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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046655
Ensembl Protein ID ENSP00000378221.1
UniProt Accession Q96CB8; B2RC48; Q3B6Z3; Q9HD71; INT12_HUMAN
Genbank Protein ID AAF99604.1; BAG37445.1; EAX06189.1; AAH14442.1; DAA05729.1
Protein Name Integrator complex subunit 12; PHD finger protein 22
Genbank Nucleotide ID AF242524; AK314939; CH471057; BC014442; BK005729
Gene Name INTS12; PHF22; SBBI22
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000138785.14 ENST00000394735.5 ENSP00000378221.1
ENSG00000138785.14 ENST00000510876.1 ENSP00000422856.1
ENSG00000138785.14 ENST00000618810.4 ENSP00000481164.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 2.10e-08 35.9 162 214
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 4    ClvCgeggedek.slveCekCrewfHpaClklsveeelpnsek..wiCpkCrs 53
           C vC++ +  +  +lveC++C++ +H +C+k++v ++  n+ +  w+C +C++
   Q: 162  CVVCRQMMVASGnQLVECQECHNLYHRDCHKPQVTDKEANDPRlvWYCARCTR 214
           ********98866********************999999987799******86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
 Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
Protein Sequence
(Fasta)
MAATVNLELD PIFLKALGFL HSKSKDSAEK LKALLDESLA RGIDSSYRPS QKDVEPPKIS 60
STKNISIKQE PKISSSLPSG NNNGKVLTTE KVKKEAEKRP ADKMKSDITE GVDIPKKPRL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046655|E3,PHD|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTCCTAATT CCCGAGCCGG GGCGAGTCGC CCTCGGGGGG CCGCGGATGG GGTCCCAGAC 60
TCGCAAGGGC GCGCCCTCTC CGCCTCGGGC GGGCACTCGG AGCCGCTGGA CCGCTCTCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046655|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00628--PHD
SMART

SM00249--PHD
Gene Ontology

GO:0032039--C:integrator complex
GO:0005654--C:nucleoplasm
GO:0008270--F:zinc ion binding
GO:0016180--P:snRNA processing
GO:0042795--P:snRNA transcription from RNA polymerase II promoter
KEGG hsa:57117
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001485 Ailuropoda melanoleuca 93.35 5.00e-174 603.00
IUUC-Apl-003539 Anas platyrhynchos 78.59 4.00e-149 521.00
IUUC-Bta-013090 Bos taurus 91.80 6.00e-156 543.00
IUUC-Cja-019984 Callithrix jacchus 97.12 4.00e-174 604.00
IUUC-Cfa-020068 Canis familiaris 93.57 2.00e-178 619.00
IUUC-Cpo-021446 Cavia porcellus 87.80 2.00e-142 499.00
IUUC-Csa-023385 Chlorocebus sabaeus 98.89 3.00e-180 624.00
IUUC-Cho-025018 Choloepus hoffmanni 93.57 6.00e-164 570.00
IUUC-Dre-027546 Danio rerio 64.04 4.00e-95 342.00
IUUC-Dno-029989 Dasypus novemcinctus 93.35 1.00e-161 563.00
IUUC-Eca-033999 Equus caballus 90.24 8.00e-161 560.00
IUUC-Fca-035522 Felis catus 94.90 4.00e-169 587.00
IUUC-Gga-041056 Gallus gallus 75.55 4.00e-147 514.00
IUUC-Gac-042508 Gasterosteus aculeatus 59.05 1.00e-87 317.00
IUUC-Ggo-044647 Gorilla gorilla 99.75 2.00e-140 492.00
IUUC-Loc-052933 Lepisosteus oculatus 70.87 7.00e-98 350.00
IUUC-Laf-054471 Loxodonta africana 92.90 3.00e-173 601.00
IUUC-Mcc-055568 Macaca mulatta 98.89 3.00e-180 624.00
IUUC-Meu-056037 Macropus eugenii 89.24 1.00e-152 532.00
IUUC-Mga-059569 Meleagris gallopavo 74.67 8.00e-145 506.00
IUUC-Mmr-061180 Microcebus murinus 95.12 3.00e-166 577.00
IUUC-Mdo-062528 Monodelphis domestica 86.88 1.00e-156 546.00
IUUC-Mmu-064122 Mus musculus 91.13 5.00e-153 534.00
IUUC-Mpu-066477 Mustela putorius furo 94.24 8.00e-166 576.00
IUUC-Mlu-067391 Myotis lucifugus 94.01 4.00e-163 567.00
IUUC-Nle-069599 Nomascus leucogenys 99.56 4.00e-165 574.00
IUUC-Opr-070713 Ochotona princeps 90.91 2.00e-142 498.00
IUUC-Ont-072565 Oreochromis niloticus 63.17 2.00e-82 299.00
IUUC-Oan-073115 Ornithorhynchus anatinus 84.39 1.00e-110 392.00
IUUC-Ocu-074717 Oryctolagus cuniculus 94.24 3.00e-162 564.00
IUUC-Ola-087458 Oryzias latipes 68.20 3.00e-86 312.00
IUUC-Oga-088704 Otolemur garnettii 95.34 3.00e-164 571.00
IUUC-Oar-089184 Ovis aries 92.90 7.00e-158 550.00
IUUC-Ptr-091021 Pan troglodytes 99.56 3.00e-177 614.00
IUUC-Pan-091963 Papio anubis 98.89 3.00e-180 624.00
IUUC-Psi-093012 Pelodiscus sinensis 79.25 2.00e-142 499.00
IUUC-Pab-097870 Pongo abelii 99.56 1.00e-172 599.00
IUUC-Pca-100164 Procavia capensis 92.24 4.00e-169 587.00
IUUC-Pva-102873 Pteropus vampyrus 94.46 3.00e-163 568.00
IUUC-Rno-104840 Rattus norvegicus 90.47 1.00e-147 516.00
IUUC-Sha-106551 Sarcophilus harrisii 85.56 5.00e-154 537.00
IUUC-Tsy-119236 Tarsius syrichta 88.47 2.00e-168 585.00
IUUC-Tni-120510 Tetraodon nigroviridis 64.38 2.00e-95 343.00
IUUC-Tbe-127947 Tupaia belangeri 85.37 4.00e-143 501.00
Created Date 25-Jun-2017

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