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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046246
UUCD1 version UUC-HoS-00245
Ensembl Protein ID ENSP00000489017.1
UniProt Accession Q8NI29; Q96C87; FBX27_HUMAN
Genbank Protein ID AAM27918.1; AAH14527.1; AAH30060.1
Protein Name F-box only protein 27; F-box/G-domain protein 5
Genbank Nucleotide ID AF436061; BC014527; BC030060
Gene Name FBXO27; FBG5; FBX27
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000283021.1 ENST00000635718.1 ENSP00000489413.1
ENSG00000283021.1 ENST00000635513.1 ENSP00000489017.1
ENSG00000283021.1 ENST00000634370.1 ENSP00000489600.1
Annotation
Cancer Mutation
TCGACOSMICCGAPIntOGen
mRNA Expression
TCGAICGCCOSMICTHPA
HPM
DNA & RNA Element
UTRdbCircNetRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Disease-associated Information
ClinVar
Post-translational Modifications (PTMs)
PhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 18203720
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 5.50e-07 31.4 10 67
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 84   papapaptptpeegpdaglldrlpeeilveilklldkee.llraarvcrrwqelasqkalw 143
            a  pap p pee  d   l++lp e+l+ +l+++++++ l+r+++vcr w+ l + +alw
   Q: 10   AARVPAPEPEPEEALD---LSQLPPELLLVVLSHVPPRTlLGRCRQVCRGWRALVDGQALW 67
           4567888888888665...79**************888889***********999889988 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.
 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.
Protein Sequence
(Fasta)
MGASVSRGRA ARVPAPEPEP EEALDLSQLP PELLLVVLSH VPPRTLLGRC RQVCRGWRAL 60
VDGQALWLLI LARDHGATGR ALLHLARSCQ SPARNARPCP LGRFCARRPI GRNLIRNPCG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046246|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTAACGAAT TAGGGACACT TCAAGGGGCC GGCTGGAGGG GACGGCTGTG AGCAGCAGGC 60
CTTGGCTCCT GGCTGCACCT GGCCCCGTCG CGGGAAGCAG GTTGGGTTTG GAGAGCGGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046246|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR007397--F-box-assoc_dom
IPR001810--F-box_dom
IPR008979--Galactose-bd-like
PROSITE

PS51114--FBA
PS50181--FBOX
Pfam

PF00646--F-box
PF04300--FBA
SMART

SM01198--FBA
SM00256--FBOX
Gene Ontology

GO:0005829--C:cytosol
GO:0019005--C:SCF ubiquitin ligase complex
GO:0001948--F:glycoprotein binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination
KEGG hsa:126433
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000489 Aegilops tauschii 23.85 3.70e-02 33.10
IUUC-Atr-002814 Amborella trichopoda 22.34 1.00e-03 38.50
IUUC-Aly-006468 Arabidopsis lyrata 23.12 1.00e-02 35.00
IUUC-Ath-006777 Arabidopsis thaliana 23.04 5.00e-03 35.80
IUUC-Aor-010203 Aspergillus oryzae 30.12 1.40e-02 33.50
IUUC-Bdi-014682 Brachypodium distachyon 22.92 3.00e-03 36.60
IUUC-Bol-016499 Brassica oleracea 23.62 7.00e-03 35.80
IUUC-Bra-017808 Brassica rapa 23.62 6.00e-03 35.80
IUUC-Cja-019871 Callithrix jacchus 93.80 5.00e-136 476.00
IUUC-Cfa-020053 Canis familiaris 88.69 3.00e-123 434.00
IUUC-Csa-023100 Chlorocebus sabaeus 90.53 6.00e-140 489.00
IUUC-Fso-038280 Fusarium solani 41.03 2.90e-01 30.00
IUUC-Gma-044397 Glycine max 23.62 3.00e-03 37.00
IUUC-Ggo-045230 Gorilla gorilla 100.00 5.00e-142 496.00
IUUC-Itr-048188 Ictidomys tridecemlineatus 85.87 2.00e-115 408.00
IUUC-Loc-052041 Lepisosteus oculatus 40.38 6.00e-49 187.00
IUUC-Mcc-054973 Macaca mulatta 95.42 8.00e-132 462.00
IUUC-Mtr-058347 Medicago truncatula 21.47 4.00e-03 36.20
IUUC-Mdo-062210 Monodelphis domestica 57.74 1.00e-78 286.00
IUUC-Mmu-063852 Mus musculus 80.17 1.00e-104 372.00
IUUC-Mac-064752 Musa acuminata 21.58 9.00e-03 35.40
IUUC-Mpu-066761 Mustela putorius furo 87.10 2.00e-109 388.00
IUUC-Ocu-074332 Oryctolagus cuniculus 85.08 7.00e-90 322.00
IUUC-Oba-075157 Oryza barthii 23.16 3.00e-03 37.00
IUUC-Ogl-076940 Oryza glaberrima 23.16 3.00e-03 37.00
IUUC-Ogu-078490 Oryza glumaepatula 23.16 3.00e-03 37.00
IUUC-Oin-080202 Oryza indica 23.16 3.00e-03 37.00
IUUC-Ome-081183 Oryza meridionalis 23.16 4.00e-03 36.60
IUUC-Oni-082316 Oryza nivara 23.16 3.00e-03 37.00
IUUC-Opu-083525 Oryza punctata 22.60 3.00e-03 37.00
IUUC-Oru-084222 Oryza rufipogon 23.16 3.00e-03 37.00
IUUC-Osa-085929 Oryza sativa 23.16 3.00e-03 37.00
IUUC-Oga-088717 Otolemur garnettii 75.35 2.00e-105 375.00
IUUC-Oar-089830 Ovis aries 53.96 8.00e-63 233.00
IUUC-Ptr-090465 Pan troglodytes 100.00 7.00e-51 193.00
IUUC-Pan-092784 Papio anubis 86.01 4.00e-83 300.00
IUUC-Ppa-095643 Physcomitrella patens 21.32 6.80e-02 32.70
IUUC-Pab-097750 Pongo abelii 99.59 4.00e-143 500.00
IUUC-Pop-099192 Populus trichocarpa 23.12 2.00e-03 37.70
IUUC-Ppe-101432 Prunus persica 22.61 1.00e-02 35.40
IUUC-Rno-104897 Rattus norvegicus 66.15 4.00e-58 217.00
IUUC-Smo-108852 Selaginella moellendorffii 21.58 2.00e-03 37.00
IUUC-Sit-109908 Setaria italica 23.68 2.00e-03 37.40
IUUC-Sbi-114081 Sorghum bicolor 23.44 3.00e-04 40.40
IUUC-Ssc-115329 Sus scrofa 55.64 4.00e-69 254.00
IUUC-Tca-121808 Theobroma cacao 23.12 7.00e-03 35.80
IUUC-Tre-122016 Trichoderma reesei 36.54 7.10e-02 32.30
IUUC-Tae-124548 Triticum aestivum 22.92 4.00e-03 36.60
IUUC-Tur-126777 Triticum urartu 24.62 7.00e-03 35.80
IUUC-Tbe-128058 Tupaia belangeri 80.62 9.00e-75 272.00
IUUC-Vpa-130584 Vicugna pacos 51.60 3.00e-52 197.00
IUUC-Vvi-131436 Vitis vinifera 23.35 2.00e-03 37.70
Created Date 25-Jun-2017

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