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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063799
Ensembl Protein ID ENSMUSP00000146638.1
UniProt Accession Q80VP1; O70446; Q6NX78; EPN1_MOUSE
Genbank Protein ID AAH46962.2; AAH67206.1; AAH99682.1; AAC97475.1
Protein Name Epsin-1; EPS-15-interacting protein 1; Intersectin-EH-binding protein 1
Genbank Nucleotide ID BC046962; BC067206; BC099682; AF057285
Gene Name Epn1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000035203.16 ENSMUST00000098845.9 ENSMUSP00000096445.3
ENSMUSG00000035203.16 ENSMUST00000208634.1 ENSMUSP00000146638.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/UIM 1.80e-08 34.6 183 201
UBD/Alpha-Helix/UIM 0.00024 12.9 208 226
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEeee 19
           +E+++LqlAla+S++E+++
   Q: 183  EEELQLQLALAMSKEEADQ 201
           79**************987 PP
   

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEeee 19
           ++d +LqlAl lS++E+++
   Q: 208  EDDVQLQLALSLSREEHDK 226
           699*************985 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.
 Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.
Protein Sequence
(Fasta)
MSTSSLRRQM KNIVHNYSEA EIKVREATSN DPWGPSSSLM SEIADLTYNV VAFSEIMSMI 60
WKRLNDHGKN WRHVYKAMTL MEYLIKTGSE RVSQQCKENM YAVQTLKDFQ YVDRDGKDQG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063799|UBD,UIM|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCGCTGCCAC CTTCGGTTGC TTCCCGTCCG CTCGGCGGCT CCCCTCCCCC GCCCGGCTCT 60
CTGCGCCCCT CCCGGGCGCC GGGGCGGCGG GGCCGTCGCT GTGCGGCCCT CCGTGCGTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063799|UBD,UIM|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0168--Coated pit
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR013809--ENTH
IPR008942--ENTH_VHS
IPR003903--UIM_dom
PROSITE

PS50942--ENTH
PS50330--UIM
Pfam

PF01417--ENTH
PF02809--UIM
SMART

SM00273--ENTH
SM00726--UIM
Gene Ontology

GO:0005905--C:clathrin-coated pit
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0008289--F:lipid binding
GO:0048568--P:embryonic organ development
GO:0006897--P:endocytosis
GO:0007565--P:female pregnancy
GO:0001701--P:in utero embryonic development
GO:0007219--P:Notch signaling pathway
KEGG mmu:13854
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002304 Ailuropoda melanoleuca 93.82 0.00e+00 765.00
IUUC-Atr-002956 Amborella trichopoda 47.65 1.00e-41 164.00
IUUC-Aca-005208 Anolis carolinensis 64.82 9.00e-166 577.00
IUUC-Ame-011460 Astyanax mexicanus 78.36 5.00e-101 362.00
IUUC-Bta-013352 Bos taurus 92.71 0.00e+00 724.00
IUUC-Cel-018350 Caenorhabditis elegans 41.19 1.00e-74 273.00
IUUC-Cfa-020367 Canis familiaris 93.92 0.00e+00 757.00
IUUC-Csa-023208 Chlorocebus sabaeus 94.44 0.00e+00 743.00
IUUC-Dre-028015 Danio rerio 74.82 5.00e-104 372.00
IUUC-Dno-029947 Dasypus novemcinctus 91.30 4.00e-173 601.00
IUUC-Dor-030137 Dipodomys ordii 100.00 3.00e-120 425.00
IUUC-Dme-032149 Drosophila melanogaster 39.90 8.00e-85 308.00
IUUC-Eca-034189 Equus caballus 94.79 0.00e+00 783.00
IUUC-Fca-036270 Felis catus 93.75 0.00e+00 781.00
IUUC-Fso-038083 Fusarium solani 40.43 3.00e-41 162.00
IUUC-Gac-042085 Gasterosteus aculeatus 76.12 2.00e-97 349.00
IUUC-Hsa-046033 Homo sapiens 94.79 0.00e+00 726.00
IUUC-Itr-048041 Ictidomys tridecemlineatus 95.31 0.00e+00 773.00
IUUC-Kpa-049233 Komagataella pastoris 37.87 2.00e-35 144.00
IUUC-Laf-054571 Loxodonta africana 94.79 0.00e+00 778.00
IUUC-Mcc-055036 Macaca mulatta 94.97 0.00e+00 724.00
IUUC-Meu-056308 Macropus eugenii 82.72 2.00e-100 359.00
IUUC-Mtr-058328 Medicago truncatula 49.66 7.00e-43 169.00
IUUC-Mmr-060634 Microcebus murinus 93.58 0.00e+00 779.00
IUUC-Mdo-062555 Monodelphis domestica 99.12 4.00e-102 365.00
IUUC-Mac-064643 Musa acuminata 50.00 3.00e-43 170.00
IUUC-Mpu-066803 Mustela putorius furo 93.23 0.00e+00 776.00
IUUC-Mlu-067895 Myotis lucifugus 81.63 1.00e-96 347.00
IUUC-Nle-069810 Nomascus leucogenys 94.59 0.00e+00 704.00
IUUC-Opr-071138 Ochotona princeps 85.92 3.00e-130 458.00
IUUC-Ont-071888 Oreochromis niloticus 54.03 4.00e-111 395.00
IUUC-Ola-087447 Oryzias latipes 52.40 1.00e-111 397.00
IUUC-Oga-088369 Otolemur garnettii 92.71 0.00e+00 791.00
IUUC-Oar-090071 Ovis aries 84.97 2.00e-154 538.00
IUUC-Ptr-091336 Pan troglodytes 90.28 0.00e+00 627.00
IUUC-Pan-091921 Papio anubis 94.79 0.00e+00 723.00
IUUC-Ppa-095284 Physcomitrella patens 48.99 4.00e-44 173.00
IUUC-Pfo-097111 Poecilia formosa 56.11 1.00e-106 380.00
IUUC-Pab-098722 Pongo abelii 94.62 0.00e+00 773.00
IUUC-Pca-100297 Procavia capensis 85.76 0.00e+00 724.00
IUUC-Pva-102305 Pteropus vampyrus 83.40 5.00e-176 610.00
IUUC-Rno-104941 Rattus norvegicus 99.13 0.00e+00 788.00
IUUC-Spo-108319 Schizosaccharomyces pombe 51.85 6.00e-41 162.00
IUUC-Smo-109370 Selaginella moellendorffii 49.02 3.00e-40 158.00
IUUC-Tru-117791 Takifugu rubripes 60.49 1.00e-92 333.00
IUUC-Ttr-128384 Tursiops truncatus 92.80 0.00e+00 657.00
IUUC-Xtr-131804 Xenopus tropicalis 61.82 1.00e-159 556.00
Created Date 25-Jun-2017

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