iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000146833.15	ENST00000447480.5	ENSP00000396229.1
ENSG00000146833.15	ENST00000355947.6	ENSP00000348216.2
ENSG00000146833.15	ENST00000349062.6	ENSP00000275736.4
ENSG00000146833.15	ENST00000354241.5	ENSP00000346186.5

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	3.70e-07	31.8	6	73
E3 activity/RING/RING	1.60e-08	36.6	12	53

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk..tcPvtrqplteedlvPnltlrrliqa 67
           + ee+ CpI l+ ++dPv +++G+ + r ++++  a gg    cP +r+p ++  l Pn +l rl ++
   Q: 6    IQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGpfPCPECRHPSAPAALRPNWALARLTEK 73
           7899***************************98556665569*******************9998776 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl+ f+d p++  CgH f++ Cl  +w        + f CP Cr
   Q: 12   CPICLDYFQD-PVSIECGHNFCRGCLhRNW----APGGGPFPCPECR 53
           **********.***************99**....779*********8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction.

Protein Sequence
(Fasta)

MEAEDIQEEL TCPICLDYFQ DPVSIECGHN FCRGCLHRNW APGGGPFPCP ECRHPSAPAA 60
LRPNWALARL TEKTQRRRLG PVPPGLCGRH WEPLRLFCED DQRPVCLVCR ESQEHQTHAM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGTCTTGCG CGCTCAGGCC GGGCAACGTC CGTGCGTTCT TTTTGGGTCC TGAACCCCGG 60
AAGAGAAACT GCGTTGTACC CTTTTACGTG AGGCGGTGAC GGCGGTTCGG AAGTCGTCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0070206--P:protein trimerization
GO:0016567--P:protein ubiquitination

KEGG

hsa:89122

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002308	Ailuropoda melanoleuca	63.40	5.00e-160	557.00
IUUC-Cel-018621	Caenorhabditis elegans	32.97	4.00e-09	56.20
IUUC-Cja-019204	Callithrix jacchus	87.40	0.00e+00	869.00
IUUC-Cfa-021283	Canis familiaris	74.05	0.00e+00	720.00
IUUC-Csa-023476	Chlorocebus sabaeus	91.40	0.00e+00	892.00
IUUC-Cho-024657	Choloepus hoffmanni	63.00	1.00e-162	565.00
IUUC-Eca-033740	Equus caballus	77.93	4.00e-162	563.00
IUUC-Mcc-055643	Macaca mulatta	94.20	0.00e+00	929.00
IUUC-Mmr-061318	Microcebus murinus	74.85	0.00e+00	754.00
IUUC-Mpu-066377	Mustela putorius furo	71.66	0.00e+00	678.00
IUUC-Mlu-067319	Myotis lucifugus	74.17	4.00e-146	511.00
IUUC-Nle-069382	Nomascus leucogenys	96.20	0.00e+00	676.00
IUUC-Opr-070278	Ochotona princeps	65.00	2.00e-174	605.00
IUUC-Oga-088830	Otolemur garnettii	66.07	1.00e-158	552.00
IUUC-Oar-089188	Ovis aries	71.26	0.00e+00	691.00
IUUC-Pan-092332	Papio anubis	93.40	0.00e+00	927.00
IUUC-Pab-097648	Pongo abelii	93.60	0.00e+00	913.00
IUUC-Pva-102131	Pteropus vampyrus	73.65	0.00e+00	720.00
IUUC-Ssc-116309	Sus scrofa	67.86	6.00e-176	610.00
IUUC-Tsy-119365	Tarsius syrichta	74.11	6.00e-137	480.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence