iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000012048.20	ENST00000357654.7	ENSP00000350283.3
ENSG00000012048.20	ENST00000352993.7	ENSP00000312236.5
ENSG00000012048.20	ENST00000468300.5	ENSP00000417148.1
ENSG00000012048.20	ENST00000586385.5	ENSP00000465818.1
ENSG00000012048.20	ENST00000591849.5	ENSP00000465347.1
ENSG00000012048.20	ENST00000471181.6	ENSP00000418960.2
ENSG00000012048.20	ENST00000491747.6	ENSP00000420705.2
ENSG00000012048.20	ENST00000484087.5	ENSP00000419481.1
ENSG00000012048.20	ENST00000478531.5	ENSP00000420412.1
ENSG00000012048.20	ENST00000493919.5	ENSP00000418819.1
ENSG00000012048.20	ENST00000487825.5	ENSP00000418212.1
ENSG00000012048.20	ENST00000461574.1	ENSP00000417241.1
ENSG00000012048.20	ENST00000354071.7	ENSP00000326002.7
ENSG00000012048.20	ENST00000634433.1	ENSP00000489431.1
ENSG00000012048.20	ENST00000412061.3	ENSP00000397145.3
ENSG00000012048.20	ENST00000477152.5	ENSP00000419988.1
ENSG00000012048.20	ENST00000492859.5	ENSP00000420253.1
ENSG00000012048.20	ENST00000473961.5	ENSP00000420201.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	miRecords	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	12431996; 19887647; 18388150; 19164445; 19261748; 17283126; 16818604; 25131202; 25355358

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	8.30e-07	31.1	24	65

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle +k+ p+++ C H+f++ C  k+    n++++  +CPlC+
   Q: 24   CPICLELIKE-PVSTKCDHIFCKFCMLKL---LNQKKGPSQCPLCK 65
           ********99.**************9666...68899********7 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator (PubMed:20160719).

Protein Sequence
(Fasta)

MDLSALRVEE VQNVINAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK LLNQKKGPSQ 60
CPLCKNDITK RSLQESTRFS QLVEELLKII CAFQLDTGLE YANSYNFAKK ENNSPEHLKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAGCGTGGG AATTACAGAT AAATTAAAAC TGTGGAACCC CTTTCCTCGG CTGCCGCCAA 60
GGTGTTCGGT CCTTCCGAGG AAGCTAAGGC CGCGTTGGGG TGAGACCCTC ACTTCATCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0024--Alternative initiation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-1017--Isopeptide bond
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0043--Tumor suppressor
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PF00097--zf-C3HC4

PRINTS

PR00493--BRSTCANCERI

SMART

SM00292--BRCT
SM00184--RING

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005694--C:chromosome
GO:0005737--C:cytoplasm
GO:0008274--C:gamma-tubulin ring complex
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0000151--C:ubiquitin ligase complex
GO:0050681--F:androgen receptor binding
GO:0003684--F:damaged DNA binding
GO:0003677--F:DNA binding
GO:0019899--F:enzyme binding
GO:0003723--F:RNA binding
GO:0003713--F:transcription coactivator activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0015631--F:tubulin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030521--P:androgen receptor signaling pathway
GO:0006915--P:apoptotic process
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007098--P:centrosome cycle
GO:0043009--P:chordate embryonic development
GO:0007059--P:chromosome segregation
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0000729--P:DNA double-strand break processing
GO:0006260--P:DNA replication
GO:0000731--P:DNA synthesis involved in DNA repair
GO:0009048--P:dosage compensation by inactivation of X chromosome
GO:0006302--P:double-strand break repair
GO:0000724--P:double-strand break repair via homologous recombination
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0006633--P:fatty acid biosynthetic process
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0046600--P:negative regulation of centriole replication
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0010628--P:positive regulation of gene expression
GO:0035066--P:positive regulation of histone acetylation
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0016579--P:protein deubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0042127--P:regulation of cell proliferation
GO:0044030--P:regulation of DNA methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006359--P:regulation of transcription from RNA polymerase III promoter
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation
GO:0000732--P:strand displacement
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:672

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002388	Ailuropoda melanoleuca	75.03	0.00e+00	2676.00
IUUC-Apl-003252	Anas platyrhynchos	36.49	6.00e-132	466.00
IUUC-Aca-004526	Anolis carolinensis	54.55	7.00e-77	281.00
IUUC-Ame-011720	Astyanax mexicanus	47.78	9.00e-53	202.00
IUUC-Bta-013433	Bos taurus	71.83	0.00e+00	2516.00
IUUC-Cel-018208	Caenorhabditis elegans	33.66	9.00e-11	62.40
IUUC-Cja-019149	Callithrix jacchus	87.63	0.00e+00	3164.00
IUUC-Cfa-020322	Canis familiaris	74.04	0.00e+00	2605.00
IUUC-Cpo-021583	Cavia porcellus	47.04	0.00e+00	1365.00
IUUC-Csa-024227	Chlorocebus sabaeus	92.91	0.00e+00	682.00
IUUC-Cho-024530	Choloepus hoffmanni	68.63	0.00e+00	1205.00
IUUC-Cin-025364	Ciona intestinalis	33.59	1.00e-14	73.90
IUUC-Csv-026245	Ciona savignyi	38.46	2.00e-13	68.90
IUUC-Dno-029247	Dasypus novemcinctus	71.78	0.00e+00	2083.00
IUUC-Dme-032032	Drosophila melanogaster	54.35	8.00e-11	58.50
IUUC-Ete-032472	Echinops telfairi	56.28	0.00e+00	1734.00
IUUC-Eca-033446	Equus caballus	76.62	0.00e+00	2776.00
IUUC-Eeu-034858	Erinaceus europaeus	60.95	0.00e+00	983.00
IUUC-Fca-035991	Felis catus	75.39	0.00e+00	2702.00
IUUC-Fal-036803	Ficedula albicollis	30.83	3.00e-101	364.00
IUUC-Gmo-038782	Gadus morhua	45.31	2.00e-45	177.00
IUUC-Ggr-039833	Gaeumannomyces graminis	36.73	1.00e-07	51.60
IUUC-Gga-040969	Gallus gallus	62.98	1.00e-79	292.00
IUUC-Gac-042296	Gasterosteus aculeatus	44.98	1.00e-50	195.00
IUUC-Ggo-044740	Gorilla gorilla	93.51	0.00e+00	3314.00
IUUC-Itr-048512	Ictidomys tridecemlineatus	74.19	0.00e+00	2698.00
IUUC-Lch-049789	Latimeria chalumnae	37.80	2.00e-97	351.00
IUUC-Loc-051952	Lepisosteus oculatus	53.18	1.00e-68	255.00
IUUC-Laf-053648	Loxodonta africana	74.08	0.00e+00	2514.00
IUUC-Mcc-055210	Macaca mulatta	91.99	0.00e+00	3378.00
IUUC-Meu-056342	Macropus eugenii	38.29	1.00e-127	452.00
IUUC-Mor-057034	Magnaporthe oryzae	38.78	3.00e-08	53.50
IUUC-Mga-060163	Meleagris gallopavo	54.34	8.00e-83	303.00
IUUC-Mmr-061402	Microcebus murinus	72.66	0.00e+00	856.00
IUUC-Mdo-062209	Monodelphis domestica	45.42	0.00e+00	1271.00
IUUC-Mmu-064003	Mus musculus	55.93	0.00e+00	1837.00
IUUC-Mpu-065825	Mustela putorius furo	78.63	0.00e+00	815.00
IUUC-Mlu-068176	Myotis lucifugus	72.35	0.00e+00	2407.00
IUUC-Nle-069178	Nomascus leucogenys	95.92	0.00e+00	3459.00
IUUC-Opr-070574	Ochotona princeps	60.47	0.00e+00	1974.00
IUUC-Ont-072380	Oreochromis niloticus	48.06	1.00e-56	215.00
IUUC-Oan-073243	Ornithorhynchus anatinus	76.19	1.00e-34	138.00
IUUC-Ocu-074424	Oryctolagus cuniculus	69.42	0.00e+00	2374.00
IUUC-Ola-086863	Oryzias latipes	48.29	6.00e-54	206.00
IUUC-Oar-089938	Ovis aries	72.39	0.00e+00	2583.00
IUUC-Ptr-090960	Pan troglodytes	98.23	0.00e+00	3526.00
IUUC-Pan-092609	Papio anubis	92.46	0.00e+00	3002.00
IUUC-Psi-093889	Pelodiscus sinensis	30.93	4.00e-55	210.00
IUUC-Pfo-096328	Poecilia formosa	50.70	2.00e-59	224.00
IUUC-Pab-097982	Pongo abelii	96.83	0.00e+00	3504.00
IUUC-Pca-100698	Procavia capensis	64.89	0.00e+00	676.00
IUUC-Pva-102631	Pteropus vampyrus	77.70	0.00e+00	1181.00
IUUC-Rno-105879	Rattus norvegicus	55.98	0.00e+00	1802.00
IUUC-Sha-106701	Sarcophilus harrisii	38.94	0.00e+00	692.00
IUUC-Spo-108335	Schizosaccharomyces pombe	32.58	2.00e-09	57.40
IUUC-Sar-113047	Sorex araneus	64.29	0.00e+00	1535.00
IUUC-Ssc-115846	Sus scrofa	74.21	0.00e+00	2658.00
IUUC-Tgu-116785	Taeniopygia guttata	29.85	2.00e-91	331.00
IUUC-Tru-117895	Takifugu rubripes	40.70	2.00e-54	208.00
IUUC-Tsy-118885	Tarsius syrichta	60.97	0.00e+00	733.00
IUUC-Tni-119654	Tetraodon nigroviridis	45.63	7.00e-50	193.00
IUUC-Tbe-127421	Tupaia belangeri	63.33	1.00e-164	574.00
IUUC-Ttr-128685	Tursiops truncatus	75.98	0.00e+00	2558.00
IUUC-Vpa-130216	Vicugna pacos	71.94	0.00e+00	883.00
IUUC-Xtr-132398	Xenopus tropicalis	35.89	2.00e-63	238.00
IUUC-Xma-133651	Xiphophorus maculatus	52.35	3.00e-45	177.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence