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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045961
UUCD1 version UUC-HoS-01121
Ensembl Protein ID ENSP00000285199.6
UniProt Accession Q70EL4; A6NDT9; B7ZLT9; B7ZVX5; Q8N2C5; Q96DQ6; UBP43_HUMAN
Genbank Protein ID CAE47744.2; BAB70869.1; EAW90022.1; AAI36369.1; AAI44042.1; AAI71759.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 43; Deubiquitinating enzyme 43; Ubiquitin thioesterase 43; Ubiquitin-specific-processing protease 43
Genbank Nucleotide ID AJ583817; AK055188; AK090821; BC136368; BC144041; BC171759
Gene Name USP43
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000154914.16 ENST00000570475.5 ENSP00000458963.1
ENSG00000154914.16 ENST00000285199.11 ENSP00000285199.6
ENSG00000154914.16 ENST00000574408.5 ENSP00000459328.3
ENSG00000154914.16 ENST00000573955.1 ENSP00000477318.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProt
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 11788588; 21298066
Classification
Family E-value Score Start End
DUB/USP 1.50e-91 308.7 101 710
Active Site
Position(s) Description Evidence
110 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
668 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDa 92
           +GlkN+gNtC+mN+v+QcLsn+  l+e+l     ++ +        +e++++l+ l+++lw+++ +     e+++a++k+ ++f+g++q+Da
   Q: 101  QGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPG------RAEVTEQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDA 186
           6****************************9955555555......479******************************************** PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsde..aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeet 182
            Efl +lld+++e+l+ +++ p++e+   + +++s++  +++ +   ++s+++  Fq q++s+++c++c ++s++++pfl +slp+p ++++
   Q: 187  LEFLLWLLDRVHEDLEGSSRGPVSEKLPPEATKTSENclSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLRQTR 278
           ***************999999999998888888888777889999999******************************************98 PP
   S: 183  kke......................................................................................... 185
            ++                                                                                         
   Q: 279  FLSvtlvfpsksqrflrvglavpilstvaalrkmvaeeggvpadevilvelypsgfqrsffdeedlntiaegdnvyafqvppspsqgtlsah 370
           888***************************************************************************************** PP
   S: 186  ............................................................................................ 185
                                                                                                       
   Q: 371  plglsasprlaaregqrfslslhseskvlilfcnlvgsgqqasrfgppfliredravswaqlqqsilskvrhlmkseapvqnlgslfsirvv 462
           ******************************************************************************************** PP
   S: 186  ..............................................................................slqdcLesftkeee 199
                                                                                         +l++c++ +tkee+
   Q: 463  glsvacsylspkdsrplchwavdrvlhlrrpggpphvklavewdssvkerlfgslqeeraqdadsvwqqqqahqqhscTLDECFQFYTKEEQ 554
           ******************************************************************************************** PP
   S: 200  legenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfctspeekqke................ 274
           l ++++++c++c+ +q+   kl+l++lP++Li+hLkRf   + +++r+k+++ v+fpl+ L+++p++++++++ +                 
   Q: 555  LAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRF--CQVGERRNKLSTLVKFPLSgLNMAPHVAQRSTSPEAglgpwpswkqpdclpt 644
           **************************************..88899************************7777766999999999999999* PP
   S: 275  ....kkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
               +  Y+L+av++H+G+l++GHY+ay++n  +g+W+ +dDs+V++++e+ev++   + aY+lfY++r
   Q: 645  syplDFLYDLYAVCNHHGNLQGGHYTAYCRNsLDGQWYSYDDSTVEPLREDEVNT---RGAYILFYQKR 710
           *999***************************55788*******************...********985 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).
 May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).
Protein Sequence
(Fasta)
MDLGPGDAAG GGPLAPRPRR RRSLRRLFSR FLLALGSRSR PGDSPPRPQP GHCDGDGEGG 60
FACAPGPVPA APGSPGEERP PGPQPQLQLP AGDGARPPGA QGLKNHGNTC FMNAVVQCLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045961|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAACCGCGTA GGGGGCGCGC CTGAGAGCCT GAAAACTTCC TGGTTAGCAA ATACTGAGGC 60
TGGAAAGGGC CTGAACTTGG CAGTCCATAG ATCCAGGTCG AGTTCCGGTT TCCCTGCTTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045961|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0019785--F:ISG15-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0019985--P:translesion synthesis
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:124739
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001922 Ailuropoda melanoleuca 78.15 0.00e+00 1451.00
IUUC-Aca-004436 Anolis carolinensis 53.87 0.00e+00 803.00
IUUC-Ame-011153 Astyanax mexicanus 50.63 0.00e+00 885.00
IUUC-Bta-013560 Bos taurus 80.14 0.00e+00 1583.00
IUUC-Cja-018737 Callithrix jacchus 92.98 0.00e+00 1877.00
IUUC-Cfa-020347 Canis familiaris 77.29 0.00e+00 1470.00
IUUC-Csa-023656 Chlorocebus sabaeus 98.45 0.00e+00 1961.00
IUUC-Cho-024864 Choloepus hoffmanni 72.16 0.00e+00 916.00
IUUC-Dre-028066 Danio rerio 50.09 0.00e+00 911.00
IUUC-Dno-028855 Dasypus novemcinctus 72.92 0.00e+00 1364.00
IUUC-Dor-030475 Dipodomys ordii 88.30 0.00e+00 722.00
IUUC-Dme-032088 Drosophila melanogaster 36.54 2.00e-110 394.00
IUUC-Eca-034147 Equus caballus 85.61 0.00e+00 1476.00
IUUC-Eeu-034703 Erinaceus europaeus 62.15 0.00e+00 753.00
IUUC-Fca-036550 Felis catus 74.70 0.00e+00 1257.00
IUUC-Gac-042087 Gasterosteus aculeatus 51.74 0.00e+00 897.00
IUUC-Ggo-045171 Gorilla gorilla 99.81 0.00e+00 1982.00
IUUC-Itr-048673 Ictidomys tridecemlineatus 75.14 0.00e+00 682.00
IUUC-Loc-052852 Lepisosteus oculatus 62.81 0.00e+00 928.00
IUUC-Laf-054033 Loxodonta africana 78.66 0.00e+00 1552.00
IUUC-Mcc-055431 Macaca mulatta 97.76 0.00e+00 1963.00
IUUC-Mmr-061035 Microcebus murinus 87.09 0.00e+00 1684.00
IUUC-Mdo-062172 Monodelphis domestica 66.71 0.00e+00 970.00
IUUC-Mmu-063966 Mus musculus 80.42 0.00e+00 1574.00
IUUC-Mpu-066307 Mustela putorius furo 78.75 0.00e+00 1424.00
IUUC-Nle-070172 Nomascus leucogenys 98.60 0.00e+00 1972.00
IUUC-Opr-070499 Ochotona princeps 74.61 0.00e+00 1402.00
IUUC-Ont-071920 Oreochromis niloticus 52.56 0.00e+00 946.00
IUUC-Ocu-074014 Oryctolagus cuniculus 83.82 0.00e+00 1217.00
IUUC-Ola-086360 Oryzias latipes 52.76 0.00e+00 944.00
IUUC-Oga-088202 Otolemur garnettii 84.10 0.00e+00 1696.00
IUUC-Oar-089819 Ovis aries 77.99 0.00e+00 1486.00
IUUC-Ptr-091076 Pan troglodytes 99.63 0.00e+00 1987.00
IUUC-Pan-092248 Papio anubis 98.06 0.00e+00 1946.00
IUUC-Pfo-096534 Poecilia formosa 60.15 0.00e+00 820.00
IUUC-Pab-098453 Pongo abelii 96.93 0.00e+00 1909.00
IUUC-Pca-100290 Procavia capensis 63.53 0.00e+00 728.00
IUUC-Pva-102317 Pteropus vampyrus 74.19 0.00e+00 1407.00
IUUC-Rno-104948 Rattus norvegicus 78.42 0.00e+00 1412.00
IUUC-Sha-106558 Sarcophilus harrisii 57.30 0.00e+00 1143.00
IUUC-Sar-113105 Sorex araneus 64.30 0.00e+00 1067.00
IUUC-Ssc-115312 Sus scrofa 80.37 0.00e+00 1565.00
IUUC-Tru-117995 Takifugu rubripes 62.95 0.00e+00 906.00
IUUC-Tsy-119325 Tarsius syrichta 77.98 0.00e+00 771.00
IUUC-Tni-120517 Tetraodon nigroviridis 57.85 0.00e+00 860.00
IUUC-Tbe-127439 Tupaia belangeri 71.90 6.00e-144 505.00
IUUC-Ttr-128829 Tursiops truncatus 73.06 0.00e+00 1396.00
IUUC-Vpa-130306 Vicugna pacos 81.86 0.00e+00 634.00
Created Date 25-Jun-2017

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