+00 1960.00
IUUC-Sha-107388 Sarcophilus harrisii 86.02 0.00e+00 1877.00
IUUC-Sar-113128 Sorex araneus 88.51 0.00e+00 1926.00
IUUC-Ssc-116117 Sus scrofa 92.88 0.00e+00 2050.00
IUUC-Tgu-116565 Taeniopygia guttata 80.53 0.00e+00 1744.00
IUUC-Tru-118591 Takifugu rubripes 66.76 0.00e+00 1413.00
IUUC-Tsy-119436 Tarsius syrichta 82.22 0.00e+00 1762.00
IUUC-Tni-120880 Tetraodon nigroviridis 66.34 0.00e+00 1400.00
IUUC-Tbe-127714 Tupaia belangeri 79.66 0.00e+00 1410.00
IUUC-Ttr-129159 Tursiops truncatus 80.32 0.00e+00 1710.00
IUUC-Vpa-130716 Vicugna pacos 90.07 0.00e+00 1895.00
IUUC-Xtr-132947 Xenopus tropicalis 70.05 0.00e+00 1529.00
Created Date 25-Jun-2017

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