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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045887
Ensembl Protein ID ENSP00000307272.3
UniProt Accession Q8N122; B2RN36; C6KEF2; F5H7J5; Q8N4V9; Q8TB32; Q9P2P3; RPTOR_HUMAN
Genbank Protein ID AAM09075.1; BAC06490.1; EAW89618.1; AAH25180.1; AAH33258.1; AAH64515.1; AAI36653.1; AAI36655.1; BAA92541.1; ACS44766.1
Protein Name Regulatory-associated protein of mTOR; p150 target of rapamycin (TOR)-scaffold protein
Genbank Nucleotide ID AY090663; AB082951; AC016245; BC025180; BC033258; BC064515; BC136652; BC136654; AB037724; GQ183898
Gene Name RPTOR; KIAA1303; RAPTOR
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000141564.13 ENST00000574767.5 ENSP00000459701.1
ENSG00000141564.13 ENST00000306801.7 ENSP00000307272.3
ENSG00000141564.13 ENST00000544334.6 ENSP00000442479.2
ENSG00000141564.13 ENST00000576366.1 ENSP00000460940.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
AREsitecircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanmiRecordsRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.40e-14 54.5 1302 1330
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 4    dsvtclaf.sd.tllvsGsdDgtikvWDl 30
           + ++claf +  ++l++Gs+D  i v+++
   Q: 1302 GAISCLAFhPHwPHLAVGSNDYYISVYSV 1330
           679******888**************997 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.
 Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.
Protein Sequence
(Fasta)
MESEMLQSPL LGLGEEDEAD LTDWNLPLAF MKKRHCEKIE GSKSLAQSWR MKDRMKTVSV 60
ALVLCLNVGV DPPDVVKTTP CARLECWIDP LSMGPQKALE TIGANLQKQY ENWQPRARYK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045887|E3,WD_repeat|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGGCCGCGGT GCATTCTGGG TCCTGGCAAT ATGGCGTCCT CCTTGATGGG CTGATGAGAT 60
GAGTTTCACT GTAGCTCCAA ACCAGAGGGC AAAGCTCCCA TGACCCAATA AGCCCACATT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045887|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0458--Lysosome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR029030--Caspase-like_dom
IPR000357--HEAT
IPR004083--Raptor
IPR029347--Raptor_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50294--WD_REPEATS_REGION
Pfam

PF02985--HEAT
PF14538--Raptor_N
PF00400--WD40
SMART

SM01302--Raptor_N
SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0010494--C:cytoplasmic stress granule
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0031931--C:TORC1 complex
GO:0071889--F:14-3-3 protein binding
GO:0030674--F:protein binding, bridging
GO:0032403--F:protein complex binding
GO:0030295--F:protein kinase activator activity
GO:0019901--F:protein kinase binding
GO:0030291--F:protein serine/threonine kinase inhibitor activity
GO:0001030--F:RNA polymerase III type 1 promoter DNA binding
GO:0001031--F:RNA polymerase III type 2 promoter DNA binding
GO:0001032--F:RNA polymerase III type 3 promoter DNA binding
GO:0001156--F:TFIIIC-class transcription factor binding
GO:0007050--P:cell cycle arrest
GO:0016049--P:cell growth
GO:0071230--P:cellular response to amino acid stimulus
GO:0031669--P:cellular response to nutrient levels
GO:0009267--P:cellular response to starvation
GO:0016236--P:macroautophagy
GO:0030307--P:positive regulation of cell growth
GO:0001938--P:positive regulation of endothelial cell proliferation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0032008--P:positive regulation of TOR signaling
GO:0045945--P:positive regulation of transcription from RNA polymerase III promoter
GO:0010506--P:regulation of autophagy
GO:0008361--P:regulation of cell size
GO:1900034--P:regulation of cellular response to heat
GO:0031929--P:TOR signaling
GO:0038202--P:TORC1 signaling
KEGG hsa:57521
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000354 Aegilops tauschii 57.30 0.00e+00 674.00
IUUC-Aml-001499 Ailuropoda melanoleuca 95.96 0.00e+00 2541.00
IUUC-Atr-002704 Amborella trichopoda 59.91 0.00e+00 734.00
IUUC-Apl-003540 Anas platyrhynchos 93.54 0.00e+00 2494.00
IUUC-Aca-004449 Anolis carolinensis 95.17 0.00e+00 1363.00
IUUC-Aly-006524 Arabidopsis lyrata 59.02 0.00e+00 761.00
IUUC-Ath-007688 Arabidopsis thaliana 40.84 0.00e+00 884.00
IUUC-Ago-007709 Ashbya gossypii 56.47 5.00e-118 419.00
IUUC-Acl-008215 Aspergillus clavatus 55.80 0.00e+00 769.00
IUUC-Afl-008401 Aspergillus flavus 54.65 0.00e+00 770.00
IUUC-Afu-008797 Aspergillus fumigatus 56.09 0.00e+00 772.00
IUUC-Ani-009268 Aspergillus nidulans 57.19 0.00e+00 762.00
IUUC-Ang-009608 Aspergillus niger 56.20 0.00e+00 761.00
IUUC-Aor-009894 Aspergillus oryzae 54.65 0.00e+00 771.00
IUUC-Ate-010357 Aspergillus terreus 55.71 0.00e+00 771.00
IUUC-Ame-011186 Astyanax mexicanus 86.04 0.00e+00 2114.00
IUUC-Bgr-012085 Blumeria graminis 52.37 0.00e+00 673.00
IUUC-Bta-013422 Bos taurus 96.48 0.00e+00 2577.00
IUUC-Bci-013736 Botrytis cinerea 54.28 0.00e+00 712.00
IUUC-Bdi-015042 Brachypodium distachyon 49.62 0.00e+00 706.00
IUUC-Bol-016048 Brassica oleracea 59.11 0.00e+00 763.00
IUUC-Bra-016961 Brassica rapa 57.16 0.00e+00 776.00
IUUC-Cel-018321 Caenorhabditis elegans 45.31 2.00e-100 361.00
IUUC-Cja-018939 Callithrix jacchus 98.35 0.00e+00 2603.00
IUUC-Cfa-020898 Canis familiaris 95.96 0.00e+00 2544.00
IUUC-Cpo-021514 Cavia porcellus 96.93 0.00e+00 2563.00
IUUC-Cre-022818 Chlamydomonas reinhardtii 63.64 8.00e-111 393.00
IUUC-Csa-023314 Chlorocebus sabaeus 99.70 0.00e+00 2642.00
IUUC-Cin-025701 Ciona intestinalis 71.35 0.00e+00 1002.00
IUUC-Csv-026362 Ciona savignyi 72.09 0.00e+00 996.00
IUUC-Cgl-026561 Colletotrichum gloeosporioides 54.23 0.00e+00 679.00
IUUC-Cne-027009 Cryptococcus neoformans 47.87 0.00e+00 669.00
IUUC-Cme-027253 Cyanidioschyzon merolae 56.36 3.00e-137 484.00
IUUC-Dre-028485 Danio rerio 85.79 0.00e+00 2367.00
IUUC-Dno-029901 Dasypus novemcinctus 93.85 0.00e+00 2306.00
IUUC-Dor-030140 Dipodomys ordii 92.38 0.00e+00 2263.00
IUUC-Dse-031462 Dothistroma septosporum 50.00 0.00e+00 691.00
IUUC-Dme-031670 Drosophila melanogaster 64.23 0.00e+00 867.00
IUUC-Ete-032578 Echinops telfairi 73.78 0.00e+00 770.00
IUUC-Eca-034076 Equus caballus 96.48 0.00e+00 2571.00
IUUC-Eeu-035140 Erinaceus europaeus 92.59 0.00e+00 1166.00
IUUC-Fca-035651 Felis catus 96.10 0.00e+00 2553.00
IUUC-Fal-037244 Ficedula albicollis 93.63 0.00e+00 2458.00
IUUC-Fox-037742 Fusarium oxysporum 54.17 0.00e+00 683.00
IUUC-Fso-038369 Fusarium solani 55.50 0.00e+00 632.00
IUUC-Gmo-039007 Gadus morhua 79.71 0.00e+00 1813.00
IUUC-Ggr-039836 Gaeumannomyces graminis 53.56 0.00e+00 692.00
IUUC-Gga-041121 Gallus gallus 92.36 0.00e+00 2502.00
IUUC-Gac-041430 Gasterosteus aculeatus 87.46 0.00e+00 2333.00
IUUC-Gma-043160 Glycine max 57.79 0.00e+00 771.00
IUUC-Ggo-044934 Gorilla gorilla 99.86 0.00e+00 1434.00
IUUC-Hvu-047823 Hordeum vulgare 42.27 0.00e+00 805.00
IUUC-Itr-048274 Ictidomys tridecemlineatus 96.42 0.00e+00 786.00
IUUC-Kpa-049399 Komagataella pastoris 59.26 6.00e-125 442.00
IUUC-Lch-050405 Latimeria chalumnae 90.72 0.00e+00 2465.00
IUUC-Lpe-050864 Leersia perrieri 64.39 2.00e-151 529.00
IUUC-Loc-051868 Lepisosteus oculatus 83.65 0.00e+00 2273.00
IUUC-Lma-052993 Leptosphaeria maculans 52.39 0.00e+00 754.00
IUUC-Laf-053339 Loxodonta africana 96.30 0.00e+00 1849.00
IUUC-Mcc-055591 Macaca mulatta 99.70 0.00e+00 2642.00
IUUC-Meu-056642 Macropus eugenii 85.02 0.00e+00 1197.00
IUUC-Mor-057204 Magnaporthe oryzae 53.38 0.00e+00 704.00
IUUC-Mpo-057532 Magnaporthe poae 53.39 0.00e+00 690.00
IUUC-Mtr-058553 Medicago truncatula 42.14 0.00e+00 917.00
IUUC-Mla-058907 Melampsora laricipopulina 44.64 1.00e-150 528.00
IUUC-Mga-059256 Meleagris gallopavo 93.94 0.00e+00 2517.00
IUUC-Mvi-060457 Microbotryum violaceum 49.66 0.00e+00 665.00
IUUC-Mmr-060874 Microcebus murinus 94.07 0.00e+00 2479.00
IUUC-Mdo-062436 Monodelphis domestica 93.56 0.00e+00 2498.00
IUUC-Mmu-063264 Mus musculus 96.63 0.00e+00 2617.00
IUUC-Mac-065524 Musa acuminata 42.04 0.00e+00 840.00
IUUC-Mpu-065899 Mustela putorius furo 94.77 0.00e+00 2326.00
IUUC-Mlu-067344 Myotis lucifugus 94.18 0.00e+00 1911.00
IUUC-Nfi-068615 Neosartorya fischeri 56.09 0.00e+00 771.00
IUUC-Ncr-068744 Neurospora crassa 53.67 0.00e+00 679.00
IUUC-Nle-069014 Nomascus leucogenys 98.95 0.00e+00 2614.00
IUUC-Opr-070548 Ochotona princeps 84.62 0.00e+00 1335.00
IUUC-Ont-072485 Oreochromis niloticus 88.32 0.00e+00 2359.00
IUUC-Oan-073253 Ornithorhynchus anatinus 91.64 0.00e+00 689.00
IUUC-Ocu-074290 Oryctolagus cuniculus 93.76 0.00e+00 810.00
IUUC-Oba-075130 Oryza barthii 56.69 0.00e+00 713.00
IUUC-Obr-076161 Oryza brachyantha 49.71 0.00e+00 756.00
IUUC-Ogl-077800 Oryza glaberrima 51.88 0.00e+00 753.00
IUUC-Ogu-078292 Oryza glumaepatula 64.66 4.00e-47 182.00
IUUC-Oin-080126 Oryza indica 47.45 0.00e+00 648.00
IUUC-Olo-080598 Oryza longistaminata 33.92 4.00e-36 146.00
IUUC-Ome-081293 Oryza meridionalis 48.35 3.00e-141 496.00
IUUC-Oni-082236 Oryza nivara 58.63 3.00e-83 304.00
IUUC-Opu-083423 Oryza punctata 51.33 0.00e+00 742.00
IUUC-Oru-085086 Oryza rufipogon 49.13 0.00e+00 686.00
IUUC-Osa-086012 Oryza sativa 50.99 0.00e+00 722.00
IUUC-Ola-086662 Oryzias latipes 86.66 0.00e+00 2028.00
IUUC-Olu-087760 Ostreococcus lucimarinus 38.88 0.00e+00 807.00
IUUC-Oga-088053 Otolemur garnettii 96.78 0.00e+00 2435.00
IUUC-Oar-089466 Ovis aries 92.58 0.00e+00 2547.00
IUUC-Ptr-090868 Pan troglodytes 99.25 0.00e+00 2638.00
IUUC-Pan-092259 Papio anubis 99.70 0.00e+00 2642.00
IUUC-Psi-093641 Pelodiscus sinensis 92.94 0.00e+00 2327.00
IUUC-Pno-094789 Phaeosphaeria nodorum 51.73 0.00e+00 716.00
IUUC-Ppa-095979 Physcomitrella patens 57.58 0.00e+00 758.00
IUUC-Pfo-096837 Poecilia formosa 86.55 0.00e+00 2357.00
IUUC-Pab-097545 Pongo abelii 99.57 0.00e+00 1308.00
IUUC-Pop-099059 Populus trichocarpa 62.18 0.00e+00 754.00
IUUC-Pca-100579 Procavia capensis 69.85 5.00e-178 619.00
IUUC-Ppe-101494 Prunus persica 58.40 0.00e+00 784.00
IUUC-Pva-103245 Pteropus vampyrus 85.05 0.00e+00 1801.00
IUUC-Pgr-103460 Puccinia graminis 47.12 5.00e-49 190.00
IUUC-Ptt-103797 Puccinia triticina 35.21 5.00e-65 244.00
IUUC-Pte-104367 Pyrenophora teres 52.64 0.00e+00 745.00
IUUC-Pyt-104771 Pyrenophora triticirepentis 49.58 0.00e+00 694.00
IUUC-Rno-104965 Rattus norvegicus 96.78 0.00e+00 2619.00
IUUC-Sce-106156 Saccharomyces cerevisiae 55.61 2.00e-119 424.00
IUUC-Sha-106474 Sarcophilus harrisii 93.18 0.00e+00 1986.00
IUUC-Sja-107888 Schizosaccharomyces japonicus 57.83 0.00e+00 771.00
IUUC-Spo-108057 Schizosaccharomyces pombe 56.94 0.00e+00 756.00
IUUC-Ssl-108423 Sclerotinia sclerotiorum 54.53 0.00e+00 717.00
IUUC-Smo-109363 Selaginella moellendorffii 57.70 0.00e+00 778.00
IUUC-Sit-109884 Setaria italica 41.37 0.00e+00 864.00
IUUC-Sly-110910 Solanum lycopersicum 56.29 0.00e+00 772.00
IUUC-Stu-112814 Solanum tuberosum 55.87 0.00e+00 763.00
IUUC-Sbi-114349 Sorghum bicolor 58.45 0.00e+00 744.00
IUUC-Sre-115168 Sporisorium reilianum 42.83 0.00e+00 684.00
IUUC-Ssc-115398 Sus scrofa 93.06 0.00e+00 1906.00
IUUC-Tgu-117361 Taeniopygia guttata 92.99 0.00e+00 2400.00
IUUC-Tsy-119587 Tarsius syrichta 99.29 0.00e+00 1160.00
IUUC-Tni-119757 Tetraodon nigroviridis 86.16 0.00e+00 2301.00
IUUC-Tca-121570 Theobroma cacao 62.61 0.00e+00 762.00
IUUC-Tre-122024 Trichoderma reesei 56.32 0.00e+00 641.00
IUUC-Tvi-122502 Trichoderma virens 55.83 0.00e+00 645.00
IUUC-Tae-125799 Triticum aestivum 58.18 0.00e+00 755.00
IUUC-Tme-127001 Tuber melanosporum 55.88 2.00e-155 543.00
IUUC-Ttr-129128 Tursiops truncatus 87.34 0.00e+00 2248.00
IUUC-Uma-129588 Ustilago maydis 44.93 0.00e+00 684.00
IUUC-Vda-129990 Verticillium dahliae 53.58 1.00e-179 624.00
IUUC-Vvi-131611 Vitis vinifera 42.15 0.00e+00 915.00
IUUC-Xtr-132727 Xenopus tropicalis 90.92 0.00e+00 2438.00
IUUC-Xma-133492 Xiphophorus maculatus 87.96 0.00e+00 2377.00
IUUC-Yli-134358 Yarrowia lipolytica 55.64 0.00e+00 696.00
IUUC-Zma-135723 Zea mays 57.62 0.00e+00 678.00
Created Date 25-Jun-2017

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