iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD	DrugBank	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/PB1	PB1	16949360; 17726178

Classification

Family	E-value	Score	Start	End
ULD/UDP/UFD/PB1	4.00e-15	57.4	43	122

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelknsevalkYeDedGDlvtlksDedldkavslla...skksllrlliqk 83
           +vrvk++++ge r+  l++++p+k+edL+++ +     ++++++l+Y++++  +++l++++dldkav+ll+   ++ksl+ ll+ +
   Q: 43   DVRVKFEHRGEKRI--LQFPRPVKLEDLRSKAKI---AFGQSMDLHYTNNEL-VIPLTTQDDLDKAVELLDrsiHMKSLKILLVIN 122
           59**********77..******************...***************.***************************999975 PP

Organism

Homo sapiens

Functional Description
(View)

Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.

Protein Sequence
(Fasta)

MDDQQALNSI MQDLAVLHKA SRPALSLQET RKAKSSSPKK QNDVRVKFEH RGEKRILQFP 60
RPVKLEDLRS KAKIAFGQSM DLHYTNNELV IPLTTQDDLD KAVELLDRSI HMKSLKILLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCTAAAGT CCCTCAGGAA AAAAATTCTG AAACTTGAGC CACAAATTAA GAGGCAGACG 60
GCTTTTCTCC TTGCAAATGA CCTGCCACAC AGTCCGTCAC TGCCTCTGCT AGCTCTGCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0832--Ubl conjugation

Interpro

IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS

PROSITE

PS51745--PB1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM

Pfam

PF00564--PB1
PF00069--Pkinase

SMART

SM00666--PB1
SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004709--F:MAP kinase kinase kinase activity
GO:0046872--F:metal ion binding
GO:0004672--F:protein kinase activity
GO:0019901--F:protein kinase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0004702--F:signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0030036--P:actin cytoskeleton organization
GO:0007257--P:activation of JUN kinase activity
GO:0000187--P:activation of MAPK activity
GO:0071260--P:cellular response to mechanical stimulus
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006468--P:protein phosphorylation

KEGG

hsa:10746

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000356	Aegilops tauschii	50.19	4.00e-60	226.00
IUUC-Aml-002019	Ailuropoda melanoleuca	93.69	0.00e+00	1104.00
IUUC-Apl-003268	Anas platyrhynchos	89.33	0.00e+00	1087.00
IUUC-Aca-004909	Anolis carolinensis	83.80	0.00e+00	1012.00
IUUC-Ame-011723	Astyanax mexicanus	81.73	0.00e+00	965.00
IUUC-Bta-012860	Bos taurus	90.52	0.00e+00	1083.00
IUUC-Cja-019658	Callithrix jacchus	98.38	0.00e+00	1152.00
IUUC-Cfa-020514	Canis familiaris	98.87	0.00e+00	1163.00
IUUC-Cpo-022288	Cavia porcellus	88.03	0.00e+00	1037.00
IUUC-Csa-023826	Chlorocebus sabaeus	99.84	0.00e+00	1174.00
IUUC-Cho-024659	Choloepus hoffmanni	85.25	3.00e-152	531.00
IUUC-Csv-026215	Ciona savignyi	47.10	8.00e-130	457.00
IUUC-Dre-028720	Danio rerio	80.13	0.00e+00	974.00
IUUC-Dno-029457	Dasypus novemcinctus	97.42	0.00e+00	1127.00
IUUC-Dor-030165	Dipodomys ordii	83.26	9.00e-174	603.00
IUUC-Ete-032341	Echinops telfairi	97.25	0.00e+00	1143.00
IUUC-Eca-033357	Equus caballus	92.36	0.00e+00	1094.00
IUUC-Eeu-034768	Erinaceus europaeus	90.63	0.00e+00	1043.00
IUUC-Fca-036450	Felis catus	88.35	0.00e+00	1073.00
IUUC-Fal-037042	Ficedula albicollis	90.71	0.00e+00	1100.00
IUUC-Gmo-038470	Gadus morhua	67.78	0.00e+00	670.00
IUUC-Gac-041545	Gasterosteus aculeatus	79.65	0.00e+00	966.00
IUUC-Ggo-044919	Gorilla gorilla	100.00	0.00e+00	1176.00
IUUC-Itr-048779	Ictidomys tridecemlineatus	98.06	0.00e+00	1149.00
IUUC-Lch-049757	Latimeria chalumnae	88.42	0.00e+00	1076.00
IUUC-Loc-052095	Lepisosteus oculatus	87.12	0.00e+00	1021.00
IUUC-Laf-054146	Loxodonta africana	98.06	0.00e+00	1152.00
IUUC-Mcc-055457	Macaca mulatta	99.84	0.00e+00	1174.00
IUUC-Meu-056073	Macropus eugenii	82.17	0.00e+00	835.00
IUUC-Mga-059921	Meleagris gallopavo	88.35	0.00e+00	1070.00
IUUC-Mmr-061086	Microcebus murinus	98.23	0.00e+00	1149.00
IUUC-Mdo-063081	Monodelphis domestica	93.71	0.00e+00	1131.00
IUUC-Mmu-063195	Mus musculus	96.28	0.00e+00	1136.00
IUUC-Mpu-066387	Mustela putorius furo	86.81	0.00e+00	1045.00
IUUC-Mlu-067395	Myotis lucifugus	94.34	0.00e+00	1124.00
IUUC-Nle-069756	Nomascus leucogenys	100.00	0.00e+00	1176.00
IUUC-Opr-070291	Ochotona princeps	91.28	0.00e+00	1109.00
IUUC-Ont-071421	Oreochromis niloticus	79.24	0.00e+00	942.00
IUUC-Ocu-074330	Oryctolagus cuniculus	97.90	0.00e+00	1159.00
IUUC-Ola-086643	Oryzias latipes	80.09	0.00e+00	965.00
IUUC-Oga-089147	Otolemur garnettii	94.37	0.00e+00	1077.00
IUUC-Oar-089464	Ovis aries	97.74	0.00e+00	1182.00
IUUC-Ptr-090928	Pan troglodytes	99.84	0.00e+00	1173.00
IUUC-Pan-092896	Papio anubis	99.81	0.00e+00	994.00
IUUC-Psi-093466	Pelodiscus sinensis	92.28	0.00e+00	971.00
IUUC-Pma-094492	Petromyzon marinus	68.38	0.00e+00	836.00
IUUC-Pab-097733	Pongo abelii	99.52	0.00e+00	1167.00
IUUC-Pca-100894	Procavia capensis	82.66	0.00e+00	944.00
IUUC-Pva-102822	Pteropus vampyrus	98.22	0.00e+00	1146.00
IUUC-Rno-106050	Rattus norvegicus	96.12	0.00e+00	1134.00
IUUC-Sha-106471	Sarcophilus harrisii	93.87	0.00e+00	1108.00
IUUC-Sar-112961	Sorex araneus	88.21	0.00e+00	1006.00
IUUC-Ssc-115588	Sus scrofa	98.39	0.00e+00	1190.00
IUUC-Tgu-116831	Taeniopygia guttata	87.28	0.00e+00	1035.00
IUUC-Tru-118223	Takifugu rubripes	78.11	0.00e+00	870.00
IUUC-Tsy-118788	Tarsius syrichta	68.34	0.00e+00	695.00
IUUC-Tni-120141	Tetraodon nigroviridis	78.06	0.00e+00	882.00
IUUC-Tbe-127378	Tupaia belangeri	77.10	0.00e+00	781.00
IUUC-Ttr-128905	Tursiops truncatus	87.48	0.00e+00	852.00
IUUC-Vpa-130781	Vicugna pacos	98.54	0.00e+00	1148.00
IUUC-Xtr-132672	Xenopus tropicalis	82.48	0.00e+00	951.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence