iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063928

Ensembl Protein ID

ENSMUSP00000026888.4

UniProt Accession

Q5HZG4; Q3U490; Q3UWX2; Q8BIU8; Q99JH4; TAF3_MOUSE

Genbank Protein ID

CAC34476.1; BAC39218.1; BAE22792.1; BAE32543.1; AAH89030.1

Protein Name

Transcription initiation factor TFIID subunit 3; 140 kDa TATA box-binding protein-associated factor; TBP-associated factor 3; Transcription initiation factor TFIID 140 kDa subunit

Genbank Nucleotide ID

AJ292189; AK084574; AK136045; AK154372; BC089030

Gene Name

Taf3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000025782.12	ENSMUST00000026888.10	ENSMUSP00000026888.4
ENSMUSG00000025782.12	ENSMUST00000114907.1	ENSMUSP00000110557.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.60e-09	37.8	869	916

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           +C+ C ++++++  ++ C++C++w+H+ C+++      p++ +w+CpkC +
   Q: 869  ICPGCNKPDDGS-PMIGCDDCDDWYHWPCVGIM--AAPPEEMQWFCPKCAN 916
           699999999987.7*******************..44444445******86 PP

Organism

Mus musculus

Functional Description
(View)

Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.

Protein Sequence
(Fasta)

MCESYSRSLL RVSVAQICQA LGWDSVQLSA CHLLTDVLQR YLQQLGRGCH RYSELYGRTD 60
PILDDVGEAF QLMGVNLHEL EDYIHNIEPV TFPHQIPSFP VSKNNVLQFP QPGSKDAEER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGAGTCCAA AATGGCGGCT CTCAGGCTGG CGCGCTCCGT GCTGCTGAGG CTTTGAGGTG 60
GTCGCTCCGG GTCGGAGGGG GGACGATTTC CCCGCCGCGG GGCCCCCAGA GAATGAATCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011989--ARM-like
IPR006565--BTP
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF07524--Bromo_TP
PF00628--PHD

SMART

SM00576--BTP
SM00249--PHD

Gene Ontology

GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005669--C:transcription factor TFIID complex
GO:0002039--F:p53 binding
GO:0008270--F:zinc ion binding
GO:0051457--P:maintenance of protein location in nucleus
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter

KEGG

mmu:209361

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003831	Anas platyrhynchos	67.15	3.00e-86	313.00
IUUC-Bta-012541	Bos taurus	83.40	0.00e+00	709.00
IUUC-Cel-018700	Caenorhabditis elegans	53.06	8.00e-14	73.20
IUUC-Cja-019753	Callithrix jacchus	83.87	1.00e-106	381.00
IUUC-Cfa-021153	Canis familiaris	83.90	0.00e+00	888.00
IUUC-Cpo-022178	Cavia porcellus	82.66	0.00e+00	697.00
IUUC-Csa-023797	Chlorocebus sabaeus	85.41	0.00e+00	723.00
IUUC-Cho-024357	Choloepus hoffmanni	83.62	2.00e-76	281.00
IUUC-Cin-025173	Ciona intestinalis	65.28	1.00e-27	115.00
IUUC-Csv-026292	Ciona savignyi	60.00	1.00e-24	107.00
IUUC-Dno-029644	Dasypus novemcinctus	76.59	1.00e-127	450.00
IUUC-Dme-031631	Drosophila melanogaster	38.17	4.00e-24	107.00
IUUC-Eeu-034542	Erinaceus europaeus	78.62	9.00e-120	424.00
IUUC-Fca-035867	Felis catus	80.94	5.00e-135	475.00
IUUC-Fal-037442	Ficedula albicollis	70.73	3.00e-161	562.00
IUUC-Gga-041093	Gallus gallus	72.23	9.00e-158	551.00
IUUC-Gac-041347	Gasterosteus aculeatus	57.79	6.00e-79	289.00
IUUC-Hsa-047012	Homo sapiens	84.54	0.00e+00	698.00
IUUC-Itr-048120	Ictidomys tridecemlineatus	87.57	0.00e+00	861.00
IUUC-Lch-049593	Latimeria chalumnae	61.40	2.00e-62	234.00
IUUC-Loc-052228	Lepisosteus oculatus	93.51	2.00e-44	171.00
IUUC-Laf-054492	Loxodonta africana	82.93	0.00e+00	718.00
IUUC-Mcc-054754	Macaca mulatta	85.41	0.00e+00	675.00
IUUC-Mmr-061146	Microcebus murinus	88.11	0.00e+00	717.00
IUUC-Mdo-062034	Monodelphis domestica	81.52	0.00e+00	667.00
IUUC-Mpu-066634	Mustela putorius furo	83.01	0.00e+00	671.00
IUUC-Mlu-067116	Myotis lucifugus	80.85	7.00e-163	567.00
IUUC-Nle-069177	Nomascus leucogenys	79.12	0.00e+00	676.00
IUUC-Opr-070692	Ochotona princeps	84.71	3.00e-90	326.00
IUUC-Oan-073680	Ornithorhynchus anatinus	75.78	1.00e-143	503.00
IUUC-Ocu-074944	Oryctolagus cuniculus	86.59	0.00e+00	994.00
IUUC-Olu-087787	Ostreococcus lucimarinus	39.66	2.00e-07	51.60
IUUC-Oga-088921	Otolemur garnettii	81.94	0.00e+00	974.00
IUUC-Oar-089568	Ovis aries	77.31	2.00e-111	396.00
IUUC-Ptr-090531	Pan troglodytes	86.04	0.00e+00	729.00
IUUC-Pan-092733	Papio anubis	85.90	0.00e+00	680.00
IUUC-Psi-093411	Pelodiscus sinensis	75.32	7.00e-143	501.00
IUUC-Pma-094511	Petromyzon marinus	39.77	4.00e-29	123.00
IUUC-Pfo-096336	Poecilia formosa	54.47	8.00e-91	328.00
IUUC-Pab-098458	Pongo abelii	84.07	0.00e+00	726.00
IUUC-Pva-102128	Pteropus vampyrus	81.83	0.00e+00	673.00
IUUC-Rno-105180	Rattus norvegicus	95.63	0.00e+00	1034.00
IUUC-Sha-107070	Sarcophilus harrisii	70.22	1.00e-101	363.00
IUUC-Ssc-115657	Sus scrofa	76.12	3.00e-107	383.00
IUUC-Tgu-117228	Taeniopygia guttata	70.86	2.00e-159	556.00
IUUC-Tru-117787	Takifugu rubripes	51.20	1.00e-99	357.00
IUUC-Tni-119879	Tetraodon nigroviridis	50.75	3.00e-101	363.00
IUUC-Tbe-127747	Tupaia belangeri	75.43	0.00e+00	724.00
IUUC-Ttr-128397	Tursiops truncatus	78.84	8.00e-97	347.00
IUUC-Xtr-132570	Xenopus tropicalis	56.66	5.00e-155	541.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence