• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046546
UUCD1 version UUC-HoS-01136
Ensembl Protein ID ENSP00000263966.3
UniProt Accession Q92995; A8K2S3; B4DYF3; D3DNS2; Q96B25; UBP13_HUMAN
Genbank Protein ID AAC63405.1; BAF83027.1; BAG63715.1; EAW78383.1; EAW78384.1; AAH16146.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinating enzyme 13; Isopeptidase T-3; Ubiquitin thioesterase 13; Ubiquitin-specific-processing protease 13
Genbank Nucleotide ID U75362; AK290338; AK302404; AC007687; CH471052; BC016146
Gene Name USP13; ISOT3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000058056.8 ENST00000263966.7 ENSP00000263966.3
ENSG00000058056.8 ENST00000497380.1 ENSP00000418651.1
ENSG00000058056.8 ENST00000497155.1 ENSP00000420057.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 12401499
UBD/Alpha-Helix/UBA UBA 22216260
Classification
Family E-value Score Start End
DUB/USP 3.50e-57 195.8 336 860
UBD/Alpha-Helix/UBA 4.60e-20 72.7 730 767
Active Site
Position(s) Description Evidence
345 Nucleophile ECO:0000305}
823 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkkavsp 70
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ +sp
   Q: 336  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppvkselieqvmkeeHKPQQNGISP 426
           7******************************788777765.79*****************8888888888888877765543388888**** PP
   S: 71   rellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnv 162
           r++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c + ++v
   Q: 427  RMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSENPSDVFRFLVEERIQCCQTRKV 489
           **********************************998.............................688899******************** PP
   S: 163  ssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekklklkklP 227
             +e   + ++lpv ++  t+k                             ++ cL++f+++e++++   ++++  ++k+  +k+ ++ ++P
   Q: 490  RYTERVDYLMQLPVAMEAATNKDeliayeltrreaeanrrplpelvrakiPFSACLQAFSEPENVDD---FWSSALQAKSAGVKTSRFASFP 578
           9999999999999999998887799****************************************97...********************** PP
   S: 228  evLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.................................................... 267
           e+L++++k+f+f  + ++++k++ ++++p+ Ld+++  ++                                                    
   Q: 579  EYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDINHLRARglqpgeeelpdisppivipddskdrlmnqlidpsdidessvmqlaemgfple 669
           ************997.*******************999889999999999999999998888888888888888888888877777777777 PP
   S: 268  ........................................................................................peek 271
                                                                                                   +   
   Q: 670  acrkavyftgnmgaevafnwiivhmeepdfaepltmpgyggaasagasvfgasgldnqppeeivaiitsmgfqrnqaiqalratnnnlE--- 758
           77777777777777777777777777777777777777777777777777777777666666666666666666666666665555550... PP
   S: 272  qke...........................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevke 319
             +                                           + +YeL+a ++H+G s+ sGHY++++k+ +g+W+ ++D+kV ++  
   Q: 759  --RaldwifshpefeedsdfviemennananiiseakpegprvkdgSGTYELFAFISHMGtSTMSGHYICHIKK-EGRWVIYNDHKVCAS-- 845
           ..05555555555555555666666666677788888888888888****************************.9***********999.. PP
   S: 320  eevleetgstaYvlfYkr 337
           e+  +   + +Y++fY+r
   Q: 846  ERPPK---DLGYMYFYRR 860
           78888...99******98 PP
   

   UBD/Alpha-Helix/UBA
   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaLra+nnnle+A+++++++
   Q: 730  EEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSH 767
           899*********************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.
 Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.
Protein Sequence
(Fasta)
MQRRGALFGM PGGSGGRKMA AGDIGELLVP HMPTIRVPRS GDRVYKNECA FSYDSPNSEG 60
GLYVCMNTFL AFGREHVERH FRKTGQSVYM HLKRHVREKV RGASGGALPK RRNSKIFLDL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046546|DUB,USP;UBD,UBA|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCCTCCTCG GAGTTGCCCC TCTGCAAGCC AACAATTCGG GATAGAAAAC ACCTCCGTGG 60
TGTTTTCCCG GGGCCCTCCC GCGCCGCGTT CGGCCGCCAG CCCGCTCGAG CTCCCGCGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046546|DUB,USP;UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP
SMART

SM00165--UBA
SM00290--ZnF_UBP
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:1904288--F:BAT3 complex binding
GO:0051087--F:chaperone binding
GO:0004197--F:cysteine-type endopeptidase activity
GO:0070628--F:proteasome binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0044389--F:ubiquitin-like protein ligase binding
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0030318--P:melanocyte differentiation
GO:1904294--P:positive regulation of ERAD pathway
GO:0016579--P:protein deubiquitination
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:8975
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001356 Ailuropoda melanoleuca 98.25 0.00e+00 1612.00
IUUC-Apl-003712 Anas platyrhynchos 83.72 0.00e+00 1354.00
IUUC-Aca-004634 Anolis carolinensis 83.43 0.00e+00 1403.00
IUUC-Ame-011470 Astyanax mexicanus 74.45 0.00e+00 1288.00
IUUC-Bta-013349 Bos taurus 98.03 0.00e+00 1653.00
IUUC-Cja-019021 Callithrix jacchus 97.45 0.00e+00 1598.00
IUUC-Cfa-020614 Canis familiaris 98.49 0.00e+00 1624.00
IUUC-Cpo-022484 Cavia porcellus 98.03 0.00e+00 1512.00
IUUC-Csa-024078 Chlorocebus sabaeus 99.54 0.00e+00 1636.00
IUUC-Cho-024522 Choloepus hoffmanni 81.41 0.00e+00 1181.00
IUUC-Cme-027335 Cyanidioschyzon merolae 25.58 3.00e-53 204.00
IUUC-Dre-027651 Danio rerio 74.94 0.00e+00 1349.00
IUUC-Dno-028975 Dasypus novemcinctus 98.27 0.00e+00 1621.00
IUUC-Dor-030130 Dipodomys ordii 73.90 0.00e+00 1075.00
IUUC-Ete-032251 Echinops telfairi 82.78 0.00e+00 1282.00
IUUC-Eca-033568 Equus caballus 98.88 0.00e+00 1514.00
IUUC-Eeu-034612 Erinaceus europaeus 79.80 0.00e+00 1151.00
IUUC-Fca-036280 Felis catus 98.76 0.00e+00 1510.00
IUUC-Fal-036610 Ficedula albicollis 84.52 0.00e+00 1330.00
IUUC-Gmo-038906 Gadus morhua 72.66 0.00e+00 1254.00
IUUC-Gga-041215 Gallus gallus 83.24 0.00e+00 1429.00
IUUC-Gac-042441 Gasterosteus aculeatus 72.25 0.00e+00 1267.00
IUUC-Ggo-044446 Gorilla gorilla 99.54 0.00e+00 1635.00
IUUC-Itr-048147 Ictidomys tridecemlineatus 89.67 0.00e+00 1435.00
IUUC-Lch-050425 Latimeria chalumnae 77.85 0.00e+00 1354.00
IUUC-Loc-052072 Lepisosteus oculatus 77.60 0.00e+00 1308.00
IUUC-Laf-053909 Loxodonta africana 96.42 0.00e+00 1608.00
IUUC-Mcc-054686 Macaca mulatta 99.54 0.00e+00 1637.00
IUUC-Meu-056361 Macropus eugenii 80.45 0.00e+00 1306.00
IUUC-Mga-059972 Meleagris gallopavo 79.11 0.00e+00 1296.00
IUUC-Mmr-060916 Microcebus murinus 97.80 0.00e+00 1615.00
IUUC-Mdo-062302 Monodelphis domestica 89.40 0.00e+00 1511.00
IUUC-Mmu-063639 Mus musculus 95.48 0.00e+00 1604.00
IUUC-Mpu-066533 Mustela putorius furo 98.61 0.00e+00 1625.00
IUUC-Mlu-067786 Myotis lucifugus 91.67 0.00e+00 1470.00
IUUC-Nle-069997 Nomascus leucogenys 99.62 0.00e+00 1504.00
IUUC-Ont-071859 Oreochromis niloticus 72.58 0.00e+00 1271.00
IUUC-Oan-072959 Ornithorhynchus anatinus 88.70 6.00e-128 449.00
IUUC-Ocu-074265 Oryctolagus cuniculus 98.02 0.00e+00 1602.00
IUUC-Ola-087344 Oryzias latipes 71.61 0.00e+00 1280.00
IUUC-Oga-088734 Otolemur garnettii 98.32 0.00e+00 1556.00
IUUC-Oar-089636 Ovis aries 98.02 0.00e+00 1573.00
IUUC-Ptr-090982 Pan troglodytes 99.77 0.00e+00 1638.00
IUUC-Pan-091991 Papio anubis 99.65 0.00e+00 1638.00
IUUC-Psi-093509 Pelodiscus sinensis 86.37 0.00e+00 1459.00
IUUC-Pfo-096029 Poecilia formosa 74.16 0.00e+00 1318.00
IUUC-Pab-098672 Pongo abelii 95.48 0.00e+00 1537.00
IUUC-Pca-100860 Procavia capensis 74.07 0.00e+00 1041.00
IUUC-Pva-102545 Pteropus vampyrus 90.15 0.00e+00 1476.00
IUUC-Rno-105210 Rattus norvegicus 94.90 0.00e+00 1588.00
IUUC-Sar-113733 Sorex araneus 96.29 0.00e+00 771.00
IUUC-Tgu-116591 Taeniopygia guttata 84.49 0.00e+00 1429.00
IUUC-Tru-118627 Takifugu rubripes 70.83 0.00e+00 1280.00
IUUC-Tsy-119278 Tarsius syrichta 89.96 0.00e+00 1355.00
IUUC-Tni-120804 Tetraodon nigroviridis 73.90 0.00e+00 1309.00
IUUC-Tbe-127699 Tupaia belangeri 79.19 0.00e+00 872.00
IUUC-Ttr-128295 Tursiops truncatus 89.93 0.00e+00 1472.00
IUUC-Vpa-130170 Vicugna pacos 87.11 0.00e+00 1333.00
IUUC-Xtr-132809 Xenopus tropicalis 74.01 0.00e+00 1272.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved